{"entity": "researcher", "timestamp": "2026-08-22T06:55:33.876Z", "family": "Kahn", "given": "Robin", "initials": "R", "orcid": "0000-0002-3167-1179", "affiliations": ["Department of Paediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.", "Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/17ecdb4f26a648ba9ee080bb72a86c82.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/17ecdb4f26a648ba9ee080bb72a86c82"}}, "publications": [{"entity": "publication", "iuid": "0f37158895584853b34b25c2f449e116", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0f37158895584853b34b25c2f449e116.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0f37158895584853b34b25c2f449e116"}}, "title": "Population-based study of multisystem inflammatory syndrome associated with COVID-19 found that 36% of children had persistent symptoms.", "authors": [{"family": "Kahn", "given": "Robin", "initials": "R", "orcid": "0000-0002-3167-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17ecdb4f26a648ba9ee080bb72a86c82.json"}}, {"family": "Berg", "given": "Stefan", "initials": "S"}, {"family": "Berntson", "given": "Lillemor", "initials": "L", "orcid": "0000-0003-3962-0453", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57e1606172654f51815c533ebb1b4f22.json"}}, {"family": "Berthold", "given": "Elisabet", "initials": "E"}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5fe1b70e79d48b1bc07ceeec842c3a3.json"}}, {"family": "B\u00e4ckstr\u00f6m", "given": "Fredrik", "initials": "F"}, {"family": "Compagno", "given": "Michele", "initials": "M"}, {"family": "Fasth", "given": "Anders", "initials": "A", "orcid": "0000-0002-0033-740X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/606310515418471aa8c67deefc761d4c.json"}}, {"family": "Lingman Framme", "given": "Jenny", "initials": "J"}, {"family": "Horne", "given": "AnnaCarin", "initials": "A"}, {"family": "H\u00e4tting", "given": "Josefin", "initials": "J"}, {"family": "Kr\u00f3l", "given": "Petra", "initials": "P"}, {"family": "Kukka", "given": "Antti J", "initials": "AJ"}, {"family": "Mossberg", "given": "Maria", "initials": "M"}, {"family": "M\u00e5nsson", "given": "Bengt", "initials": "B"}, {"family": "Nordenh\u00e4ll", "given": "Charlotta", "initials": "C"}, {"family": "Idring Nordstr\u00f6m", "given": "Selma", "initials": "S"}, {"family": "Khammari Nystr\u00f6m", "given": "Fatine", "initials": "F"}, {"family": "Palmblad", "given": "Karin", "initials": "K"}, {"family": "Rasti", "given": "Reza", "initials": "R"}, {"family": "Rudolph", "given": "Andr\u00e9", "initials": "A"}, {"family": "Rydenman", "given": "Karin", "initials": "K"}, {"family": "Sundberg", "given": "Erik", "initials": "E"}, {"family": "S\u00e4ve-S\u00f6derbergh", "given": "Eva", "initials": "E"}, {"family": "Altman", "given": "Maria", "initials": "M", "orcid": "0000-0001-8316-0154", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32f8e4ab4b9443e28169230f35385087.json"}}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Acta Paediatr", "issn": "1651-2227", "volume": "111", "issue": "2", "pages": "354-362", "issn-l": null}, "abstract": "Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19.\n\nThis national, population-based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS-C. The outcomes 2 and 8 weeks after diagnosis are presented, and follow-up protocols are suggested.\n\nWe identified 152 cases, and 133 (87%) participated. When followed up 2 weeks after MIS-C was diagnosed, 43% of the 119 patients had abnormal results, including complete blood cell counts, platelet counts, albumin levels, electrocardiograms and echocardiograms. After 8 weeks, 36% of 89 had an abnormal patient history, but clinical findings were uncommon. Echocardiogram results were abnormal in 5% of 67, and the most common complaint was fatigue. Older children and those who received intensive care were more likely to report symptoms and have abnormal cardiac results.