{"entity": "researcher", "timestamp": "2026-08-20T21:38:42.299Z", "family": "Ferre", "given": "Elise M N", "initials": "EMN", "orcid": "0000-0002-3285-7768", "affiliations": ["Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, United States."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/224d21056bde4f0288e965318dea6cd3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/224d21056bde4f0288e965318dea6cd3"}}, "publications": [{"entity": "publication", "iuid": "050e6f424a234d3ab5face7cda58b935", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/050e6f424a234d3ab5face7cda58b935.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/050e6f424a234d3ab5face7cda58b935"}}, "title": "Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'.", "authors": [{"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Eriksson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5473-3312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8847907a59147cf95d312afa115a3d3.json"}}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Smith", "given": "Gustav", "initials": "G"}, {"family": "Ferre", "given": "Elise M N", "initials": "EMN", "orcid": "0000-0002-3285-7768", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/224d21056bde4f0288e965318dea6cd3.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5fe1b70e79d48b1bc07ceeec842c3a3.json"}}, {"family": "Sharon", "given": "Donald", "initials": "D"}, {"family": "Snyder", "given": "Michael", "initials": "M"}, {"family": "Lionakis", "given": "Michail", "initials": "M"}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O", "orcid": "0000-0001-6091-9914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48f52710708f4b3291e5b5a4eefca8f5.json"}}], "type": "journal article", "published": "2019-06-27", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "8", "issn-l": "2050-084X"}, "abstract": "The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.", "doi": "10.7554/eLife.43578", "pmid": "31244471", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6597240"}, {"db": "pii", "key": "43578"}], "notes": [], "created": "2026-08-20T13:52:42.493Z", "modified": "2026-08-20T13:52:42.635Z"}, {"entity": "publication", "iuid": "64c59ee5394a413682ea9eacce3738a5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/64c59ee5394a413682ea9eacce3738a5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/64c59ee5394a413682ea9eacce3738a5"}}, "title": "Author response: Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'", "authors": [{"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Eriksson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5473-3312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8847907a59147cf95d312afa115a3d3.json"}}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Smith", "given": "Gustav", "initials": "G"}, {"family": "Ferre", "given": "Elise M N", "initials": "EMN", "orcid": "0000-0002-3285-7768", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/224d21056bde4f0288e965318dea6cd3.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5fe1b70e79d48b1bc07ceeec842c3a3.json"}}, {"family": "Sharon", "given": "Donald", "initials": "D"}, {"family": "Snyder", "given": "Michael", "initials": "M"}, {"family": "Lionakis", "given": "Michail", "initials": "M"}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O", "orcid": "0000-0001-6091-9914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48f52710708f4b3291e5b5a4eefca8f5.json"}}], "type": "peer-review", "published": "2019-05-31", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.43578.018", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:52:44.648Z", "modified": "2026-08-20T13:52:44.689Z"}]}