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"https://publications-affiliated.scilifelab.se/researcher/28e45f00f5f247389409f0411d412da1.json"}}, {"family": "Tran-Minh", "given": "Khue Hua", "initials": "KH", "orcid": "0000-0002-8964-7489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef15425523a24bae98e18b18f267560e.json"}}, {"family": "T\u00fcrkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Unge", "given": "Christian", "initials": "C"}, {"family": "Venge", "given": "Per", "initials": "P", "orcid": "0000-0001-5863-790X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/579f2ac07d8b45a2a57fad65d4ba5f5f.json"}}, {"family": "Wahren-Herlenius", "given": "Marie", "initials": "M", "orcid": "0000-0002-0915-7245", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0db5190dbe894a5e9cd961e66ba5c75d.json"}}, {"family": "Woessmann", "given": "Jakob", "initials": "J", "orcid": "0000-0002-2283-7237", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a4b10f5f96244b98122eddcee694ec0.json"}}, {"family": "Yang", "given": "Hong", "initials": "H", "orcid": "0009-0002-0414-2471", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f6b6c1901bc4c4daf3101f3de8b7029.json"}}, {"family": "Ye\u015filkaya", "given": "Umit Haluk", "initials": "UH"}, {"family": "Yuan", "given": "Meng", "initials": "M", "orcid": "0000-0002-9248-3294", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe547a601454a23acb16b1952400baf.json"}}, {"family": "Zeybel", "given": "Mujdat", "initials": "M", "orcid": "0000-0001-5440-4623", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7bfd631ded14746be0b94b8f1cac968.json"}}, {"family": "Zhang", "given": "Cheng", "initials": "C", "orcid": "0000-0002-3721-8586", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f46e4161be08458994efddb75ed75874.json"}}, {"family": "Zhong", "given": "Wen", "initials": "W", "orcid": "0000-0002-7422-6104", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6ffb1140aaa42c5ac63fe76653fc63b.json"}}, {"family": "Zwahlen", "given": "Martin", "initials": "M", "orcid": "0000-0002-0064-4776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/456805fa3f4f47328f3923b78bf66996.json"}}, {"family": "von Feilitzen", "given": "Kalle", "initials": "K", "orcid": "0000-0002-0257-7554", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4c4545bd2324b7d9b6696dab5bcb7dd.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e213b04f8984c8eb00c68f5bc2f6a36.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}], "type": "journal article", "published": "2025-12-18", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "390", "issue": "6779", "pages": "eadx2678", "issn-l": "0036-8075"}, "abstract": "The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.", "doi": "10.1126/science.adx2678", "pmid": "41066540", "labels": {"SciLifeLab Fellow": "", "Adil Mardinoglu": ""}, "xrefs": [], "notes": [], "created": "2026-09-23T08:47:54.949Z", "modified": "2026-09-23T08:47:57.223Z"}, {"entity": "publication", "iuid": "82646e11f8fe457c8f73f7cc2ad8dba1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/82646e11f8fe457c8f73f7cc2ad8dba1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/82646e11f8fe457c8f73f7cc2ad8dba1"}}, "title": "Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19.", "authors": [{"family": "Yu", "given": "Meng", "initials": "M", "orcid": "0000-0002-9798-6624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f84fdd49f44048aabed4a6158dcbc054.json"}}, {"family": "Charles", "given": "Afandi", "initials": "A", "orcid": "0000-0003-0022-3303", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77e038d2bbad40b4a7245320d8ed3393.json"}}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c3d94a38dda465b83f13ec070fef017.json"}}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Azizmohammadi", "given": "Lida", "initials": "L"}, {"family": "\u00c5hlberg", "given": "Eric", "initials": "E"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R", "orcid": "0000-0002-0985-8658", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6886b0c153c940298130477dc0bbb86e.json"}}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Nie", "given": "Mu", "initials": "M"}, {"family": "Warnqvist", "given": "Anna", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Lenart", "given": "Klara", "initials": "K", "orcid": "0000-0002-4984-2618", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b59c59772714231a670ba7c4f01e72c.json"}}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06fd44d1b18443a88b9fc5632989602d.