{"entity": "researcher", "timestamp": "2026-09-28T23:04:32.579Z", "family": "H\u00f6glund", "given": "P", "initials": "P", "orcid": "0000-0002-9233-626X", "affiliations": ["Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f601bbc209342f68e104feb01a54f2f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f601bbc209342f68e104feb01a54f2f"}}, "publications": [{"entity": "publication", "iuid": "06e9238a5d4d4f229fafec87204fbcd6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/06e9238a5d4d4f229fafec87204fbcd6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/06e9238a5d4d4f229fafec87204fbcd6"}}, "title": "The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education.", "authors": [{"family": "Ganesan", "given": "S", "initials": "S"}, {"family": "Luu", "given": "T T", "initials": "TT"}, {"family": "Chambers", "given": "B J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/164ec85f86504556beafe8fe34405592.json"}}, {"family": "Meinke", "given": "S", "initials": "S"}, {"family": "Brodin", "given": "P", "initials": "P"}, {"family": "Vivier", "given": "E", "initials": "E"}, {"family": "Wetzel", "given": "D M", "initials": "DM"}, {"family": "Koleske", "given": "A J", "initials": "AJ"}, {"family": "Kadri", "given": "N", "initials": "N"}, {"family": "H\u00f6glund", "given": "P", "initials": "P", "orcid": "0000-0002-9233-626X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f601bbc209342f68e104feb01a54f2f.json"}}], "type": "journal article", "published": "2017-09-00", "journal": {"title": "Scand. J. Immunol.", "issn": "1365-3083", "volume": "86", "issue": "3", "pages": "135-142", "issn-l": "0300-9475"}, "abstract": "Natural killer (NK) cell responsiveness in the mouse is determined in an education process guided by inhibitory Ly49 and NKG2A receptors binding to MHC class I molecules. It has been proposed that inhibitory signalling in human NK cells involves Abl-1 (c-Abl)-mediated phosphorylation of Crk, lowering NK cell function via disruption of a signalling complex including C3G and c-Cbl, suggesting that NK cell education might involve c-Abl. Mice deficient in c-Abl expression specifically in murine NK cells displayed normal inhibitory and activating receptor repertoires. Furthermore, c-Abl-deficient NK cells fluxed Ca2+ normally after triggering of ITAM receptors, killed YAC-1 tumour cells efficiently and showed normal, or even slightly elevated, capacity to produce IFN-\u03b3 after activating receptor stimulation. Consistent with these results, c-Abl deficiency in NK cells did not affect NK cell inhibition via the receptors Ly49G2, Ly49A and NKG2A. We conclude that signalling downstream of murine inhibitory receptors does not involve c-Abl and that c-Abl plays no major role in NK cell education in the mouse.", "doi": "10.1111/sji.12574", "pmid": "28605050", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS883530"}, {"db": "pmc", "key": "PMC5568956"}], "notes": [], "created": "2018-12-05T12:56:59.675Z", "modified": "2026-09-23T13:05:21.697Z"}]}