{"entity": "researcher", "timestamp": "2026-09-26T12:08:13.691Z", "family": "Stevens", "given": "Marc Y", "initials": "MY", "orcid": "0000-0002-9441-3767", "affiliations": ["Department of Medicinal Chemistry Division of Organic Pharmaceutical Chemistry Uppsala University 75123 Uppsala Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/16a85bfb5fa641718998e521c81452ef.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/16a85bfb5fa641718998e521c81452ef"}}, "publications": [{"entity": "publication", "iuid": "f345ba12ba2e4856a57a5379a26bb748", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f345ba12ba2e4856a57a5379a26bb748.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f345ba12ba2e4856a57a5379a26bb748"}}, "title": "Synthesis of 11C-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [11C]CO.", "authors": [{"family": "Stevens", "given": "Marc Y", "initials": "MY", "orcid": "0000-0002-9441-3767", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/16a85bfb5fa641718998e521c81452ef.json"}}, {"family": "Chow", "given": "Shiao Y", "initials": "SY"}, {"family": "Estrada", "given": "Sergio", "initials": "S"}, {"family": "Eriksson", "given": "Jonas", "initials": "J"}, {"family": "Asplund", "given": "Veronika", "initials": "V"}, {"family": "Orlova", "given": "Anna", "initials": "A"}, {"family": "Mitran", "given": "Bogdan", "initials": "B"}, {"family": "Antoni", "given": "Gunnar", "initials": "G"}, {"family": "Larhed", "given": "Mats", "initials": "M"}, {"family": "\u00c5berg", "given": "Ola", "initials": "O"}, {"family": "Odell", "given": "Luke R", "initials": "LR", "orcid": "0000-0001-7658-5103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49395660c6af4fce9ad0f7f8fc793744.json"}}], "type": "journal article", "published": "2016-12-00", "journal": {"volume": "5", "issn": "2191-1363", "issue": "6", "pages": "566-573", "title": "ChemistryOpen", "issn-l": "2191-1363"}, "abstract": "We describe the development of a new methodology focusing on 11C-labeling of sulfonyl carbamates in a multicomponent reaction comprised of a sulfonyl azide, an alkyl alcohol, and [11C]CO. A number of 11C-labeled sulfonyl carbamates were synthesized and isolated, and the developed methodology was then applied in the preparation of a biologically active molecule. The target compound was obtained in 24\u00b110 % isolated radiochemical yield and was evaluated for binding properties in a tumor cell assay; in vivo biodistribution and imaging studies were also performed. This represents the first successful radiolabeling of a non-peptide angiotensin II receptor subtype 2 agonist, C21, currently in clinical trials for the treatment of idiopathic pulmonary fibrosis.", "doi": "10.1002/open.201600091", "pmid": "28032026", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5167284"}, {"db": "pii", "key": "OPEN201600091"}], "notes": [], "created": "2018-12-05T11:59:28.681Z", "modified": "2026-09-23T12:38:02.491Z"}]}