{"entity": "researcher", "timestamp": "2026-08-22T07:49:57.207Z", "family": "Engberg", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-1659-5232", "affiliations": ["Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden. goran.engberg@ki.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ed974354c3642578dc0b176794a4ea3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ed974354c3642578dc0b176794a4ea3"}}, "publications": [{"entity": "publication", "iuid": "033f62b785654d3196670ec6b2958c10", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/033f62b785654d3196670ec6b2958c10.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/033f62b785654d3196670ec6b2958c10"}}, "title": "Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients.", "authors": [{"family": "Shang", "given": "Pei", "initials": "P"}, {"family": "Ho", "given": "Ada Man-Choi", "initials": "AM", "orcid": "0000-0003-4989-8782", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e126db882fd4f5da9861769eb2b0f83.json"}}, {"family": "Tufvesson-Alm", "given": "Maximilian", "initials": "M"}, {"family": "Lindberg", "given": "Daniel R", "initials": "DR"}, {"family": "Grant", "given": "Caroline W", "initials": "CW"}, {"family": "Orhan", "given": "Funda", "initials": "F"}, {"family": "Eren", "given": "Feride", "initials": "F", "orcid": "0000-0001-6068-5329", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e56a29b236d84ac68f3951dc2e90241d.json"}}, {"family": "Bhat", "given": "Maria", "initials": "M"}, {"family": "Engberg", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-1659-5232", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ed974354c3642578dc0b176794a4ea3.json"}}, {"family": "Schwieler", "given": "Lilly", "initials": "L"}, {"family": "Fatouros-Bergman", "given": "Helena", "initials": "H"}, {"family": "Imbeault", "given": "Sophie", "initials": "S"}, {"family": "Iverson", "given": "Ryan M", "initials": "RM"}, {"family": "Dasari", "given": "Surendra", "initials": "S"}, {"family": "Piehl", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-8329-5219", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/512835c06e9e476bbefa2734c08c8f7e.json"}}, {"family": "Cervenka", "given": "Simon", "initials": "S", "orcid": "0000-0001-8103-6977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c25d656e59c44a77813ebdb0b741c552.json"}}, {"family": "Sellgren", "given": "Carl M", "initials": "CM"}, {"family": "Erhardt", "given": "Sophie", "initials": "S", "orcid": "0000-0001-7359-5250", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/30dc5c99c5b249b5bc8afdee8f43d6ac.json"}}, {"family": "Choi", "given": "Doo-Sup", "initials": "DS", "orcid": "0000-0002-6796-9938", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a83dc2e41af40b8a590f6cf2d403d0d.json"}}], "type": "journal article", "published": "2022-06-03", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "12", "issue": "1", "pages": "229", "issn-l": "2158-3188"}, "abstract": "Psychotic disorders are currently diagnosed by examining the patient's mental state and medical history. Identifying reliable diagnostic, monitoring, predictive, or prognostic biomarkers would be useful in clinical settings and help to understand the pathophysiology of schizophrenia. Here, we performed an untargeted metabolomics analysis using ultra-high pressure liquid chromatography coupled with time-of-flight mass spectroscopy on cerebrospinal fluid (CSF) and serum samples of 25 patients at their first-episode psychosis (FEP) manifestation (baseline) and after 18 months (follow-up). CSF and serum samples of 21 healthy control (HC) subjects were also analyzed. By comparing FEP and HC groups at baseline, we found eight CSF and 32 serum psychosis-associated metabolites with non-redundant identifications. Most remarkable was the finding of increased CSF serotonin (5-HT) levels. Most metabolites identified at baseline did not differ between groups at 18-month follow-up with significant improvement of positive symptoms and cognitive functions. Comparing FEP patients at baseline and 18-month follow-up, we identified 20 CSF metabolites and 90 serum metabolites that changed at follow-up. We further utilized Ingenuity Pathway Analysis (IPA) and identified candidate signaling pathways involved in psychosis pathogenesis and progression. In an extended cohort, we validated that CSF 5-HT levels were higher in FEP patients than in HC at baseline by reversed-phase high-pressure liquid chromatography. To conclude, these findings provide insights into the pathophysiology of psychosis and identify potential psychosis-associated biomarkers.", "doi": "10.1038/s41398-022-02000-1", "pmid": "35665740", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9166796"}, {"db": "pii", "key": "10.1038/s41398-022-02000-1"}], "notes": [], "created": "2026-08-21T11:47:17.461Z", "modified": "2026-08-21T11:47:17.693Z"}, {"entity": "publication", "iuid": "6abced2cd4b14635bc1fb01a680b4f06", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6abced2cd4b14635bc1fb01a680b4f06.