{"entity": "researcher", "timestamp": "2026-10-13T20:00:17.361Z", "family": "Yin", "given": "Xiushan", "initials": "X", "orcid": "0000-0001-8124-7387", "affiliations": ["SciLifeLab, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Tomtebodav\u00e4gen 23A, 17165, Solna, Sweden.", "Biotech and Biomedicine Science (Shenyang) Co. Ltd, Shenyang, 110000, China.", "Applied Biology Laboratory, Shenyang University of Chemical Technology, Shenyang, 110142, China."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/10f57a1b340547ebb74092bd2c6acdfe.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/10f57a1b340547ebb74092bd2c6acdfe"}}, "publications": [{"entity": "publication", "iuid": "c09e73d358cb42d597c1dc38d2424c6a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c09e73d358cb42d597c1dc38d2424c6a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c09e73d358cb42d597c1dc38d2424c6a"}}, "title": "A streamlined nanopore-compatible 5PSeq protocol for rapid phenotypic antimicrobial sensitivity testing", "authors": [{"family": "Liu", "given": "Honglian", "initials": "H", "orcid": "0009-0004-9808-3031", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5472825003fa4e22b9593c2571eb1a61.json"}}, {"family": "Huch", "given": "Susanne", "initials": "S", "orcid": "0000-0003-3956-7197", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0b94cf87e4243efa8e6229f49403d0f.json"}}, {"family": "Hull", "given": "Ryan", "initials": "R", "orcid": "0000-0001-7153-4198", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4adfcc02af0b422aa81206bf3c56471d.json"}}, {"family": "Romero Garcia", "given": "Fabricio", "initials": "F"}, {"family": "Nersisyan", "given": "Lilit", "initials": "L", "orcid": "0000-0001-8525-420X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c77363d1fa7f4ea6b50c22590c23a163.json"}}, {"family": "Yin", "given": "Xiushan", "initials": "X", "orcid": "0000-0001-8124-7387", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10f57a1b340547ebb74092bd2c6acdfe.json"}}, {"family": "Chen", "given": "Wei Hua", "initials": "WH", "orcid": "0000-0003-2168-6147", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8f64f5242024f9bb25b2d4b5e7696e5.json"}}, {"family": "Du", "given": "Juan", "initials": "J", "orcid": "0000-0001-7649-9571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f67834a614ca4cd4aff026e5e9a1a1e4.json"}}, {"family": "Pelechano", "given": "Vicent", "initials": "V", "orcid": "0000-0002-9415-788X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e893b93b7654d10b4072e1b5de0bd71.json"}}], "type": "posted-content", "published": "2025-11-12", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2025.11.12.687992", "pmid": null, "labels": {"SciLifeLab Fellow": ""}, "xrefs": [], "notes": [], "created": "2026-08-20T11:07:33.503Z", "modified": "2026-09-23T15:53:03.083Z"}, {"entity": "publication", "iuid": "b07323c92b2a46a7abf1df532fe692c2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b07323c92b2a46a7abf1df532fe692c2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b07323c92b2a46a7abf1df532fe692c2"}}, "title": "Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples.", "authors": [{"family": "Alekseenko", "given": "Alisa", "initials": "A", "orcid": "0000-0002-4269-4894", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85f8ac2ec1a54cf79e4b1fbfc8a44aaf.json"}}, {"family": "Barrett", "given": "Donal", "initials": "D", "orcid": "0000-0001-5381-5391", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7fb0f798fb9e4095af7146e8bc79feee.json"}}, {"family": "Pareja-Sanchez", "given": "Yerma", "initials": "Y", "orcid": "0000-0003-2008-5390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c66abc222f14d7b80591307113af56e.json"}}, {"family": "Howard", "given": "Rebecca J", "initials": "RJ", "orcid": "0000-0003-2049-3378", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ce04593b5b24aaa8978fda1447dd0bf.json"}}, {"family": "Strandback", "given": "Emilia", "initials": "E"}, {"family": "Ampah-Korsah", "given": "Henry", "initials": "H", "orcid": "0000-0002-8363-1697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5f166b865a7483c88415aa9c607d039.json"}}, {"family": "Rov\u0161nik", "given": "Ur\u0161ka", "initials": "U", "orcid": "0000-0001-5889-6899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0ab87a8712f4ad886da61c1edcf679f.json"}}, {"family": "Zuniga-Veliz", "given": "Silvia", "initials": "S"}, {"family": "Klenov", "given": "Alexander", "initials": "A"}, {"family": "Malloo", "given": "Jayshna", "initials": "J"}, {"family": "Ye", "given": "Shenglong", "initials": "S"}, {"family": "Liu", "given": "Xiyang", "initials": "X"}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7c1abacc8d446bf8855254246b8d899.json"}}, {"family": "Els\u00e4sser", "given": "Simon J", "initials": "SJ", "orcid": "0000-0001-8724-4849", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/faaf7145e4044091a2fed9069f56b92e.json"}}, {"family": "Nyman", "given": "Tomas", "initials": "T"}, {"family": "Sandh", "given": "Gustaf", "initials": "G"}, {"family": "Yin", "given": "Xiushan", "initials": "X", "orcid": "0000-0001-8124-7387", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10f57a1b340547ebb74092bd2c6acdfe.json"}}, {"family": "Pelechano", "given": "Vicent", "initials": "V", "orcid": "0000-0002-9415-788X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e893b93b7654d10b4072e1b5de0bd71.json"}}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "1820", "issn-l": "2045-2322"}, "abstract": "RT-LAMP detection of SARS-CoV-2 has been shown to be a valuable approach to scale up COVID-19 diagnostics and thus contribute to limiting the spread of the disease. Here we present the optimization of highly cost-effective in-house produced enzymes, and we benchmark their performance against commercial alternatives. We explore the compatibility between multiple DNA polymerases with high strand-displacement activity and thermostable reverse transcriptases required for RT-LAMP. We optimize reaction conditions and demonstrate their applicability using both synthetic RNA and clinical patient samples. Finally, we validate the optimized RT-LAMP assay for the detection of SARS-CoV-2 in unextracted heat-inactivated nasopharyngeal samples from 184 patients. We anticipate that optimized and affordable reagents for RT-LAMP will facilitate the expansion of SARS-CoV-2 testing globally, especially in sites and settings where the need for large scale testing cannot be met by commercial alternatives.", "doi": "10.1038/s41598-020-80352-8", "pmid": "33469065", "labels": {"Simon Els\u00e4sser": "", "SciLifeLab Fellow": ""}, "xrefs": [{"db": "pmc", "key": "PMC7815738"}, {"db": "pii", "key": "10.1038/s41598-020-80352-8"}], "notes": [], "created": "2021-12-02T18:33:50.940Z", "modified": "2026-09-23T08:38:25.774Z"}, {"entity": "publication", "iuid": "5a89e65e397d496295d57f04a753540e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5a89e65e397d496295d57f04a753540e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5a89e65e397d496295d57f04a753540e"}}, "title": "Engineered human mesenchymal stem cells as new vaccine platform for COVID-19", "authors": [{"family": "Liu", "given": "Junhua", "initials": "J"}, {"family": "Jiao", "given": "Huping", "initials": "H"}, {"family": "Yin", "given": "Xiushan", "initials": "X", "orcid": "0000-0001-8124-7387", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10f57a1b340547ebb74092bd2c6acdfe.json"}}], "type": "posted-content", "published": "2020-06-20", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.06.20.163030", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T13:50:28.667Z", "modified": "2026-09-23T13:50:28.688Z"}]}