{"entity": "researcher", "timestamp": "2026-04-12T02:41:57.257Z", "family": "Ballantyne", "given": "Christie M", "initials": "CM", "orcid": "0000-0002-6432-1730", "affiliations": ["Department of Medicine, Baylor College of Medicine, Houston, TX (C.M.B.)."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/27dc5297c262410bad3bbb66a488d4b4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/27dc5297c262410bad3bbb66a488d4b4"}}, "publications": [{"entity": "publication", "iuid": "e201025534c2440d959f408409bef326", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e201025534c2440d959f408409bef326.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e201025534c2440d959f408409bef326"}}, "title": "Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis.", "authors": [{"family": "Uddin", "given": "Md Mesbah", "initials": "MM", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Saadatagah", "given": "Seyedmohammad", "initials": "S"}, {"family": "Niroula", "given": "Abhishek", "initials": "A", "orcid": "0000-0002-5904-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05df7afc7a494ba5af8a378e5ffa53f0.json"}}, {"family": "Yu", "given": "Bing", "initials": "B", "orcid": "0000-0003-4818-1077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e408849bd8f14fd99a2ae255990c1f49.json"}}, {"family": "Hornsby", "given": "Whitney E", "initials": "WE"}, {"family": "Ganesh", "given": "Shriienidhie", "initials": "S", "orcid": "0000-0002-4226-7526", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab02750ae47045b08d78ad814c146e00.json"}}, {"family": "Lannery", "given": "Kim", "initials": "K"}, {"family": "Schuermans", "given": "Art", "initials": "A", "orcid": "0000-0001-8146-9692", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af284c3bd9304f54ac7b8c9970ce56be.json"}}, {"family": "Honigberg", "given": "Michael C", "initials": "MC", "orcid": "0000-0001-8630-5021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c541cd0864c947a6bafa7ad6e78bfe49.json"}}, {"family": "Bick", "given": "Alexander G", "initials": "AG", "orcid": "0000-0001-5824-9595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2da5a35a4984921b19dfafe64cea2de.json"}}, {"family": "Libby", "given": "Peter", "initials": "P", "orcid": "0000-0002-1502-502X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/39fb20acff0442bd92fc7931d3ee6cf9.json"}}, {"family": "Ebert", "given": "Benjamin L", "initials": "BL", "orcid": "0000-0003-0197-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56e4f1c53a4348e2b0ceb44a38850a17.json"}}, {"family": "Ballantyne", "given": "Christie M", "initials": "CM", "orcid": "0000-0002-6432-1730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27dc5297c262410bad3bbb66a488d4b4.json"}}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}], "type": "journal article", "published": "2024-09-09", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "7858", "issn-l": "2041-1723"}, "abstract": "Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related diseases, including hematologic malignancy and atherosclerotic cardiovascular disease (ASCVD). While CHIP is common among older adults, the underlying factors driving its development are largely unknown. To address this, we performed whole-exome sequencing on 8,374 blood DNA samples collected from 4,187 Atherosclerosis Risk in Communities Study (ARIC) participants over a median follow-up of 21 years. During this period, 735 participants developed incident CHIP. Splicing factor genes (SF3B1, SRSF2, U2AF1, and ZRSR2) and TET2 CHIP grow significantly faster than DNMT3A non-R882 clones. We find that age at baseline and sex significantly influence the incidence of CHIP, while ASCVD and other traditional ASCVD risk factors do not exhibit such associations. Additionally, baseline synonymous passenger mutations are strongly associated with CHIP status and are predictive of new CHIP clone acquisition and clonal growth over extended follow-up, providing valuable insights into clonal dynamics of aging hematopoietic stem and progenitor cells. This study also reveals associations between germline genetic variants and incident CHIP. Our comprehensive longitudinal assessment yields insights into cell-intrinsic and -extrinsic factors contributing to the development and progression of CHIP clones in older adults.", "doi": "10.1038/s41467-024-52302-9", "pmid": "39251642", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11385577"}, {"db": "pii", "key": "10.1038/s41467-024-52302-9"}], "notes": [], "created": "2025-03-18T15:48:55.530Z", "modified": "2025-04-08T06:09:52.431Z"}, {"entity": "publication", "iuid": "2e800d3226134053b0cc35a85b918107", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2e800d3226134053b0cc35a85b918107.