{"entity": "researcher", "timestamp": "2026-08-20T20:40:41.330Z", "family": "Lindroos", "given": "Robert", "initials": "R", "orcid": "0000-0002-9134-3601", "affiliations": ["Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e27a33b27214884a0563693dc4c96e5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e27a33b27214884a0563693dc4c96e5"}}, "publications": [{"entity": "publication", "iuid": "8eac5a60871b43c1a0df4de26e89da8d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8eac5a60871b43c1a0df4de26e89da8d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8eac5a60871b43c1a0df4de26e89da8d"}}, "title": "Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem.", "authors": [{"family": "Khodadadi", "given": "Zahra", "initials": "Z", "orcid": "0000-0001-6124-949X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f4d9f5bc2194a5ebfe98cd6ddcceea5.json"}}, {"family": "Trpevski", "given": "Daniel", "initials": "D", "orcid": "0000-0001-9068-6744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b007cf92b2cb4bc8a4c61436e4e3cefc.json"}}, {"family": "Lindroos", "given": "Robert", "initials": "R", "orcid": "0000-0002-9134-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e27a33b27214884a0563693dc4c96e5.json"}}, {"family": "Hellgren Kotaleski", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-0550-0739", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a920517bd1c142878f03bee05e843b62.json"}}], "type": "journal article", "published": "2025-11-17", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "13", "issn-l": "2050-084X"}, "abstract": "This study investigates the computational potential of single striatal projection neurons (SPNs), emphasizing dendritic nonlinearities and their crucial role in solving complex integration problems. Utilizing a biophysically detailed multicompartmental model of an SPN, we introduce a calcium-based, local synaptic learning rule dependent on dendritic plateau potentials. According to what is known about excitatory corticostriatal synapses, the learning rule is governed by local calcium dynamics from NMDA and L-type calcium channels and dopaminergic reward signals. In order to devise a self-adjusting learning rule, which ensures stability for individual synaptic weights, metaplasticity is also used. We demonstrate that this rule allows single neurons with sufficiently nonlinear dendrites to solve the nonlinear feature binding problem, a task traditionally attributed to neuronal networks. We also detail an inhibitory plasticity mechanism that contributes to dendritic compartmentalization, further enhancing computational efficiency in dendrites. This in silico study highlights the computational potential of single neurons, providing deeper insights into neuronal information processing and the mechanisms by which the brain executes complex computations.", "doi": "10.7554/eLife.97274", "pmid": "41247161", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12622965"}, {"db": "pii", "key": "97274"}], "notes": [], "created": "2026-08-20T13:56:17.083Z", "modified": "2026-08-20T13:56:17.169Z"}, {"entity": "publication", "iuid": "e821c61781074c6f93da5a91df5c0cd4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e821c61781074c6f93da5a91df5c0cd4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e821c61781074c6f93da5a91df5c0cd4"}}, "title": "Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem", "authors": [{"family": "Khodadadi", "given": "Zahra", "initials": "Z", "orcid": "0000-0001-6124-949X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f4d9f5bc2194a5ebfe98cd6ddcceea5.json"}}, {"family": "Trpevski", "given": "Daniel", "initials": "D", "orcid": "0000-0001-9068-6744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b007cf92b2cb4bc8a4c61436e4e3cefc.json"}}, {"family": "Lindroos", "given": "Robert", "initials": "R", "orcid": "0000-0002-9134-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e27a33b27214884a0563693dc4c96e5.json"}}, {"family": "Hellgren Kotaleski", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-0550-0739", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a920517bd1c142878f03bee05e843b62.json"}}], "type": "journal-article", "published": "2025-11-17", "journal": {"issn": "2050-084X", "volume": "13", "title": "Elife", "issn-l": "2050-084X"}, "abstract": null, "doi": "10.7554/elife.97274.4", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:56:28.056Z", "modified": "2026-08-20T13:56:28.114Z"}, {"entity": "publication", "iuid": "c797720352fa4867ae3dd20d599de456", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c797720352fa4867ae3dd20d599de456.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c797720352fa4867ae3dd20d599de456"}}, "title": "Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem", "authors": [{"family": "Khodadadi", "given": "Zahra", "initials": "Z", "orcid": "0000-0001-6124-949X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f4d9f5bc2194a5ebfe98cd6ddcceea5.json"}}, {"family": "Trpevski", "given": "Daniel", "initials": "D", "orcid": "0000-0001-9068-6744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b007cf92b2cb4bc8a4c61436e4e3cefc.json"}}, {"family": "Lindroos", "given": "Robert", "initials": "R", "orcid": "0000-0002-9134-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e27a33b27214884a0563693dc4c96e5.json"}}, {"family": "Hellgren Kotaleski", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-0550-0739", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a920517bd1c142878f03bee05e843b62.json"}}], "type": "posted-content", "published": "2025-09-10", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.97274.3", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:56:26.278Z", "modified": "2026-08-20T13:56:26.350Z"}, {"entity": "publication", "iuid": "3c4574b2e8f144a2b67e9e899534b096", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3c4574b2e8f144a2b67e9e899534b096.