{"entity": "researcher", "timestamp": "2026-09-24T02:37:06.957Z", "family": "Yaghmaeian-Salmani", "given": "Behzad", "initials": "B", "orcid": "0000-0002-4221-6243", "affiliations": ["Department of Cell and Molecular Biology, Karolinska Institutet, Solnav\u00e4gen 9, SE-171 65 Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a2cd9cba2dc43f29a4fff6d0c729c83.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a2cd9cba2dc43f29a4fff6d0c729c83"}}, "publications": [{"entity": "publication", "iuid": "1bc0029003084ee0a1c88200b879eb3a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1bc0029003084ee0a1c88200b879eb3a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1bc0029003084ee0a1c88200b879eb3a"}}, "title": "Sox9 and Nfi transcription factors regulate the timing of neurogenesis and ependymal maturation in dopamine progenitors", "authors": [{"family": "Lahti", "given": "Laura", "initials": "L", "orcid": "0000-0003-2929-1975", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42edbf7bcb3b44a5a818a50e70a2b6bc.json"}}, {"family": "Volakakis", "given": "Nikolaos", "initials": "N"}, {"family": "Gillberg", "given": "Linda", "initials": "L"}, {"family": "Salmani", "given": "Behzad Yaghmaeian", "initials": "BY", "orcid": "0000-0002-4221-6243", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a2cd9cba2dc43f29a4fff6d0c729c83.json"}}, {"family": "Tiklov\u00e1", "given": "Katar\u00edna", "initials": "K"}, {"family": "Kee", "given": "Nigel", "initials": "N"}, {"family": "Lund\u00e9n-Miguel", "given": "Hilda", "initials": "H"}, {"family": "Piper", "given": "Michael", "initials": "M", "orcid": "0000-0002-6759-2560", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9336826498c49169351adc4a345285c.json"}}, {"family": "Gronostajski", "given": "Richard", "initials": "R"}, {"family": "Perlmann", "given": "Thomas", "initials": "T"}], "type": "posted-content", "published": "2024-11-14", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.11.12.623209", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T15:42:19.953Z", "modified": "2026-09-23T15:42:20.049Z"}, {"entity": "publication", "iuid": "f98dbb1664c44b5a8643ba272b89f74c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f98dbb1664c44b5a8643ba272b89f74c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f98dbb1664c44b5a8643ba272b89f74c"}}, "title": "Claustrum and dorsal endopiriform cortex complex cell-identity is determined by Nurr1 and regulates hallucinogenic-like states in mice.", "authors": [{"family": "Mantas", "given": "Ioannis", "initials": "I", "orcid": "0000-0001-6288-5439", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1039fe5afaeb467ebfbfc5b99a4a13b9.json"}}, {"family": "Flais", "given": "Ivana", "initials": "I"}, {"family": "Masarapu", "given": "Yuvarani", "initials": "Y", "orcid": "0000-0002-3267-2085", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecae6e58dddd40b7a547bd7eb38aa4fd.json"}}, {"family": "Ionescu", "given": "Tudor", "initials": "T"}, {"family": "Frapard", "given": "Sol\u00e8ne", "initials": "S", "orcid": "0000-0002-2649-7225", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e911ee0112d04fe89b254e4624490460.json"}}, {"family": "Jung", "given": "Felix", "initials": "F"}, {"family": "Le Merre", "given": "Pierre", "initials": "P", "orcid": "0000-0003-4205-7411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ebebeabbd3a4bc89ea05d00cc47013a.json"}}, {"family": "Saarinen", "given": "Marcus", "initials": "M"}, {"family": "Tiklova", "given": "Katarina", "initials": "K"}, {"family": "Salmani", "given": "Behzad Yaghmaeian", "initials": "BY", "orcid": "0000-0002-4221-6243", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a2cd9cba2dc43f29a4fff6d0c729c83.json"}}, {"family": "Gillberg", "given": "Linda", "initials": "L"}, {"family": "Zhang", "given": "Xiaoqun", "initials": "X", "orcid": "0000-0002-9461-8682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4395a11b24bf40308b6d3a8467763517.json"}}, {"family": "Chergui", "given": "Karima", "initials": "K"}, {"family": "Carl\u00e9n", "given": "Marie", "initials": "M", "orcid": "0000-0003-1658-1631", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5bb1bfff3214cca8753a75f5a251b93.json"}}, {"family": "Giacomello", "given": "Stefania", "initials": "S", "orcid": "0000-0003-0738-1574", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a9c4a7494ba4284ab52158e6cbc85da.json"}}, {"family": "Hengerer", "given": "Bastian", "initials": "B", "orcid": "0000-0002-7811-9795", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/baaddee4cd7548998431491d4d85d14e.json"}}, {"family": "Perlmann", "given": "Thomas", "initials": "T"}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}], "type": "journal article", "published": "2024-09-18", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "8176", "issn-l": "2041-1723"}, "abstract": "The Claustrum/dorsal endopiriform cortex complex (CLA) is an enigmatic