{"entity": "researcher", "timestamp": "2026-08-20T20:43:10.013Z", "family": "Ghorbani Gorji", "given": "Sara", "initials": "S", "orcid": "0000-0002-7413-1228", "affiliations": ["Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba 4102 Queensland, Australia."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a235dbe8ac44f1f8b067ebb2183fdb4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a235dbe8ac44f1f8b067ebb2183fdb4"}}, "publications": [{"entity": "publication", "iuid": "44a116c32dae492391309c47a915abfb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/44a116c32dae492391309c47a915abfb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/44a116c32dae492391309c47a915abfb"}}, "title": "Discovery of Previously Unreported Per- and Polyfluoroalkyl Substances (PFAS) in Pooled Australian Human Serum Using Nontarget Analysis.", "authors": [{"family": "Dewapriya", "given": "Pradeep", "initials": "P", "orcid": "0000-0002-6383-1843", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20fa77980f284da0bf7e2d4d6a8d38cb.json"}}, {"family": "Nilsson", "given": "Sandra", "initials": "S", "orcid": "0000-0002-1030-7167", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/acc9b99839b94d70be6e4f57d9081dc6.json"}}, {"family": "Ghorbani Gorji", "given": "Sara", "initials": "S", "orcid": "0000-0002-7413-1228", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a235dbe8ac44f1f8b067ebb2183fdb4.json"}}, {"family": "O'Brien", "given": "Jake W", "initials": "JW", "orcid": "0000-0001-9336-9656", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/449a21afc3fe4470a98e0db190468675.json"}}, {"family": "Br\u00e4unig", "given": "Jennifer", "initials": "J"}, {"family": "Jos\u00e9 G\u00f3mez Ramos", "given": "Mar\u00eda", "initials": "M"}, {"family": "Samanipour", "given": "Saer", "initials": "S", "orcid": "0000-0001-8270-6979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5c5e087f1414ed19838084b5113f775.json"}}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02199c0d99674e2ea5e96e6589c07a00.json"}}, {"family": "Toms", "given": "Leisa-Maree L", "initials": "LL", "orcid": "0000-0002-1444-1638", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b8b63fc625f4745b5c7a5ecbeeec1bd.json"}}, {"family": "Mueller", "given": "Jochen F", "initials": "JF"}, {"family": "Kaserzon", "given": "Sarit L", "initials": "SL", "orcid": "0000-0002-6744-1279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7cf9ea83a284fb4be5ab894ea7142aa.json"}}, {"family": "Thomas", "given": "Kevin V", "initials": "KV", "orcid": "0000-0002-2155-100X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8702b01e942e43afb0d963004a571a0f.json"}}], "type": "journal article", "published": "2025-12-09", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "volume": "59", "issue": "48", "pages": "26081-26091", "issn-l": "0013-936X"}, "abstract": "Humans may be exposed to thousands of per- and polyfluoroalkyl substances (PFAS), yet only a small fraction of these are regularly monitored, potentially underestimating the associated risks. This study employed high-resolution mass spectrometry (HRMS)-based nontarget analysis to investigate previously unreported PFAS in pooled serum from Australians. Samples collected between 2002 and 2021 from men aged > 30 years in the general population (GP, n = 27) and firefighters (FF, n = 18), categorized into three age groups (31-45, 46-60, and \u2265 60), were analyzed. Fourteen PFAS were identified or structurally annotated, including six known (level 1a-1b) and seven suspects (level 2b-3a). Additionally, six suspects with CHF2 or CF3 functionalities were tentatively annotated. Two previously unreported PFAS in human serum, hydrogen-substituted 2:1 perfluoroether sulfonic acid (2:1 H-PFESA) and hexafluoro-1,2-propanediol (HFPrD), were detected in 42% and 56% of samples, respectively. Further analysis of these two compounds in broader GP serum pools, including six age groups and both sexes, revealed their presence even in children under five, with relatively high intensities. No clear temporal, age, sex, or occupation-related trends were observed, suggesting widespread ongoing population exposure. These findings underscore the need for expanded HRMS-based monitoring to better assess human PFAS