{"entity": "researcher", "timestamp": "2026-09-28T13:21:36.807Z", "family": "Krieger", "given": "Jose E", "initials": "JE", "orcid": "0000-0001-5464-1792", "affiliations": ["Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/15968b7f70c1488983df28fbd4942c2a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/15968b7f70c1488983df28fbd4942c2a"}}, "publications": [{"entity": "publication", "iuid": "6d611371a9e24369b0541f194047301d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6d611371a9e24369b0541f194047301d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6d611371a9e24369b0541f194047301d"}}, "title": "Multi-ethnic genome-wide association study for atrial fibrillation.", "authors": [{"family": "Roselli", "given": "Carolina", "initials": "C", "orcid": "0000-0001-5267-6756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f57487a2d5bd4b5abac02ffbb46660e3.json"}}, {"family": "Chaffin", "given": "Mark D", "initials": "MD", "orcid": "0000-0002-1234-5562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/193f10917f1944c3b486cee6d8478dd7.json"}}, {"family": "Weng", "given": "Lu-Chen", "initials": "LC"}, {"family": "Aeschbacher", "given": "Stefanie", "initials": "S"}, {"family": "Ahlberg", "given": "Gustav", "initials": "G"}, {"family": "Albert", "given": "Christine M", "initials": "CM"}, {"family": "Almgren", "given": "Peter", "initials": "P", "orcid": "0000-0002-0473-0241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38c129298565453d84f62b9138d0634e.json"}}, {"family": "Alonso", "given": "Alvaro", "initials": "A", "orcid": "0000-0002-2225-8323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6707daa85da845408f0dba0de1447f67.json"}}, {"family": "Anderson", "given": "Christopher D", "initials": "CD"}, {"family": "Aragam", "given": "Krishna G", "initials": "KG"}, {"family": "Arking", "given": "Dan E", "initials": "DE"}, {"family": "Barnard", "given": "John", "initials": "J", "orcid": "0000-0003-2403-8268", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c279a7a7e984d4491312768292ce611.json"}}, {"family": "Bartz", "given": "Traci M", "initials": "TM"}, {"family": "Benjamin", "given": "Emelia J", "initials": "EJ", "orcid": "0000-0003-4076-2336", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/89bc31f5dd38446b9ffb36e68201e2da.json"}}, {"family": "Bihlmeyer", "given": "Nathan A", "initials": "NA"}, {"family": "Bis", "given": "Joshua C", "initials": "JC"}, {"family": "Bloom", "given": "Heather L", "initials": "HL"}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Bottinger", "given": "Erwin B", "initials": "EB"}, {"family": "Brody", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0001-8509-148X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5e5e63068a4762ba2c4ca10f30aa78.json"}}, {"family": "Calkins", "given": "Hugh", "initials": "H"}, {"family": "Campbell", "given": "Archie", "initials": "A", "orcid": "0000-0003-0198-5078", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0727bde0027c4a8a9d2737bb486f1bad.json"}}, {"family": "Cappola", "given": "Thomas P", "initials": "TP"}, {"family": "Carlquist", "given": "John", "initials": "J"}, {"family": "Chasman", "given": "Daniel I", "initials": "DI"}, {"family": "Chen", "given": "Lin Y", "initials": "LY"}, {"family": "Chen", "given": "Yii-Der Ida", "initials": "YI"}, {"family": "Choi", "given": "Eue-Keun", "initials": "EK"}, {"family": "Choi", "given": "Seung Hoan", "initials": "SH"}, {"family": "Christophersen", "given": "Ingrid E", "initials": "IE", "orcid": "0000-0002-6141-4712", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66cf18798d82477a8771ce40cf067fed.json"}}, {"family": "Chung", "given": "Mina K", "initials": "MK"}, {"family": "Cole", "given": "John W", "initials": "JW"}, {"family": "Conen", "given": "David", "initials": "D"}, {"family": "Cook", "given": "James", "initials": "J"}, {"family": "Crijns", "given": "Harry J", "initials": "HJ"}, {"family": "Cutler", "given": "Michael J", "initials": "MJ"}, {"family": "Damrauer", "given": "Scott M", "initials": "SM"}, {"family": "Daniels", "given": "Brian R", "initials": "BR"}, {"family": "Darbar", "given": "Dawood", "initials": "D"}, {"family": "Delgado", "given": "Graciela", "initials": "G"}, {"family": "Denny", "given": "Joshua