brain region with extensive glutamatergic projections to multiple cortical areas. The transcription factor Nurr1 is highly expressed in the CLA, but its role in this region is not understood. By using conditional gene-targeted mice, we show that Nurr1 is a crucial regulator of CLA neuron identity. Although CLA neurons remain intact in the absence of Nurr1, the distinctive gene expression pattern in the CLA is abolished. CLA has been hypothesized to control hallucinations, but little is known of how the CLA responds to hallucinogens. After the deletion of Nurr1 in the CLA, both hallucinogen receptor expression and signaling are lost. Furthermore, functional ultrasound and Neuropixel electrophysiological recordings revealed that the hallucinogenic-receptor agonists' effects on functional connectivity between prefrontal and sensorimotor cortices are altered in Nurr1-ablated mice. Our findings suggest that Nurr1-targeted strategies provide additional avenues for functional studies of the CLA.", "doi": "10.1038/s41467-024-52429-9", "pmid": "39289358", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11408527"}, {"db": "pii", "key": "10.1038/s41467-024-52429-9"}, {"db": "GEO", "key": "GSE229770"}, {"db": "GEO", "key": "GSE229732"}], "notes": [], "created": "2026-09-23T11:12:28.263Z", "modified": "2026-09-23T11:12:28.442Z"}, {"entity": "publication", "iuid": "57d0deaf2620480298b1ba98da92c15f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/57d0deaf2620480298b1ba98da92c15f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/57d0deaf2620480298b1ba98da92c15f"}}, "title": "PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons.", "authors": [{"family": "Toskas", "given": "Konstantinos", "initials": "K", "orcid": "0000-0002-5897-9501", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60922b95bb654b73b6b6131e6ecc63f1.json"}}, {"family": "Yaghmaeian-Salmani", "given": "Behzad", "initials": "B", "orcid": "0000-0002-4221-6243", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a2cd9cba2dc43f29a4fff6d0c729c83.json"}}, {"family": "Skiteva", "given": "Olga", "initials": "O"}, {"family": "Paslawski", "given": "Wojciech", "initials": "W", "orcid": "0000-0003-2141-4547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9cd03bf75b24a37884524e605253073.json"}}, {"family": "Gillberg", "given": "Linda", "initials": "L"}, {"family": "Skara", "given": "Vasiliki", "initials": "V", "orcid": "0000-0002-0017-6116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d3a2022f27b44778a9b97f60c28b105.json"}}, {"family": "Antoniou", "given": "Irene", "initials": "I", "orcid": "0000-0002-3616-9049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/54c3a31e9a7e46428f433912ac89ccf9.json"}}, {"family": "S\u00f6dersten", "given": "Erik", "initials": "E"}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Chergui", "given": "Karima", "initials": "K", "orcid": "0000-0001-5702-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef27363b774241d79eae4b8447bda6f4.json"}}, {"family": "Ringn\u00e9r", "given": "Markus", "initials": "M", "orcid": "0000-0001-5469-8940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/949fda08083846abae1c0ee20e6bceb1.json"}}, {"family": "Perlmann", "given": "Thomas", "initials": "T"}, {"family": "Holmberg", "given": "Johan", "initials": "J", "orcid": "0000-0002-3018-001X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1e57469beda43bcbf7b9b3ad59cb96d.json"}}], "type": "journal article", "published": "2022-08-26", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "34", "pages": "eabo1543", "issn-l": "2375-2548"}, "abstract": "How neurons can maintain cellular identity over an entire life span remains largely unknown. Here, we show that maintenance of identity in differentiated dopaminergic and serotonergic neurons is critically reliant on the Polycomb repressive complex 2 (PRC2). Deletion of the obligate PRC2 component, Eed, in these neurons resulted in global loss of H3K27me3, followed by a gradual activation of genes harboring both H3K27me3 and H3K9me3 modifications. Notably, H3K9me3 was lost at these PRC2 targets before gene activation. Neuronal survival was not compromised; instead, there was a reduction in subtype-specific gene expression and a progressive impairment of dopaminergic and serotonergic neuronal function, leading to behavioral deficits characteristic of Parkinson's disease and anxiety. Single-cell analysis revealed subtype-specific vulnerability to loss of PRC2 repression in dopamine neurons of the substantia nigra. Our study reveals that a PRC2-dependent nonpermissive chromatin state is essential to maintain the subtype identity and function of dopaminergic and serotonergic neurons.", "doi": "10.1126/sciadv.abo1543", "pmid": "36026451", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9417181"}], "notes": [], "created": "2026-09-23T10:15:17.249Z", "modified": "2026-09-23T10:53:45.122Z"}]}