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/53b1b006cbd5453892092be445705616.json"}}, {"family": "Lindgren", "given": "Gustaf", "initials": "G"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Maecker", "given": "Holden", "initials": "H", "orcid": "0000-0003-0795-9946", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/907c7565d5ae41c380024e1b01f61399.json"}}, {"family": "Bell", "given": "Max", "initials": "M", "orcid": "0000-0001-7464-0324", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/97bff95cb9014c8fb848e3c1c470df5d.json"}}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5945a41c8836474a8decf9c8b8db52ab.json"}}, {"family": "Sundling", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6138-690X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1304f32971904c4e901803d46c5f7ffe.json"}}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6265be732af0469d9d58bf5a46e8cf7d.json"}}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1fe004217b9b4c5ab49fae1023ddedf1.json"}}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f747dcba0d814f518dea6be7f16729c7.json"}}], "type": "journal article", "published": "2023-04-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "2164", "issn-l": "2041-1723"}, "abstract": "Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh) cell interactions. Whether these interactions are impaired and associated with COVID-19 disease severity is unclear. Here, longitudinal blood samples across COVID-19 disease severity are analysed. We find that during acute infection SARS-CoV-2-specific circulating Tfh (cTfh) cells expand with disease severity. SARS-CoV-2-specific cTfh cell frequencies correlate with plasmablast frequencies and SARS-CoV-2 antibody titers, avidity and neutralization. Furthermore, cTfh cells but not other memory CD4 T cells, from severe patients better induce plasmablast differentiation and antibody production compared to cTfh cells from mild patients. However, virus-specific cTfh cell development is delayed in patients that display or later develop severe disease compared to those with mild disease, which correlates with delayed induction of high-avidity neutralizing antibodies. Our study suggests that impaired generation of functional virus-specific cTfh cells delays high-quality antibody production at an early stage, potentially enabling progression to severe disease.", "doi": "10.1038/s41467-023-37835-9", "pmid": "37061513", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10105364"}, {"db": "pii", "key": "10.1038/s41467-023-37835-9"}], "notes": [], "created": "2026-09-23T09:04:34.180Z", "modified": "2026-09-23T09:04:34.927Z"}, {"entity": "publication", "iuid": "086497e9f2954570a6882a733bb14396", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/086497e9f2954570a6882a733bb14396.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/086497e9f2954570a6882a733bb14396"}}, "title": "Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure.", "authors": [{"family": "Yman", "given": "Victor", "initials": "V", "orcid": "0000-0001-7267-0749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76833e4e23414d9f8c2cbfefbc8068ac.json"}}, {"family": "Tuju", "given": "James", "initials": "J"}, {"family": "White", "given": "Michael T", "initials": "MT", "orcid": "0000-0002-7472-4138", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3aba9bb56c6544ad842f7caa90eee6d9.json"}}, {"family": "Kamuyu", "given": "Gathoni", "initials": "G"}, {"family": "Mwai", "given": "Kennedy", "initials": "K"}, {"family": "Kibinge", "given": "Nelson", "initials": "N"}, {"family": "Asghar", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-9017-2206", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e4570c139a47fd92db657f99e849d6.json"}}, {"family": "Sundling", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6138-690X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1304f32971904c4e901803d46c5f7ffe.json"}}, {"family": "Sond\u00e9n", "given": "Klara", "initials": "K"}, {"family": "Murungi", "given": "Linda", "initials": "L"}, {"family": "Kiboi", "given": "Daniel", "initials": "D"}, {"family": "Kimathi", "given": "Rinter", "initials": "R"}, {"family": "Chege", "given": "Timothy", "initials": "T"}, {"family": "Chepsat", "given": "Emily", "initials": "E"}, {"family": "Kiyuka", "given": "Patience", "initials": "P"}, {"family": "Nyamako", "given": "Lydia", "initials": "L"}, {"family": "Osier", "given": "Faith H A", "initials": "FHA", "orcid": "0000-0001-7133-5375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/86ad7d95f10140028f759ca1488d6dcc.json"}}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2022-01-17", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "331", "issn-l": "2041-1723"}, "abstract": "Strengthening malaria surveillance is a key intervention needed to reduce the global