{"entity": "researcher", "timestamp": "2026-08-22T06:55:34.702Z", "family": "Valdimarsd\u00f3ttir", "given": "Unnur", "initials": "U", "orcid": "0000-0001-5382-946X", "affiliations": ["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.", "Centre of Public Health Sciences Faculty of Medicine, University of Iceland, Reykjav\u00edk, Iceland."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/16dcb423ea4947bc9bfaf3cd91a7e769.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/16dcb423ea4947bc9bfaf3cd91a7e769"}}, "publications": [{"entity": "publication", "iuid": "bf7742a629e94fa2bc314fa79f7a3262", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf7742a629e94fa2bc314fa79f7a3262.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf7742a629e94fa2bc314fa79f7a3262"}}, "title": "Use of Antibiotics and Risk of Psychiatric Disorders in Newly Diagnosed Cancer Patients: A Population-Based Cohort Study in Sweden.", "authors": [{"family": "Hu", "given": "Kejia", "initials": "K", "orcid": "0000-0001-6680-8107", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3db50670ad8437f92e155073db5d667.json"}}, {"family": "Smedby", "given": "Karin E", "initials": "KE"}, {"family": "Sj\u00f6lander", "given": "Arvid", "initials": "A"}, {"family": "Montgomery", "given": "Scott", "initials": "S", "orcid": "0000-0001-6328-5494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/558159f8c8934d25b30effc337433350.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur", "initials": "U", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/16dcb423ea4947bc9bfaf3cd91a7e769.json"}}, {"family": "Engstrand", "given": "Lars", "initials": "L", "orcid": "0000-0002-7713-2373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02d8684df81e42169e613de803446fbf.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c65cfa2c711f41428a39a9cdac12b2db.json"}}, {"family": "Fall", "given": "Katja", "initials": "K", "orcid": "0000-0002-3649-2639", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71681e4b08b94f4392ef89dba1eca16e.json"}}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "Cancer Epidemiol Biomarkers Prev", "issn": "1538-7755", "volume": "31", "issue": "3", "pages": "528-535", "issn-l": null}, "abstract": "Antibiotic-induced dysbiosis is associated with an increased risk of depression and anxiety in the general population. A diagnosis of cancer is associated with an immediately and dramatically elevated risk of psychiatric disorders, but the potential influence of prediagnostic antibiotic-induced dysbiosis is unknown.\n\nBased on a national cohort of cancer patients in Sweden, we included 309,419 patients who were diagnosed with a first primary malignancy between July 2006 and December 2013. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of first-onset psychosis, depression, anxiety, or stress-related disorders during the first year after cancer diagnosis for antibiotic use during the year before cancer diagnosis.\n\nCompared with no antibiotic use, use of antibiotics was associated with a higher rate of the aforementioned psychiatric disorders (HR, 1.23; 95% CI, 1.16-1.30) after adjustment for sociodemographic factors, comorbidity, potential indications for antibiotics, and cancer stage and type. The magnitude of the association was higher for broad-spectrum antibiotics (HR, 1.27; 95% CI, 1.18-1.37), higher doses (HR, 1.32; 95% CI, 1.22-1.44), more frequent use (HR, 1.33; 95% CI, 1.21-1.46), and recent use (HR, 1.26; 95% CI, 1.17-1.35).\n\nUse of antibiotics, especially of broad-spectrum type, of high dose and frequency, with recent use, was associated with an aggravated risk of psychiatric disorders, compared with no antibiotic use.\n\nA better understanding of the microbiota-gut-brain axis may open up a wide avenue for the prevention and treatment of psychiatric disorders in cancer patients.", "doi": "10.1158/1055-9965.EPI-21-1095", "pmid": "35027429", "labels": [], "xrefs": [{"db": "pii", "key": "1055-9965.EPI-21-1095"}], "notes": [], "created": "2026-08-21T12:29:01.816Z", "modified": "2026-08-21T12:29:02.009Z"}, {"entity": "publication", "iuid": "d260c726f2c941bdb343579a5dc50d26", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d260c726f2c941bdb343579a5dc50d26.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d260c726f2c941bdb343579a5dc50d26"}}, "title": "Adverse childhood experiences and resilience among adult women: A population-based study.", "authors": [{"family": "Dan\u00edelsd\u00f3ttir", "given": "Hilda Bj\u00f6rk", "initials": "HB", "orcid": "0000-0002-4967-2495", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0ab044a9687454482c8f2baadfc1915.json"}}, {"family": "Aspelund", "given": "Thor", "initials": "T", "orcid": "0000-0002-7998-5433", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca3c59baa65740a4a34c26841ba70005.json"}}, {"family": "Thordardottir", "given": "Edda Bjork", "initials": "EB", "orcid": "0000-0003-3775-9611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d396505fd384494ba682598110d047d.json"}}, {"family": "Fall", "given": "Katja", "initials": "K", "orcid": "0000-0002-3649-2639", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71681e4b08b94f4392ef89dba1eca16e.