{"entity": "researcher", "timestamp": "2026-08-25T09:38:21.807Z", "family": "Sedlacek", "given": "Radislav", "initials": "R", "orcid": "0000-0002-3352-392X", "affiliations": ["Institute of Molecular Genetics of the Czech Academy of Science, Czech Centre for Phenogenomics, Vestec, Czech Republic."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a4e65e5d3324132bba133349f00ae15.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a4e65e5d3324132bba133349f00ae15"}}, "publications": [{"entity": "publication", "iuid": "3505a36a8a2f4e438b0bad9b6208098b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3505a36a8a2f4e438b0bad9b6208098b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3505a36a8a2f4e438b0bad9b6208098b"}}, "title": "A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology.", "authors": [{"family": "Petersen", "given": "Julian", "initials": "J", "orcid": "0000-0002-7444-0610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2df2dd8db04447fa78bf79bac1a17d2.json"}}, {"family": "Englmaier", "given": "Lukas", "initials": "L", "orcid": "0000-0002-0082-2616", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/749ce625110d4f3b8839cbb733906219.json"}}, {"family": "Artemov", "given": "Artem V", "initials": "AV"}, {"family": "Poverennaya", "given": "Irina", "initials": "I"}, {"family": "Mahmoud", "given": "Ruba", "initials": "R"}, {"family": "Bouderlique", "given": "Thibault", "initials": "T"}, {"family": "Tesarova", "given": "Marketa", "initials": "M", "orcid": "0000-0002-5200-7365", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e26a2a23d8454d6d9dd6e1a498788877.json"}}, {"family": "Deviatiiarov", "given": "Ruslan", "initials": "R", "orcid": "0000-0003-0019-2076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/049ccf52c8b54a098f99f13a37c43b12.json"}}, {"family": "Szilv\u00e1sy-Szab\u00f3", "given": "Anett", "initials": "A"}, {"family": "Akkuratov", "given": "Evgeny E", "initials": "EE"}, {"family": "Pajuelo Reguera", "given": "David", "initials": "D", "orcid": "0000-0002-7715-9402", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45df782ef520405d9415c463b2d331b1.json"}}, {"family": "Zeberg", "given": "Hugo", "initials": "H", "orcid": "0000-0001-7118-1249", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c306297a4a0490c84a1d748b9f302a2.json"}}, {"family": "Kaucka", "given": "Marketa", "initials": "M", "orcid": "0000-0002-8781-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a458c8d68ec049a287848d4051ff84e7.json"}}, {"family": "Kastriti", "given": "Maria Eleni", "initials": "ME"}, {"family": "Krivanek", "given": "Jan", "initials": "J", "orcid": "0000-0002-7590-187X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f33f0fc83079412580418299f8879226.json"}}, {"family": "Radaszkiewicz", "given": "Tomasz", "initials": "T", "orcid": "0000-0003-4850-9933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9dd0b5c08064cfa87205d3834a9d9bd.json"}}, {"family": "G\u00f6m\u00f6ryov\u00e1", "given": "Krist\u00edna", "initials": "K", "orcid": "0000-0003-4407-3917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6c751c1c5244d68a1aa28e249e581f2.json"}}, {"family": "Knauth", "given": "Sarah", "initials": "S"}, {"family": "Potesil", "given": "David", "initials": "D", "orcid": "0000-0003-0390-0904", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dab523231d494d34ac17b5446719a311.json"}}, {"family": "Zdrahal", "given": "Zbynek", "initials": "Z"}, {"family": "Ganji", "given": "Ranjani Sri", "initials": "RS"}, {"family": "Grabowski", "given": "Anna", "initials": "A", "orcid": "0000-0001-7304-5697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d089c19710d7467194b18b6897ec4422.json"}}, {"family": "Buhl", "given": "Miriam E", "initials": "ME", "orcid": "0000-0003-0627-9228", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb226d8b7096471392cf53465baba018.json"}}, {"family": "Zikmund", "given": "Tomas", "initials": "T", "orcid": "0000-0003-2948-5198", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4b38496f264c418cb9ddd696b04cc03f.json"}}, {"family": "Kavkova", "given": "Michaela", "initials": "M", "orcid": "0000-0001-7435-9292", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e2e699409f24b488c1caef8b65bfc1f.json"}}, {"family": "Axelson", "given": "H\u00e5kan", "initials": "H"}, {"family": "Lindgren", "given": "David", "initials": "D"}, {"family": "Kramann", "given": "Rafael", "initials": "R"}, {"family": "Kuppe", "given": "Christoph", "initials": "C", "orcid": "0000-0003-4597-9833", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f713e30a89c24e13a30bbed513f0bcf4.json"}}, {"family": "Erd\u00e9lyi", "given": "Ferenc", "initials": "F"}, {"family": "M\u00e1t\u00e9", "given": "Zolt\u00e1n", "initials": "Z"}, {"family": "Szab\u00f3", "given": "G\u00e1bor", "initials": "G"}, {"family": "Koehne", "given": "Till", "initials": "T"}, {"family": "Harkany", "given": "Tibor", "initials": "T", "orcid": "0000-0002-6637-5900", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f93a408b60e744fab7e3ecc88f3ab4de.json"}}, {"family": "Fried", "given": "Kaj", "initials": "K", "orcid": "0000-0002-9997-7078", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e105f61b4238430f8796cddde76e109e.json"}}, {"family": "Kaiser", "given": "Jozef", "initials": "J", "orcid": "0000-0002-7397-125X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/254f4eaaabed4c129962666eae39778f.json"}}, {"family": "Boor", "given": "Peter", "initials": "P", "orcid": "0000-0001-9921-4284", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b63df3a10ae4a30ace9ed532d5cbbe9.json"}}, {"family": "Fekete", "given": "Csaba", "initials": "C", "orcid": "0000-0002-8206-562X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/287c626305474cd2b978353f6142c6d0.json"}}, {"family": "Rozman", "given": "Jan", "initials": "J", "orcid": "0000-0002-8035-8904", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3cc50094159441eca0b7a607b9b0d651.json"}}, {"family": "Kasparek", "given": "Petr", "initials": "P"}, {"family": "Prochazka", "given": "Jan", "initials": "J", "orcid": "0000-0003-4675-8995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/25072706ca4845299319b9478d25ac06.json"}}, {"family": "Sedlacek", "given": "Radislav", "initials": "R", "orcid": "0000-0002-3352-392X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a4e65e5d3324132bba133349f00ae15.json"}}, {"family": "Bryja", "given": "Vitezslav", "initials": "V", "orcid": "0000-0002-9136-5085", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1727f2bb33eb418eb3f700448c293f69.json"}}, {"family": "Gusev", "given": "Oleg", "initials": "O"}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9991e2eddb0840dca291de18a9d77d13.json"}}], "type": "journal article", "published": "2023-05-29", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "3092", "issn-l": "2041-1723"}, "abstract": "In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and mammals. Through the comparison of single nucleotide polymorphisms, we identify gene flow of FAME from Neandertals into modern humans. We conduct knockout experiments on animals and observe altered body weight and decreased energy expenditure in Fame knockout animals, corresponding to genome-wide association studies linking FAME with higher body mass index in humans. Gene expression and subcellular localization analyses reveal that FAME is a membrane-bound protein enriched in the kidneys. Although the gene knockout results in structurally normal kidneys, we detect higher albumin in urine and lowered ferritin in the blood. Through experimental validation, we confirm interactions between FAME and ferritin and show co-localization in vesicular and plasma membranes.", "doi": "10.1038/s41467-023-38663-7", "pmid": "37248239", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10226981"}, {"db": "pii", "key": "10.1038/s41467-023-38663-7"}], "notes": [], "created": "2026-08-21T11:49:24.558Z", "modified": "2026-08-21T11:49:25.693Z"}, {"entity": "publication", "iuid": "2685d7e34fd34229af83908c92df76b0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2685d7e34fd34229af83908c92df76b0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2685d7e34fd34229af83908c92df76b0"}}, "title": "MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.", "authors": [{"family": "Kaiser", "given": "Karol", "initials": "K", "orcid": "0000-0003-4705-2003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09c00012dd2f4665944fca6273b36fa4.json"}}, {"family": "Jang", "given": "Ahram", "initials": "A", "orcid": "0000-0002-4286-4718", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbbbbb431d35417ab153013c90d75a4e.json"}}, {"family": "Kompanikova", "given": "Petra", "initials": "P", "orcid": "0000-0002-3742-4523", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22c4518148aa453fa4baf4cbaf41f763.json"}}, {"family": "Lun", "given": "Melody