{"entity": "researcher", "timestamp": "2026-09-27T00:21:57.885Z", "family": "Hennink", "given": "Wim E", "initials": "WE", "orcid": "0000-0002-5750-714X", "affiliations": ["Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Science for Life, Faculty of Science, Utrecht University, P. O. Box 80082, 3508 TB Utrecht, The Netherlands. T.Vermonden@uu.nl."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c0571fba35d4f9e855e155d502763d5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c0571fba35d4f9e855e155d502763d5"}}, "publications": [{"entity": "publication", "iuid": "00a3187289bc4277a6605b4bde8c1c2c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/00a3187289bc4277a6605b4bde8c1c2c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/00a3187289bc4277a6605b4bde8c1c2c"}}, "title": "LCST polymers with UCST behavior.", "authors": [{"family": "Najafi", "given": "Marzieh", "initials": "M"}, {"family": "Habibi", "given": "Mehdi", "initials": "M", "orcid": "0000-0003-4672-0516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d84a99fec3cf440087a10bd9919b4af3.json"}}, {"family": "Fokkink", "given": "Remco", "initials": "R"}, {"family": "Hennink", "given": "Wim E", "initials": "WE", "orcid": "0000-0002-5750-714X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c0571fba35d4f9e855e155d502763d5.json"}}, {"family": "Vermonden", "given": "Tina", "initials": "T", "orcid": "0000-0002-6047-5900", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8cbf6d1567214a2ca80e241437a27601.json"}}], "type": "journal article", "published": "2021-03-04", "journal": {"title": "Soft Matter", "issn": "1744-6848", "volume": "17", "issue": "8", "pages": "2132-2141", "issn-l": null}, "abstract": "In this study, temperature dependent behavior of dense dispersions of core crosslinked flower-like micelles is investigated. Micelles were prepared by mixing aqueous solutions of two ABA block copolymers with PEG B-blocks and thermosensitive A-blocks containing PNIPAM and crosslinkable moieties. At a temperature above the lower critical solution temperature (LCST), self-assembly of the polymers resulted in the formation of flower-like micelles with a hydrophilic PEG shell and a hydrophobic core. The micellar core was stabilized by native chemical ligation (NCL). Above the LCST, micelles displayed a radius of \u223c35 nm, while a radius of \u223c48 nm was found below the LCST due to hydration of the PNIPAM core. Concentrated dispersions of these micelles (\u22657.5 wt%) showed glassy state behavior below a critical temperature (Tc: 28 \u00b0C) which is close to the LCST of the polymers. Below this Tc, the increase in the micelle volume resulted in compression of micelles together above a certain concentration and formation of a glass. We quantified and compared micelle packing at different concentrations and temperatures. The storage moduli (G') of the dispersions showed a universal dependence on the effective volume fraction, which increased substantially above a certain effective volume fraction of \u03c6 = 1.2. Furthermore, a disordered lattice model describing this behavior fitted the experimental data and revealed a critical volume fraction of \u03c6c = 1.31 close to the experimental value of \u03c6 = 1.2. The findings reported provide insights for the molecular design of novel thermosensitive PNIPAM nanoparticles with tunable structural and mechanical properties.", "doi": "10.1039/d0sm01505a", "pmid": "33439188", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T09:46:32.753Z", "modified": "2026-09-23T10:20:43.036Z"}]}