C", "initials": "JC"}, {"family": "Dichgans", "given": "Martin", "initials": "M", "orcid": "0000-0002-0654-387X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a258c2b7f8d24b14b5cafce3bafbc3cb.json"}}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M"}, {"family": "Dudink", "given": "Elton A", "initials": "EA", "orcid": "0000-0003-4572-3969", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fc7202f5444407b9dee9654c56511b0.json"}}, {"family": "Dudley", "given": "Samuel C", "initials": "SC"}, {"family": "Esa", "given": "Nada", "initials": "N"}, {"family": "Esko", "given": "Tonu", "initials": "T", "orcid": "0000-0003-1982-6569", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45dd48f2bc61400db209bc5543f86e0b.json"}}, {"family": "Eskola", "given": "Markku", "initials": "M"}, {"family": "Fatkin", "given": "Diane", "initials": "D"}, {"family": "Felix", "given": "Stephan B", "initials": "SB"}, {"family": "Ford", "given": "Ian", "initials": "I"}, {"family": "Franco", "given": "Oscar H", "initials": "OH"}, {"family": "Geelhoed", "given": "Bastiaan", "initials": "B"}, {"family": "Grewal", "given": "Raji P", "initials": "RP"}, {"family": "Gudnason", "given": "Vilmundur", "initials": "V"}, {"family": "Guo", "given": "Xiuqing", "initials": "X"}, {"family": "Gupta", "given": "Namrata", "initials": "N"}, {"family": "Gustafsson", "given": "Stefan", "initials": "S", "orcid": "0000-0001-5894-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fedf8897d75744f5b17f7c91c892acbf.json"}}, {"family": "Gutmann", "given": "Rebecca", "initials": "R"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Harris", "given": "Tamara B", "initials": "TB"}, {"family": "Hayward", "given": "Caroline", "initials": "C", "orcid": "0000-0002-9405-9550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/542b00d650124ce4a3776ae95571e2c1.json"}}, {"family": "Heckbert", "given": "Susan R", "initials": "SR"}, {"family": "Hernesniemi", "given": "Jussi", "initials": "J"}, {"family": "Hocking", "given": "Lynne J", "initials": "LJ"}, {"family": "Hofman", "given": "Albert", "initials": "A"}, {"family": "Horimoto", "given": "Andrea R V R", "initials": "ARVR"}, {"family": "Huang", "given": "Jie", "initials": "J"}, {"family": "Huang", "given": "Paul L", "initials": "PL"}, {"family": "Huffman", "given": "Jennifer", "initials": "J", "orcid": "0000-0002-9672-2491", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db300ba51fe547bbaa3c7dd94a48ae93.json"}}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Ipek", "given": "Esra Gucuk", "initials": "EG"}, {"family": "Ito", "given": "Kaoru", "initials": "K"}, {"family": "Jimenez-Conde", "given": "Jordi", "initials": "J"}, {"family": "Johnson", "given": "Renee", "initials": "R"}, {"family": "Jukema", "given": "J Wouter", "initials": "JW", "orcid": "0000-0002-3246-8359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51be7e89ccfd4bbe93b216028c57a376.json"}}, {"family": "K\u00e4\u00e4b", "given": "Stefan", "initials": "S"}, {"family": "K\u00e4h\u00f6nen", "given": "Mika", "initials": "M"}, {"family": "Kamatani", "given": "Yoichiro", "initials": "Y", "orcid": "0000-0001-8748-5597", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd8ede58f99d4881985d64d4b5848396.json"}}, {"family": "Kane", "given": "John P", "initials": "JP"}, {"family": "Kastrati", "given": "Adnan", "initials": "A"}, {"family": "Kathiresan", "given": "Sekar", "initials": "S", "orcid": "0000-0002-6724-032X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc6443809e2048b189070618dbf870ba.json"}}, {"family": "Katschnig-Winter", "given": "Petra", "initials": "P"}, {"family": "Kavousi", "given": "Maryam", "initials": "M"}, {"family": "Kessler", "given": "Thorsten", "initials": "T"}, {"family": "Kietselaer", "given": "Bas L", "initials": "BL"}, {"family": "Kirchhof", "given": "Paulus", "initials": "P"}, {"family": "Kleber", "given": "Marcus E", "initials": "ME", "orcid": "0000-0003-0663-7275", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22bc3077d1244542bcd6222f70dd7c96.json"}}, {"family": "Knight", "given": "Stacey", "initials": "S"}, {"family": "Krieger", "given": "Jose E", "initials": "JE", "orcid": "0000-0001-5464-1792", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/15968b7f70c1488983df28fbd4942c2a.json"}}, {"family": "Kubo", "given": "Michiaki", "initials": "M"}, {"family": "Launer", "given": "Lenore