exposure.", "doi": "10.1021/acs.est.5c04623", "pmid": "41297907", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T08:10:02.352Z", "modified": "2026-08-20T08:10:02.478Z"}, {"entity": "publication", "iuid": "6bfcd96de31f4c39a810c6dd89b5249f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6bfcd96de31f4c39a810c6dd89b5249f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6bfcd96de31f4c39a810c6dd89b5249f"}}, "title": "Novel Per- and Polyfluoroalkyl Substances Discovered in Cattle Exposed to AFFF-Impacted Groundwater.", "authors": [{"family": "Dewapriya", "given": "Pradeep", "initials": "P", "orcid": "0000-0002-6383-1843", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20fa77980f284da0bf7e2d4d6a8d38cb.json"}}, {"family": "Nilsson", "given": "Sandra", "initials": "S", "orcid": "0000-0002-1030-7167", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/acc9b99839b94d70be6e4f57d9081dc6.json"}}, {"family": "Ghorbani Gorji", "given": "Sara", "initials": "S", "orcid": "0000-0002-7413-1228", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a235dbe8ac44f1f8b067ebb2183fdb4.json"}}, {"family": "O'Brien", "given": "Jake W", "initials": "JW", "orcid": "0000-0001-9336-9656", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/449a21afc3fe4470a98e0db190468675.json"}}, {"family": "Br\u00e4unig", "given": "Jennifer", "initials": "J"}, {"family": "G\u00f3mez Ramos", "given": "Mar\u00eda Jos\u00e9", "initials": "MJ"}, {"family": "Donaldson", "given": "Eric", "initials": "E"}, {"family": "Samanipour", "given": "Saer", "initials": "S", "orcid": "0000-0001-8270-6979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5c5e087f1414ed19838084b5113f775.json"}}, {"family": "Martin", "given": "Jonathan W", "initials": "JW", "orcid": "0000-0001-6265-4294", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02199c0d99674e2ea5e96e6589c07a00.json"}}, {"family": "Mueller", "given": "Jochen F", "initials": "JF"}, {"family": "Kaserzon", "given": "Sarit L", "initials": "SL", "orcid": "0000-0002-6744-1279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7cf9ea83a284fb4be5ab894ea7142aa.json"}}, {"family": "Thomas", "given": "Kevin V", "initials": "KV", "orcid": "0000-0002-2155-100X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8702b01e942e43afb0d963004a571a0f.json"}}], "type": "journal article", "published": "2023-09-12", "journal": {"title": "Environ. Sci. Technol.", "issn": "1520-5851", "volume": "57", "issue": "36", "pages": "13635-13645", "issn-l": "0013-936X"}, "abstract": "The leaching of per- and polyfluoroalkyl substances (PFASs) from Australian firefighting training grounds has resulted in extensive contamination of groundwater and nearby farmlands. Humans, farm animals, and wildlife in these areas may have been exposed to complex mixtures of PFASs from aqueous film-forming foams (AFFFs). This study aimed to identify PFAS classes in pooled whole blood (n = 4) and serum (n = 4) from cattle exposed to AFFF-impacted groundwater and potentially discover new PFASs in blood. Thirty PFASs were identified at various levels of confidence (levels 1a-5a), including three novel compounds: (i) perfluorohexanesulfonamido 2-hydroxypropanoic acid (FHxSA-HOPrA), (ii) methyl((perfluorohexyl)sulfonyl)sulfuramidous acid, and (iii) methyl((perfluorooctyl)sulfonyl)sulfuramidous acid, belonging to two different classes. Biotransformation intermediate, perfluorohexanesulfonamido propanoic acid (FHxSA-PrA), hitherto unreported in biological samples, was detected in both whole blood and serum. Furthermore, perfluoroalkyl sulfonamides, including perfluoropropane sulfonamide (FPrSA), perfluorobutane sulfonamide (FBSA), and perfluorohexane sulfonamide (FHxSA) were predominantly detected in whole blood, suggesting that these accumulate in the cell fraction of blood. The suspect screening revealed several fluoroalkyl chain-substituted PFAS. The results suggest that targeting only the major PFASs in the plasma or serum of AFFF-exposed mammals likely underestimates the toxicological risks associated with exposure. Future studies of AFFF-exposed populations should include whole-blood analysis with high-resolution mass spectrometry to understand the true extent of PFAS exposure.", "doi": "10.1021/acs.est.3c03852", "pmid": "37648245", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10501377"}], "notes": [], "created": "2026-08-20T08:09:48.528Z", "modified": "2026-08-20T08:09:48.863Z"}]}