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3c4574b2e8f144a2b67e9e899534b096"}}, "title": "Author response: Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem", "authors": [{"family": "Khodadadi", "given": "Zahra", "initials": "Z", "orcid": "0000-0001-6124-949X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f4d9f5bc2194a5ebfe98cd6ddcceea5.json"}}, {"family": "Trpevski", "given": "Daniel", "initials": "D", "orcid": "0000-0001-9068-6744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b007cf92b2cb4bc8a4c61436e4e3cefc.json"}}, {"family": "Lindroos", "given": "Robert", "initials": "R", "orcid": "0000-0002-9134-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e27a33b27214884a0563693dc4c96e5.json"}}, {"family": "Hellgren Kotaleski", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-0550-0739", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a920517bd1c142878f03bee05e843b62.json"}}], "type": "peer-review", "published": "2025-04-24", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.97274.2.sa0", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:56:24.448Z", "modified": "2026-08-20T13:56:24.519Z"}, {"entity": "publication", "iuid": "720df4eed1904229a46ba6e81a23ab1e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/720df4eed1904229a46ba6e81a23ab1e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/720df4eed1904229a46ba6e81a23ab1e"}}, "title": "Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem", "authors": [{"family": "Khodadadi", "given": "Zahra", "initials": "Z", "orcid": "0000-0001-6124-949X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f4d9f5bc2194a5ebfe98cd6ddcceea5.json"}}, {"family": "Trpevski", "given": "Daniel", "initials": "D", "orcid": "0000-0001-9068-6744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b007cf92b2cb4bc8a4c61436e4e3cefc.json"}}, {"family": "Lindroos", "given": "Robert", "initials": "R", "orcid": "0000-0002-9134-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e27a33b27214884a0563693dc4c96e5.json"}}, {"family": "Hellgren Kotaleski", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-0550-0739", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a920517bd1c142878f03bee05e843b62.json"}}], "type": "posted-content", "published": "2025-04-24", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.97274.2", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:56:22.459Z", "modified": "2026-08-20T13:56:22.493Z"}, {"entity": "publication", "iuid": "ae565990469145588d6314f332884309", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ae565990469145588d6314f332884309.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ae565990469145588d6314f332884309"}}, "title": "Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine.", "authors": [{"family": "Lindroos", "given": "Robert", "initials": "R", "orcid": "0000-0002-9134-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e27a33b27214884a0563693dc4c96e5.json"}}, {"family": "Hellgren Kotaleski", "given": "Jeanette", "initials": "J", "orcid": "0000-0002-0550-0739", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a920517bd1c142878f03bee05e843b62.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Eur. J. Neurosci.", "issn": "1460-9568", "volume": "53", "issue": "7", "pages": "2117-2134", "issn-l": "0953-816X"}, "abstract": "The input structure of the basal ganglia, striatum, receives dense neuromodulatory input in the form of dopamine and acetylcholine. The two systems are tightly connected, for example, synchronized activity of cholinergic interneurons, leading to increased acetylcholine release, has been shown to directly trigger dopamine release from dopaminergic terminals in striatum. Both signals are further needed for induction of locomotion. High dopamine concentration leads to increased excitability of the direct pathway striatal projection neurons. High cholinergic tone inhibits various potassium channels further increasing the excitability of striatal projection neurons. Here, we investigate the combined effect of concurrent high acetylcholine and dopamine using biophysically detailed models based on rodent data. The aim of the study is to investigate how neuromodulation affects dendritic integration. The result shows that neuromodulation paired with synaptic activation of dendrites can give rise to complex spiking patterns, resembling spike shapes seen in the hippocampus. In the hippocampus, these complex spikes are associated with behavioral time scale plasticity and place cell tuning. We further investigate the mechanisms behind the complex spikes and find that there are two components, one axo-somatic and one dendritic in origin.", "doi": "10.1111/ejn.14891", "pmid": "32609903", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:17:44.496Z", "modified": "2026-08-20T11:17:44.601Z"}]}