{"entity": "researcher", "timestamp": "2026-08-20T20:57:57.623Z", "family": "Jeannot", "given": "Pauline", "initials": "P", "orcid": "0000-0003-0158-440X", "affiliations": ["Division of Translational Cancer Research, Department of Laboratory Medicine, Lund, Lund University, Lund 221 00, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/167869db86f0456fbb7a535ae8d89b35.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/167869db86f0456fbb7a535ae8d89b35"}}, "publications": [{"entity": "publication", "iuid": "b48ded17901f445fb5121eb3348ab401", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b48ded17901f445fb5121eb3348ab401.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b48ded17901f445fb5121eb3348ab401"}}, "title": "Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted.", "authors": [{"family": "Governa", "given": "Valeria", "initials": "V", "orcid": "0000-0001-9999-0590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38fa13ff35d2468e9a61eec381c1f91f.json"}}, {"family": "de Oliveira", "given": "Kelin Gon\u00e7alves", "initials": "KG", "orcid": "0000-0003-1646-5657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f774f99247314765b97114edc82199f1.json"}}, {"family": "B\u00e5ng-Rudenstam", "given": "Anna", "initials": "A", "orcid": "0000-0003-2706-9502", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fea3b51f73f4175b859cde49e99e5e7.json"}}, {"family": "Offer", "given": "Svenja", "initials": "S", "orcid": "0009-0005-1159-4769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cae1ab36ab44c918c0eaa3fcc21c68b.json"}}, {"family": "Cerezo-Maga\u00f1a", "given": "Myriam", "initials": "M", "orcid": "0000-0001-9752-8917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c8019362baf45b394e839c00f7ac1d5.json"}}, {"family": "Li", "given": "Jiaxin", "initials": "J", "orcid": "0000-0002-5401-6855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf6133b6e1c1438db5a2cafb42eae2fb.json"}}, {"family": "Beyer", "given": "Sarah", "initials": "S", "orcid": "0000-0001-8021-9624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7460c1560454e29805fae14da7f99e2.json"}}, {"family": "Johansson", "given": "Maria C", "initials": "MC", "orcid": "0000-0003-0075-3187", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ce5f12cf2e24399b8b1a2f90a647e6e.json"}}, {"family": "M\u00e5nsson", "given": "Ann-Sofie", "initials": "AS", "orcid": "0000-0002-5984-3470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b3c8e6d27ad4029be4738d5816e0234.json"}}, {"family": "Edvardsson", "given": "Charlotte", "initials": "C", "orcid": "0009-0001-2046-7826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66126ee2a8bb40e2b20b131bacda396a.json"}}, {"family": "Durmo", "given": "Faris", "initials": "F", "orcid": "0000-0001-7364-5991", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/848a1ef86fe3467cad9437801dbd66f0.json"}}, {"family": "Gustafsson", "given": "Emma", "initials": "E", "orcid": "0009-0007-7005-912X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d13e2b988714edc8b43efde369feec5.json"}}, {"family": "Boukredine", "given": "Axel", "initials": "A", "orcid": "0009-0006-3714-6769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a59ab55aa0794efc870cdec487e9dbde.json"}}, {"family": "Jeannot", "given": "Pauline", "initials": "P", "orcid": "0000-0003-0158-440X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/167869db86f0456fbb7a535ae8d89b35.json"}}, {"family": "Schmidt", "given": "Katja", "initials": "K", "orcid": "0000-0002-0973-6933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64466e9e703d46c985f6705573168bd0.json"}}, {"family": "Gezelius", "given": "Emelie", "initials": "E", "orcid": "0000-0002-7349-8108", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b141ce31bda40039dd006c2bfa8f661.json"}}, {"family": "Menard", "given": "Julien A", "initials": "JA", "orcid": "0009-0007-4652-399X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b32e557ab6fa450e9d0b4173b2a7b6a1.json"}}, {"family": "Garza", "given": "Raquel", "initials": "R", "orcid": "0000-0002-2524-3055", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dad049ba2c40499ba3587f6cc5d6a706.json"}}, {"family": "Jakobsson", "given": "Johan", "initials": "J", "orcid": "0000-0003-0669-7673", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1387f53f92df4c5f9c1fc91dd5230fba.json"}}, {"family": "de Neergaard", "given": "Therese", "initials": "T", "orcid": "0000-0002-6969-0375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24f61a7c404b495bbb184a3af049a921.json"}}, {"family": "Sundgren", "given": "Pia C", "initials": "PC", "orcid": "0000-0001-9237-1236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e580179d7d74958a5c1d509e581ddcc.json"}}, {"family": "Tiihonen", "given": "Aliisa M", "initials": "AM", "orcid": "0000-0003-3703-9673", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02077b27162c411388742c9094e1d165.json"}}, {"family": "Haapasalo", "given": "Hannu", "initials": "H"}, {"family": "Rautajoki", "given": "Kirsi J", "initials": "KJ", "orcid": "0000-0001-6549-7810", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ac12df0ec93441f90dcad31fe170143.json"}}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P", "orcid": "0000-0002-9481-9951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81dea1d4ace2429f8082a127bc93c691.json"}}, {"family": "Darabi", "given": "Anna", "initials": "A", "orcid": "0000-0003-4326-8149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb9f19a0c8694ee79ca515a79976d146.json"}}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K", "orcid": "0000-0003-0692-6245", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6636b7d9d0e24ac2a15ccd0e9f631ed1.json"}}, {"family": "Pietras", "given": "Alexander", "initials": "A", "orcid": "0000-0002-5783-9347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9d48aa66cee48b9828c0ac374c75362.json"}}, {"family": "Talbot", "given": "Hugo", "initials": "H", "orcid": "0000-0001-9774-8573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28e1c9cf68e6408dbcf4ac2c031fb468.json"}}, {"family": "Bengzon", "given": "Johan", "initials": "J"}, {"family": "Belting", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1585-5434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9763a47486d410fb5034fb2603f3a02.json"}}], "type": "journal