{"entity": "researcher", "timestamp": "2026-08-22T06:58:54.184Z", "family": "Adori", "given": "Csaba", "initials": "C", "orcid": "0000-0002-6084-5588", "affiliations": ["Department of Neuroscience, Karolinska Institutet, Solnav\u00e4gen 9, 17177, Stockholm, Sweden. csaba.adori@ki.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/20ce63912d2f43da85fc0047757accd7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/20ce63912d2f43da85fc0047757accd7"}}, "publications": [{"entity": "publication", "iuid": "68de143924ae4fc79b7fef2b15cfac26", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/68de143924ae4fc79b7fef2b15cfac26.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/68de143924ae4fc79b7fef2b15cfac26"}}, "title": "Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging.", "authors": [{"family": "Gilvesy", "given": "Abris", "initials": "A"}, {"family": "Husen", "given": "Evelina", "initials": "E"}, {"family": "Magloczky", "given": "Zsofia", "initials": "Z"}, {"family": "Mihaly", "given": "Orsolya", "initials": "O"}, {"family": "Hortob\u00e1gyi", "given": "Tibor", "initials": "T"}, {"family": "Kanatani", "given": "Shigeaki", "initials": "S"}, {"family": "Heinsen", "given": "Helmut", "initials": "H"}, {"family": "Renier", "given": "Nicolas", "initials": "N"}, {"family": "H\u00f6kfelt", "given": "Tomas", "initials": "T"}, {"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Kovacs", "given": "Gabor G", "initials": "GG"}, {"family": "Adori", "given": "Csaba", "initials": "C", "orcid": "0000-0002-6084-5588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20ce63912d2f43da85fc0047757accd7.json"}}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Acta Neuropathol.", "issn": "1432-0533", "volume": "144", "issue": "4", "pages": "651-676", "issn-l": "0001-6322"}, "abstract": "Tau pathology of the noradrenergic locus coeruleus (LC) is a hallmark of several age-related neurodegenerative disorders, including Alzheimer's disease. However, a comprehensive neuropathological examination of the LC is difficult due to its small size and rod-like shape. To investigate the LC cytoarchitecture and tau cytoskeletal pathology in relation to possible propagation patterns of disease-associated tau in an unprecedented large-scale three-dimensional view, we utilized volume immunostaining and optical clearing technology combined with light sheet fluorescence microscopy. We examined AT8+ pathological tau in the LC/pericoerulear region of 20 brains from Braak neurofibrillary tangle (NFT) stage 0-6. We demonstrate an intriguing morphological complexity and heterogeneity of AT8+ cellular structures in the LC, representing various intracellular stages of NFT maturation and their diverse transition forms. We describe novel morphologies of neuronal tau pathology such as AT8+ cells with fine filamentous somatic protrusions or with disintegrating soma. We show that gradual dendritic atrophy is the first morphological sign of the degeneration of tangle-bearing neurons, even preceding axonal lesions. Interestingly, irrespective of the Braak NFT stage, tau pathology is more advanced in the dorsal LC that preferentially projects to vulnerable forebrain regions in Alzheimer's disease, like the hippocampus or neocortical areas, compared to the ventral LC projecting to the cerebellum and medulla. Moreover, already in the precortical Braak 0 stage, 3D analysis reveals clustering tendency and dendro-dendritic close appositions of AT8+ LC neurons, AT8+ long axons of NFT-bearing cells that join the ascending dorsal noradrenergic bundle after leaving the LC, as well as AT8+ processes of NFT-bearing LC neurons that target the 4th ventricle wall. Our study suggests that the unique cytoarchitecture, comprised of a densely packed and dendritically extensively interconnected neuronal network with long projections, makes the human LC to be an ideal anatomical template for early accumulation and trans-neuronal spreading of hyperphosphorylated