{"entity": "researcher", "timestamp": "2026-08-20T20:46:33.876Z", "family": "Oscier", "given": "David", "initials": "D", "orcid": "0000-0001-8486-2051", "affiliations": ["Molecular Pathology, University Hospitals Dorset, Royal Bournemouth Hospital, Bournemouth, United Kingdom."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/220096a970af4fcc99a358e4f0d6f239.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/220096a970af4fcc99a358e4f0d6f239"}}, "publications": [{"entity": "publication", "iuid": "048922da2a384daa953047cd1a0fa998", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/048922da2a384daa953047cd1a0fa998.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/048922da2a384daa953047cd1a0fa998"}}, "title": "Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.", "authors": [{"family": "Visentin", "given": "Andrea", "initials": "A", "orcid": "0000-0003-0271-7200", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10a25bb174034d55a6a2f0fccb036f02.json"}}, {"family": "Gaffo", "given": "Enrico", "initials": "E", "orcid": "0000-0001-6338-7677", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a30412a5d86429d99d9ab62bf7be0b2.json"}}, {"family": "F\u00fcrstenau", "given": "Moritz", "initials": "M", "orcid": "0000-0002-6593-0140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f3c1950a80040ada1cda908470910c9.json"}}, {"family": "Rogers", "given": "Kerry A", "initials": "KA"}, {"family": "Panagiotis", "given": "Baliakas", "initials": "B", "orcid": "0000-0002-5634-7156", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a31997db1ee4ef1aaff75e423b8ccfb.json"}}, {"family": "Cui", "given": "Chenghua", "initials": "C"}, {"family": "Miller", "given": "Cecelia", "initials": "C", "orcid": "0000-0001-6110-6069", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1123529d141447bafd9b556d5990544.json"}}, {"family": "Haferlach", "given": "Claudia", "initials": "C", "orcid": "0000-0002-6333-5049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b317dae860d040cfa971ea54ed81558a.json"}}, {"family": "Plevova", "given": "Karla", "initials": "K", "orcid": "0000-0002-6148-8877", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a4174bc21ce468a90d6f7cba6688179.json"}}, {"family": "Oscier", "given": "David", "initials": "D", "orcid": "0000-0001-8486-2051", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/220096a970af4fcc99a358e4f0d6f239.json"}}, {"family": "Davis", "given": "Zadie", "initials": "Z", "orcid": "0000-0001-6959-4853", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b62e8caa4c348e1b0c9504ba6eb1221.json"}}, {"family": "Nguyen-Khac", "given": "Florence", "initials": "F"}, {"family": "Roncaglia", "given": "Eleonora", "initials": "E"}, {"family": "Rigolin", "given": "Gian Matteo", "initials": "GM", "orcid": "0000-0002-8370-5190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f66f2d62db5d49d2a7443f5e0b5d3eed.json"}}, {"family": "Athanasiadou", "given": "Anastasia", "initials": "A"}, {"family": "Baran-Marszak", "given": "Fanny", "initials": "F", "orcid": "0000-0002-3723-2927", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5491ee5f3a3f4e7fa082ea29a6f11383.json"}}, {"family": "Valiente", "given": "Alberto", "initials": "A"}, {"family": "Terol", "given": "Maria Jos\u00e9", "initials": "MJ"}, {"family": "Abrisqueta", "given": "Pau", "initials": "P"}, {"family": "Espinet", "given": "Blanca", "initials": "B", "orcid": "0000-0002-4294-8145", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b59addc668aa47be999e82efa5a6a9df.json"}}, {"family": "Puiggros", "given": "Anna", "initials": "A"}, {"family": "Martines", "given": "Annalisa", "initials": "A", "orcid": "0000-0002-4701-8457", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/46bc8f8fc7264a689ceec23d5131c5f3.json"}}, {"family": "Bonaldi", "given": "Laura", "initials": "L"}, {"family": "Mauro", "given": "Francesca Romana", "initials": "FR", "orcid": "0000-0003-2425-9474", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/588b17f8a7544766bdfcd763978dad5d.json"}}, {"family": "Scarf\u00f2", "given": "Lydia", "initials": "L", "orcid": "0000-0002-0844-0989", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7697d7b279ae48a387843c617f30fa3c.json"}}, {"family": "Chatzikonstantinou", "given": "Thomas", "initials": "T", "orcid": "0000-0003-4105-1253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a205228c1594457fbd55004721eb19c3.json"}}, {"family": "Tausch", "given": "Eugen", "initials": "E"}, {"family": "Kreuzer", "given": "Karl-Anton", "initials": "KA"}, {"family": "Kater", "given": "Arnon", "initials": "A", "orcid": "0000-0003-3190-1891", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf8f235e28f2429dabfe12465a298e5b.json"}}, {"family": "Bosch", "given": "Francesc", "initials": "F"}, {"family": "Doubek", "given": "Michael", "initials": "M"}, {"family": "Panagiotidis", "given": "Panagiotis", "initials": "P"}, {"family": "Kalashnikova", "given": "Olga", "initials": "O", "orcid": "0000-0002-1856-1055", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6e234bc02a543cfa5fe0aace31cca64.json"}}, {"family": "Frezzato", "given": "Federica", "initials": "F", "orcid": "0000-0001-7093-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b62b4d97d5cf449d9682e8be5c145284.json"}}, {"family": "Calabretto", "given": "Giulia", "initials": "G"}, {"family": "Ruocco", "given": "Valeria", "initials": "V"}, {"family": "Orsi", "given": "Silvia", "initials": "S", "orcid": "0009-0009-8860-5875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43396caacda04fd295d0239acccb814e.json"}}, {"family": "Cellini", "given": "Alessandro", "initials": "A"}, {"family": "Angotzi", "given": "Francesco", "initials": "F"}, {"family": "Serafin", "given": "Andrea", "initials": "A"}, {"family": "Yi", "given": "Shuhua", "initials": "S", "orcid": "0000-0002-6291-812X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/035067b80e0e4efa9edf81ffa61c8e1c.json"}}, {"family": "Eichhorst", "given": "Barbara", "initials": "B"}, {"family": "Woyach", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0002-3403-9144", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f223eed5e0dc4decad48346341db0f6b.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06f6107d6f774ee6acb2c66ecfcb90cc.json"}}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/820ab4c1a5534ada88d9c318fa8aa2e1.json"}}, {"family": "Bortoluzzi", "given": "Stefania", "initials": "S", "orcid": "0000-0001-8240-3070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0831daa98b3b4ea980ccd20da78a22fb.json"}}], "type": "journal article", "published": "2025-12-00", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": "39", "issue": "12", "pages": "2957-2967", "issn-l": "0887-6924"}, "abstract": "In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the clinical and biological features of CLL with t(14;19)(q32;q13) (tCLL) involving the BCL3 gene. Patients with tCLL were younger and more commonly presented unmutated IGHV gene, subset #8 stereotypy, trisomy of chromosome 12, and complex karyotype than other patients without t(14;19) (oCLL). The presence of t(14;19) was associated with a shorter time to treatment and overall survival compared to oCLL. Gene expression analysis revealed a unique transcriptome profile in tCLL, characterized by the upregulation of BCL3 and the activation of B-cell receptor, PI3K-Akt. Conversely, apoptosis-related pathways were suppressed in tCLL. While the BTK gene was upregulated, the BCL2L11 gene, coding for the pro-apoptotic protein BIM, was downregulated. Notably, patients with tCLL were characterized by a trend (p = 0.058) for a longer time to the next treatment with BTK inhibitors (BTKi) compared to those treated with a venetoclax-based (Ven-based) regimen. We underscore the adverse outcomes of tCLL, its distinct molecular features and gene expression patterns. Therefore, our data suggest that identifying tCLL could help tailor therapeutic approaches.", "doi": "10.1038/s41375-025-02755-8", "pmid": "40973766", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12634426"}, {"db": "pii", "key": "10.1038/s41375-025-02755-8"}], "notes": [], "created": "2026-08-20T08:47:27.388Z", "modified": "2026-08-20T08:47:52.757Z"}]}