{"entity": "researcher", "timestamp": "2026-08-20T21:04:52.215Z", "family": "Vandenbrouck", "given": "Yves", "initials": "Y", "orcid": "0000-0002-1292-373X", "affiliations": ["Universit\u00e9 Grenoble Alpes, CEA, Inserm U1292, Grenoble 38000, France."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ed616edf97c454aa6b79c56e565ce64.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ed616edf97c454aa6b79c56e565ce64"}}, "publications": [{"entity": "publication", "iuid": "47fd732a27064ac6ad542fa347d7dc8b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/47fd732a27064ac6ad542fa347d7dc8b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/47fd732a27064ac6ad542fa347d7dc8b"}}, "title": "The Circulating Proteome\u2500Technological Developments, Current Challenges, and Future Trends.", "authors": [{"family": "Geyer", "given": "Philipp E", "initials": "PE", "orcid": "0000-0001-7980-4826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d69184685884e28ac1557b8bf354920.json"}}, {"family": "Hornburg", "given": "Daniel", "initials": "D", "orcid": "0000-0002-6618-7774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cee5a39e5314a03ab14899eff0f9b11.json"}}, {"family": "Pernemalm", "given": "Maria", "initials": "M"}, {"family": "Hauck", "given": "Stefanie M", "initials": "SM", "orcid": "0000-0002-1630-6827", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c34e958b66ea4d4f90bc5d77a1ef2fbb.json"}}, {"family": "Palaniappan", "given": "Krishnan K", "initials": "KK", "orcid": "0000-0003-0203-9016", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ad180add9d14755b44834d00ea88fb4.json"}}, {"family": "Albrecht", "given": "Vincent", "initials": "V"}, {"family": "Dagley", "given": "Laura F", "initials": "LF", "orcid": "0000-0003-4171-3712", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37484d809bd244978484d49d685d5520.json"}}, {"family": "Moritz", "given": "Robert L", "initials": "RL"}, {"family": "Yu", "given": "Xiaobo", "initials": "X"}, {"family": "Edfors", "given": "Fredrik", "initials": "F"}, {"family": "Vandenbrouck", "given": "Yves", "initials": "Y", "orcid": "0000-0002-1292-373X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ed616edf97c454aa6b79c56e565ce64.json"}}, {"family": "Mueller-Reif", "given": "Johannes B", "initials": "JB"}, {"family": "Sun", "given": "Zhi", "initials": "Z"}, {"family": "Brun", "given": "Virginie", "initials": "V", "orcid": "0000-0002-9098-8707", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/075e825949ea4031bbcf6a2449ce1051.json"}}, {"family": "Ahadi", "given": "Sara", "initials": "S"}, {"family": "Omenn", "given": "Gilbert S", "initials": "GS", "orcid": "0000-0002-8976-6074", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8271c48d1bc6477ca3ba90d05d3854ad.json"}}, {"family": "Deutsch", "given": "Eric W", "initials": "EW", "orcid": "0000-0001-8732-0928", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2463c206245a4dbb979cad9d201d73c4.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}], "type": "journal article", "published": "2024-12-06", "journal": {"title": "J. Proteome Res.", "issn": "1535-3907", "volume": "23", "issue": "12", "pages": "5279-5295", "issn-l": "1535-3893"}, "abstract": "Recent improvements in proteomics technologies have fundamentally altered our capacities to characterize human biology. There is an ever-growing interest in using these novel methods for studying the circulating proteome, as blood offers an accessible window into human health. However, every methodological innovation and analytical progress calls for reassessing our existing approaches and routines to ensure that the new data will add value to the greater biomedical research community and avoid previous errors. As representatives of HUPO's Human Plasma Proteome Project (HPPP), we present our 2024 survey of the current progress in our community, including the latest build of the Human Plasma Proteome PeptideAtlas that now comprises 4608 proteins detected in 113 data sets. We then discuss the updates of established proteomics methods, emerging technologies, and investigations of proteoforms, protein networks, extracellualr vesicles, circulating antibodies and microsamples. Finally, we provide a prospective view of using the current and emerging proteomics tools in studies of circulating proteins.", "doi": "10.1021/acs.jproteome.4c00586", "pmid": "39479990", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11629384"}], "notes": [], "created": "2026-08-20T08:11:51.037Z", "modified": "2026-08-20T08:11:51.256Z"}, {"entity": "publication", "iuid": "209b1e6bec59490f9922fab7244b452a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/209b1e6bec59490f9922fab7244b452a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/209b1e6bec59490f9922fab7244b452a"}}, "title": "Advances