article", "published": "2024-10-30", "journal": {"title": "Sci Transl Med", "issn": "1946-6242", "volume": "16", "issue": "771", "pages": "eadk1168", "issn-l": "1946-6234"}, "abstract": "Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we found that TAFs exhibit distinct protumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, and impaired phagocytosis, and their presence correlates with worse outcomes for patients with glioma. We further demonstrated that TAF formation is facilitated by lipid scavenging from extracellular vesicles released by glioblastoma cells. We found that targeting key enzymes involved in lipid droplet formation, such as diacylglycerol O-acyltransferase or long-chain acyl-CoA synthetase, effectively disrupted TAF functionality. Together, these data highlight TAFs as a prominent immune cell population in glioblastoma and provide insights into their contribution to the tumor microenvironment. Disrupting lipid droplet formation to target TAFs may represent an avenue for future therapeutic development for glioblastoma.", "doi": "10.1126/scitranslmed.adk1168", "pmid": "39475570", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:59:55.851Z", "modified": "2026-08-20T11:59:56.532Z"}, {"entity": "publication", "iuid": "dffb9a243b2544118016c0930cbc08bd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/dffb9a243b2544118016c0930cbc08bd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/dffb9a243b2544118016c0930cbc08bd"}}, "title": "The Irradiated Brain Microenvironment Supports Glioma Stemness and Survival via Astrocyte-Derived Transglutaminase 2.", "authors": [{"family": "Berg", "given": "Tracy J", "initials": "TJ"}, {"family": "Marques", "given": "Carolina", "initials": "C", "orcid": "0000-0002-8308-5630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc65829f36d243dc94f21a4650ed9c27.json"}}, {"family": "Pantazopoulou", "given": "Vasiliki", "initials": "V", "orcid": "0000-0002-5965-5795", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4e8f1e6335241148a153f34611d9145.json"}}, {"family": "Johansson", "given": "Elinn", "initials": "E"}, {"family": "von Stedingk", "given": "Kristoffer", "initials": "K"}, {"family": "Lindgren", "given": "David", "initials": "D"}, {"family": "Jeannot", "given": "Pauline", "initials": "P", "orcid": "0000-0003-0158-440X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/167869db86f0456fbb7a535ae8d89b35.json"}}, {"family": "Pietras", "given": "Elin J", "initials": "EJ", "orcid": "0000-0002-5783-9347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9d48aa66cee48b9828c0ac374c75362.json"}}, {"family": "Bergstr\u00f6m", "given": "Tobias", "initials": "T", "orcid": "0000-0002-4557-2390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad8f5ab0560d4b7596ddd5e407b96d8f.json"}}, {"family": "Swartling", "given": "Fredrik J", "initials": "FJ", "orcid": "0000-0002-8460-4367", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e673fa8c86348fb8c1a2ae34ba7ba9a.json"}}, {"family": "Governa", "given": "Valeria", "initials": "V"}, {"family": "Bengzon", "given": "Johan", "initials": "J"}, {"family": "Belting", "given": "Mattias", "initials": "M"}, {"family": "Axelson", "given": "H\u00e5kan", "initials": "H"}, {"family": "Squatrito", "given": "Massimo", "initials": "M"}, {"family": "Pietras", "given": "Alexander", "initials": "A", "orcid": "0000-0002-5783-9347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9d48aa66cee48b9828c0ac374c75362.json"}}], "type": "journal article", "published": "2021-04-15", "journal": {"title": "Cancer Res.", "issn": "1538-7445", "volume": "81", "issue": "8", "pages": "2101-2115", "issn-l": "0008-5472"}, "abstract": "The tumor microenvironment plays an essential role in supporting glioma stemness and radioresistance. Following radiotherapy, recurrent gliomas form in an irradiated microenvironment. Here we report that astrocytes, when pre-irradiated, increase stemness and survival of cocultured glioma cells. Tumor-na\u00efve brains increased reactive astrocytes in response to radiation, and mice subjected to radiation prior to implantation of glioma cells developed more aggressive tumors. Extracellular matrix derived from irradiated astrocytes were found to be a major driver of this phenotype and astrocyte-derived transglutaminase 2 (TGM2) was identified as a promoter of glioma stemness and radioresistance. TGM2 levels increased after radiation in vivo and in recurrent human glioma, and TGM2 inhibitors abrogated glioma stemness and survival. These data suggest that irradiation of the brain results in the formation of a tumor-supportive microenvironment. Therapeutic targeting of radiation-induced, astrocyte-derived extracellular matrix proteins may enhance the efficacy of standard-of-care radiotherapy by reducing stemness in glioma. SIGNIFICANCE: These findings presented here indicate that radiotherapy can result in a tumor-supportive microenvironment, the targeting of which may be necessary to overcome tumor cell therapeutic resistance and recurrence. GRAPHICAL ABSTRACT: http://cancerres.aacrjournals.org/content/canres/81/8/2101/F1.large.jpg.", "doi": "10.1158/0008-5472.CAN-20-1785", "pmid": "33483373", "labels": [], "xrefs": [{"db": "pii", "key": "0008-5472.CAN-20-1785"}], "notes": [], "created": "2026-08-20T12:11:03.084Z", "modified": "2026-08-20T12:11:03.255Z"}]}