J", "initials": "LJ"}, {"family": "Laurikka", "given": "Jari", "initials": "J"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Leineweber", "given": "Kirsten", "initials": "K"}, {"family": "Lemaitre", "given": "Rozenn N", "initials": "RN"}, {"family": "Li", "given": "Man", "initials": "M", "orcid": "0000-0002-3839-0281", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5436bf44eb30448d8ff5b2d9216500f5.json"}}, {"family": "Lim", "given": "Hong Euy", "initials": "HE"}, {"family": "Lin", "given": "Henry J", "initials": "HJ"}, {"family": "Lin", "given": "Honghuang", "initials": "H", "orcid": "0000-0003-3043-3942", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fcff923f48845b88239000f20875e7c.json"}}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Lindgren", "given": "Cecilia M", "initials": "CM"}, {"family": "Lokki", "given": "Marja-Liisa", "initials": "ML"}, {"family": "London", "given": "Barry", "initials": "B"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF", "orcid": "0000-0002-8532-5087", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/179eb6511eba4d33b633599c5652e344.json"}}, {"family": "Low", "given": "Siew-Kee", "initials": "SK"}, {"family": "Lu", "given": "Yingchang", "initials": "Y"}, {"family": "Lyytik\u00e4inen", "given": "Leo-Pekka", "initials": "LP", "orcid": "0000-0002-7200-5455", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d541c99c43642538b7578fc4ff810ad.json"}}, {"family": "Macfarlane", "given": "Peter W", "initials": "PW"}, {"family": "Magnusson", "given": "Patrik K", "initials": "PK", "orcid": "0000-0002-7315-7899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6fa8b01df9f4bf68607603c51c5a106.json"}}, {"family": "Mahajan", "given": "Anubha", "initials": "A", "orcid": "0000-0001-5585-3420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41b3d44662484e0289f07fa25d045cf4.json"}}, {"family": "Malik", "given": "Rainer", "initials": "R"}, {"family": "Mansur", "given": "Alfredo J", "initials": "AJ"}, {"family": "Marcus", "given": "Gregory M", "initials": "GM"}, {"family": "Margolin", "given": "Lauren", "initials": "L"}, {"family": "Margulies", "given": "Kenneth B", "initials": "KB"}, {"family": "M\u00e4rz", "given": "Winfried", "initials": "W"}, {"family": "McManus", "given": "David D", "initials": "DD"}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Mohanty", "given": "Sanghamitra", "initials": "S"}, {"family": "Montgomery", "given": "Jay A", "initials": "JA"}, {"family": "Morley", "given": "Michael P", "initials": "MP"}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M", "orcid": "0000-0003-3793-5910", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29665b981f714acda0ab36b09ab04a22.json"}}, {"family": "Natale", "given": "Andrea", "initials": "A"}, {"family": "Nazarian", "given": "Saman", "initials": "S"}, {"family": "Neumann", "given": "Benjamin", "initials": "B"}, {"family": "Newton-Cheh", "given": "Christopher", "initials": "C"}, {"family": "Niemeijer", "given": "Maartje N", "initials": "MN"}, {"family": "Nikus", "given": "Kjell", "initials": "K"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Noordam", "given": "Raymond", "initials": "R"}, {"family": "Oellers", "given": "Heidi", "initials": "H"}, {"family": "Olesen", "given": "Morten S", "initials": "MS"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M"}, {"family": "Padmanabhan", "given": "Sandosh", "initials": "S"}, {"family": "Pak", "given": "Hui-Nam", "initials": "HN"}, {"family": "Par\u00e9", "given": "Guillaume", "initials": "G"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Pera", "given": "Joanna", "initials": "J"}, {"family": "Pereira", "given": "Alexandre", "initials": "A"}, {"family": "Porteous", "given": "David", "initials": "D"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM"}, {"family": "Pulit", "given": "Sara L", "initials": "SL", "orcid": "0000-0002-2502-3669", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/109857e8eeae4ec9aa432ea8393cd12f.json"}}, {"family": "Pullinger", "given": "Clive R", "initials": "CR"}, {"family": "Rader", "given": "Daniel