{"entity": "researcher", "timestamp": "2026-09-29T12:00:08.402Z", "family": "Karlsson", "given": "Niclas G", "initials": "NG", "orcid": "0000-0002-3045-2628", "affiliations": ["Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 40530, Sweden. niclas.karlsson@medkem.gu.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c08a75b6d56459bbd00e8e3fe8004bf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c08a75b6d56459bbd00e8e3fe8004bf"}}, "publications": [{"entity": "publication", "iuid": "f3ba37fee1514362b3dfe942ae230410", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f3ba37fee1514362b3dfe942ae230410.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f3ba37fee1514362b3dfe942ae230410"}}, "title": "Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.", "authors": [{"family": "Spelat", "given": "Renza", "initials": "R", "orcid": "0000-0001-5794-8976", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a75758dfbb60443bb0321351827d27fb.json"}}, {"family": "Ferro", "given": "Federico", "initials": "F", "orcid": "0000-0002-6023-8227", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad5d7f730e874aa381810f9425928345.json"}}, {"family": "Contessotto", "given": "Paolo", "initials": "P"}, {"family": "Aljaabary", "given": "Amal", "initials": "A", "orcid": "0000-0003-0361-166X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca41b354baf94470bb02a684b57fff55.json"}}, {"family": "Martin-Salda\u00f1a", "given": "Sergio", "initials": "S", "orcid": "0000-0002-9506-8483", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8e9dde0abce4eeaa8a0a556e3d895b4.json"}}, {"family": "Jin", "given": "Chunsheng", "initials": "C", "orcid": "0000-0002-0229-102X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a101a608bfd24b54856d1ca422a0ffcf.json"}}, {"family": "Karlsson", "given": "Niclas G", "initials": "NG", "orcid": "0000-0002-3045-2628", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c08a75b6d56459bbd00e8e3fe8004bf.json"}}, {"family": "Grealy", "given": "Maura", "initials": "M"}, {"family": "Hilscher", "given": "Markus M", "initials": "MM", "orcid": "0000-0001-7782-0830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec435b1759284c98aa17c7dfd11c3617.json"}}, {"family": "Magni", "given": "Fulvio", "initials": "F"}, {"family": "Chinello", "given": "Clizia", "initials": "C"}, {"family": "Kilcoyne", "given": "Michelle", "initials": "M", "orcid": "0000-0002-8870-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/efa8bcd7e34541209600e3a554cf5765.json"}}, {"family": "Pandit", "given": "Abhay", "initials": "A", "orcid": "0000-0002-6292-4933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee7eede49c3c4a6493ffc0d2d7a7c3df.json"}}], "type": "journal article", "published": "2022-12-13", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "5", "issue": "1", "pages": "1365", "issn-l": "2399-3642"}, "abstract": "The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages. Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question. Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration. Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration. Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.", "doi": "10.1038/s42003-022-04328-2", "pmid": "36509839", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9744865"}, {"db": "pii", "key": "10.1038/s42003-022-04328-2"}], "notes": [], "created": "2026-09-23T11:57:10.884Z", "modified": "2026-09-23T11:57:11.188Z"}, {"entity": "publication", "iuid": "aeef9c3669b84ca7a4afcdb10beedc76", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/aeef9c3669b84ca7a4afcdb10beedc76.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/aeef9c3669b84ca7a4afcdb10beedc76"}}, "title": "Cathepsin g degrades synovial fluid lubricin: relevance for osteoarthritis pathogenesis", "authors": [{"family": "Huang", "given": "Shan", "initials": "S"}, {"family": "Thomsson", "given": "Kristina A", "initials": "KA"}, {"family": "Jin", "given": "Chunsheng", "initials": "C"}, {"family": "Alweddi", "given": "Sally", "initials": "S"}, {"family": "Struglics", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rolfson", "given": "Ola", "initials": "O"}, {"family": "Bj\u00f6rkman", "given": "Lena I", "initials": "LI"}, {"family": "Kalamajski", "given": "Sebastian", "initials": "S"}, {"family": "Schmidt", "given": "Tannin A", "initials": "TA"}, {"family": "Jay", "given": "Gregory D", "initials": "GD"}, {"family": "Krawetz", "given": "Roman", "initials": "R"}, {"family": "Karlsson", "given": "Niclas G", "initials": "NG", "orcid": "0000-0002-3045-2628", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c08a75b6d56459bbd00e8e3fe8004bf.json"}}, {"family": "Eisler", "given": "Thomas", "initials": "T"}], "type": "posted-content", "published": "2019-10-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/792184", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T14:30:11.937Z", "modified": "2026-09-23T14:30:11.981Z"}, {"entity": "publication", "iuid": "cca4db03747946478f4549164d9eb849", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cca4db03747946478f4549164d9eb849.