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c65cfa2c711f41428a39a9cdac12b2db.json"}}, {"family": "T\u00f3masson", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-1797-7091", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f9a72c8995f4694a0b401824d540a6c.json"}}, {"family": "R\u00fanarsd\u00f3ttir", "given": "Harpa", "initials": "H"}, {"family": "Yang", "given": "Qian", "initials": "Q", "orcid": "0000-0001-6389-3975", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4474231b7144be9e224f3dc4605233.json"}}, {"family": "Choi", "given": "Karmel W", "initials": "KW", "orcid": "0000-0002-3914-2431", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49cf8a8de3d346f79210216223f4c6ef.json"}}, {"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb88fcd6bead49978b129dffe779d8a0.json"}}, {"family": "Halldorsdottir", "given": "Thorhildur", "initials": "T", "orcid": "0000-0003-0637-8912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0300b11e9bf40c0bf028c3cc71748a1.json"}}, {"family": "Lu", "given": "Donghao", "initials": "D", "orcid": "0000-0002-4186-8661", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d0b4e38740e4691955ea288a4de7151.json"}}, {"family": "Song", "given": "Huan", "initials": "H", "orcid": "0000-0003-3845-8079", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67c48e3f62ce4e5da5bf4eefb2e20507.json"}}, {"family": "Jakobsd\u00f3ttir", "given": "J\u00f3hanna", "initials": "J", "orcid": "0000-0002-8019-9683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7981bea08c8a48f9bb309bf9811edfed.json"}}, {"family": "Hauksd\u00f3ttir", "given": "Arna", "initials": "A", "orcid": "0000-0002-4253-1059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc71918718b643b685b35e5c014aadab.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur Anna", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/16dcb423ea4947bc9bfaf3cd91a7e769.json"}}], "type": "journal article", "published": "2022-02-01", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "11", "issn-l": "2050-084X"}, "abstract": "Adverse childhood experiences (ACEs) have consistently been associated with elevated risk of multiple adverse health outcomes, yet their contribution to coping ability and psychiatric resilience in adulthood is unclear.\n\nCross-sectional data were derived from the ongoing Stress-And-Gene-Analysis cohort, representing 30% of the Icelandic nationwide female population, 18-69 years. Participants in the current study were 26,198 women with data on 13 ACEs measured with the ACE-International Questionnaire. Self-reported coping ability was measured with the Connor-Davidson Resilience Scale and psychiatric resilience was operationalized as absence of psychiatric morbidity. Generalized linear regression assuming normal or Poisson distribution were used to assess the associations of ACEs with coping ability and psychiatric resilience controlling for multiple confounders.\n\nNumber of ACEs was inversely associated with adult resilience in a dose-dependent manner; every 1SD unit increase in ACE scores was associated with both lower levels of coping ability (\u03b2 = -0.14; 95% CI-0.15,-0.13) and lower psychiatric resilience (\u03b2 = -0.28; 95% CI-0.29,-0.27) in adulthood. Compared to women with 0 ACEs, women with \u22655 ACEs had 36% lower prevalence of high coping ability (PR = 0.64, 95% CI 0.59,0.70) and 58% lower prevalence of high psychiatric resilience (PR = 0.42; 95% CI 0.39,0.45). Specific ACEs including emotional neglect, bullying, sexual abuse and mental illness of household member were consistently associated with reduced adult resilience. We observed only slightly attenuated associations after controlling for adult socioeconomic factors and social support in adulthood.\n\nCumulative ACE exposure is associated with lower adult resilience among women, independent of adult socioeconomic factors and social support, indicating that adult resilience may be largely determined in childhood.\n\nThis work was supported by the European Research Council (Consolidator grant; UAV, grant number 726413), and the Icelandic Center for Research (Grant of excellence; UAV, grant number 163362-051). HBD was supported by a doctoral grant from the University of Iceland Research Fund.", "doi": "10.7554/eLife.71770", "pmid": "35101173", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8806181"}, {"db": "pii", "key": "71770"}], "notes": [], "created": "2026-08-21T13:07:46.506Z", "modified": "2026-08-21T13:07:47.007Z"}]}