J", "initials": "DJ"}, {"family": "Refsgaard", "given": "Lena", "initials": "L"}, {"family": "Ribas\u00e9s", "given": "Marta", "initials": "M", "orcid": "0000-0003-1039-1116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b569893813a4a3f8eaaf394184962f6.json"}}, {"family": "Ridker", "given": "Paul M", "initials": "PM"}, {"family": "Rienstra", "given": "Michiel", "initials": "M", "orcid": "0000-0002-2581-070X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad216f41c13e4e619e01e5d98dfc3ca8.json"}}, {"family": "Risch", "given": "Lorenz", "initials": "L"}, {"family": "Roden", "given": "Dan M", "initials": "DM"}, {"family": "Rosand", "given": "Jonathan", "initials": "J"}, {"family": "Rosenberg", "given": "Michael A", "initials": "MA"}, {"family": "Rost", "given": "Natalia", "initials": "N"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "Saba", "given": "Samir", "initials": "S"}, {"family": "Sandhu", "given": "Roopinder K", "initials": "RK"}, {"family": "Schnabel", "given": "Renate B", "initials": "RB"}, {"family": "Schramm", "given": "Katharina", "initials": "K"}, {"family": "Schunkert", "given": "Heribert", "initials": "H"}, {"family": "Schurman", "given": "Claudia", "initials": "C"}, {"family": "Scott", "given": "Stuart A", "initials": "SA", "orcid": "0000-0001-5720-1864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/996702411c224c58a0f162518fecf580.json"}}, {"family": "Sepp\u00e4l\u00e4", "given": "Ilkka", "initials": "I", "orcid": "0000-0002-5595-2573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0bf23c1b3b34d8789b46f2f425c37c9.json"}}, {"family": "Shaffer", "given": "Christian", "initials": "C"}, {"family": "Shah", "given": "Svati", "initials": "S"}, {"family": "Shalaby", "given": "Alaa A", "initials": "AA"}, {"family": "Shim", "given": "Jaemin", "initials": "J"}, {"family": "Shoemaker", "given": "M Benjamin", "initials": "MB"}, {"family": "Siland", "given": "Joylene E", "initials": "JE", "orcid": "0000-0003-4404-1245", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/25e2a98ef15047adadd6afb1290b5de6.json"}}, {"family": "Sinisalo", "given": "Juha", "initials": "J", "orcid": "0000-0002-0169-5137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3bd9a39dac594dda9eb2d137b3792daf.json"}}, {"family": "Sinner", "given": "Moritz F", "initials": "MF"}, {"family": "Slowik", "given": "Agnieszka", "initials": "A"}, {"family": "Smith", "given": "Albert V", "initials": "AV", "orcid": "0000-0003-1942-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51752e0d35a74befa66a65b95ceaad38.json"}}, {"family": "Smith", "given": "Blair H", "initials": "BH", "orcid": "0000-0002-5362-9430", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f30912f5a8e443eac572814f3990d7f.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Smith", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-0415-386X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f08d6773c2134268bda75050772d397f.json"}}, {"family": "Smith", "given": "Nicholas L", "initials": "NL"}, {"family": "Soliman", "given": "Elsayed Z", "initials": "EZ", "orcid": "0000-0001-5632-8150", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4d53591cd5a46cab26b9e1dd2ce46c2.json"}}, {"family": "Sotoodehnia", "given": "Nona", "initials": "N"}, {"family": "Stricker", "given": "Bruno H", "initials": "BH"}, {"family": "Sun", "given": "Albert", "initials": "A"}, {"family": "Sun", "given": "Han", "initials": "H"}, {"family": "Svendsen", "given": "Jesper H", "initials": "JH", "orcid": "0000-0001-8466-8515", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b16248b14854a00b1a289c5c624b50c.json"}}, {"family": "Tanaka", "given": "Toshihiro", "initials": "T", "orcid": "0000-0001-6201-9784", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76061df47a364337a534ddafa3176e79.json"}}, {"family": "Tanriverdi", "given": "Kahraman", "initials": "K"}, {"family": "Taylor", "given": "Kent D", "initials": "KD"}, {"family": "Teder-Laving", "given": "Maris", "initials": "M"}, {"family": "Teumer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8309-094X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a40a959d1b8480cb8268e00f77a0449.json"}}, {"family": "Th\u00e9riault", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Trompet", "given": "Stella", "initials": "S"}, {"family": "Tucker", "given": "Nathan