{"entity": "researcher", "timestamp": "2026-08-20T21:03:10.213Z", "family": "Janasch", "given": "Markus", "initials": "M", "orcid": "0000-0001-7745-720X", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/115ab90674ba4090be1b3ef9a01549e4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/115ab90674ba4090be1b3ef9a01549e4"}}, "publications": [{"entity": "publication", "iuid": "0be796669e584dfa8ea662af78c39431", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0be796669e584dfa8ea662af78c39431.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0be796669e584dfa8ea662af78c39431"}}, "title": "Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation", "authors": [{"family": "Sporre", "given": "Emil", "initials": "E", "orcid": "0000-0003-4105-7567", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2250c46520424ec69e3d736c2bf30099.json"}}, {"family": "Karlsen", "given": "Jan", "initials": "J", "orcid": "0000-0002-2821-9026", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a1c2fa8404749b0a797e90e9c6cb09e.json"}}, {"family": "Schriever", "given": "Karen", "initials": "K", "orcid": "0000-0002-3677-5508", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/282cce0f6c054fd8a7858977be549b24.json"}}, {"family": "Samuelsson", "given": "Johannes Asplund", "initials": "JA", "orcid": "0000-0001-8077-5305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1cf0c49cbb849b194b0b46582441d09.json"}}, {"family": "Janasch", "given": "Markus", "initials": "M", "orcid": "0000-0001-7745-720X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/115ab90674ba4090be1b3ef9a01549e4.json"}}, {"family": "Strandberg", "given": "Linn\u00e9a", "initials": "L", "orcid": "0000-0001-5386-5460", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ea4741b77234afe83e92c3dfff0a799.json"}}, {"family": "Kotol", "given": "David", "initials": "D", "orcid": "0000-0002-5388-3826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c41f8f491c474e6bba2047b5d04b4af5.json"}}, {"family": "Zeckey", "given": "Luise", "initials": "L"}, {"family": "Piazza", "given": "Ilaria", "initials": "I", "orcid": "0000-0001-5895-6134", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5258dce396444d9a8f5e5bc2fd13b282.json"}}, {"family": "Syr\u00e9n", "given": "Per Olof", "initials": "PO", "orcid": "0000-0002-4066-2776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b035f26bd71e42f9942f9a4943ed0d1a.json"}}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e213b04f8984c8eb00c68f5bc2f6a36.json"}}, {"family": "Hudson", "given": "Elton P", "initials": "EP", "orcid": "0000-0003-1899-7649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b1c894d4c8b48569b9879d0342b91dd.json"}}], "type": "posted-content", "published": "2022-03-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.03.15.483797", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:10:14.448Z", "modified": "2026-08-20T10:10:14.574Z"}, {"entity": "publication", "iuid": "528655f581ae4d1b9b8554c427c8e589", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/528655f581ae4d1b9b8554c427c8e589.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/528655f581ae4d1b9b8554c427c8e589"}}, "title": "Thermodynamic limitations of metabolic strategies for PHB production from formate and fructose in Cupriavidus necator", "authors": [{"family": "Janasch", "given": "Markus", "initials": "M", "orcid": "0000-0001-7745-720X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/115ab90674ba4090be1b3ef9a01549e4.json"}}, {"family": "Crang", "given": "Nick", "initials": "N", "orcid": "0000-0002-7569-6597", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26cd5ec03dd2404a8de98cef8ab06187.json"}}, {"family": "Bruch", "given": "Manuel", "initials": "M"}, {"family": "Asplund-Samuelsson", "given": "Johannes", "initials": "J", "orcid": "0000-0001-8077-5305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1cf0c49cbb849b194b0b46582441d09.json"}}, {"family": "Gynn\u00e5", "given": "Arvid", "initials": "A", "orcid": "0000-0001-8087-7715", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6ad0db3cd4e4c0cba5eff0e6d31ec81.json"}}, {"family": "Jahn", "given": "Michael", "initials": "M", "orcid": "0000-0002-3913-153X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ce2ef4c47b24946876c12a549785e36.json"}}, {"family": "Hudson", "given": "Elton