{"entity": "researcher", "timestamp": "2026-09-28T11:18:12.033Z", "family": "Kouznetsova", "given": "Anna", "initials": "A", "orcid": "0000-0001-9059-4567", "affiliations": ["Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/286ac79354a94d4db4bed27bc96bc0bc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/286ac79354a94d4db4bed27bc96bc0bc"}}, "publications": [{"entity": "publication", "iuid": "3621184f76394beebcbbbab9720a78eb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3621184f76394beebcbbbab9720a78eb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3621184f76394beebcbbbab9720a78eb"}}, "title": "Age-dependent aneuploidy in mammalian oocytes instigated at the second meiotic division.", "authors": [{"family": "Kouznetsova", "given": "Anna", "initials": "A", "orcid": "0000-0001-9059-4567", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/286ac79354a94d4db4bed27bc96bc0bc.json"}}, {"family": "Liu", "given": "Jian Guo", "initials": "JG"}, {"family": "Valentiniene", "given": "Sonata", "initials": "S"}, {"family": "Brismar", "given": "Hjalmar", "initials": "H", "orcid": "0000-0003-0578-4003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04321d9fb805493db538489927a42c8f.json"}}, {"family": "H\u00f6\u00f6g", "given": "Christer", "initials": "C"}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Aging Cell", "issn": "1474-9726", "volume": "21", "issue": "7", "pages": "e13649", "issn-l": "1474-9718"}, "abstract": "Ageing severely affects the chromosome segregation process in human oocytes resulting in aneuploidy, infertility and developmental disorders. A considerable amount of segregation errors in humans are introduced at the second meiotic division. We have here compared the chromosome segregation process in young adult and aged female mice during the second meiotic division. More than half of the oocytes in aged mice displayed chromosome segregation irregularities at anaphase II, resulting in dramatically increased level of aneuploidy in haploid gametes, from 4% in young adult mice to 30% in aged mice. We find that the post-metaphase II process that efficiently corrects aberrant kinetochore-microtubule attachments in oocytes in young adult mice is approximately 10-fold less efficient in aged mice, in particular affecting chromosomes that show small inter-centromere distances at the metaphase II stage in aged mice. Our results reveal that post-metaphase II processes have critical impact on age-dependent aneuploidy in mammalian eggs.", "doi": "10.1111/acel.13649", "pmid": "35665589", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9282850"}], "notes": [], "created": "2026-09-23T09:03:48.454Z", "modified": "2026-09-23T14:50:26.711Z"}, {"entity": "publication", "iuid": "5ef7fea58f404716bb001559d6ddc7dd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5ef7fea58f404716bb001559d6ddc7dd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5ef7fea58f404716bb001559d6ddc7dd"}}, "title": "Post-metaphase correction of aberrant kinetochore-microtubule attachments in mammalian eggs.", "authors": [{"family": "Kouznetsova", "given": "Anna", "initials": "A", "orcid": "0000-0001-9059-4567", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/286ac79354a94d4db4bed27bc96bc0bc.json"}}, {"family": "Kitajima", "given": "Tomoya S", "initials": "TS"}, {"family": "Brismar", "given": "Hjalmar", "initials": "H"}, {"family": "H\u00f6\u00f6g", "given": "Christer", "initials": "C"}], "type": "journal article", "published": "2019-08-00", "journal": {"title": "EMBO Rep.", "issn": "1469-3178", "volume": "20", "issue": "8", "pages": "e47905", "issn-l": "1469-221X"}, "abstract": "The accuracy of the two sequential meiotic divisions in oocytes is essential for creating a haploid gamete with a normal chromosomal content. Here, we have analysed the 3D dynamics of chromosomes during the second meiotic division in live mouse oocytes. We find that chromosomes form stable kinetochore-microtubule attachments at the end of prometaphase II stage that are retained until anaphase II onset. Remarkably, we observe that more than 20% of the kinetochore-microtubule attachments at the metaphase II stage are merotelic or lateral. However, < 1% of all chromosomes at onset of anaphase II are found to lag at the spindle equator and < 10% of the laggards missegregate and give rise to aneuploid gametes. Our results demonstrate that aberrant kinetochore-microtubule attachments are not corrected at the metaphase stage of the second meiotic division. Thus, the accuracy of the chromosome segregation process in mouse oocytes during meiosis II is ensured by an efficient correction process acting at the anaphase stage.", "doi": "10.15252/embr.201947905", "pmid": "31290587", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6680117"}], "notes": [], "created": "2026-09-23T10:59:54.171Z", "modified": "2026-09-23T10:59:54.229Z"}]}