and Utility of the Human Plasma Proteome.", "authors": [{"family": "Deutsch", "given": "Eric W", "initials": "EW", "orcid": "0000-0001-8732-0928", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2463c206245a4dbb979cad9d201d73c4.json"}}, {"family": "Omenn", "given": "Gilbert S", "initials": "GS", "orcid": "0000-0002-8976-6074", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8271c48d1bc6477ca3ba90d05d3854ad.json"}}, {"family": "Sun", "given": "Zhi", "initials": "Z", "orcid": "0000-0003-3324-6851", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d5076a80c046441482472dea34610eb6.json"}}, {"family": "Maes", "given": "Michal", "initials": "M", "orcid": "0000-0002-7406-3982", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81e9fc09132c4e5685870c00b35717ea.json"}}, {"family": "Pernemalm", "given": "Maria", "initials": "M", "orcid": "0000-0003-4624-031X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c34e0806a3d142019ae8e16de8d720ef.json"}}, {"family": "Palaniappan", "given": "Krishnan K", "initials": "KK", "orcid": "0000-0003-0203-9016", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ad180add9d14755b44834d00ea88fb4.json"}}, {"family": "Letunica", "given": "Natasha", "initials": "N", "orcid": "0000-0003-3604-1536", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca1b9a786b064d6aa7b8c68331fc25f0.json"}}, {"family": "Vandenbrouck", "given": "Yves", "initials": "Y", "orcid": "0000-0002-1292-373X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ed616edf97c454aa6b79c56e565ce64.json"}}, {"family": "Brun", "given": "Virginie", "initials": "V", "orcid": "0000-0002-9098-8707", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/075e825949ea4031bbcf6a2449ce1051.json"}}, {"family": "Tao", "given": "Sheng-Ce", "initials": "SC", "orcid": "0000-0002-9210-1823", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95665a9e4ff6496dbe47132ddf08ef3b.json"}}, {"family": "Yu", "given": "Xiaobo", "initials": "X"}, {"family": "Geyer", "given": "Philipp E", "initials": "PE", "orcid": "0000-0001-7980-4826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d69184685884e28ac1557b8bf354920.json"}}, {"family": "Ignjatovic", "given": "Vera", "initials": "V", "orcid": "0000-0002-5548-5813", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8fa9f5752da349a79a4969866f014edb.json"}}, {"family": "Moritz", "given": "Robert L", "initials": "RL", "orcid": "0000-0002-3216-9447", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/505eb37634de49d4b6a29f41c18f142b.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}], "type": "journal article", "published": "2021-12-03", "journal": {"title": "J. Proteome Res.", "issn": "1535-3907", "volume": "20", "issue": "12", "pages": "5241-5263", "issn-l": "1535-3893"}, "abstract": "The study of proteins circulating in blood offers tremendous opportunities to diagnose, stratify, or possibly prevent diseases. With recent technological advances and the urgent need to understand the effects of COVID-19, the proteomic analysis of blood-derived serum and plasma has become even more important for studying human biology and pathophysiology. Here we provide views and perspectives about technological developments and possible clinical applications that use mass-spectrometry(MS)- or affinity-based methods. We discuss examples where plasma proteomics contributed valuable insights into SARS-CoV-2 infections, aging, and hemostasis and the opportunities offered by combining proteomics with genetic data. As a contribution to the Human Proteome Organization (HUPO) Human Plasma Proteome Project (HPPP), we present the Human Plasma PeptideAtlas build 2021-07 that comprises 4395 canonical and 1482 additional nonredundant human proteins detected in 240 MS-based experiments. In addition, we report the new Human Extracellular Vesicle PeptideAtlas 2021-06, which comprises five studies and 2757 canonical proteins detected in extracellular vesicles circulating in blood, of which 74% (2047) are in common with the plasma PeptideAtlas. Our overview summarizes the recent advances, impactful applications, and ongoing challenges for translating plasma proteomics into utility for precision medicine.", "doi": "10.1021/acs.jproteome.1c00657", "pmid": "34672606", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1833436"}, {"db": "pmc", "key": "PMC9469506"}], "notes": [], "created": "2026-08-20T08:11:22.145Z", "modified": "2026-08-20T08:11:22.712Z"}]}