{"entity": "researcher", "timestamp": "2026-08-20T21:12:15.782Z", "family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22"}}, "publications": [{"entity": "publication", "iuid": "327b76ce89e14812bcff35c6b96d4942", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/327b76ce89e14812bcff35c6b96d4942.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/327b76ce89e14812bcff35c6b96d4942"}}, "title": "The association between the gut microbiome and 24-hour blood pressure measurements in the SCAPIS study", "authors": [{"family": "Lin", "given": "Yi Ting", "initials": "YT", "orcid": "0000-0002-5833-0040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36368cfa632140839b84bc166dd09b1a.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Holm", "given": "Jacob B", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": 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"given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2023-12-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.12.08.23299598", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:50:52.048Z", "modified": "2026-08-20T10:50:52.175Z"}, {"entity": "publication", "iuid": "8af06b272b154fac9f50b3bc455e6b3e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8af06b272b154fac9f50b3bc455e6b3e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8af06b272b154fac9f50b3bc455e6b3e"}}, "title": "Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort.", "authors": [{"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF"}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G"}, {"family": "J\u00f6nsson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-8298-539X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6a28f0ea6264c3893bbd362355ec85c.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Lin", "given": "Yi-Ting", "initials": "YT"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-3873-7943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13bd5f11f5cc4420a1c57183bb8323c9.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Pita", "given": "Sara", "initials": "S", "orcid": "0000-0002-5163-7306", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc61e356bdb84493813be139de58922a.json"}}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Holm", "given": "Jacob B", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Ericson", "given": "Ulrika", "initials": "U"}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Ottosson", "given": "Filip", "initials": "F"}, {"family": "Larsson", "given": "Anna", "initials": "A"}, {"family": "Ericson", "given": "Dan", "initials": "D", "orcid": "0000-0003-0356-2351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a89ea38f5bb6487abe6f6973a3886019.json"}}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Nilsson", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1fa67d262984bccbb6b45e913a09393.json"}}, {"family": "Malinovschi", "given": "Andrei", "initials": "A", "orcid": "0000-0002-4098-7765", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/394a2f4dcf5847ce98e1c758f5c4d710.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d414b3352a4540a68227ca7eec73cfa6.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "journal article", "published": "2023-08-08", "journal": {"title": "Circulation", "issn": "1524-4539", "volume": "148", "issue": "6", "pages": "459-472", "issn-l": "0009-7322"}, "abstract": "Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis and to explore relevant clinical correlates.\n\nWe conducted a cross-sectional study of 8973 participants (50 to 65 years of age) without overt atherosclerotic disease from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study). Coronary atherosclerosis was measured using coronary artery calcium score and coronary computed tomography angiography. Gut microbiota species abundance and functional potential were assessed with shotgun metagenomics sequencing of fecal samples, and associations with coronary atherosclerosis were evaluated with multivariable regression models adjusted for cardiovascular risk factors. Associated species were evaluated for association with inflammatory markers, metabolites, and corresponding species in saliva.\n\nThe mean age of the study sample was 57.4 years, and 53.7% were female. Coronary artery calcification was detected in 40.3%, and 5.4% had at least 1 stenosis with >50% occlusion. Sixty-four species were associated with coronary artery calcium score independent of cardiovascular risk factors, with the strongest associations observed for Streptococcus anginosus and Streptococcus oralis subsp oralis (P<1\u00d710-5). Associations were largely similar across coronary computed tomography angiography-based measurements. Out of the 64 species, 19 species, including streptococci and other species commonly found in the oral cavity, were associated with high-sensitivity C-reactive protein plasma concentrations, and 16 with neutrophil counts. Gut microbial species that are commonly found in the oral cavity were negatively associated with plasma indole propionate and positively associated with plasma secondary bile acids and imidazole propionate. Five species, including 3 streptococci, correlated with the same species in saliva and were associated with worse dental health in the Malm\u00f6 Offspring Dental Study. Microbial functional potential of dissimilatory nitrate reduction, anaerobic fatty acid \u03b2-oxidation, and amino acid degradation were associated with coronary artery calcium score.\n\nThis study provides evidence of an association of a gut microbiota composition characterized by increased abundance of Streptococcus spp and other species commonly found in the oral cavity with coronary atherosclerosis and systemic inflammation markers. Further longitudinal and experimental studies are warranted to explore the potential implications of a bacterial component in atherogenesis.", "doi": "10.1161/CIRCULATIONAHA.123.063914", "pmid": "37435755", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10399955"}], "notes": [], "created": "2026-08-20T12:16:07.214Z", "modified": "2026-08-20T12:16:07.530Z"}, {"entity": "publication", "iuid": "39bcafc7c8f4498b8a39ae492dc30f85", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/39bcafc7c8f4498b8a39ae492dc30f85.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/39bcafc7c8f4498b8a39ae492dc30f85"}}, "title": "ACCELEROMETER-BASED SEDENTARY BEHAVIOUR AND PHYSICAL ACTIVITY ARE ASSOCIATED WITH THE GUT MICROBIOTA IN 8507 INDIVIDUALS FROM THE POPULATION-BASED SCAPIS", "authors": [{"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Ekblom-Bak", "given": "Elin", "initials": "E", "orcid": "0000-0002-3901-7833", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1db422e63016471ca7e9a2030d77d727.json"}}, {"family": "Ekblom", "given": "\u00d6rjan", "initials": "\u00d6", "orcid": "0000-0001-6058-4982", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ef59def17c34c159bf2b7ad7b358a44.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "Ericson", "given": "Ulrika", "initials": "U", "orcid": "0000-0003-4629-4318", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f7a231a3bc84f2d99732325be9c92ad.json"}}, {"family": "Arvidsson", "given": "Daniel", "initials": "D", "orcid": "0000-0002-3112-5434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ddce14555f514266bf1be0bbae23f4ce.json"}}, {"family": "B\u00f6rjesson", "given": "Mats", "initials": "M"}, {"family": "Johanson", "given": "Peter J", "initials": "PJ"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d414b3352a4540a68227ca7eec73cfa6.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb88fcd6bead49978b129dffe779d8a0.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2023-06-04", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.06.01.23290817", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:46:18.098Z", "modified": "2026-08-20T10:46:18.388Z"}, {"entity": "publication", "iuid": "53dc2332a9ca4907bdcfdb318e887e97", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/53dc2332a9ca4907bdcfdb318e887e97.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/53dc2332a9ca4907bdcfdb318e887e97"}}, "title": "Obstructive sleep apnea is associated with specific gut microbiota species and functions in the population-based Swedish CardioPulmonary bioImage Study (SCAPIS)", "authors": [{"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Theorell-Hagl\u00f6w", "given": "Jenny", "initials": "J", "orcid": "0000-0003-2819-2799", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdbe4f0179eb46f890bbcc54805cf291.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Lin", "given": "Yi Ting", "initials": "YT", "orcid": "0000-0002-5833-0040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36368cfa632140839b84bc166dd09b1a.json"}}, {"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-1914-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/edbc11d091084a2392a8dfc062f070e8.json"}}, {"family": "Holm", "given": "Jacob Bak", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "Henrik Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Benedict", "given": "Christian", "initials": "C", "orcid": "0000-0002-8911-4068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4754abd3a35249109dfe62d79808cf23.json"}}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-9052-8372", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af9c0c50c8dc475daf410655475ea64d.json"}}, {"family": "Koskiniemi", "given": "Sanna", "initials": "S", "orcid": "0000-0002-3275-0936", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd05acc7311e433abf784f6e96841941.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/265c9b3e11de4fcaa270a0eb20faf65c.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d414b3352a4540a68227ca7eec73cfa6.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb88fcd6bead49978b129dffe779d8a0.json"}}, {"family": "Lindberg", "given": "Eva", "initials": "E", "orcid": "0000-0002-8552-4510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fc99a1fb25c4bd98a45beb18e300aa2.