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2e800d3226134053b0cc35a85b918107"}}, "title": "Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1.", "authors": [{"family": "Saadatagah", "given": "Seyedmohammad", "initials": "S"}, {"family": "Naderian", "given": "Mohammadreza", "initials": "M"}, {"family": "Uddin", "given": "Mesbah", "initials": "M", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Dikilitas", "given": "Ozan", "initials": "O"}, {"family": "Niroula", "given": "Abhishek", "initials": "A", "orcid": "0000-0002-5904-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05df7afc7a494ba5af8a378e5ffa53f0.json"}}, {"family": "Schuermans", "given": "Art", "initials": "A", "orcid": "0000-0001-8146-9692", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af284c3bd9304f54ac7b8c9970ce56be.json"}}, {"family": "Selvin", "given": "Elizabeth", "initials": "E"}, {"family": "Hoogeveen", "given": "Ron C", "initials": "RC"}, {"family": "Matsushita", "given": "Kunihiro", "initials": "K"}, {"family": "Nambi", "given": "Vijay", "initials": "V"}, {"family": "Yu", "given": "Bing", "initials": "B", "orcid": "0000-0003-4818-1077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e408849bd8f14fd99a2ae255990c1f49.json"}}, {"family": "Chen", "given": "Lin Yee", "initials": "LY"}, {"family": "Bick", "given": "Alexander G", "initials": "AG", "orcid": "0000-0001-5824-9595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2da5a35a4984921b19dfafe64cea2de.json"}}, {"family": "Ebert", "given": "Benjamin L", "initials": "BL", "orcid": "0000-0003-0197-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56e4f1c53a4348e2b0ceb44a38850a17.json"}}, {"family": "Honigberg", "given": "Michael C", "initials": "MC", "orcid": "0000-0001-8630-5021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c541cd0864c947a6bafa7ad6e78bfe49.json"}}, {"family": "Li", "given": "Na", "initials": "N"}, {"family": "Shah", "given": "Amil", "initials": "A"}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}, {"family": "Kullo", "given": "Iftikhar J", "initials": "IJ"}, {"family": "Ballantyne", "given": "Christie M", "initials": "CM", "orcid": "0000-0002-6432-1730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27dc5297c262410bad3bbb66a488d4b4.json"}}], "type": "journal article", "published": "2024-06-01", "journal": {"title": "JAMA Cardiol", "issn": "2380-6591", "volume": "9", "issue": "6", "pages": "497-506", "issn-l": "2380-6583"}, "abstract": "Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to the risk of atrial fibrillation (AF) through its association with inflammation and cardiac remodeling.\n\nTo determine whether CHIP was associated with AF, inflammatory and cardiac biomarkers, and cardiac structural changes.\n\nThis was a population-based, prospective cohort study in participants of the Atherosclerosis Risk in Communities (ARIC) study and UK Biobank (UKB) cohort. Samples were collected and echocardiography was performed from 2011 to 2013 in the ARIC cohort, and samples were collected from 2006 to 2010 in the UKB cohort. Included in this study were adults without hematologic malignancies, mitral valve stenosis, or previous mitral valve procedure from both the ARIC and UKB cohorts; additionally, participants without hypertrophic cardiomyopathy and congenital heart disease from the UKB cohort were also included. Data analysis was completed in 2023.\n\nCHIP (variant allele frequency [VAF] \u22652%), common gene-specific CHIP subtypes (DNMT3A, TET2, ASXL1), large CHIP (VAF \u226510%), inflammatory and cardiac biomarkers (high-sensitivity C-reactive protein, interleukin 6 [IL-6], IL-18, high-sensitivity troponin T [hs-TnT] and hs-TnI, N-terminal pro-B-type natriuretic peptide), and echocardiographic indices.\n\nIncident AF.