\n\nMore than a third (36%) of the patients had persistent symptoms 8 weeks after MIS-C, and 5% had abnormal echocardiograms. Older age and higher levels of initial care appeared to be risk factors. Structured follow-up visits are important after MIS-C.", "doi": "10.1111/apa.16191", "pmid": "34806789", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9011862"}], "notes": [], "created": "2026-08-21T12:17:16.127Z", "modified": "2026-08-21T12:17:16.295Z"}, {"entity": "publication", "iuid": "6538516184c34387bbd73b670be1f443", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6538516184c34387bbd73b670be1f443.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6538516184c34387bbd73b670be1f443"}}, "title": "NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus.", "authors": [{"family": "Linge", "given": "Petrus", "initials": "P", "orcid": "0000-0001-8906-2715", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c83a8ed6a2ac4711b0465b6dfbcabcc9.json"}}, {"family": "Arve", "given": "Sabine", "initials": "S", "orcid": "0000-0002-3347-5550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d063b42c4af42efbba4afb26b9a9fd3.json"}}, {"family": "Olsson", "given": "Lina M", "initials": "LM"}, {"family": "Leonard", "given": "Dag", "initials": "D"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b.json"}}, {"family": "Tyd\u00e9n", "given": "Helena", "initials": "H"}, {"family": "J\u00f6nsen", "given": "Andreas", "initials": "A"}, {"family": "Kahn", "given": "Robin", "initials": "R", "orcid": "0000-0002-3167-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17ecdb4f26a648ba9ee080bb72a86c82.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aef6264212044f46a28c24d5fc147438.json"}}, {"family": "Bengtsson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Ann. Rheum. Dis.", "issn": "1468-2060", "volume": "79", "issue": "2", "pages": "254-261", "issn-l": "0003-4967"}, "abstract": "\u200bOBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE). This study aimed at characterising NCF1-339 effects on neutrophil extracellular trap (NET) formation, type I interferon activity and antibody profile in patients with SLE. \u200bMETHODS: Neutrophil NET-release pathways (n=31), serum interferon (n=141) and finally antibody profiles (n=305) were investigated in SLE subjects from Lund, genotyped for NCF1-339. Then, 1087 SLE subjects from the rheumatology departments of four Swedish SLE centres, genotyped for NCF1-339, were clinically characterised to validate these findings. \u200bRESULTS: Compared with patients with normal-ROS NCF1-339 genotypes, neutrophils from patients with SLE with low-ROS NCF1-339 genotypes displayed impaired NET formation (p<0.01) and increased dependence on mitochondrial ROS (p<0.05). Low-ROS patients also had increased frequency of high serum interferon activity (80% vs 21.4%, p<0.05) and positivity for anti-\u03b22 glycoprotein I (p<0.01) and anticardiolipin antibodies (p<0.05) but were not associated with other antibodies. We confirmed an over-representation of having any antiphospholipid antibody, OR 1.40 (95% CI 1.01 to 1.95), anti-\u03b22 glycoprotein I, OR 1.82 (95% CI 1.02 to 3.24) and the antiphospholipid syndrome (APS), OR 1.74 (95% CI 1.19 to 2.55) in all four cohorts (n=1087). \u200bCONCLUSIONS: The NCF1-339 SNP mediated decreased NADPH oxidase function, is associated with high interferon activity and impaired formation of NETs in SLE, allowing dependence on mitochondrial ROS. Unexpectedly, we revealed a striking connection between the ROS deficient NCF1-339 genotypes and the presence of phospholipid antibodies and APS.", "doi": "10.1136/annrheumdis-2019-215820", "pmid": "31704719", "labels": [], "xrefs": [{"db": "pii", "key": "S0003-4967(24)01509-7"}], "notes": [], "created": "2026-08-21T12:25:45.018Z", "modified": "2026-08-21T12:25:45.336Z"}]}