{"entity": "researcher", "timestamp": "2026-04-12T02:46:11.924Z", "family": "Gl\u00e9min", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-7260-4573", "affiliations": ["Department of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden", "ECOBIO UMR 6553 CNRS University of Rennes 1, Rennes, France"], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/29fc40d151df40ada3c5caf7ddc6049f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/29fc40d151df40ada3c5caf7ddc6049f"}}, "publications": [{"entity": "publication", "iuid": "e2e00852af6d4402b419bbb2fc4b3041", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e2e00852af6d4402b419bbb2fc4b3041.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e2e00852af6d4402b419bbb2fc4b3041"}}, "title": "How broad is the selfing syndrome? Insights from convergent evolution of gene expression across species and tissues in the Capsella genus.", "authors": [{"family": "Zhang", "given": "Zebin", "initials": "Z", "orcid": "0000-0002-9828-4245", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12a87b7eb74b4f9889755dd7c54670fe.json"}}, {"family": "Kryvokhyzha", "given": "Dmytro", "initials": "D", "orcid": "0000-0001-6498-1977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a652c836aef945e08076f3ddc88debf2.json"}}, {"family": "Orsucci", "given": "Marion", "initials": "M", "orcid": "0000-0001-8516-1361", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/44bddb691cd349b19e8111c778f51402.json"}}, {"family": "Gl\u00e9min", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-7260-4573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29fc40d151df40ada3c5caf7ddc6049f.json"}}, {"family": "Milesi", "given": "Pascal", "initials": "P", "orcid": "0000-0001-8580-4291", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6025546b69354721b8a16fbe8124fa71.json"}}, {"family": "Lascoux", "given": "Martin", "initials": "M", "orcid": "0000-0003-1699-9042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0730d0f9c2524eb19383640612924701.json"}}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "New Phytol.", "issn": "1469-8137", "volume": "236", "issue": "6", "pages": "2344-2357", "issn-l": "0028-646X"}, "abstract": "The shift from outcrossing to selfing is one of the main evolutionary transitions in plants. It is accompanied by profound effects on reproductive traits, the so-called selfing syndrome. Because the transition to selfing also implies deep genomic and ecological changes, one also expects to observe a genomic selfing syndrome. We took advantage of the three independent transitions from outcrossing to selfing in the Capsella genus to characterize the overall impact of mating system change on RNA expression, in flowers but also in leaves and roots. We quantified the extent of both selfing and genomic syndromes, and tested whether changes in expression corresponded to adaptation to selfing or to relaxed selection on traits that were constrained in outcrossers. Mating system change affected gene expression in all three tissues but more so in flowers than in roots and leaves. Gene expression in selfing species tended to converge in flowers but diverged in the two other tissues. Hence, convergent adaptation to selfing dominates in flowers, whereas genetic drift plays a more important role in leaves and roots. The effect of mating system transition is not limited to reproductive tissues and corresponds to both adaptation to selfing and relaxed selection on previously constrained traits.", "doi": "10.1111/nph.18477", "pmid": "36089898", "labels": {"Pascal Milesi": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2022-12-05T11:42:07.190Z", "modified": "2022-12-05T11:42:07.262Z"}, {"entity": "publication", "iuid": "507cb5965e7e4e1e9fba4ac0432de139", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/507cb5965e7e4e1e9fba4ac0432de139.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/507cb5965e7e4e1e9fba4ac0432de139"}}, "title": "Shift in ecological strategy helps marginal populations of shepherd's purse (Capsella bursa-pastoris) to overcome a high genetic load.", "authors": [{"family": "Orsucci", "given": "Marion", "initials": "M", "orcid": "0000-0001-8516-1361", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/44bddb691cd349b19e8111c778f51402.json"}}, {"family": "Milesi", "given": "Pascal", "initials": "P"}, {"family": "Hansen", "given": "Johanna", "initials": "J"}, {"family": "Girodolle", "given": "Johanna", "initials": "J"}, {"family": "Gl\u00e9min", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-7260-4573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29fc40d151df40ada3c5caf7ddc6049f.json"}}, {"family": "Lascoux", "given": "Martin", "initials": "M"}], "type": "journal article", "published": "2020-05-27", "journal": {"title": "Proc. Biol. Sci.", "issn": "1471-2954", "issn-l": "0962-8452", "volume": "287", "issue": "1927", "pages": "20200463"}, "abstract": "The outcome of species range expansion depends on the interplay of demographic, environmental and genetic factors. Self-fertilizing species usually show a higher invasive ability