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6abced2cd4b14635bc1fb01a680b4f06"}}, "title": "GRK3 deficiency elicits brain immune activation and psychosis.", "authors": [{"family": "Sellgren", "given": "Carl M", "initials": "CM"}, {"family": "Imbeault", "given": "Sophie", "initials": "S"}, {"family": "Larsson", "given": "Markus K", "initials": "MK"}, {"family": "Oliveros", "given": "Alfredo", "initials": "A"}, {"family": "Nilsson", "given": "Ida A K", "initials": "IAK", "orcid": "0000-0002-7676-4299", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/753f315f9a5f46fda0557803628524d9.json"}}, {"family": "Codeluppi", "given": "Simone", "initials": "S"}, {"family": "Orhan", "given": "Funda", "initials": "F"}, {"family": "Bhat", "given": "Maria", "initials": "M"}, {"family": "Tufvesson-Alm", "given": "Maximilian", "initials": "M"}, {"family": "Gracias", "given": "Jessica", "initials": "J", "orcid": "0000-0002-1730-7821", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/952d37a55c254487935a673309f83a39.json"}}, {"family": "Kegel", "given": "Magdalena E", "initials": "ME"}, {"family": "Zheng", "given": "Yiran", "initials": "Y"}, {"family": "Faka", "given": "Anthi", "initials": "A"}, {"family": "Svedberg", "given": "Marie", "initials": "M"}, {"family": "Powell", "given": "Susan B", "initials": "SB"}, {"family": "Caldwell", "given": "Sorana", "initials": "S"}, {"family": "Kamenski", "given": "Mary E", "initials": "ME"}, {"family": "Vawter", "given": "Marquis P", "initials": "MP"}, {"family": "Schulmann", "given": "Anton", "initials": "A", "orcid": "0000-0002-6323-4969", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2710f4e7bf94c1c9aa1f36d7a6051c5.json"}}, {"family": "Goiny", "given": "Michel", "initials": "M"}, {"family": "Svensson", "given": "Camilla I", "initials": "CI"}, {"family": "H\u00f6kfelt", "given": "Tomas", "initials": "T"}, {"family": "Schalling", "given": "Martin", "initials": "M"}, {"family": "Schwieler", "given": "Lilly", "initials": "L"}, {"family": "Cervenka", "given": "Simon", "initials": "S"}, {"family": "Choi", "given": "Doo-Sup", "initials": "DS", "orcid": "0000-0002-6796-9938", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a83dc2e41af40b8a590f6cf2d403d0d.json"}}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M"}, {"family": "Engberg", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-1659-5232", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ed974354c3642578dc0b176794a4ea3.json"}}, {"family": "Erhardt", "given": "Sophie", "initials": "S"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Mol. Psychiatry", "issn": "1476-5578", "volume": "26", "issue": "11", "pages": "6820-6832", "issn-l": "1359-4184"}, "abstract": "The G protein-coupled receptor kinase (GRK) family member protein GRK3 has been linked to the pathophysiology of schizophrenia and bipolar disorder. Expression, as well as protein levels, of GRK3 are reduced in post-mortem prefrontal cortex of schizophrenia subjects. Here, we investigate functional behavior and neurotransmission related to immune activation and psychosis using mice lacking functional Grk3 and utilizing a variety of methods, including behavioral, biochemical, electrophysiological, molecular, and imaging methods. Compared to wildtype controls, the Grk3-/- mice show a number of aberrations linked to psychosis, including elevated brain levels of IL-1\u03b2, increased turnover of kynurenic acid (KYNA), hyper-responsiveness to D-amphetamine, elevated spontaneous firing of midbrain dopamine neurons, and disruption in prepulse inhibition. Analyzing human genetic data, we observe a link between psychotic features in bipolar disorder, decreased GRK expression, and increased concentration of CSF KYNA. Taken together, our data suggest that Grk3-/- mice show face and construct validity relating to the psychosis phenotype with glial activation and would be suitable for translational studies of novel immunomodulatory agents in psychotic disorders.", "doi": "10.1038/s41380-021-01106-0", "pmid": "33976392", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8760053"}, {"db": "pii", "key": "10.1038/s41380-021-01106-0"}], "notes": [], "created": "2026-08-21T11:47:00.060Z", "modified": "2026-08-21T11:47:00.286Z"}]}