R", "initials": "NR", "orcid": "0000-0002-5071-4218", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a084d5794114fcd924cb8962a6053f7.json"}}, {"family": "Tveit", "given": "Arnljot", "initials": "A"}, {"family": "Uitterlinden", "given": "Andre G", "initials": "AG"}, {"family": "Van Der Harst", "given": "Pim", "initials": "P", "orcid": "0000-0002-2713-686X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/808139762faf4ad8a4eeb39f3a60b61f.json"}}, {"family": "Van Gelder", "given": "Isabelle C", "initials": "IC"}, {"family": "Van Wagoner", "given": "David R", "initials": "DR", "orcid": "0000-0001-8250-9828", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6528e043f2445d1a87e83cf65906450.json"}}, {"family": "Verweij", "given": "Niek", "initials": "N", "orcid": "0000-0002-4303-7685", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ce7bbbc0c7c48d699dc9fc3ee251bf3.json"}}, {"family": "Vlachopoulou", "given": "Efthymia", "initials": "E"}, {"family": "V\u00f6lker", "given": "Uwe", "initials": "U"}, {"family": "Wang", "given": "Biqi", "initials": "B"}, {"family": "Weeke", "given": "Peter E", "initials": "PE"}, {"family": "Weijs", "given": "Bob", "initials": "B", "orcid": "0000-0003-3202-4931", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cc03d79573e433497debd2c81eb26af.json"}}, {"family": "Weiss", "given": "Raul", "initials": "R"}, {"family": "Weiss", "given": "Stefan", "initials": "S", "orcid": "0000-0002-3553-4315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ebf58f688caa49ab9e0a3e56349b1031.json"}}, {"family": "Wells", "given": "Quinn S", "initials": "QS"}, {"family": "Wiggins", "given": "Kerri L", "initials": "KL", "orcid": "0000-0003-2749-1279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81a494bbde4e455295116301551c8cb8.json"}}, {"family": "Wong", "given": "Jorge A", "initials": "JA"}, {"family": "Woo", "given": "Daniel", "initials": "D"}, {"family": "Worrall", "given": "Bradford B", "initials": "BB"}, {"family": "Yang", "given": "Pil-Sung", "initials": "PS"}, {"family": "Yao", "given": "Jie", "initials": "J"}, {"family": "Yoneda", "given": "Zachary T", "initials": "ZT"}, {"family": "Zeller", "given": "Tanja", "initials": "T"}, {"family": "Zeng", "given": "Lingyao", "initials": "L"}, {"family": "Lubitz", "given": "Steven A", "initials": "SA", "orcid": "0000-0002-9599-4866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60efe6f9ed234eaca23702a92b8aa49f.json"}}, {"family": "Lunetta", "given": "Kathryn L", "initials": "KL"}, {"family": "Ellinor", "given": "Patrick T", "initials": "PT", "orcid": "0000-0002-2067-0533", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd1830794e884e6e849fd4f7645c9b61.json"}}], "type": "journal article", "published": "2018-06-11", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "50", "issue": "9", "pages": "1225-1233", "issn-l": "1061-4036"}, "abstract": "Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.", "doi": "10.1038/s41588-018-0133-9", "pmid": "29892015", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS986675"}, {"db": "pmc", "key": "PMC6136836"}, {"db": "pii", "key": "10.1038/s41588-018-0133-9"}], "notes": [], "created": "2019-01-17T14:00:58.837Z", "modified": "2026-09-23T06:29:56.965Z"}, {"entity": "publication", "iuid": "f5ca9acda2394f8ca8555d14dcec24a4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f5ca9acda2394f8ca8555d14dcec24a4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f5ca9acda2394f8ca8555d14dcec24a4"}}, "title": "Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.", "authors": [{"family": "Christophersen", "given": "Ingrid E", "initials": "IE", "orcid": "0000-0002-6141-4712", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66cf18798d82477a8771ce40cf067fed.json"}}, {"family": "Rienstra", "given": "Michiel", "initials": "M"}, {"family": "Roselli", "given": "Carolina", "initials": "C"}, {"family": "Yin", "given": "Xiaoyan", "initials": "X"}, {"family": "Geelhoed", "given": "Bastiaan", "initials": "B"}, {"family": "Barnard", "given": "John", "initials": "J", "orcid": "0000-0003-2403-8268", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c279a7a7e984d4491312768292ce611.json"}}, {"family": "Lin", "given": "Honghuang", "initials": "H", "orcid": "0000-0003-3043-3942", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fcff923f48845b88239000f20875e7c.json"}}, {"family": "Arking", "given": "Dan