tau.", "doi": "10.1007/s00401-022-02477-6", "pmid": "36040521", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9468059"}, {"db": "pii", "key": "10.1007/s00401-022-02477-6"}], "notes": [], "created": "2026-08-20T06:39:44.293Z", "modified": "2026-08-20T06:39:44.375Z"}, {"entity": "publication", "iuid": "5f65151a20bb4f32af480152e8c72ec8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5f65151a20bb4f32af480152e8c72ec8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5f65151a20bb4f32af480152e8c72ec8"}}, "title": "Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging.", "authors": [{"family": "Adori", "given": "Csaba", "initials": "C", "orcid": "0000-0002-6084-5588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20ce63912d2f43da85fc0047757accd7.json"}}, {"family": "Daraio", "given": "Teresa", "initials": "T"}, {"family": "Kuiper", "given": "Raoul", "initials": "R"}, {"family": "Barde", "given": "Swapnali", "initials": "S", "orcid": "0000-0003-1452-4465", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aed9fb26aebc4f4e9220c33a87195852.json"}}, {"family": "Horvathova", "given": "Lubica", "initials": "L", "orcid": "0000-0002-5280-7805", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5904619929b4d85b58b87c13cef7ea6.json"}}, {"family": "Yoshitake", "given": "Takashi", "initials": "T", "orcid": "0000-0002-2445-0132", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/086bd3ecbf834161815c4320c7227208.json"}}, {"family": "Ihnatko", "given": "Robert", "initials": "R", "orcid": "0000-0001-5751-3622", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9bf4df66368941b18ca6080ddef3ee54.json"}}, {"family": "Valladolid-Acebes", "given": "Ismael", "initials": "I", "orcid": "0000-0002-7699-9207", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce7ad3dd9b5a4c66bef3b3a4dd914abe.json"}}, {"family": "Vercruysse", "given": "Pauline", "initials": "P"}, {"family": "Wellendorf", "given": "Ashley M", "initials": "AM"}, {"family": "Gramignoli", "given": "Roberto", "initials": "R", "orcid": "0000-0003-3362-4170", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a68ade86efde42e89d9e76ae394bac43.json"}}, {"family": "Bozoky", "given": "Bela", "initials": "B"}, {"family": "Kehr", "given": "Jan", "initials": "J"}, {"family": "Theodorsson", "given": "Elvar", "initials": "E", "orcid": "0000-0003-0756-7723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/89fe23c2f2bf422ead8a6c0328f7cf58.json"}}, {"family": "Cancelas", "given": "Jose A", "initials": "JA"}, {"family": "Mravec", "given": "Boris", "initials": "B", "orcid": "0000-0002-3177-6819", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a084b817fbfb4506a04f16dd7c26fd24.json"}}, {"family": "Jorns", "given": "Carl", "initials": "C", "orcid": "0000-0001-7727-8113", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef68cb234b3141278a29a407ed988b32.json"}}, {"family": "Ellis", "given": "Ewa", "initials": "E", "orcid": "0000-0002-3057-5337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0f976a75ff7429480a5b940f9cf349a.json"}}, {"family": "Mulder", "given": "Jan", "initials": "J", "orcid": "0000-0003-3717-5018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40ed8170792444b491519e499d51c434.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Bark", "given": "Christina", "initials": "C", "orcid": "0000-0002-0724-6017", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b386bbd3b8ba4a7cafe9dc4fabe32931.json"}}, {"family": "H\u00f6kfelt", "given": "Tomas", "initials": "T"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "7", "issue": "30", "issn-l": "2375-2548"}, "abstract": "Hepatic nerves have a complex role in synchronizing liver metabolism. Here, we used three-dimensional (3D) immunoimaging to explore the integrity of the hepatic nervous system in experimental and human nonalcoholic fatty liver disease (NAFLD). We demonstrate parallel signs of mild degeneration and axonal sprouting of sympathetic innervations in early stages of experimental NAFLD and a collapse of sympathetic arborization in steatohepatitis. Human fatty livers display a similar pattern of sympathetic nerve degeneration, correlating with the severity of NAFLD pathology. We show that chronic sympathetic hyperexcitation is a key factor in the axonal degeneration, here genetically phenocopied in mice deficient of the Rac-1 activator Vav3. In experimental steatohepatitis, 3D imaging reveals a severe portal vein contraction, spatially correlated with the extension of the remaining nerves around the portal vein, enlightening a potential intrahepatic neuronal mechanism of portal hypertension. These fundamental alterations in liver innervation and vasculature uncover previously unidentified neuronal components in NAFLD pathomechanisms.", "doi": "10.1126/sciadv.abg5733", "pmid": "34290096", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8294768"}, {"db": "pii", "key": "7/30/eabg5733"}], "notes": [], "created": "2026-08-21T12:22:18.863Z", "modified": "2026-08-21T12:22:19.207Z"}]}