{"entity": "researcher", "timestamp": "2026-08-22T09:10:54.373Z", "family": "Quintana-Murci", "given": "Lluis", "initials": "L", "orcid": "0000-0003-2429-6320", "affiliations": ["Human Evolutionary Genetics Unit, Institut Pasteur, UMR 2000, CNRS, Paris, France. quintana@pasteur.fr.", "Coll\u00e8ge de France, Paris, France. quintana@pasteur.fr."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/2709c80c82e746a0a43e692724658fa4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/2709c80c82e746a0a43e692724658fa4"}}, "publications": [{"entity": "publication", "iuid": "17d25a1eccb44b25ba125f3502d9edae", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/17d25a1eccb44b25ba125f3502d9edae.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/17d25a1eccb44b25ba125f3502d9edae"}}, "title": "Genomic insights into population history and biological adaptation in Oceania.", "authors": [{"family": "Choin", "given": "Jeremy", "initials": "J", "orcid": "0000-0002-2189-8767", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0b8b364f73a4c30aacc9a4238ef13b8.json"}}, {"family": "Mendoza-Revilla", "given": "Javier", "initials": "J", "orcid": "0000-0002-4026-9333", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d45f6d8827a04a4492edf2c43866bfe4.json"}}, {"family": "Arauna", "given": "Lara R", "initials": "LR", "orcid": "0000-0003-3317-4261", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1f9713a73604ec68a109a4c34f9ee92.json"}}, {"family": "Cuadros-Espinoza", "given": "Sebastian", "initials": "S"}, {"family": "Cassar", "given": "Olivier", "initials": "O"}, {"family": "Larena", "given": "Maximilian", "initials": "M", "orcid": "0000-0002-8799-7645", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0599353a0534df49f4d09a55bc3a313.json"}}, {"family": "Ko", "given": "Albert Min-Shan", "initials": "AM"}, {"family": "Harmant", "given": "Christine", "initials": "C"}, {"family": "Laurent", "given": "Romain", "initials": "R"}, {"family": "Verdu", "given": "Paul", "initials": "P"}, {"family": "Laval", "given": "Guillaume", "initials": "G"}, {"family": "Boland", "given": "Anne", "initials": "A", "orcid": "0000-0001-8789-5676", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dcfe6d903d30427598f9d5e867dd5eb3.json"}}, {"family": "Olaso", "given": "Robert", "initials": "R", "orcid": "0000-0001-7631-9657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/47a97b681b7b48489aa34612596c7216.json"}}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "JF", "orcid": "0000-0002-5358-4463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33bb50dc6b8045bd9dbbde4423f66129.json"}}, {"family": "Valentin", "given": "Fr\u00e9d\u00e9rique", "initials": "F", "orcid": "0000-0002-0575-7681", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed343a95223742de9ce5662a7b379d56.json"}}, {"family": "Ko", "given": "Ying-Chin", "initials": "YC", "orcid": "0000-0003-1759-2279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fcf8758b91d5489faa1ebf68c52fb990.json"}}, {"family": "Jakobsson", "given": "Mattias", "initials": "M", "orcid": "0000-0001-7840-7853", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/377f1b52aa8d4bf394f82148a2b23d40.json"}}, {"family": "Gessain", "given": "Antoine", "initials": "A"}, {"family": "Excoffier", "given": "Laurent", "initials": "L", "orcid": "0000-0002-7507-6494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12217b8d181644518ae2d928a1f83ae6.json"}}, {"family": "Stoneking", "given": "Mark", "initials": "M", "orcid": "0000-0001-9044-6679", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e9d178252cf147b8888921aaa5ea5261.json"}}, {"family": "Patin", "given": "Etienne", "initials": "E", "orcid": "0000-0002-9911-4459", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6a3e21475c2417091634a306c5e4246.json"}}, {"family": "Quintana-Murci", "given": "Lluis", "initials": "L", "orcid": "0000-0003-2429-6320", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2709c80c82e746a0a43e692724658fa4.json"}}], "type": "historical article", "published": "2021-04-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "592", "issue": "7855", "pages": "583-589", "issn-l": "0028-0836"}, "abstract": "The Pacific region is of major importance for addressing questions regarding human dispersals, interactions with archaic hominins and natural selection processes1. However, the demographic and adaptive history of Oceanian populations remains largely uncharacterized. Here we report high-coverage genomes of 317 individuals from 20 populations from the Pacific region. We find that the ancestors of Papuan-related ('Near Oceanian') groups underwent a strong bottleneck before the settlement of the region, and separated around 20,000-40,000 years ago. We infer that the East Asian ancestors of Pacific populations may have diverged from Taiwanese Indigenous peoples before the Neolithic expansion, which is thought to have started from Taiwan around 5,000 years ago2-4. Additionally, this dispersal was not followed by an immediate, single admixture event with Near Oceanian populations, but involved recurrent episodes of genetic interactions. Our analyses reveal marked differences in the proportion and nature of Denisovan heritage among Pacific groups, suggesting that independent interbreeding with highly structured archaic populations occurred. Furthermore, whereas introgression of Neanderthal genetic information facilitated the adaptation of modern humans related to multiple phenotypes (for example, metabolism, pigmentation and neuronal development), Denisovan introgression was primarily beneficial for