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cca4db03747946478f4549164d9eb849"}}, "title": "Towards a standardized bioinformatics infrastructure for N- and O-glycomics.", "authors": [{"family": "Rojas-Macias", "given": "Miguel A", "initials": "MA"}, {"family": "Mariethoz", "given": "Julien", "initials": "J", "orcid": "0000-0001-8974-4417", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/950dfb0f623241b194cbc73353c2cbcd.json"}}, {"family": "Andersson", "given": "Peter", "initials": "P"}, {"family": "Jin", "given": "Chunsheng", "initials": "C"}, {"family": "Venkatakrishnan", "given": "Vignesh", "initials": "V", "orcid": "0000-0001-5671-1547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/14e0a16d5fa24934a7c3579ef6ff0bf3.json"}}, {"family": "Aoki", "given": "Nobuyuki P", "initials": "NP"}, {"family": "Shinmachi", "given": "Daisuke", "initials": "D", "orcid": "0000-0002-2591-3987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ce8f794aed74c649b554dc3f4314be4.json"}}, {"family": "Ashwood", "given": "Christopher", "initials": "C", "orcid": "0000-0001-5944-6179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ccff636a2ca4e78a920d5b708ca710f.json"}}, {"family": "Madunic", "given": "Katarina", "initials": "K", "orcid": "0000-0002-9310-4110", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a592cb9d7214c97a076eee799cf24c6.json"}}, {"family": "Zhang", "given": "Tao", "initials": "T"}, {"family": "Miller", "given": "Rebecca L", "initials": "RL", "orcid": "0000-0001-8574-1948", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1841c5b27fd54915a28cf8f044c94aa8.json"}}, {"family": "Horlacher", "given": "Oliver", "initials": "O"}, {"family": "Struwe", "given": "Weston B", "initials": "WB"}, {"family": "Watanabe", "given": "Yu", "initials": "Y"}, {"family": "Okuda", "given": "Shujiro", "initials": "S", "orcid": "0000-0002-7704-8104", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5e1a0e6688d40d899b2e11349a1f406.json"}}, {"family": "Levander", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0710-9792", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3aaa3dcdb4f4e9f9b4bd44097d85d0c.json"}}, {"family": "Kolarich", "given": "Daniel", "initials": "D", "orcid": "0000-0002-8452-1350", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/14374e53213348daa0598b92d87219de.json"}}, {"family": "Rudd", "given": "Pauline M", "initials": "PM"}, {"family": "Wuhrer", "given": "Manfred", "initials": "M"}, {"family": "Kettner", "given": "Carsten", "initials": "C", "orcid": "0000-0002-8697-6842", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b462e7906cbd494488035045e227c6e0.json"}}, {"family": "Packer", "given": "Nicolle H", "initials": "NH", "orcid": "0000-0002-7532-4021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f88f96eb06e40718d01e4ae2d01916f.json"}}, {"family": "Aoki-Kinoshita", "given": "Kiyoko F", "initials": "KF", "orcid": "0000-0002-6662-8015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac843f0320cc48948f948928d2149add.json"}}, {"family": "Lisacek", "given": "Fr\u00e9d\u00e9rique", "initials": "F", "orcid": "0000-0002-0948-4537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76908c4fa6f8427d84e5edfc56f49b0a.json"}}, {"family": "Karlsson", "given": "Niclas G", "initials": "NG", "orcid": "0000-0002-3045-2628", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c08a75b6d56459bbd00e8e3fe8004bf.json"}}], "type": "journal article", "published": "2019-07-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "10", "issue": "1", "pages": "3275", "issn-l": "2041-1723"}, "abstract": "The mass spectrometry (MS)-based analysis of free polysaccharides and glycans released from proteins, lipids and proteoglycans increasingly relies on databases and software. Here, we review progress in the bioinformatics analysis of protein-released N- and O-linked glycans (N- and O-glycomics) and propose an e-infrastructure to overcome current deficits in data and experimental transparency. This workflow enables the standardized submission of MS-based glycomics information into the public repository UniCarb-DR. It implements the MIRAGE (Minimum Requirement for A Glycomics Experiment) reporting guidelines, storage of unprocessed MS data in the GlycoPOST repository and glycan structure registration using the GlyTouCan registry, thereby supporting the development and extension of a glycan structure knowledgebase.", "doi": "10.1038/s41467-019-11131-x", "pmid": "31332201", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6796180"}, {"db": "pii", "key": "10.1038/s41467-019-11131-x"}], "notes": [], "created": "2026-09-23T07:39:01.722Z", "modified": "2026-09-23T07:39:02.353Z"}]}