E", "initials": "DE"}, {"family": "Smith", "given": "Albert V", "initials": "AV", "orcid": "0000-0003-1942-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51752e0d35a74befa66a65b95ceaad38.json"}}, {"family": "Albert", "given": "Christine M", "initials": "CM"}, {"family": "Chaffin", "given": "Mark", "initials": "M"}, {"family": "Tucker", "given": "Nathan R", "initials": "NR", "orcid": "0000-0002-5071-4218", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a084d5794114fcd924cb8962a6053f7.json"}}, {"family": "Li", "given": "Molong", "initials": "M"}, {"family": "Klarin", "given": "Derek", "initials": "D"}, {"family": "Bihlmeyer", "given": "Nathan A", "initials": "NA", "orcid": "0000-0002-4415-7419", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc2aae22d7d242d6934dd1fddfb7cfcd.json"}}, {"family": "Low", "given": "Siew-Kee", "initials": "SK"}, {"family": "Weeke", "given": "Peter E", "initials": "PE"}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Brody", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0001-8509-148X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5e5e63068a4762ba2c4ca10f30aa78.json"}}, {"family": "Niemeijer", "given": "Maartje N", "initials": "MN"}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M"}, {"family": "Trompet", "given": "Stella", "initials": "S"}, {"family": "Huffman", "given": "Jennifer", "initials": "J", "orcid": "0000-0002-9672-2491", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db300ba51fe547bbaa3c7dd94a48ae93.json"}}, {"family": "Gustafsson", "given": "Stefan", "initials": "S", "orcid": "0000-0001-5894-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fedf8897d75744f5b17f7c91c892acbf.json"}}, {"family": "Schurmann", "given": "Claudia", "initials": "C"}, {"family": "Kleber", "given": "Marcus E", "initials": "ME", "orcid": "0000-0003-0663-7275", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22bc3077d1244542bcd6222f70dd7c96.json"}}, {"family": "Lyytik\u00e4inen", "given": "Leo-Pekka", "initials": "LP", "orcid": "0000-0002-7200-5455", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d541c99c43642538b7578fc4ff810ad.json"}}, {"family": "Sepp\u00e4l\u00e4", "given": "Ilkka", "initials": "I", "orcid": "0000-0002-5595-2573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0bf23c1b3b34d8789b46f2f425c37c9.json"}}, {"family": "Malik", "given": "Rainer", "initials": "R"}, {"family": "Horimoto", "given": "Andrea R V R", "initials": "ARVR"}, {"family": "Perez", "given": "Marco", "initials": "M"}, {"family": "Sinisalo", "given": "Juha", "initials": "J"}, {"family": "Aeschbacher", "given": "Stefanie", "initials": "S"}, {"family": "Th\u00e9riault", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Yao", "given": "Jie", "initials": "J"}, {"family": "Radmanesh", "given": "Farid", "initials": "F"}, {"family": "Weiss", "given": "Stefan", "initials": "S", "orcid": "0000-0002-3553-4315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ebf58f688caa49ab9e0a3e56349b1031.json"}}, {"family": "Teumer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8309-094X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a40a959d1b8480cb8268e00f77a0449.json"}}, {"family": "Choi", "given": "Seung Hoan", "initials": "SH"}, {"family": "Weng", "given": "Lu-Chen", "initials": "LC"}, {"family": "Clauss", "given": "Sebastian", "initials": "S"}, {"family": "Deo", "given": "Rajat", "initials": "R"}, {"family": "Rader", "given": "Daniel J", "initials": "DJ"}, {"family": "Shah", "given": "Svati H", "initials": "SH"}, {"family": "Sun", "given": "Albert", "initials": "A"}, {"family": "Hopewell", "given": "Jemma C", "initials": "JC"}, {"family": "Debette", "given": "Stephanie", "initials": "S"}, {"family": "Chauhan", "given": "Ganesh", "initials": "G"}, {"family": "Yang", "given": "Qiong", "initials": "Q", "orcid": "0000-0002-3658-1375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f83a12a89464005914934998b2b2ac3.json"}}, {"family": "Worrall", "given": "Bradford B", "initials": "BB"}, {"family": "Par\u00e9", "given": "Guillaume", "initials": "G"}, {"family": "Kamatani", "given": "Yoichiro", "initials": "Y"}, {"family": "Hagemeijer", "given": "Yanick