immune-related functions. Finally, we report evidence of selective sweeps and polygenic adaptation associated with pathogen exposure and lipid metabolism in the Pacific region, increasing our understanding of the mechanisms of biological adaptation to island environments.", "doi": "10.1038/s41586-021-03236-5", "pmid": "33854233", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41586-021-03236-5"}], "notes": [], "created": "2026-08-21T11:51:03.213Z", "modified": "2026-08-21T11:51:03.752Z"}, {"entity": "publication", "iuid": "c2a8d44a726c48e6b2f53eb3f3a8912a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c2a8d44a726c48e6b2f53eb3f3a8912a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c2a8d44a726c48e6b2f53eb3f3a8912a"}}, "title": "Autoantibodies against type I IFNs in patients with life-threatening COVID-19.", "authors": [{"family": "Bastard", "given": "Paul", "initials": "P", "orcid": "0000-0002-5926-8437", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/beec83103d55467291f2b8c160df3a04.json"}}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB", "orcid": "0000-0001-5894-3878", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d488197e6f341e28d29def150d840a7.json"}}, {"family": "Zhang", "given": "Qian", "initials": "Q", "orcid": "0000-0002-9040-3289", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/795511c3379342db94ff419e265ce3f1.json"}}, {"family": "Michailidis", "given": "Eleftherios", "initials": "E", "orcid": "0000-0002-9907-4346", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1184660af464b4dbd30e3ae5cf269ef.json"}}, {"family": "Hoffmann", "given": "Hans-Heinrich", "initials": "HH", "orcid": "0000-0003-0554-0244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45f721832c5f461e9ab81b9e4d603351.json"}}, {"family": "Zhang", "given": "Yu", "initials": "Y"}, {"family": "Dorgham", "given": "Karim", "initials": "K", "orcid": "0000-0001-9539-3203", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7ab515073ac4be8b5d928596f9682b7.json"}}, {"family": "Philippot", "given": "Quentin", "initials": "Q"}, {"family": "Rosain", "given": "J\u00e9r\u00e9mie", "initials": "J"}, {"family": "B\u00e9ziat", "given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9eccfef230a0494d87395d92b9618fb5.json"}}, {"family": "Manry", "given": "J\u00e9r\u00e9my", "initials": "J", "orcid": "0000-0001-5998-2051", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd17cb7568a947a78a843de6e2986a64.json"}}, {"family": "Shaw", "given": "Elana", "initials": "E", "orcid": "0000-0001-9265-8026", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e56954c0e1f41f49922ec36fd102380.json"}}, {"family": "Haljasm\u00e4gi", "given": "Liis", "initials": "L", "orcid": "0000-0001-7162-9808", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b42e397c1d1248d7ae9c69a6d5c73209.json"}}, {"family": "Peterson", "given": "P\u00e4rt", "initials": "P", "orcid": "0000-0001-6755-791X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ef5b3c93c814f73b0a2c5a6a81a9d1b.json"}}, {"family": "Lorenzo", "given": "Lazaro", "initials": "L", "orcid": "0000-0001-6648-8684", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b786a0c65ffd42059765eeb38e5f228a.json"}}, {"family": "Bizien", "given": "Lucy", "initials": "L", "orcid": "0000-0001-9163-9122", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80bd83b0bfc4457fb119befd5b87a2b4.json"}}, {"family": "Trouillet-Assant", "given": 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Covid-19 Biobank", "given": "", "initials": ""}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Tsang", "given": "John S", "initials": "JS", "orcid": "0000-0003-3186-3047", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/274e51d6e6f24512a177604add810d4b.json"}}, {"family": "Goldbach-Mansky", "given": "Raphaela", "initials": "R", "orcid": "0000-0001-7865-5769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06ab2f730fca45fb8dce02dafc811d37.json"}}, {"family": "Kisand", "given": "Kai", "initials": "K", "orcid": "0000-0002-5426-4648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd7352f8a0254478add242528188ffdc.json"}}, {"family": "Lionakis", "given": "Michail S", "initials": "MS"}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d106604b8ad84e67870302b906a94963.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Holland", "given": "Steven M", "initials": "SM", "orcid": "0000-0003-3207-5464", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b90f9be3102e4cf4894e11bdad4c0d5f.json"}}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de52d6ee013c4d18888fed695f547f54.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55186a4757e7417389f415061b59ab5c.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c24b272de580450caee36c6e772b6bc6.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80da2e422a014973a981c891c6c38070.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4d439536e38409595738548b17c7871.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/264335517ad94440b23a027fe66f767d.json"}}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "370", "issue": "6515", "issn-l": "0036-8075"}, "abstract": "Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-\u03c9 (IFN-\u03c9) (13 patients), against the 13 types of IFN-\u03b1 (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.", "doi": "10.1126/science.abd4585", "pmid": "32972996", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1668509"}, {"db": "pmc", "key": "PMC7857397"}, {"db": "pii", "key": "science.abd4585"}], "notes": [], "created": "2026-08-21T12:23:22.474Z", "modified": "2026-08-21T12:23:24.271Z"}]}