than outcrossers but selfing and bottlenecks during colonization also lead to an increased genetic load. The relationship between genomic and phenotypic characteristics of expanding populations has, hitherto, rarely been tested experimentally. We analysed how accessions of the shepherd's purse, Capsella bursa-pastoris, from the colonization front or from the core of the natural range performed under increasing density of competitors. First, accessions from the front showed a lower fitness than those from the core. Second, for all accessions, competitor density impacted negatively both vegetative growth and fruit production. However, despite their higher genetic load and lower absolute performances, accessions from the front were less affected by competition than accessions from the core. This seems to be due to phenotypic trade-offs and a shift in phenology that allow accessions from the front to avoid competition.", "doi": "10.1098/rspb.2020.0463", "pmid": "32429810", "labels": {"Pascal Milesi": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC7287375"}, {"db": "Dryad", "key": "10.5061/dryad.vt4b8gtp7"}, {"db": "figshare", "key": "10.6084/m9.figshare.c.4955732"}], "notes": [], "created": "2020-11-30T09:24:19.300Z", "modified": "2022-11-04T11:32:14.955Z"}, {"entity": "publication", "iuid": "0925f34589a94b1494a38847a10e5780", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0925f34589a94b1494a38847a10e5780.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0925f34589a94b1494a38847a10e5780"}}, "title": "Towards the new normal: Transcriptomic convergence and genomic legacy of the two subgenomes of an allopolyploid weed (Capsella bursa-pastoris).", "authors": [{"family": "Kryvokhyzha", "given": "Dmytro", "initials": "D", "orcid": "0000-0001-6498-1977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a652c836aef945e08076f3ddc88debf2.json"}}, {"family": "Milesi", "given": "Pascal", "initials": "P"}, {"family": "Duan", "given": "Tianlin", "initials": "T", "orcid": "0000-0002-8719-7998", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c891d186a1b477797a361d72494aaac.json"}}, {"family": "Orsucci", "given": "Marion", "initials": "M", "orcid": "0000-0001-8516-1361", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/44bddb691cd349b19e8111c778f51402.json"}}, {"family": "Wright", "given": "Stephen I", "initials": "SI", "orcid": "0000-0001-9973-9697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bac777ee8504c9188f056cc20a1919d.json"}}, {"family": "Gl\u00e9min", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-7260-4573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29fc40d151df40ada3c5caf7ddc6049f.json"}}, {"family": "Lascoux", "given": "Martin", "initials": "M", "orcid": "0000-0003-1699-9042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0730d0f9c2524eb19383640612924701.json"}}], "type": "journal article", "published": "2019-05-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "issn-l": "1553-7390", "volume": "15", "issue": "5", "pages": "e1008131"}, "abstract": "Allopolyploidy has played a major role in plant evolution but its impact on genome diversity and expression patterns remains to be understood. Some studies found important genomic and transcriptomic changes in allopolyploids, whereas others detected a strong parental legacy and more subtle changes. The allotetraploid C. bursa-pastoris originated around 100,000 years ago and one could expect the genetic polymorphism of the two subgenomes to follow similar trajectories and their transcriptomes to start functioning together. To test this hypothesis, we sequenced the genomes and the transcriptomes (three tissues) of allotetraploid C. bursa-pastoris and its parental species, the outcrossing C. grandiflora and the self-fertilizing C. orientalis. Comparison of the divergence in expression between subgenomes, on the one hand, and divergence in expression between the parental species, on the other hand, indicated a strong parental legacy with a majority of genes exhibiting a conserved pattern and cis-regulation. However, a large proportion of the genes that were differentially expressed between the two subgenomes, were also under trans-regulation reflecting the establishment of a new regulatory pattern. Parental dominance varied among tissues: expression in flowers was closer to that of C. orientalis and expression in root and leaf to that of C. grandiflora. Since deleterious mutations accumulated preferentially on the C. orientalis subgenome, the bias in expression towards C. orientalis observed in flowers indicates that expression changes could be adaptive and related to the selfing syndrome, while biases in the roots and leaves towards the C. grandiflora subgenome may be reflective of the differential genetic load.", "doi": "10.1371/journal.pgen.1008131", "pmid": "31083657", "labels": {"Pascal Milesi": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "PGENETICS-D-18-02366"}, {"db": "pmc", "key": "PMC6532933"}], "notes": [], "created": "2020-11-30T09:18:19.866Z", "modified": "2022-11-04T11:32:16.505Z"}]}