{"entity": "researcher", "timestamp": "2026-07-22T16:25:08.436Z", "family": "Gourdy", "given": "Pierre", "initials": "P", "orcid": "0000-0002-5362-3813", "affiliations": ["Institut des Maladies M\u00e9taboliques et Cardiovasculaires (I2MC), UMR1297, INSERM/UPS, Universit\u00e9 de Toulouse, Toulouse, France herve.guillou@inrae.fr pierre.gourdy@inserm.fr.", "Endocrinology-Diabetology-Nutrition Department, Toulouse University Hospital, Toulouse, France."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/184aaac222a843aca96be4b16d97969a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/184aaac222a843aca96be4b16d97969a"}}, "publications": [{"entity": "publication", "iuid": "ed945573ae864ba28e23e60d4909aa91", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ed945573ae864ba28e23e60d4909aa91.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ed945573ae864ba28e23e60d4909aa91"}}, "title": "Integrative study of diet-induced mouse models of NAFLD identifies PPAR\u03b1 as a sexually dimorphic drug target.", "authors": [{"family": "Smati", "given": "Sarra", "initials": "S", "orcid": "0000-0002-5749-983X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9c523f25a1d4ae185656e3ed1156709.json"}}, {"family": "Polizzi", "given": "Arnaud", "initials": "A"}, {"family": "Fougerat", "given": "Anne", "initials": "A"}, {"family": "Ellero-Simatos", "given": "Sandrine", "initials": "S"}, {"family": "Blum", "given": "Yuna", "initials": "Y"}, {"family": "Lippi", "given": "Yannick", "initials": "Y"}, {"family": "R\u00e9gnier", "given": "Marion", "initials": "M"}, {"family": "Laroyenne", "given": "Alexia", "initials": "A"}, {"family": "Huillet", "given": "Marine", "initials": "M"}, {"family": "Arif", "given": "Muhammad", "initials": "M"}, {"family": "Zhang", "given": "Cheng", "initials": "C"}, {"family": "Lasserre", "given": "Frederic", "initials": "F"}, {"family": "Marrot", "given": "Alain", "initials": "A"}, {"family": "Al Saati", "given": "Talal", "initials": "T"}, {"family": "Wan", "given": "JingHong", "initials": "J"}, {"family": "Sommer", "given": "Caroline", "initials": "C"}, {"family": "Naylies", "given": "Claire", "initials": "C"}, {"family": "Batut", "given": "Aurelie", "initials": "A"}, {"family": "Lukowicz", "given": "Celine", "initials": "C"}, {"family": "Fougeray", "given": "Tiffany", "initials": "T"}, {"family": "Tramunt", "given": "Blandine", "initials": "B"}, {"family": "Dubot", "given": "Patricia", "initials": "P"}, {"family": "Smith", "given": "Lorraine", "initials": "L"}, {"family": "Bertrand-Michel", "given": "Justine", "initials": "J"}, {"family": "Hennuyer", "given": "Nathalie", "initials": "N"}, {"family": "Pradere", "given": "Jean-Philippe", "initials": "JP"}, {"family": "Staels", "given": "Bart", "initials": "B", "orcid": "0000-0002-3784-1503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d4403d33764d45af8a864123ec7ab822.json"}}, {"family": "Burcelin", "given": "Remy", "initials": "R", "orcid": "0000-0002-7942-8346", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb654f4e5c5c4b86b9ba2e041196d514.json"}}, {"family": "Lenfant", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "Arnal", "given": "Jean-Fran\u00e7ois", "initials": "JF"}, {"family": "Levade", "given": "Thierry", "initials": "T"}, {"family": "Gamet-Payrastre", "given": "Laurence", "initials": "L"}, {"family": "Lagarrigue", "given": "Sandrine", "initials": "S"}, {"family": "Loiseau", "given": "Nicolas", "initials": "N"}, {"family": "Lotersztajn", "given": "Sophie", "initials": "S"}, {"family": "Postic", "given": "Catherine", "initials": "C"}, {"family": "Wahli", "given": "Walter", "initials": "W", "orcid": "0000-0002-5966-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee554b81a79143599b984946397a41fe.json"}}, {"family": "Bureau", "given": "Christophe", "initials": "C"}, {"family": "Guillaume", "given": "Maeva", "initials": "M"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}, {"family": "Montagner", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-4800-5105", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/46373ea8c82c4f6c93b2493f2003b1ff.json"}}, {"family": "Gourdy", "given": "Pierre", "initials": "P", "orcid": "0000-0002-5362-3813", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/184aaac222a843aca96be4b16d97969a.json"}}, {"family": "Guillou", "given": "Herv\u00e9", "initials": "H", "orcid": "0000-0002-5363-9081", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/abef7b3bf4574b87a90ab2c3f67c5d4d.json"}}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Gut", "issn": "1468-3288", "volume": "71", "issue": "4", "pages": "807-821", "issn-l": "0017-5749"}, "abstract": "We evaluated the influence of sex on the pathophysiology of non-alcoholic fatty liver disease (NAFLD). We investigated diet-induced phenotypic responses to define sex-specific regulation between healthy liver and NAFLD to identify influential pathways in different preclinical murine models and their relevance in humans.\n\nDifferent models of diet-induced NAFLD (high-fat diet, choline-deficient high-fat diet, Western diet or Western diet supplemented with fructose and glucose in drinking water) were compared with a control diet in male and female mice. We performed metabolic phenotyping, including plasma biochemistry and liver histology, untargeted large-scale approaches (liver metabolome, lipidome and transcriptome), gene expression profiling and network analysis to identify sex-specific pathways in the mouse liver.\n\nThe different diets induced sex-specific responses that illustrated an increased susceptibility to NAFLD in male mice. The most severe lipid accumulation and inflammation/fibrosis occurred in males receiving the high-fat diet and Western diet, respectively. Sex-biased hepatic gene signatures were identified for these different dietary challenges. The peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1) co-expression network was identified as sexually dimorphic, and in vivo experiments in mice demonstrated that hepatocyte PPAR\u03b1 determines a sex-specific response to fasting and treatment with pemafibrate, a selective PPAR\u03b1 agonist. Liver molecular signatures in humans also provided evidence of sexually dimorphic gene expression profiles and the sex-specific co-expression network for PPAR\u03b1.\n\nThese findings underscore the sex specificity of NAFLD pathophysiology in preclinical studies and identify PPAR\u03b1 as a pivotal, sexually dimorphic, pharmacological target.\n\nNCT02390232.", "doi": "10.1136/gutjnl-2020-323323", "pmid": "33903148", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "gutjnl-2020-323323"}, {"db": "ClinicalTrials.gov", "key": "NCT02390232"}], "notes": [], "created": "2023-12-04T15:08:04.605Z", "modified": "2023-12-04T15:08:04.914Z"}]}