\n\nA total of 199 982 adults were included in this study. In ARIC participants (4131 [2.1%]; mean [SD] age, 76 [5] years; 2449 female [59%]; 1682 male [41%]; 935 Black [23%] and 3196 White [77%]), 1019 had any CHIP (24.7%), and 478 had large CHIP (11.6%). In UKB participants (195 851 [97.9%]; mean [SD] age, 56 [8] years; 108 370 female [55%]; 87 481 male [45%]; 3154 Black [2%], 183 747 White [94%], and 7971 other race [4%]), 11 328 had any CHIP (5.8%), and 5189 had large CHIP (2.6%). ARIC participants were followed up for a median (IQR) period of 7.0 (5.3-7.7) years, and UKB participants were followed up for a median (IQR) period of 12.2 (11.3-13.0) years. Meta-analyzed hazard ratios for AF were 1.12 (95% CI, 1.01-1.25; P = .04) for participants with vs without large CHIP, 1.29 (95% CI, 1.05-1.59; P = .02) for those with vs without large TET2 CHIP (seen in 1340 of 197 209 [0.67%]), and 1.45 (95% CI, 1.02-2.07; P = .04) for those with vs without large ASXL1 CHIP (seen in 314 of 197 209 [0.16%]). Large TET2 CHIP was associated with higher IL-6 levels. Additionally, large ASXL1 was associated with higher hs-TnT level and increased left ventricular mass index.\n\nLarge TET2 and ASXL1, but not DNMT3A, CHIP was associated with higher IL-6 level, indices of cardiac remodeling, and increased risk for AF. Future research is needed to elaborate on the mechanisms driving the associations and to investigate potential interventions to reduce the risk.", "doi": "10.1001/jamacardio.2024.0459", "pmid": "38598228", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11007653"}, {"db": "pii", "key": "2817222"}], "notes": [], "created": "2025-03-18T15:48:50.593Z", "modified": "2025-04-08T06:09:30.928Z"}, {"entity": "publication", "iuid": "ec7c5372a6954d0186cb4fa27ef713d9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ec7c5372a6954d0186cb4fa27ef713d9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ec7c5372a6954d0186cb4fa27ef713d9"}}, "title": "Clonal haematopoiesis and risk of chronic liver disease.", "authors": [{"family": "Wong", "given": "Waihay J", "initials": "WJ", "orcid": "0000-0003-2023-6590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a4e1a5be5c54646ab5881bc338bf6cd.json"}}, {"family": "Emdin", "given": "Connor", "initials": "C"}, {"family": "Bick", "given": "Alexander G", "initials": "AG"}, {"family": "Zekavat", "given": "Seyedeh M", "initials": "SM", "orcid": "0000-0003-4026-8944", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6234b31f08e442a9b71a711ec7b1147a.json"}}, {"family": "Niroula", "given": "Abhishek", "initials": "A"}, {"family": "Pirruccello", "given": "James P", "initials": "JP", "orcid": "0000-0001-6088-4037", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60d2e9f23cce41f5b1f40ce0f010e9d9.json"}}, {"family": "Dichtel", "given": "Laura", "initials": "L"}, {"family": "Griffin", "given": "Gabriel", "initials": "G"}, {"family": "Uddin", "given": "Md Mesbah", "initials": "MM", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Gibson", "given": "Christopher J", "initials": "CJ", "orcid": "0000-0002-3700-5310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71ce9f64755e483496f8c28a76a2a1ff.json"}}, {"family": "Kovalcik", "given": "Veronica", "initials": "V"}, {"family": "Lin", "given": "Amy E", "initials": "AE"}, {"family": "McConkey", "given": "Marie E", "initials": "ME"}, {"family": "Vromman", "given": "Amelie", "initials": "A", "orcid": "0000-0002-1724-2095", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5297e9d22b24ac7beaab07f94c6d1f7.json"}}, {"family": "Sellar", "given": "Rob S", "initials": "RS"}, {"family": "Kim", "given": "Peter G", "initials": "PG", "orcid": "0000-0002-8716-8759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bab07a767447416fa8e4004c6cbe7b7f.json"}}, {"family": "Agrawal", "given": "Mridul", "initials": "M"}, {"family": "Weinstock", "given": "Joshua", "initials": "J", "orcid": "0000-0001-7013-1899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2501ed5d8a4e43d488e7267e58ad68cd.json"}}, {"family": "Long", "given": "Michelle T", "initials": "MT", "orcid": "0000-0001-6131-3981", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3d2425beb9d4716a378684bbf3817f3.json"}}, {"family": "Yu", "given": "Bing", "initials": "B"}, {"family": "Banerjee", "given": "Rajarshi", "initials": "R"}, {"family": "Nicholls", "given": "Rowan