P", "initials": "EP", "orcid": "0000-0003-1899-7649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b1c894d4c8b48569b9879d0342b91dd.json"}}], "type": "posted-content", "published": "2022-02-23", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.02.22.481442", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:09:48.833Z", "modified": "2026-08-20T10:09:48.921Z"}, {"entity": "publication", "iuid": "60cd3a459c71424794afa8c155ef529b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/60cd3a459c71424794afa8c155ef529b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/60cd3a459c71424794afa8c155ef529b"}}, "title": "Protein allocation and utilization in the versatile chemolithoautotroph Cupriavidus necator.", "authors": [{"family": "Jahn", "given": "Michael", "initials": "M", "orcid": "0000-0002-3913-153X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ce2ef4c47b24946876c12a549785e36.json"}}, {"family": "Crang", "given": "Nick", "initials": "N", "orcid": "0000-0002-7569-6597", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26cd5ec03dd2404a8de98cef8ab06187.json"}}, {"family": "Janasch", "given": "Markus", "initials": "M", "orcid": "0000-0001-7745-720X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/115ab90674ba4090be1b3ef9a01549e4.json"}}, {"family": "Hober", "given": "Andreas", "initials": "A", "orcid": "0000-0001-8947-2562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06cbc187628340278395a00ab9dd6c89.json"}}, {"family": "Forsstr\u00f6m", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-5248-8568", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6982072448e4e8889c71fc14d214fed.json"}}, {"family": "Kimler", "given": "Kyle", "initials": "K"}, {"family": "Mattausch", "given": "Alexander", "initials": "A"}, {"family": "Chen", "given": "Qi", "initials": "Q"}, {"family": "Asplund-Samuelsson", "given": "Johannes", "initials": "J", "orcid": "0000-0001-8077-5305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1cf0c49cbb849b194b0b46582441d09.json"}}, {"family": "Hudson", "given": "Elton Paul", "initials": "EP", "orcid": "0000-0003-1899-7649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b1c894d4c8b48569b9879d0342b91dd.json"}}], "type": "journal article", "published": "2021-11-01", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "10", "issn-l": "2050-084X"}, "abstract": "Bacteria must balance the different needs for substrate assimilation, growth functions, and resilience in order to thrive in their environment. Of all cellular macromolecules, the bacterial proteome is by far the most important resource and its size is limited. Here, we investigated how the highly versatile 'knallgas' bacterium Cupriavidus necator reallocates protein resources when grown on different limiting substrates and with different growth rates. We determined protein quantity by mass spectrometry and estimated enzyme utilization by resource balance analysis modeling. We found that C. necator invests a large fraction of its proteome in functions that are hardly utilized. Of the enzymes that are utilized, many are present in excess abundance. One prominent example is the strong expression of CBB cycle genes such as Rubisco during growth on fructose. Modeling and mutant competition experiments suggest that CO2-reassimilation through Rubisco does not provide a fitness benefit for heterotrophic growth, but is rather an investment in readiness for autotrophy.", "doi": "10.7554/eLife.69019", "pmid": "34723797", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8591527"}, {"db": "pii", "key": "69019"}], "notes": [], "created": "2026-08-20T13:53:53.482Z", "modified": "2026-08-20T13:53:53.584Z"}, {"entity": "publication", "iuid": "99b513d8cf5f44f980f027a612c4eaa7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/99b513d8cf5f44f980f027a612c4eaa7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/99b513d8cf5f44f980f027a612c4eaa7"}}, "title": "Author response: Protein allocation and utilization in the versatile chemolithoautotroph Cupriavidus