P", "initials": "YP", "orcid": "0000-0001-6036-3741", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76b2c76095b149a89e349830770c5cc7.json"}}, {"family": "Verweij", "given": "Niek", "initials": "N"}, {"family": "Siland", "given": "Joylene E", "initials": "JE"}, {"family": "Kubo", "given": "Michiaki", "initials": "M"}, {"family": "Smith", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-0415-386X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f08d6773c2134268bda75050772d397f.json"}}, {"family": "Van Wagoner", "given": "David R", "initials": "DR", "orcid": "0000-0001-8250-9828", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6528e043f2445d1a87e83cf65906450.json"}}, {"family": "Bis", "given": "Joshua C", "initials": "JC"}, {"family": "Perz", "given": "Siegfried", "initials": "S"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM"}, {"family": "Ridker", "given": "Paul M", "initials": "PM"}, {"family": "Magnani", "given": "Jared W", "initials": "JW"}, {"family": "Harris", "given": "Tamara B", "initials": "TB"}, {"family": "Launer", "given": "Lenore J", "initials": "LJ"}, {"family": "Shoemaker", "given": "M Benjamin", "initials": "MB"}, {"family": "Padmanabhan", "given": "Sandosh", "initials": "S"}, {"family": "Haessler", "given": "Jeffrey", "initials": "J"}, {"family": "Bartz", "given": "Traci M", "initials": "TM"}, {"family": "Waldenberger", "given": "Melanie", "initials": "M"}, {"family": "Lichtner", "given": "Peter", "initials": "P"}, {"family": "Arendt", "given": "Marina", "initials": "M"}, {"family": "Krieger", "given": "Jose E", "initials": "JE", "orcid": "0000-0001-5464-1792", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/15968b7f70c1488983df28fbd4942c2a.json"}}, {"family": "K\u00e4h\u00f6nen", "given": "Mika", "initials": "M"}, {"family": "Risch", "given": "Lorenz", "initials": "L"}, {"family": "Mansur", "given": "Alfredo J", "initials": "AJ"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Smith", "given": "Blair H", "initials": "BH", "orcid": "0000-0002-5362-9430", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f30912f5a8e443eac572814f3990d7f.json"}}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Scott", "given": "Stuart A", "initials": "SA", "orcid": "0000-0001-5720-1864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/996702411c224c58a0f162518fecf580.json"}}, {"family": "Lu", "given": "Yingchang", "initials": "Y"}, {"family": "Bottinger", "given": "Erwin B", "initials": "EB"}, {"family": "Hernesniemi", "given": "Jussi", "initials": "J"}, {"family": "Lindgren", "given": "Cecilia M", "initials": "CM"}, {"family": "Wong", "given": "Jorge A", "initials": "JA"}, {"family": "Huang", "given": "Jie", "initials": "J"}, {"family": "Eskola", "given": "Markku", "initials": "M"}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "Ford", "given": "Ian", "initials": "I"}, {"family": "Reiner", "given": "Alex P", "initials": "AP"}, {"family": "Delgado", "given": "Graciela", "initials": "G"}, {"family": "Chen", "given": "Lin Y", "initials": "LY"}, {"family": "Chen", "given": "Yii-Der Ida", "initials": "YI"}, {"family": "Sandhu", "given": "Roopinder K", "initials": "RK"}, {"family": "Li", "given": "Man", "initials": "M", "orcid": "0000-0002-3839-0281", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5436bf44eb30448d8ff5b2d9216500f5.json"}}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Eisele", "given": "Lewin", "initials": "L"}, {"family": "Lannfelt", "given": "Lars", "initials": "L"}, {"family": "Rost", "given": "Natalia", "initials": "N"}, {"family": "Anderson", "given": "Christopher D", "initials": "CD"}, {"family": "Taylor", "given": "Kent D", "initials": "KD"}, {"family": "Campbell", "given": "Archie", "initials": "A", "orcid": "0000-0003-0198-5078", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0727bde0027c4a8a9d2737bb486f1bad.json"}}, {"family": "Magnusson", "given": "Patrik K", "initials": "PK"}, {"family": "Porteous", "given": "David", "initials": "D"}, {"family": "Hocking", "given": "Lynne J", "initials": "LJ"}, {"family": "Vlachopoulou", "given": "Efthymia", "initials": "E"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Nikus", "given": "Kjell", "initials": "K"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Heeringa", "given": "Jan", "initials": "J"}, {"family": "Denny", "given": "Joshua