{"entity": "researcher", "timestamp": "2026-04-13T05:44:42.855Z", "family": "Went", "given": "Molly", "initials": "M", "orcid": "0000-0003-3271-975X", "affiliations": ["Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ec75486d11444c89b8f8a8d81d22bda.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ec75486d11444c89b8f8a8d81d22bda"}}, "publications": [{"entity": "publication", "iuid": "c0fc1ac6d9704cacb375132e24f50c91", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c0fc1ac6d9704cacb375132e24f50c91.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c0fc1ac6d9704cacb375132e24f50c91"}}, "title": "Deciphering the genetics and mechanisms of predisposition to multiple myeloma.", "authors": [{"family": "Went", "given": "Molly", "initials": "M", "orcid": "0000-0003-3271-975X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ec75486d11444c89b8f8a8d81d22bda.json"}}, {"family": "Duran-Lozano", "given": "Laura", "initials": "L"}, {"family": "Halldorsson", "given": "Gisli H", "initials": "GH", "orcid": "0000-0001-7067-9862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28549aa56c4543178dd7626dbc9e4667.json"}}, {"family": "Gunnell", "given": "Andrea", "initials": "A", "orcid": "0000-0001-5162-5391", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/879f235469b443259ce663d029e7cdf8.json"}}, {"family": "Ugidos-Damboriena", "given": "Nerea", "initials": "N"}, {"family": "Law", "given": "Philip", "initials": "P", "orcid": "0000-0001-9663-4611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/499974f99dfe4fdd87a73034acb98d3e.json"}}, {"family": "Ekdahl", "given": "Ludvig", "initials": "L"}, {"family": 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{"family": "Stefansdottir", "given": "Lilja", "initials": "L"}, {"family": "Kristinsson", "given": "Sigurdur Y", "initials": "SY"}, {"family": "Stacey", "given": "Simon N", "initials": "SN", "orcid": "0000-0002-4732-7380", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dcdf7567e1416482442d565b8005c0.json"}}, {"family": "Love", "given": "Thorvardur J", "initials": "TJ"}, {"family": "Rognvaldsson", "given": "Saemundur", "initials": "S"}, {"family": "Hajek", "given": "Roman", "initials": "R", "orcid": "0000-0001-6955-6267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7099912b8d2d400d864ba440cacd434c.json"}}, {"family": "Vodicka", "given": "Pavel", "initials": "P"}, {"family": "Pettersson-Kymmer", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-0557-9803", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e219143aebf4a5386f19f01f6e1d237.json"}}, {"family": "Sp\u00e4th", "given": 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"researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98aff0e76e114696aaaabadc5ec18388.json"}}, {"family": "Mellqvist", "given": "Ulf-Henrik", "initials": "UH"}, {"family": "Jonsdottir", "given": "Ingileif", "initials": "I", "orcid": "0000-0001-8339-150X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f4e82de44504a55b50b0378447318f8.json"}}, {"family": "Morgan", "given": "Gareth", "initials": "G", "orcid": "0000-0002-4271-6360", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf94973d06d4414a98855c4506453f6c.json"}}, {"family": "Sonneveld", "given": "Pieter", "initials": "P"}, {"family": "Waage", "given": "Anders", "initials": "A", "orcid": "0000-0001-9072-1220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04b9b219373b4dea9950e8a7ae9f6f0b.json"}}, {"family": "Weinhold", "given": "Niels", "initials": "N"}, {"family": "Thomsen", "given": "Hauke", "initials": "H"}, {"family": "F\u00f6rsti", "given": "Asta", "initials": "A", "orcid": "0000-0002-9857-4728", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2356cdc19c040348a7924e3dd4b8c32.json"}}, {"family": "Hansson", "given": "Markus", "initials": "M", "orcid": "0000-0002-7715-4548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9aabef8e26ba40d9abd8e229d954795d.json"}}, {"family": "Juul-Vangsted", "given": "Annette", "initials": "A", "orcid": "0000-0002-2131-731X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7eadc85ce9564aeb838718479df147ff.json"}}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Hemminki", "given": "Kari", "initials": "K"}, {"family": "Kaiser", "given": "Martin", "initials": "M", "orcid": "0000-0002-3677-4804", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/61695044f08e4490a7feaf7db2aacc07.json"}}, {"family": "Rafnar", "given": "Thorunn", "initials": "T", "orcid": "0000-0003-0491-7046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67a01e1ebd79473dbc0059d38f066e55.json"}}, {"family": "Stefansson", "given": "Kari", "initials": "K", "orcid": "0000-0003-1676-864X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9edf80871ac84e76a4d1316fc7079d7d.json"}}, {"family": "Houlston", "given": "Richard", "initials": "R", "orcid": "0000-0002-5268-0242", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e7605f3f03f94e1b95c011318f5e5d4c.json"}}, {"family": "Nilsson", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-5542-0254", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e9df5bbe6f948b196a65176963748c8.json"}}], "type": "journal article", "published": "2024-08-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "6644", "issn-l": "2041-1723"}, "abstract": "Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying mechanisms remain unclear. Here, in a genome-wide association study totaling 10,906 cases and 366,221 controls, we identify 35 MM risk loci, 12 of which are novel. Through functional fine-mapping and Mendelian randomization, we uncover two causal mechanisms for inherited MM risk: longer telomeres; and elevated levels of B-cell maturation antigen (BCMA) and interleukin-5 receptor alpha (IL5RA) in plasma. The largest increase in BCMA and IL5RA levels is mediated by the risk variant rs34562254-A at TNFRSF13B. While individuals with loss-of-function variants in TNFRSF13B develop B-cell immunodeficiency, rs34562254-A exerts a gain-of-function effect, increasing MM risk through amplified B-cell responses. Our results represent an analysis of genetic MM predisposition, highlighting causal mechanisms contributing to MM development.", "doi": "10.1038/s41467-024-50932-7", "pmid": "39103364", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11300596"}, {"db": "pii", "key": "10.1038/s41467-024-50932-7"}], "notes": [], "created": "2025-03-18T15:48:53.213Z", "modified": "2025-03-18T15:49:12.903Z"}]}