necator", "authors": [{"family": "Jahn", "given": "Michael", "initials": "M", "orcid": "0000-0002-3913-153X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ce2ef4c47b24946876c12a549785e36.json"}}, {"family": "Crang", "given": "Nick", "initials": "N", "orcid": "0000-0002-7569-6597", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26cd5ec03dd2404a8de98cef8ab06187.json"}}, {"family": "Janasch", "given": "Markus", "initials": "M", "orcid": "0000-0001-7745-720X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/115ab90674ba4090be1b3ef9a01549e4.json"}}, {"family": "Hober", "given": "Andreas", "initials": "A", "orcid": "0000-0001-8947-2562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06cbc187628340278395a00ab9dd6c89.json"}}, {"family": "Forsstr\u00f6m", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-5248-8568", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6982072448e4e8889c71fc14d214fed.json"}}, {"family": "Kimler", "given": "Kyle", "initials": "K"}, {"family": "Mattausch", "given": "Alexander", "initials": "A"}, {"family": "Chen", "given": "Qi", "initials": "Q"}, {"family": "Asplund-Samuelsson", "given": "Johannes", "initials": "J", "orcid": "0000-0001-8077-5305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1cf0c49cbb849b194b0b46582441d09.json"}}, {"family": "Hudson", "given": "Elton Paul", "initials": "EP", "orcid": "0000-0003-1899-7649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b1c894d4c8b48569b9879d0342b91dd.json"}}], "type": "peer-review", "published": "2021-09-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.69019.sa2", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:53:55.324Z", "modified": "2026-08-20T13:53:55.418Z"}, {"entity": "publication", "iuid": "3eb84a1927c8461a98b0b8ef04f69512", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3eb84a1927c8461a98b0b8ef04f69512.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3eb84a1927c8461a98b0b8ef04f69512"}}, "title": "Protein allocation and utilization in the versatile chemolithoautotroph Cupriavidus necator", "authors": [{"family": "Jahn", "given": "Michael", "initials": "M", "orcid": "0000-0002-3913-153X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ce2ef4c47b24946876c12a549785e36.json"}}, {"family": "Crang", "given": "Nick", "initials": "N", "orcid": "0000-0002-7569-6597", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26cd5ec03dd2404a8de98cef8ab06187.json"}}, {"family": "Janasch", "given": "Markus", "initials": "M", "orcid": "0000-0001-7745-720X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/115ab90674ba4090be1b3ef9a01549e4.json"}}, {"family": "Hober", "given": "Andreas", "initials": "A", "orcid": "0000-0001-8947-2562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06cbc187628340278395a00ab9dd6c89.json"}}, {"family": "Forsstr\u00f6m", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-5248-8568", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6982072448e4e8889c71fc14d214fed.json"}}, {"family": "Kimler", "given": "Kyle", "initials": "K", "orcid": "0000-0003-4735-9064", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f919fe867feb48acb57913bbc1fde0de.json"}}, {"family": "Mattausch", "given": "Alexander", "initials": "A", "orcid": "0000-0003-0901-8701", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ea370e86d354873ba74124ceddaf561.json"}}, {"family": "Chen", "given": "Qi", "initials": "Q", "orcid": "0000-0002-0606-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0acd5c7de3824e88a8c565d45840dbbf.json"}}, {"family": "Asplund-Samuelsson", "given": "Johannes", "initials": "J", "orcid": "0000-0001-8077-5305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1cf0c49cbb849b194b0b46582441d09.json"}}, {"family": "Hudson", "given": "Elton P", "initials": "EP", "orcid": "0000-0003-1899-7649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b1c894d4c8b48569b9879d0342b91dd.json"}}], "type": "posted-content", "published": "2021-03-22", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.03.21.436304", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:03:22.592Z", "modified": "2026-08-20T10:03:22.846Z"}, {"entity": "publication", "iuid": "275f73c4c16c465eb130115dc9918717", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/275f73c4c16c465eb130115dc9918717.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/275f73c4c16c465eb130115dc9918717"}}, "title": "CO2 fixation gets a second chance", "authors": [{"family": "Janasch", "given": "Markus", "initials": "M", "orcid": "0000-0001-7745-720X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/115ab90674ba4090be1b3ef9a01549e4.json"}}, {"family": "Hudson", "given": "Elton P", "initials": "EP", "orcid": "0000-0003-1899-7649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b1c894d4c8b48569b9879d0342b91dd.json"}}], "type": "journal-article", "published": "2021-02-19", "journal": {"title": "Nat Catal", "issn": "2520-1158", "volume": "4", "issue": "2", "pages": "94-95", "issn-l": null}, "abstract": null, "doi": "10.1038/s41929-021-00581-6", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:24:46.975Z", "modified": "2026-08-20T09:24:47.088Z"}]}