{"entity": "researcher", "timestamp": "2026-08-22T07:48:36.072Z", "family": "Alashkar Alhamwe", "given": "Bilal", "initials": "B", "orcid": "0000-0002-7120-0013", "affiliations": ["Institute of Laboratory Medicine, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-University Marburg, Germany.", "International Inflammation (in-VIVO) Network, Worldwide Universities Network (WUN), West New York, NJ, USA.", "College of Pharmacy, International University for Science and Technology (IUST), Daraa, Syria."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/19df596478ee42a69c39a058d768ee43.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/19df596478ee42a69c39a058d768ee43"}}, "publications": [{"entity": "publication", "iuid": "a51c6a1a8cf4478fb5329aeb1c2a03d3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a51c6a1a8cf4478fb5329aeb1c2a03d3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a51c6a1a8cf4478fb5329aeb1c2a03d3"}}, "title": "Epigenetic Modifications in Placenta are Associated with the Child's Sensitization to Allergens.", "authors": [{"family": "Harb", "given": "Hani", "initials": "H"}, {"family": "Alashkar Alhamwe", "given": "Bilal", "initials": "B", "orcid": "0000-0002-7120-0013", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/19df596478ee42a69c39a058d768ee43.json"}}, {"family": "Acevedo", "given": "Nathalie", "initials": "N"}, {"family": "Frumento", "given": "Paolo", "initials": "P"}, {"family": "Johansson", "given": "Catharina", "initials": "C"}, {"family": "Eick", "given": "Lisa", "initials": "L"}, {"family": "Papadogiannakis", "given": "Nikos", "initials": "N"}, {"family": "Alm", "given": "Johan", "initials": "J"}, {"family": "Renz", "given": "Harald", "initials": "H", "orcid": "0000-0003-1159-0854", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d0d8e64078e4127a777b78432950376.json"}}, {"family": "Potaczek", "given": "Daniel P", "initials": "DP", "orcid": "0000-0003-0324-8506", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/464232f982ad48c2a05c62317f451a03.json"}}, {"family": "Scheynius", "given": "Annika", "initials": "A"}], "type": "journal article", "published": "2019-04-17", "journal": {"title": "Biomed Res Int", "issn": "2314-6141", "volume": "2019", "pages": "1315257", "issn-l": "2314-6133"}, "abstract": "Prenatal environmental exposures are considered to contribute to the development of allergic sensitization by epigenetic mechanisms. The role of histone acetylation in the placenta has not been examined yet. We hypothesized that placental histone acetylation at the promoter regions of allergy-related immune regulatory genes is associated with the development of sensitization to allergens in the child. Histones H3 and H4 acetylation at the promoter regions of 6 selected allergy-related immune regulatory genes was assessed by a chromatin immunoprecipitation assay in 173 term placentas collected in the prospective birth-cohort ALADDIN. The development of IgE sensitization to allergens in the children was followed from 6 months up to 5 years of age. We discovered significant associations of histone acetylation levels with decreased risk of allergic sensitization in 3 genes. Decreased risk of sensitization to food allergens was associated with higher H3 acetylation levels in placentas at the IFNG and SH2B3 genes, and for H4 acetylation in HDAC4. Higher HDAC4 H4 acetylation levels were also associated with a decreased risk of sensitization to aeroallergens. In conclusion, our results suggest that acetylation of histones in placenta has a potential to predict the development of sensitization to allergens in children.", "doi": "10.1155/2019/1315257", "pmid": "31111043", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6500694"}], "notes": [], "created": "2026-08-21T12:28:21.689Z", "modified": "2026-08-21T12:28:21.863Z"}, {"entity": "publication", "iuid": "8119c69158aa4250b434ccfa9446a399", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8119c69158aa4250b434ccfa9446a399.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8119c69158aa4250b434ccfa9446a399"}}, "title": "Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption.", "authors": [{"family": "Acevedo", "given": "Nathalie", "initials": "N", "orcid": "0000-0002-5154-2964", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be22f41f7e6a4daaa896400aecc03938.json"}}, {"family": "Frumento", "given": "Paolo", "initials": "P"}, {"family": "Harb", "given": "Hani", "initials": "H", "orcid": "0000-0001-8218-2538", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8273427c608465eb65126b36a12ec6e.json"}}, {"family": "Alashkar Alhamwe", "given": "Bilal", "initials": "B", "orcid": "0000-0002-7120-0013", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/19df596478ee42a69c39a058d768ee43.json"}}, {"family": "Johansson", "given": "Catharina", "initials": "C", "orcid": "0000-0003-1303-3795", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7b7d1ed2715943e390f942028b418a18.json"}}, {"family": "Eick", "given": "Lisa", "initials": "L"}, {"family": "Alm", "given": "Johan", "initials": "J", "orcid": "0000-0002-9062-4479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8a4f5b121e34f6480dacab9f9fe8729.json"}}, {"family": "Renz", "given": "Harald", "initials": "H", "orcid": "0000-0003-0602-7215", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/000b0831890541c8b97ac5602dddd90e.json"}}, {"family": "Scheynius", "given": "Annika", "initials": "A", "orcid": "0000-0001-5520-990X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c815af1a90f7440da03fbc06347fa9cd.json"}}, {"family": "Potaczek", "given": "Daniel P", "initials": "DP"}], "type": "journal article", "published": "2019-03-01", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "20", "issue": "5", "issn-l": null}, "abstract": "Maternal diet modifies epigenetic programming in offspring, a potentially critical factor in the immune dysregulation of modern societies. We previously found that prenatal fish oil supplementation affects neonatal T-cell histone acetylation of genes implicated in adaptive immunity including PRKCZ, IL13, and TBX21. In this study, we measured H3 and H4 histone acetylation levels by chromatin immunoprecipitation in 173 term placentas collected in the prospective birth cohort, ALADDIN, in which information on lifestyle and diet is thoroughly recorded. In anthroposophic families, regular olive oil usage during pregnancy was associated with increased H3 acetylation at FOXP3 (p = 0.004), IL10RA (p = 0.008), and IL7R (p = 0.007) promoters, which remained significant after adjustment by offspring gender. Furthermore, maternal fish consumption was associated with increased H4 acetylation at the CD14 gene in placentas of female offspring (p = 0.009). In conclusion, prenatal olive oil intake can affect placental histone acetylation in immune regulatory genes, confirming previously observed pro-acetylation effects of olive oil polyphenols. The association with fish consumption may implicate \u03c9-3 polyunsaturated fatty acids present in fish oil. Altered histone acetylation in placentas from mothers who regularly include fish or olive oil in their diets could influence immune priming in the newborn.", "doi": "10.3390/ijms20051060", "pmid": "30823645", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6429118"}, {"db": "pii", "key": "ijms20051060"}], "notes": [], "created": "2026-08-21T13:02:55.041Z", "modified": "2026-08-21T13:02:55.275Z"}]}