C", "initials": "RC", "orcid": "0000-0002-3311-4974", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9861d98d104414aa96c7646418b04e7.json"}}, {"family": "Dennis", "given": "Andrea", "initials": "A"}, {"family": "Kelly", "given": "Matt", "initials": "M", "orcid": "0000-0002-5834-635X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1f150673cd0427ea54c82ecadd62a15.json"}}, {"family": "Loh", "given": "Po-Ru", "initials": "PR", "orcid": "0000-0001-5542-9064", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ace35329adf34fc6a3ea3d31c880d5c2.json"}}, {"family": "McCarroll", "given": "Steve", "initials": "S", "orcid": "0000-0002-6954-8184", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bde6c6c1092647c090d29dae413b2073.json"}}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Vasan", "given": "Ramachandran S", "initials": "RS", "orcid": "0000-0001-7357-5970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22de41f77ce541d09a9b04aa59de33f7.json"}}, {"family": "Jaiswal", "given": "Siddhartha", "initials": "S", "orcid": "0000-0002-9597-0477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1901e08f989434fb01dfa17b0a85470.json"}}, {"family": "Johnson", "given": "Andrew D", "initials": "AD", "orcid": "0000-0001-6369-5178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b268f8da3f247ba90dc37ea73d93c2f.json"}}, {"family": "Chung", "given": "Raymond T", "initials": "RT"}, {"family": "Corey", "given": "Kathleen", "initials": "K"}, {"family": "Levy", "given": "Daniel", "initials": "D", "orcid": "0000-0003-1843-8724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57605ba755d44792ab87cf14114ec757.json"}}, {"family": "Ballantyne", "given": "Christie", "initials": "C", "orcid": "0000-0002-6432-1730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27dc5297c262410bad3bbb66a488d4b4.json"}}, {"family": "NHLBI TOPMed Hematology Working Group", "given": "", "initials": ""}, {"family": "Ebert", "given": "Benjamin L", "initials": "BL", "orcid": "0000-0003-0197-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56e4f1c53a4348e2b0ceb44a38850a17.json"}}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "616", "issue": "7958", "pages": "747-754", "issn-l": "0028-0836"}, "abstract": "Chronic liver disease is a major public health burden worldwide1. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis2. Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 independent cohorts with whole-exome sequencing data (Framingham Heart Study, Atherosclerosis Risk in Communities Study, UK Biobank and Mass General Brigham Biobank). CHIP was associated with an increased risk of prevalent and incident chronic liver disease (odds ratio = 2.01, 95% confidence interval (95% CI) [1.46, 2.79]; P < 0.001). Individuals with CHIP were more likely to demonstrate liver inflammation and fibrosis detectable by magnetic resonance imaging compared to those without CHIP (odds ratio = 1.74, 95% CI [1.16, 2.60]; P = 0.007). To assess potential causality, Mendelian randomization analyses showed that genetic predisposition to CHIP was associated with a greater risk of chronic liver disease (odds ratio = 2.37, 95% CI [1.57, 3.6]; P < 0.001). In a dietary model of non-alcoholic steatohepatitis, mice transplanted with Tet2-deficient haematopoietic cells demonstrated more severe liver inflammation and fibrosis. These effects were mediated by the NLRP3 inflammasome and increased levels of expression of downstream inflammatory cytokines in Tet2-deficient macrophages. In summary, clonal haematopoiesis is associated with an elevated risk of liver inflammation and chronic liver disease progression through an aberrant inflammatory response.", "doi": "10.1038/s41586-023-05857-4", "pmid": "37046084", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "mid", "key": "NIHMS1912281"}, {"db": "pmc", "key": "PMC10405350"}, {"db": "pii", "key": "10.1038/s41586-023-05857-4"}], "notes": [], "created": "2023-11-20T11:39:32.404Z", "modified": "2023-11-20T11:39:32.756Z"}, {"entity": "publication", "iuid": "5a4b7afcc7f14c88b78aa139fc346ea0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5a4b7afcc7f14c88b78aa139fc346ea0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5a4b7afcc7f14c88b78aa139fc346ea0"}}, "title": "Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.", "authors": 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P", "initials": "AP"}, {"family": "Mathias", "given": "Rasika