C", "initials": "JC"}, {"family": "Kriebel", "given": "Jennifer", "initials": "J", "orcid": "0000-0003-4270-018X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f77841a88d74185a43c7d5826062d7b.json"}}, {"family": "Darbar", "given": "Dawood", "initials": "D"}, {"family": "Newton-Cheh", "given": "Christopher", "initials": "C"}, {"family": "Shaffer", "given": "Christian", "initials": "C"}, {"family": "Macfarlane", "given": "Peter W", "initials": "PW"}, {"family": "Heilmann-Heimbach", "given": "Stefanie", "initials": "S"}, {"family": "Almgren", "given": "Peter", "initials": "P"}, {"family": "Huang", "given": "Paul L", "initials": "PL"}, {"family": "Sotoodehnia", "given": "Nona", "initials": "N"}, {"family": "Soliman", "given": "Elsayed Z", "initials": "EZ", "orcid": "0000-0001-5632-8150", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4d53591cd5a46cab26b9e1dd2ce46c2.json"}}, {"family": "Uitterlinden", "given": "Andre G", "initials": "AG"}, {"family": "Hofman", "given": "Albert", "initials": "A"}, {"family": "Franco", "given": "Oscar H", "initials": "OH"}, {"family": "V\u00f6lker", "given": "Uwe", "initials": "U"}, {"family": "J\u00f6ckel", "given": "Karl-Heinz", "initials": "KH"}, {"family": "Sinner", "given": "Moritz F", "initials": "MF"}, {"family": "Lin", "given": "Henry J", "initials": "HJ"}, {"family": "Guo", "given": "Xiuqing", "initials": "X"}, {"family": "METASTROKE Consortium of the ISGC", "given": "", "initials": ""}, {"family": "Neurology Working Group of the CHARGE Consortium", "given": "", "initials": ""}, {"family": "Dichgans", "given": "Martin", "initials": "M"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Laurikka", "given": "Jari", "initials": "J"}, {"family": "Conen", "given": "David", "initials": "D"}, {"family": "Rosand", "given": "Jonathan", "initials": "J"}, {"family": "van der Harst", "given": "Pim", "initials": "P"}, {"family": "Lokki", "given": "Marja-Liisa", "initials": "ML"}, {"family": "Kathiresan", "given": "Sekar", "initials": "S"}, {"family": "Pereira", "given": "Alexandre", "initials": "A"}, {"family": "Jukema", "given": "J Wouter", "initials": "JW", "orcid": "0000-0002-3246-8359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51be7e89ccfd4bbe93b216028c57a376.json"}}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "M\u00e4rz", "given": "Winfried", "initials": "W"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Stricker", "given": "Bruno H", "initials": "BH"}, {"family": "Chung", "given": "Mina K", "initials": "MK"}, {"family": "Felix", "given": "Stephan B", "initials": "SB"}, {"family": "Gudnason", "given": "Vilmundur", "initials": "V"}, {"family": "Alonso", "given": "Alvaro", "initials": "A"}, {"family": "Roden", "given": "Dan M", "initials": "DM"}, {"family": "K\u00e4\u00e4b", "given": "Stefan", "initials": "S"}, {"family": "Chasman", "given": "Daniel I", "initials": "DI"}, {"family": "Heckbert", "given": "Susan R", "initials": "SR"}, {"family": "Benjamin", "given": "Emelia J", "initials": "EJ", "orcid": "0000-0003-4076-2336", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/89bc31f5dd38446b9ffb36e68201e2da.json"}}, {"family": "Tanaka", "given": "Toshihiro", "initials": "T", "orcid": "0000-0001-6201-9784", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76061df47a364337a534ddafa3176e79.json"}}, {"family": "Lunetta", "given": "Kathryn L", "initials": "KL"}, {"family": "Lubitz", "given": "Steven A", "initials": "SA"}, {"family": "Ellinor", "given": "Patrick T", "initials": "PT", "orcid": "0000-0002-2067-0533", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd1830794e884e6e849fd4f7645c9b61.json"}}, {"family": "AFGen Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2017-06-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "49", "issue": "6", "pages": "946-952", "issn-l": "1061-4036"}, "abstract": "Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,142 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilitate the identification of new potential targets for drug discovery.", "doi": "10.1038/ng.3843", "pmid": "28416818", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS901319"}, {"db": "pmc", "key": "PMC5585859"}, {"db": "pii", "key": "ng.3843"}], "notes": [], "created": "2018-12-05T09:14:27.701Z", "modified": "2026-09-23T06:35:46.851Z"}]}