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2022-06-14", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.06.10.22276241", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:11:44.910Z", "modified": "2026-08-20T10:11:45.181Z"}, {"entity": "publication", "iuid": "bc8fc51866a542c19f79ee7f75f0e3cf", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bc8fc51866a542c19f79ee7f75f0e3cf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bc8fc51866a542c19f79ee7f75f0e3cf"}}, "title": "Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multicohort Nontargeted Metabolomics Observational and Mendelian Randomization Study.", "authors": [{"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-3873-7943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13bd5f11f5cc4420a1c57183bb8323c9.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Kennedy", "given": "Beatrice", "initials": "B"}, {"family": "Salihovic", "given": "Samira", "initials": "S"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Berne", "given": "Christian", "initials": "C"}, {"family": "Ris\u00e9rus", "given": "Ulf", "initials": "U"}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE"}, {"family": "Larsson", "given": "Susanna C", "initials": "SC"}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "journal article", "published": "2022-02-01", "journal": {"title": "Diabetes", "issn": "1939-327X", "volume": "71", "issue": "2", "pages": "329-339", "issn-l": "0012-1797"}, "abstract": "Obesity is associated with adverse health outcomes, but the metabolic effects have not yet been fully elucidated. We aimed to investigate the association between adiposity and circulating metabolites and to address causality with Mendelian randomization (MR). Metabolomics data were generated with nontargeted ultraperformance liquid chromatography coupled to time-of-flight mass spectrometry in plasma and serum from three population-based Swedish cohorts: ULSAM (N = 1,135), PIVUS (N = 970), and TwinGene (N = 2,059). We assessed associations of general adiposity measured as BMI and central body fat distribution measured as waist-to-hip ratio adjusted for BMI (WHRadjBMI) with 210 annotated metabolites. We used MR analysis to assess causal effects. Lastly, we attempted to replicate the MR findings in the KORA and TwinsUK cohorts (N = 7,373), the CHARGE Consortium (N = 8,631), the Framingham Heart Study (N = 2,076), and the DIRECT Consortium (N = 3,029). BMI was associated with 77 metabolites, while WHRadjBMI was associated with 11 and 3 metabolites in women and men, respectively. The MR analyses in the Swedish cohorts suggested a causal association (P value <0.05) of increased general adiposity and reduced levels of arachidonic acid, dodecanedioic acid, and lysophosphatidylcholine (P-16:0) as well as with increased creatine levels. The results of the replication effort provided support for a causal association of adiposity with reduced levels of arachidonic acid (P value = 0.03). Adiposity is associated with variation of large parts of the circulating metabolome; however, further investigation of causality is required in well-powered cohorts.", "doi": "10.2337/db20-1120", "pmid": "34785567", "labels": [], "xrefs": [{"db": "pii", "key": "db20-1120"}, {"db": "figshare", "key": "10.2337/figshare.17000116"}], "notes": [], "created": "2026-08-20T13:02:51.221Z", "modified": "2026-08-20T13:02:51.292Z"}, {"entity": "publication", "iuid": "1bdae64c008244cd8ad1d2488fa9e21d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1bdae64c008244cd8ad1d2488fa9e21d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1bdae64c008244cd8ad1d2488fa9e21d"}}, "title": "An online atlas of human plasma metabolite signatures of gut microbiome composition", "authors": [{"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Nowak", "given": "Christoph", "initials": "C", "orcid": "0000-0001-8435-3978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b9c212e2234dae88d48ac2ce701915.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Nielsen", "given": "Nynne", "initials": "N", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Holm", "given": "Jacob Bak", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB"}, {"family": "Ottosson", "given": "Filip", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f18bcbc718e74439b675ea98e23a0e99.json"}}, {"family": "Lin", "given": "Yi Ting", "initials": "YT", "orcid": "0000-0002-5833-0040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36368cfa632140839b84bc166dd09b1a.json"}}, {"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-1914-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/edbc11d091084a2392a8dfc062f070e8.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2021-12-30", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.23.21268179", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:07:54.099Z", "modified": "2026-08-20T10:07:54.434Z"}]}