{"entity": "researcher", "timestamp": "2026-08-20T21:05:56.623Z", "family": "Guldevall", "given": "K", "initials": "K", "orcid": "0000-0003-1016-2460", "affiliations": ["Department of Applied Physics, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/24a750602b1a47d48d92974f972f1c72.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/24a750602b1a47d48d92974f972f1c72"}}, "publications": [{"entity": "publication", "iuid": "6087ac4b304c4b82a815ab2e05edcc5b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6087ac4b304c4b82a815ab2e05edcc5b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6087ac4b304c4b82a815ab2e05edcc5b"}}, "title": "Correction to: IL\u201115 superagonist N\u2011803 improves IFN\u03b3 production and killing of leukemia and ovarian cancer cells by CD34+ progenitor\u2011derived NK cells.", "authors": [{"family": "Van der Meer", "given": "J M R", "initials": "JMR", "orcid": "0000-0001-9288-1500", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec374420f13d480ba3e342acba183a7c.json"}}, {"family": "Maas", "given": "R J A", "initials": "RJA", "orcid": "0000-0002-3185-5226", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4de8f2b519342279c7578490873c4a6.json"}}, {"family": "Guldevall", "given": "K", "initials": "K", "orcid": "0000-0003-1016-2460", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24a750602b1a47d48d92974f972f1c72.json"}}, {"family": "Klarenaar", "given": "K", "initials": "K"}, {"family": "De Jonge", "given": "P K J D", "initials": "PKJD"}, {"family": "Hoogstad-van Evert", "given": "J S", "initials": "JS", "orcid": "0000-0001-9838-0977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c4e67260bf64a2d963820d64cd4b162.json"}}, {"family": "van der Waart", "given": "A B", "initials": "AB", "orcid": "0000-0001-5986-3060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a4ab943bebb4a518668d1f1e9dd7363.json"}}, {"family": "Cany", "given": "J", "initials": "J", "orcid": "0000-0002-5214-639X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a526e4e6cde24c6c8807b27101e35ea3.json"}}, {"family": "Safrit", "given": "J T", "initials": "JT", "orcid": "0000-0001-7441-4423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb8265befd554a1aba34b695852a1016.json"}}, {"family": "Lee", "given": "J H", "initials": "JH"}, {"family": "Wagena", "given": "E", "initials": "E"}, {"family": "Friedl", "given": "P", "initials": "P", "orcid": "0000-0002-0119-4041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d4fb98a43c1442f9cd904e323dc2769.json"}}, {"family": "\u00d6nfelt", "given": "B", "initials": "B", "orcid": "0000-0001-5178-7593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b4b8fcbedb54e2ba38633687f417ae8.json"}}, {"family": "Massuger", "given": "L F", "initials": "LF", "orcid": "0000-0002-1539-8985", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd1dab07b61e43b29f9bcdda0383ed00.json"}}, {"family": "Schaap", "given": "N P M", "initials": "NPM", "orcid": "0000-0001-7696-4752", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e6c952987b149e1b97baab1b815b600.json"}}, {"family": "Jansen", "given": "J H", "initials": "JH", "orcid": "0000-0001-9459-568X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4dda0ce64c04555834f61ba0d31278d.json"}}, {"family": "Hobo", "given": "W", "initials": "W", "orcid": "0000-0002-8206-8185", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d9d1653bbb04e1cb8ec62f49217057d.json"}}, {"family": "Dolstra", "given": "H", "initials": "H", "orcid": "0000-0002-3998-687X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a45d0970dc374c218087801fef1baa2a.json"}}], "type": "published erratum", "published": "2021-11-00", "journal": {"title": "Cancer Immunol. Immunother.", "issn": "1432-0851", "volume": "70", "issue": "11", "pages": "3367", "issn-l": "0340-7004"}, "abstract": null, "doi": "10.1007/s00262-021-03049-5", "pmid": "34524494", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8505330"}, {"db": "pii", "key": "10.1007/s00262-021-03049-5"}], "notes": [], "created": "2026-08-20T06:39:30.255Z", "modified": "2026-08-20T06:39:30.394Z"}, {"entity": "publication", "iuid": "960e80f94c714e4d9469b1e3e2d8d29d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/960e80f94c714e4d9469b1e3e2d8d29d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/960e80f94c714e4d9469b1e3e2d8d29d"}}, "title": "IL-15 superagonist N-803 improves