disease burden. Reliable serological markers of recent malaria exposure could improve current surveillance methods by allowing for accurate estimates of infection incidence from limited data. We studied the IgG antibody response to 111 Plasmodium falciparum proteins in 65 adult travellers followed longitudinally after a natural malaria infection in complete absence of re-exposure. We identified a combination of five serological markers that detect exposure within the previous three months with >80% sensitivity and specificity. Using mathematical modelling, we examined the antibody kinetics and determined that responses informative of recent exposure display several distinct characteristics: rapid initial boosting and decay, less inter-individual variation in response kinetics, and minimal persistence over time. Such serological exposure markers could be incorporated into routine malaria surveillance to guide efforts for malaria control and elimination.", "doi": "10.1038/s41467-021-27863-8", "pmid": "35039519", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8764098"}, {"db": "pii", "key": "10.1038/s41467-021-27863-8"}], "notes": [], "created": "2026-09-23T08:53:33.419Z", "modified": "2026-09-23T08:53:33.609Z"}, {"entity": "publication", "iuid": "1be5ac0b937a462c80cdb9f62078585d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1be5ac0b937a462c80cdb9f62078585d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1be5ac0b937a462c80cdb9f62078585d"}}, "title": "Systems analysis shows a role of cytophilic antibodies in shaping innate tolerance to malaria", "authors": [{"family": "Lautenbach", "given": "Maximilian Julius", "initials": "MJ", "orcid": "0000-0001-5763-6964", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da6876eefb5b41ff8ecd556bc34362b9.json"}}, {"family": "Yman", "given": "Victor", "initials": "V", "orcid": "0000-0001-7267-0749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76833e4e23414d9f8c2cbfefbc8068ac.json"}}, {"family": "Kadri", "given": "Nadir", "initials": "N", "orcid": "0000-0003-2623-4094", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/045ed52efb9f4590937eb6bf63fde1fa.json"}}, {"family": "Plaza", "given": "David Fernando", "initials": "DF", "orcid": "0000-0003-0366-4112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a0a7b11a20b4a959edbc6a5d3c6ddcc.json"}}, {"family": "Angenendt", "given": "Sina", "initials": "S"}, {"family": "Sond\u00e9n", "given": "Klara", "initials": "K", "orcid": "0000-0003-1585-8475", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ec27bcfa63b41dfa2f6d4a827141d28.json"}}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A", "orcid": "0000-0001-7583-282X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f05316417e504199887a72196da4e516.json"}}, {"family": "Sundling", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6138-690X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1304f32971904c4e901803d46c5f7ffe.json"}}], "type": "posted-content", "published": "2021-09-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.09.02.458668", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T14:16:37.139Z", "modified": "2026-09-23T14:16:37.374Z"}, {"entity": "publication", "iuid": "01bc5fc353d74c1f8cec4d7acb11b2d4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/01bc5fc353d74c1f8cec4d7acb11b2d4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/01bc5fc353d74c1f8cec4d7acb11b2d4"}}, "title": "Stimulation with mycobacterial glycolipids and PPD reveals different innate immune response profiles in active and latent TB", "authors": [{"family": "Silva", "given": "Carolina S", "initials": "CS"}, {"family": "Sundling", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6138-690X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1304f32971904c4e901803d46c5f7ffe.json"}}, {"family": "Folkeson", "given": "Elin", "initials": "E"}, {"family": "Fr\u00f6berg", "given": "Gabrielle", "initials": "G"}, {"family": "Nobrega", "given": "Claudia", "initials": "C"}, {"family": "Canto-Gomes", "given": "Jo\u00e3o", "initials": "J"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/164ec85f86504556beafe8fe34405592.json"}}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Bruchfeld", "given": "Judith", "initials": "J"}, {"family": "Nigou", "given": "Jerome", "initials": "J"}, {"family": "Correia-Neves", "given": "Margarida", "initials": "M"}, {"family": "K\u00e4llenius", "given": "Gunilla", "initials": "G"}], "type": "posted-content", "published": "2021-04-05", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.04.04.434373", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T15:06:34.267Z", "modified": "2026-09-23T15:06:34.316Z"}]}