P", "initials": "MP"}, {"family": "Prochazka", "given": "Jan", "initials": "J", "orcid": "0000-0003-4675-8995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/25072706ca4845299319b9478d25ac06.json"}}, {"family": "Machon", "given": "Ondrej", "initials": "O", "orcid": "0000-0002-5139-1406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/657c612ad66d4263b333f875ebfaac92.json"}}, {"family": "Dani", "given": "Neil", "initials": "N"}, {"family": "Prochazkova", "given": "Michaela", "initials": "M", "orcid": "0000-0002-3773-8995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5386c96e6c854ba089e8fa7df8c097a9.json"}}, {"family": "Laurent", "given": "Benoit", "initials": "B"}, {"family": "Gyllborg", "given": "Daniel", "initials": "D", "orcid": "0000-0002-1429-6426", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a6778b611eb4a62a76b763daa8955f5.json"}}, {"family": "van Amerongen", "given": "Renee", "initials": "R", "orcid": "0000-0002-8808-2092", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/650b96cead134709976cb15c11ed230f.json"}}, {"family": "Fame", "given": "Ryann M", "initials": "RM", "orcid": "0000-0002-8244-2624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9c9ba211b7447abab5f86f329d937fa.json"}}, {"family": "Gupta", "given": "Suhasini", "initials": "S"}, {"family": "Wu", "given": "Feizhen", "initials": "F", "orcid": "0000-0002-1265-9887", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cd7829d9dd841afb15bb5cab380c3ff.json"}}, {"family": "Barker", "given": "Roger A", "initials": "RA", "orcid": "0000-0001-8843-7730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fdf70a36e0074e10bc4771ab2d331b0d.json"}}, {"family": "Bukova", "given": "Ivana", "initials": "I"}, {"family": "Sedlacek", "given": "Radislav", "initials": "R", "orcid": "0000-0002-3352-392X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a4e65e5d3324132bba133349f00ae15.json"}}, {"family": "Kozmik", "given": "Zbynek", "initials": "Z", "orcid": "0000-0002-5850-2105", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d93389df438146f792a4428b35978b67.json"}}, {"family": "Arenas", "given": "Ernest", "initials": "E", "orcid": "0000-0003-0197-6577", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e53fdb2d3bd0445da4de60c63cc50585.json"}}, {"family": "Lehtinen", "given": "Maria K", "initials": "MK", "orcid": "0000-0002-7243-2967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cfe421cf1324ab980f5292ba71d611d.json"}}, {"family": "Bryja", "given": "Vitezslav", "initials": "V", "orcid": "0000-0002-9136-5085", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1727f2bb33eb418eb3f700448c293f69.json"}}], "type": "journal article", "published": "2021-05-15", "journal": {"title": "Development", "issn": "1477-9129", "volume": "148", "issue": "10", "issn-l": "0950-1991"}, "abstract": "The choroid plexus (ChP) produces cerebrospinal fluid and forms an essential brain barrier. ChP tissues form in each brain ventricle, each one adopting a distinct shape, but remarkably little is known about the mechanisms underlying ChP development. Here, we show that epithelial WNT5A is crucial for determining fourth ventricle (4V) ChP morphogenesis and size in mouse. Systemic Wnt5a knockout, or forced Wnt5a overexpression beginning at embryonic day 10.5, profoundly reduced ChP size and development. However, Wnt5a expression was enriched in Foxj1-positive epithelial cells of 4V ChP plexus, and its conditional deletion in these cells affected the branched, villous morphology of the 4V ChP. We found that WNT5A was enriched in epithelial cells localized to the distal tips of 4V ChP villi, where WNT5A acted locally to activate non-canonical WNT signaling via ROR1 and ROR2 receptors. During 4V ChP development, MEIS1 bound to the proximal Wnt5a promoter, and gain- and loss-of-function approaches demonstrated that MEIS1 regulated Wnt5a expression. Collectively, our findings demonstrate a dual function of WNT5A in ChP development and identify MEIS transcription factors as upstream regulators of Wnt5a in the 4V ChP epithelium.", "doi": "10.1242/dev.192054", "pmid": "34032267", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8180257"}, {"db": "pii", "key": "268365"}], "notes": [], "created": "2026-08-21T12:42:28.157Z", "modified": "2026-08-21T12:42:28.665Z"}]}