IFN\u03b3 production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells.", "authors": [{"family": "Van der Meer", "given": "J M R", "initials": "JMR", "orcid": "0000-0001-9288-1500", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec374420f13d480ba3e342acba183a7c.json"}}, {"family": "Maas", "given": "R J A", "initials": "RJA", "orcid": "0000-0002-3185-5226", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4de8f2b519342279c7578490873c4a6.json"}}, {"family": "Guldevall", "given": "K", "initials": "K", "orcid": "0000-0003-1016-2460", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24a750602b1a47d48d92974f972f1c72.json"}}, {"family": "Klarenaar", "given": "K", "initials": "K"}, {"family": "de Jonge", "given": "P K J D", "initials": "PKJD"}, {"family": "Evert", "given": "J S Hoogstad-van", "initials": "JSH", "orcid": "0000-0001-9838-0977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c4e67260bf64a2d963820d64cd4b162.json"}}, {"family": "van der Waart", "given": "A B", "initials": "AB", "orcid": "0000-0001-5986-3060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a4ab943bebb4a518668d1f1e9dd7363.json"}}, {"family": "Cany", "given": "J", "initials": "J", "orcid": "0000-0002-5214-639X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a526e4e6cde24c6c8807b27101e35ea3.json"}}, {"family": "Safrit", "given": "J T", "initials": "JT", "orcid": "0000-0001-7441-4423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb8265befd554a1aba34b695852a1016.json"}}, {"family": "Lee", "given": "J H", "initials": "JH"}, {"family": "Wagena", "given": "E", "initials": "E"}, {"family": "Friedl", "given": "P", "initials": "P", "orcid": "0000-0002-0119-4041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d4fb98a43c1442f9cd904e323dc2769.json"}}, {"family": "\u00d6nfelt", "given": "B", "initials": "B", "orcid": "0000-0001-5178-7593", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b4b8fcbedb54e2ba38633687f417ae8.json"}}, {"family": "Massuger", "given": "L F", "initials": "LF", "orcid": "0000-0002-1539-8985", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd1dab07b61e43b29f9bcdda0383ed00.json"}}, {"family": "Schaap", "given": "N P M", "initials": "NPM", "orcid": "0000-0001-7696-4752", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e6c952987b149e1b97baab1b815b600.json"}}, {"family": "Jansen", "given": "J H", "initials": "JH", "orcid": "0000-0001-9459-568X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4dda0ce64c04555834f61ba0d31278d.json"}}, {"family": "Hobo", "given": "W", "initials": "W", "orcid": "0000-0002-8206-8185", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d9d1653bbb04e1cb8ec62f49217057d.json"}}, {"family": "Dolstra", "given": "H", "initials": "H", "orcid": "0000-0002-3998-687X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a45d0970dc374c218087801fef1baa2a.json"}}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Cancer Immunol. Immunother.", "issn": "1432-0851", "volume": "70", "issue": "5", "pages": "1305-1321", "issn-l": "0340-7004"}, "abstract": "Allogeneic natural killer (NK) cell transfer is a potential immunotherapy to eliminate and control cancer. A promising source are CD34 + hematopoietic progenitor cells (HPCs), since large numbers of cytotoxic NK cells can be generated. Effective boosting of NK cell function can be achieved by interleukin (IL)-15. However, its in vivo half-life is short and potent trans-presentation by IL-15 receptor \u03b1 (IL-15R\u03b1) is absent. Therefore, ImmunityBio developed IL-15 superagonist N-803, which combines IL-15 with an activating mutation, an IL-15R\u03b1 sushi domain for trans-presentation, and IgG1-Fc for increased half-life. Here, we investigated whether and how N-803 improves HPC-NK cell functionality in leukemia and ovarian cancer (OC) models in vitro and in vivo in OC-bearing immunodeficient mice. We used flow cytometry-based assays, enzyme-linked immunosorbent assay, microscopy-based serial killing assays, and bioluminescence imaging, for in vitro and in vivo experiments. N-803 increased HPC-NK cell proliferation and interferon (IFN)\u03b3 production. On leukemia cells, co-culture with HPC-NK cells and N-803 increased ICAM-1 expression. Furthermore, N-803 improved HPC-NK cell-mediated (serial) leukemia killing. Treating OC spheroids with HPC-NK cells and N-803 increased IFN\u03b3-induced CXCL10 