{"entity": "researcher", "timestamp": "2026-08-20T21:11:24.445Z", "family": "Bj\u00f6rklund", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0003-2224-7090", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0"}}, "publications": [{"entity": "publication", "iuid": "57b68793aa824f6f891b6f7e0f485c6d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/57b68793aa824f6f891b6f7e0f485c6d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/57b68793aa824f6f891b6f7e0f485c6d"}}, "title": "Postnatal FGFR-signaling establishes gradients of secretory cell identities along the proximal-distal axis of the lung airways", "authors": [{"family": "Sountoulidis", "given": "Alexandros", "initials": "A", "orcid": "0000-0002-8837-4642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/618bb4684ceb4d839a2a83d4a7bca479.json"}}, {"family": "Firsova", "given": "Alexandra B", "initials": "AB", "orcid": "0000-0002-7345-7429", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b52d4946b347c5b99cab25b958cc43.json"}}, {"family": "Liontos", "given": "Andreas", "initials": "A", "orcid": "0000-0003-0838-3571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5690cc0920d42aaae3dae9eaaedd2e6.json"}}, {"family": "Theelke", "given": "Jonas", "initials": "J", "orcid": "0000-0002-5074-1793", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3ffb6926be74c11928edb174a245718.json"}}, {"family": "Koepke", "given": "Janine", "initials": "J"}, {"family": "Millar-B\u00fcchner", "given": "Pamela", "initials": "P", "orcid": "0000-0002-0079-6200", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1d73ee7c0004665af7e3406a2e3b9a9.json"}}, {"family": "Manner\u00e5s-Holm", "given": "Louise", "initials": "L", "orcid": "0000-0001-8783-6107", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1da5a99df644b72adf7bd3524dbdfa3.json"}}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0003-2224-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}}, {"family": "Fysikopoulos", "given": "Athanasios", "initials": "A", "orcid": "0000-0002-8081-0198", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9fbd975bb6524e31a9ee8f079bc1513e.json"}}, {"family": "Gaengel", "given": "Konstantin", "initials": "K", "orcid": "0000-0002-2682-2833", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/725dce05043142eca1ebfa7c05494037.json"}}, {"family": "B\u00e4ckhed", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-4871-8818", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6340409dae344947868b4d6c79413cb5.json"}}, {"family": "Betsholtz", "given": "Christer", "initials": "C", "orcid": "0000-0002-8494-971X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7839aedc01354442a552955542cfc754.json"}}, {"family": "Seeger", "given": "Werner", "initials": "W", "orcid": "0000-0003-1946-0894", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/59c1a6af6c4240a89064d5a0b5abfc25.json"}}, {"family": "Bellusci", "given": "Saverio", "initials": "S", "orcid": "0000-0001-5987-4579", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/775bd6384dc94fc98c87fef871bcaba3.json"}}, {"family": "Samakovlis", "given": "Christos", "initials": "C", "orcid": "0000-0002-9153-6040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8ef864cc7c34dba830faa9caeafc3e7.json"}}], "type": "posted-content", "published": "2023-12-12", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.12.11.571142", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:50:55.983Z", "modified": "2026-08-20T10:50:56.293Z"}, {"entity": "publication", "iuid": "84b68e9019d34d52aecd219380bdb7bb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/84b68e9019d34d52aecd219380bdb7bb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/84b68e9019d34d52aecd219380bdb7bb"}}, "title": "Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients.", "authors": [{"family": "Sar\u00e9n", "given": "Tina", "initials": "T", "orcid": "0000-0001-5227-6779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed75a6dcbb9940e49481280af6183d69.json"}}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M", "orcid": "0000-0003-2685-0575", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd947633edf949aba9e680e63a1e178b.json"}}, {"family": "Gammelg\u00e5rd", "given": "Gustav", "initials": "G", "orcid": "0009-0008-5522-0103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/23c14e3d3bf445a7b3ff9d45eafbc5e1.json"}}, {"family": "L\u00f6vgren", "given": "Tanja", "initials": "T", "orcid": "0000-0003-2170-0682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4a04a7c6e904ff0945c058fcaa3151d.json"}}, {"family": "Mirabello", "given": "Claudio", "initials": "C", "orcid": "0000-0001-7868-034X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4ca88bb3cf24e2591c447ec929502e6.json"}}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0003-2224-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}}, {"family": "Wikstr\u00f6m", "given": "Kristina", "initials": "K", "orcid": "0009-0000-1027-2534", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c1933e2ca1f494998c1681623af5ce9.json"}}, {"family": "Hashemi", "given": "Jamileh", "initials": "J", "orcid": "0000-0002-4997-3765", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2e89291626e4f3eb73835d352bf67f4.json"}}, {"family": "Freyhult", "given": "Eva", "initials": "E", "orcid": "0000-0003-0226-1047", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13486bb11790445fa37f592a42e6a7ed.json"}}, {"family": "Ahlstr\u00f6m", "given": "H\u00e5kan", "initials": "H", "orcid": "0000-0002-8701-969X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e0504d2b7e14415b7c20229df25c0aa.json"}}, {"family": "Amini", "given": "Rose-Marie", "initials": "RM", "orcid": "0000-0003-0901-5252", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae2f974dbafa4cdbbe268c635adcd278.json"}}, {"family": "Hagberg", "given": "Hans", "initials": "H", "orcid": "0000-0001-7855-2452", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f525112ab8e94ce790be483b56d7cbd6.json"}}, {"family": "Loskog", "given": "Angelica", "initials": "A", "orcid": "0000-0001-8583-6138", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/572e5b01b3bd48779252b9020732cb09.json"}}, {"family": "Enblad", "given": "Gunilla", "initials": "G", "orcid": "0000-0002-0594-724X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a285fb437854e2c998356b1a3124416.json"}}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}], "type": "journal article", "published": "2023-10-13", "journal": {"title": "Clin. Cancer Res.", "issn": "1557-3265", "volume": "29", "issue": "20", "pages": "4139-4152", "issn-l": "1078-0432"}, "abstract": "Although CD19 chimeric antigen receptor T cells (CAR-T) therapy has shown remarkable success in B-cell malignancies, a substantial fraction of patients do not obtain a long-term clinical response. This could be influenced by the quality of the individual CAR-T infusion product. To shed some light on this, clinical outcome was correlated to characteristics of CAR-T infusion products.\n\nIn this phase II study, patients with B-cell lymphoma (n = 23) or leukemia (n = 1) received one or two infusions of third-generation CD19-directed CAR-Ts (2 \u00d7 108/m2). The clinical trial was registered at clinicaltrials.gov: NCT03068416. We investigated the transcriptional profile of individual CD19 CAR-T infusion products using targeted single-cell RNA sequencing and multicolor flow cytometry.\n\nTwo CAR-T infusions were not better than one in the settings used in this study. As for the CAR-T infusion products, we found that effector-like CD8+CAR-Ts with a high polyfunctionality, high cytotoxic and cytokine production profile, and low dysfunctional signature were associated with clinical response. An extended ex vivo expansion time during CAR-T manufacturing negatively influenced the proportion of effector CD8+CAR-Ts in the infusion product.\n\nWe identified cell-intrinsic characteristics of effector CD8+CAR-Ts correlating with response that could be used as an indicator for clinical outcome. The results in the study also serve as a guide to CAR-T manufacturing practices.", "doi": "10.1158/1078-0432.CCR-23-0178", "pmid": "37540566", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10570681"}, {"db": "pii", "key": "728314"}, {"db": "ClinicalTrials.gov", "key": "NCT03068416"}, {"db": "figshare", "key": "20208764"}], "notes": [], "created": "2026-08-20T12:12:20.782Z", "modified": "2026-08-20T12:12:21.097Z"}, {"entity": "publication", "iuid": "190b9ad3f2254c088c8b42ae5247e521", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/190b9ad3f2254c088c8b42ae5247e521.