A", "initials": "RA", "orcid": "0000-0002-2282-9042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71dfe469451f4573bcccc96f981f7915.json"}}, {"family": "Do", "given": "Ron", "initials": "R", "orcid": "0000-0002-3144-3627", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ab0c452994042219ca6120d45e72604.json"}}, {"family": "NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium", "given": "", "initials": ""}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}], "type": "journal article", "published": "2022-04-08", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "14", "pages": "eabl6579", "issn-l": "2375-2548"}, "abstract": "Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion of hematopoietic cells bearing leukemogenic mutations, predisposes both hematologic malignancy and CAD. TERT (which encodes telomerase reverse transcriptase) is the most significantly associated germline locus for CHIP in genome-wide association studies. Here, we investigated the relationship between CHIP, LTL, and CAD in the Trans-Omics for Precision Medicine (TOPMed) program (n = 63,302) and UK Biobank (n = 47,080). Bidirectional Mendelian randomization studies were consistent with longer genetically imputed LTL increasing propensity to develop CHIP, but CHIP then, in turn, hastens to shorten measured LTL (mLTL). We also demonstrated evidence of modest mediation between CHIP and CAD by mLTL. Our data promote an understanding of potential causal relationships across CHIP and LTL toward prevention of CAD.", "doi": "10.1126/sciadv.abl6579", "pmid": "35385311", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC8986098"}], "notes": [], "created": "2023-11-20T11:36:14.966Z", "modified": "2023-11-20T11:36:17.765Z"}, {"entity": "publication", "iuid": "2ceeb693d6a344a3a3e5349640de619b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2ceeb693d6a344a3a3e5349640de619b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2ceeb693d6a344a3a3e5349640de619b"}}, "title": "Clonal Hematopoiesis Is Associated With Higher Risk of Stroke.", "authors": [{"family": "Bhattacharya", "given": "Romit", "initials": "R", "orcid": "0000-0002-0782-4753", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/adea681afe7c431c91b30900a92baf8f.json"}}, {"family": "Zekavat", "given": "Seyedeh M", "initials": "SM", "orcid": "0000-0003-4026-8944", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6234b31f08e442a9b71a711ec7b1147a.json"}}, {"family": "Haessler", "given": "Jeffrey", "initials": "J"}, {"family": "Fornage", "given": "Myriam", "initials": "M", "orcid": "0000-0003-0677-8158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f637ca1a5edd4ece9dd2f88f3620f0b2.json"}}, {"family": "Raffield", "given": "Laura", "initials": "L", "orcid": "0000-0002-7892-193X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/686393c583e94c919f8e39fc8a03d4bc.json"}}, {"family": "Uddin", "given": "Md Mesbah", "initials": "MM", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Bick", "given": "Alexander G", "initials": "AG", "orcid": "0000-0001-5824-9595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2da5a35a4984921b19dfafe64cea2de.json"}}, {"family": "Niroula", "given": "Abhishek", "initials": "A", "orcid": "0000-0002-5904-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05df7afc7a494ba5af8a378e5ffa53f0.json"}}, {"family": "Yu", "given": "Bing", "initials": "B", "orcid": "0000-0003-4818-1077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e408849bd8f14fd99a2ae255990c1f49.json"}}, {"family": "Gibson", "given": "Christopher", "initials": "C", "orcid": "0000-0002-3700-5310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71ce9f64755e483496f8c28a76a2a1ff.json"}}, {"family": "Griffin", "given": "Gabriel", "initials": "G"}, {"family": "Morrison", "given": "Alanna C", "initials": "AC", "orcid": "0000-0001-6381-4296", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe80874c488943cfb7a5590b7e8d6159.json"}}, {"family": "Psaty", "given": "Bruce M", "initials": "BM", "orcid": "0000-0002-7278-2190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b4dfcdad9074df781cd6c8f3c303789.json"}}, {"family": "Longstreth", "given": "William T", "initials": "WT"}, {"family": "Bis", "given": "Joshua C", "initials": "JC", "orcid": "0000-0002-3409-1110", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de8dd43c6fe64ebbaf718500e4fef3d9.json"}}, {"family": "Rich", "given": "Stephen S", "initials": "SS", "orcid": "0000-0003-3872-7793", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b55061262f4541c1b28d3081e4001833.json"}}, {"family": "Rotter", "given": "Jerome