secretion, and target killing after prolonged exposure. In immunodeficient mice bearing human OC, N-803 supported HPC-NK cell persistence in combination with total human immunoglobulins to prevent Fc-mediated HPC-NK cell depletion. Moreover, this combination treatment decreased tumor growth. In conclusion, N-803 is a promising IL-15-based compound that boosts HPC-NK cell expansion and functionality in vitro and in vivo. Adding N-803 to HPC-NK cell therapy could improve cancer immunotherapy.", "doi": "10.1007/s00262-020-02749-8", "pmid": "33140189", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8053152"}, {"db": "pii", "key": "10.1007/s00262-020-02749-8"}], "notes": [], "created": "2026-08-20T06:39:27.597Z", "modified": "2026-08-20T06:39:28.213Z"}, {"entity": "publication", "iuid": "a0591dd3b92d4d829c82c74adf0e2f86", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a0591dd3b92d4d829c82c74adf0e2f86.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a0591dd3b92d4d829c82c74adf0e2f86"}}, "title": "Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1.", "authors": [{"family": "Walwyn-Brown", "given": "Katherine", "initials": "K", "orcid": "0000-0003-2325-5180", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81f5ff408c734443a9feaa36bbf60b9c.json"}}, {"family": "Guldevall", "given": "Karolin", "initials": "K", "orcid": "0000-0003-1016-2460", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24a750602b1a47d48d92974f972f1c72.json"}}, {"family": "Saeed", "given": "Mezida", "initials": "M"}, {"family": "Pende", "given": "Daniela", "initials": "D", "orcid": "0000-0003-1565-451X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7896cd7139bf4b2597666de64a22adf2.json"}}, {"family": "\u00d6nfelt", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "MacDonald", "given": "Andrew S", "initials": "AS", "orcid": "0000-0002-5356-1149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6f7cbf80c2d456ea8399f91d2289eb9.json"}}, {"family": "Davis", "given": "Daniel M", "initials": "DM", "orcid": "0000-0002-9182-291X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/693c6f441beb4a4e836e534e441ee793.json"}}], "type": "journal article", "published": "2018-10-01", "journal": {"title": "J. Immunol.", "issn": "1550-6606", "volume": "201", "issue": "7", "pages": "2028-2041", "issn-l": "0022-1767"}, "abstract": "Cross-talk between NK cells and dendritic cells (DCs) is important in Th1 immune responses, including antitumor immunity and responses to infections. DCs also play a crucial role in polarizing Th2 immunity, but the impact of NK cell-DC interactions in this context remains unknown. In this study, we stimulated human monocyte-derived DCs in vitro with different pathogen-associated molecules: LPS or polyinosinic-polycytidylic acid, which polarize a Th1 response, or soluble egg Ag from the helminth worm Schistosoma mansoni, a potent Th2-inducing Ag. Th2-polarizing DCs were functionally distinguishable from Th1-polarizing DCs, and both showed distinct morphology and dynamics from immature DCs. We then assessed the outcome of autologous NK cells interacting with these differently stimulated DCs. Confocal microscopy showed polarization of the NK cell microtubule organizing center and accumulation of LFA-1 at contacts between NK cells and immature or Th2-polarizing DCs but not Th1-polarizing DCs, indicative of the assembly of an activating immune synapse. Autologous NK cells lysed immature DCs but not DCs treated with LPS or polyinosinic-polycytidylic acid as reported previously. In this study, we demonstrated that NK cells also degranulated in the presence of Th2-polarizing DCs. Moreover, time-lapse live-cell microscopy showed that DCs that had internalized fluorescently labeled soluble egg Ag were efficiently lysed. Ab blockade of NK cell-activating receptors NKp30 or DNAM-1 abrogated NK cell lysis of Th2-polarizing DCs. Thus, these data indicate a previously unrecognized role of NK cell cytotoxicity and NK cell-activating receptors NKp30 and DNAM-1 in restricting the pool of DCs involved in Th2 immune responses.", "doi": "10.4049/jimmunol.1800475", "pmid": "30120122", "labels": [], "xrefs": [{"db": "mid", "key": "EMS78799"}, {"db": "pmc", "key": "PMC6139540"}, {"db": "pii", "key": "jimmunol.1800475"}], "notes": [], "created": "2026-08-20T13:44:39.639Z", "modified": "2026-08-20T13:44:39.878Z"}]}