{"entity": "researcher", "timestamp": "2026-09-28T23:51:54.274Z", "family": "Jandrasits", "given": "Christine", "initials": "C", "orcid": "0000-0003-1357-4401", "affiliations": ["Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b931395937446e0b9e0d25235ad0098.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b931395937446e0b9e0d25235ad0098"}}, "publications": [{"entity": "publication", "iuid": "49f0c13be8f54e739fb04e275ffc40ca", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/49f0c13be8f54e739fb04e275ffc40ca.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/49f0c13be8f54e739fb04e275ffc40ca"}}, "title": "Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.", "authors": [{"family": "Sch\u00fctte", "given": "Moritz", "initials": "M"}, {"family": "Risch", "given": "Thomas", "initials": "T"}, {"family": "Abdavi-Azar", "given": "Nilofar", "initials": "N"}, {"family": "Boehnke", "given": "Karsten", "initials": "K"}, {"family": "Schumacher", "given": "Dirk", "initials": "D"}, {"family": "Keil", "given": "Marlen", "initials": "M"}, {"family": "Yildiriman", "given": "Reha", "initials": "R"}, {"family": "Jandrasits", "given": "Christine", "initials": "C", "orcid": "0000-0003-1357-4401", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b931395937446e0b9e0d25235ad0098.json"}}, {"family": "Borodina", "given": "Tatiana", "initials": "T"}, {"family": "Amstislavskiy", "given": "Vyacheslav", "initials": "V", "orcid": "0000-0002-1384-7599", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee79e8f281014ccb829afedef2864d47.json"}}, {"family": "Worth", "given": "Catherine L", "initials": "CL"}, {"family": "Schweiger", "given": "Caroline", "initials": "C"}, {"family": "Liebs", "given": "Sandra", "initials": "S"}, {"family": "Lange", "given": "Martin", "initials": "M", "orcid": "0000-0002-4045-3915", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/03197bd5651e4b45b48fffe9c21859fa.json"}}, {"family": "Warnatz", "given": "Hans-J\u00f6rg", "initials": "HJ"}, {"family": "Butcher", "given": "Lee M", "initials": "LM"}, {"family": "Barrett", "given": "James E", "initials": "JE"}, {"family": "Sultan", "given": "Marc", "initials": "M"}, {"family": "Wierling", "given": "Christoph", "initials": "C"}, {"family": "Golob-Schwarzl", "given": "Nicole", "initials": "N"}, {"family": "Lax", "given": "Sigurd", "initials": "S"}, {"family": "Uranitsch", "given": "Stefan", "initials": "S"}, {"family": "Becker", "given": "Michael", "initials": "M"}, {"family": "Welte", "given": "Yvonne", "initials": "Y"}, {"family": "Regan", "given": "Joseph Lewis", "initials": "JL"}, {"family": "Silvestrov", "given": "Maxine", "initials": "M"}, {"family": "Kehler", "given": "Inge", "initials": "I"}, {"family": "Fusi", "given": "Alberto", "initials": "A"}, {"family": "Kessler", "given": "Thomas", "initials": "T"}, {"family": "Herwig", "given": "Ralf", "initials": "R", "orcid": "0000-0002-9335-1760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3c5548fafa940bf91f96d652eb8a96e.json"}}, {"family": "Landegren", "given": "Ulf", "initials": "U", "orcid": "0000-0002-7820-1000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8749cdcda45a43d8bb2df04b0b211f36.json"}}, {"family": "Wienke", "given": "Dirk", "initials": "D"}, {"family": "Nilsson", "given": "Mats", "initials": "M"}, {"family": "Velasco", "given": "Juan A", "initials": "JA"}, {"family": "Garin-Chesa", "given": "Pilar", "initials": "P"}, {"family": "Reinhard", "given": "Christoph", "initials": "C"}, {"family": "Beck", "given": "Stephan", "initials": "S", "orcid": "0000-0001-5290-2151", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58ba6524fdd2421ca7cede1f3a32b613.json"}}, {"family": "Sch\u00e4fer", "given": "Reinhold", "initials": "R"}, {"family": "Regenbrecht", "given": "Christian R A", "initials": "CR"}, {"family": "Henderson", "given": "David", "initials": "D"}, {"family": "Lange", "given": "Bodo", "initials": "B"}, {"family": "Haybaeck", "given": "Johannes", "initials": "J", "orcid": "0000-0001-5518-3359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/931e14d9fc85417aa970b3e7b63128a5.json"}}, {"family": "Keilholz", "given": "Ulrich", "initials": "U"}, {"family": "Hoffmann", "given": "Jens", "initials": "J"}, {"family": "Lehrach", "given": "Hans", "initials": "H"}, {"family": "Yaspo", "given": "Marie-Laure", "initials": "ML", "orcid": "0000-0002-9555-9979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ebf21a0d8494c82a40c417243ef3fbb.json"}}], "type": "journal article", "published": "2017-02-10", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "8", "issue": null, "pages": "14262", "issn-l": "2041-1723"}, "abstract": "Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling >4,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.", "doi": "10.1038/ncomms14262", "pmid": "28186126", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5309787"}, {"db": "pii", "key": "ncomms14262"}], "notes": [], "created": "2018-12-05T09:15:43.553Z", "modified": "2026-09-23T06:35:58.196Z"}]}