I", "initials": "JI", "orcid": "0000-0001-7191-1723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/50edc25b80cc48b699db367e372fded5.json"}}, {"family": "Tracy", "given": "Russell P", "initials": "RP"}, {"family": "Correa", "given": "Adolfo", "initials": "A", "orcid": "0000-0002-9501-600X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5148730ad2904845aafb1bf3c4d30211.json"}}, {"family": "Seshadri", "given": "Sudha", "initials": "S"}, {"family": "Johnson", "given": "Andrew", "initials": "A", "orcid": "0000-0001-6369-5178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b268f8da3f247ba90dc37ea73d93c2f.json"}}, {"family": "Collins", "given": "Jason M", "initials": "JM", "orcid": "0000-0002-2903-797X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e55c6f4136342ad8c1874d0c0e13924.json"}}, {"family": "Hayden", "given": "Kathleen M", "initials": "KM", "orcid": "0000-0002-7745-3513", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4200bc918d4a4142a39f93b3985fc067.json"}}, {"family": "Madsen", "given": "Tracy E", "initials": "TE", "orcid": "0000-0001-5101-0776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58814b872ec4412c9ff2f0a446410966.json"}}, {"family": "Ballantyne", "given": "Christie M", "initials": "CM", "orcid": "0000-0002-6432-1730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27dc5297c262410bad3bbb66a488d4b4.json"}}, {"family": "Jaiswal", "given": "Siddhartha", "initials": "S", "orcid": "0000-0002-9597-0477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1901e08f989434fb01dfa17b0a85470.json"}}, {"family": "Ebert", "given": "Benjamin L", "initials": "BL", "orcid": "0000-0003-0197-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56e4f1c53a4348e2b0ceb44a38850a17.json"}}, {"family": "Kooperberg", "given": "Charles", "initials": "C", "orcid": "0000-0002-7986-8560", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8fbc0fa2df5467ca8c6e65def4485cd.json"}}, {"family": "Manson", "given": "JoAnn E", "initials": "JE", "orcid": "0000-0002-9426-7595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e39f122c5fd4f0ea0dcf2353ed4a274.json"}}, {"family": "Whitsel", "given": "Eric A", "initials": "EA", "orcid": "0000-0003-4843-3641", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a41a19cd08a4908993b3a9a7cd46395.json"}}, {"family": "NHLBI Trans-Omics for Precision Medicine Program", "given": "", "initials": ""}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}, {"family": "Reiner", "given": "Alexander P", "initials": "AP", "orcid": "0000-0002-1427-4470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/244e81f4f21645e9b66f7b2ba6a8eb07.json"}}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Stroke", "issn": "1524-4628", "volume": "53", "issue": "3", "pages": "788-797", "issn-l": "0039-2499"}, "abstract": "Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was reported previously in an exploratory analysis including a small number of incident stroke cases without replication and lack of stroke subphenotyping. The purpose of this study was to discover whether CHIP is a risk factor for ischemic or hemorrhagic stroke.\n\nWe utilized plasma genome sequence data of blood DNA to identify CHIP in 78 752 individuals from 8 prospective cohorts and biobanks. We then assessed the association of CHIP and commonly mutated individual CHIP driver genes (DNMT3A, TET2, and ASXL1) with any stroke, ischemic stroke, and hemorrhagic stroke.\n\nCHIP was associated with an increased risk of total stroke (hazard ratio, 1.14 [95% CI, 1.03-1.27]; P=0.01) after adjustment for age, sex, and race. We observed associations with CHIP with risk of hemorrhagic stroke (hazard ratio, 1.24 [95% CI, 1.01-1.51]; P=0.04) and with small vessel ischemic stroke subtypes. In gene-specific association results, TET2 showed the strongest association with total stroke and ischemic stroke, whereas DMNT3A and TET2 were each associated with increased risk of hemorrhagic stroke.\n\nCHIP is associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke. Future studies clarifying the relationship between CHIP and subtypes of stroke are needed.", "doi": "10.1161/STROKEAHA.121.037388", "pmid": "34743536", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "mid", "key": "NIHMS1751326"}, {"db": "pmc", "key": "PMC8885769"}], "notes": [], "created": "2023-11-20T11:28:04.969Z", "modified": "2023-11-20T11:28:06.112Z"}]}