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/190b9ad3f2254c088c8b42ae5247e521"}}, "title": "Spatially resolved multiomics on the neuronal effects induced by spaceflight", "authors": [{"family": "Masarapu", "given": "Yuvarani", "initials": "Y"}, {"family": "Cekanaviciute", "given": "Egle", "initials": "E"}, {"family": "Andrusivova", "given": "Zaneta", "initials": "Z"}, {"family": "Westholm", "given": "Jakub Orzechowski", "initials": "JO", "orcid": "0000-0002-6849-6220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/966341b184974f0f81c34e36cadd74e0.json"}}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0003-2224-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}}, {"family": "Fallegger", "given": "Robin", "initials": "R", "orcid": "0000-0003-3264-6028", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c0497384810432fb0a9e166ece4712f.json"}}, {"family": "Badia-i-Mompel", "given": "Pau", "initials": "P", "orcid": "0000-0002-1004-3923", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1840e6190eae436f86ee079f4364d45f.json"}}, {"family": "Boyko", "given": "Valery", "initials": "V"}, {"family": "Vasisht", "given": "Shubha", "initials": "S"}, {"family": "Saravia-Butler", "given": "Amanda", "initials": "A"}, {"family": "Gebre", "given": "Samrawit", "initials": "S"}, {"family": "L\u00e1z\u00e1r", "given": "Enik\u00f6", "initials": "E", "orcid": "0000-0001-8664-7531", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/422fbfd83b1646e28d5021ac7b8f598c.json"}}, {"family": "Bergmann", "given": "Olaf", "initials": "O", "orcid": "0000-0003-1065-4107", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5c930ddb65b49a4962c6c3d223e39ea.json"}}, {"family": "Taylor", "given": "Deanne", "initials": "D"}, {"family": "Wallace", "given": "Douglas", "initials": "D", "orcid": "0000-0002-7480-8278", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e305f45b4ac4631a6cd05d2a426b6c1.json"}}, {"family": "Sylv\u00e9n", "given": "Christer", "initials": "C"}, {"family": "Rodriguez", "given": "Julio Saez", "initials": "JS", "orcid": "0000-0002-8552-8976", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/504df2e61c124714b9afecf767798a00.json"}}, {"family": "Galazka", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-4153-0249", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8ee9225af3242c694262e35105782b9.json"}}, {"family": "Costes", "given": "Sylvain", "initials": "S", "orcid": "0000-0002-8542-2389", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05e9f957d1fa4a6bb16528119f2d71bc.json"}}, {"family": "Giacomello", "given": "Stefania", "initials": "S", "orcid": "0000-0003-0738-1574", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a9c4a7494ba4284ab52158e6cbc85da.json"}}], "type": "posted-content", "published": "2023-05-31", "journal": {"issn-l": null}, "abstract": null, "doi": "10.21203/rs.3.rs-2865086/v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:59:03.166Z", "modified": "2026-08-20T12:59:03.485Z"}, {"entity": "publication", "iuid": "f7c4bc34360b47389f0ce5b6ad77b3c6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f7c4bc34360b47389f0ce5b6ad77b3c6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f7c4bc34360b47389f0ce5b6ad77b3c6"}}, "title": "Characterization of the nuclear and cytosolic transcriptomes in human brain tissue reveals new insights into the subcellular distribution of RNA transcripts", "authors": [{"family": "Zaghlool", "given": "Ammar", "initials": "A", "orcid": "0000-0003-1544-8070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/113ecbaaf81344b08b31314429926252.json"}}, {"family": "Niazi", "given": "Adnan", "initials": "A", "orcid": "0000-0003-0311-5279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4fe465f7bda44afba9b5c58c1c0a478.json"}}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0003-2224-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}}, {"family": "Westholm", "given": "Jakub Orzechowski", "initials": "JO", "orcid": "0000-0002-6849-6220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/966341b184974f0f81c34e36cadd74e0.json"}}, {"family": "Ameur", "given": "Adam", "initials": "A", "orcid": "0000-0001-6085-6749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8b8ce05cf7f49aeb3199b5938b9f160.json"}}, {"family": "Feuk", "given": "Lars", "initials": "L", "orcid": "0000-0003-2355-2919", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fbdc6712238248f28392139dacb6df99.json"}}], "type": "posted-content", "published": "2020-04-08", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.04.08.031419", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:56:46.976Z", "modified": "2026-08-20T09:56:47.097Z"}]}