{"entity": "researcher", "timestamp": "2026-09-23T15:08:38.716Z", "family": "Liu", "given": "Ching-Ti", "initials": "CT", "orcid": "0000-0002-0703-0742", "affiliations": ["Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0df836bc876845a6af66828561f24a27.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0df836bc876845a6af66828561f24a27"}}, "publications": [{"entity": "publication", "iuid": "b2c48a1a100a4407bb90e7530afbd9a8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b2c48a1a100a4407bb90e7530afbd9a8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b2c48a1a100a4407bb90e7530afbd9a8"}}, "title": "Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation", "authors": [{"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Spracklen", "given": "Cassandra N", "initials": "CN"}, {"family": "Zhang", "given": "Weihua", "initials": "W"}, {"family": "Ng", "given": "Maggie CY", "initials": "MC"}, {"family": "Petty", "given": "Lauren E", "initials": "LE"}, {"family": "Kitajima", "given": "Hidetoshi", "initials": "H"}, {"family": "Yu", "given": "Grace Z", "initials": "GZ"}, {"family": "R\u00fceger", "given": "Sina", "initials": "S"}, {"family": "Speidel", "given": "Leo", "initials": "L"}, {"family": "Kim", "given": "Young Jin", "initials": "YJ"}, {"family": "Horikoshi", "given": "Momoko", "initials": "M"}, {"family": "Mercader", "given": "Josep M", "initials": "JM"}, {"family": "Taliun", "given": "Daniel", "initials": "D"}, {"family": "Moon", "given": "Sanghoon", "initials": "S"}, {"family": "Kwak", "given": "Soo Heon", "initials": "SH"}, {"family": "Robertson", "given": "Neil R", "initials": "NR"}, {"family": "Rayner", "given": "Nigel W", "initials": "NW"}, {"family": "Loh", "given": "Marie", "initials": "M"}, {"family": "Kim", "given": "Bong Jo", "initials": "BJ"}, {"family": "Chiou", "given": "Joshua", "initials": "J", "orcid": "0000-0002-4618-0647", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8156252e81648d8a8c6b001b1f933af.json"}}, {"family": "Miguel-Escalada", "given": "Irene", "initials": "I"}, {"family": "Briotta Parolo", "given": "Pietro della", "initials": "Pd"}, {"family": "Lin", "given": "Kuang", "initials": "K"}, {"family": "Bragg", "given": "Fiona", "initials": "F"}, {"family": "Preuss", "given": "Michael H", "initials": "MH"}, {"family": "Takeuchi", "given": "Fumihiko", "initials": "F", "orcid": "0000-0003-3185-5661", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b91c81f9a3242c080a08e774702691d.json"}}, {"family": "Nano", "given": "Jana", "initials": "J"}, {"family": "Guo", "given": "Xiuqing", "initials": "X"}, {"family": "Lamri", "given": "Amel", "initials": "A"}, {"family": "Nakatochi", "given": "Masahiro", "initials": "M"}, {"family": "Scott", "given": "Robert A", "initials": "RA"}, {"family": "Lee", "given": "Jung Jin", "initials": "JJ"}, {"family": "Huerta-Chagoya", "given": "Alicia", "initials": "A"}, {"family": "Graff", "given": "Mariaelisa", "initials": "M"}, {"family": "Chai", "given": "Jin Fang", "initials": "JF"}, {"family": "Parra", "given": "Esteban J", "initials": "EJ"}, {"family": "Yao", "given": "Jie", "initials": "J"}, {"family": "Bielak", "given": "Lawrence F", "initials": "LF"}, {"family": "Tabara", "given": "Yasuharu", "initials": "Y"}, {"family": "Hai", "given": "Yang", "initials": "Y"}, {"family": "Steinthorsdottir", "given": "Valgerdur", "initials": "V"}, {"family": "Cook", "given": "James P", "initials": "JP"}, {"family": "Kals", "given": "Mart", "initials": "M"}, {"family": "Grarup", "given": "Niels", "initials": "N"}, {"family": "Schmidt", "given": "Ellen M", "initials": "EM"}, {"family": "Pan", "given": "Ian", "initials": "I"}, {"family": "Sofer", "given": "Tamar", "initials": "T"}, {"family": "Wuttke", "given": "Matthias", "initials": "M"}, {"family": "Sarnowski", "given": "Chloe", "initials": "C"}, {"family": "Gieger", "given": "Christian", "initials": "C"}, {"family": "Nousome", "given": "Darryl", "initials": "D"}, {"family": "Trompet", "given": "Stella", "initials": "S"}, {"family": "Long", "given": "Jirong", "initials": "J"}, {"family": "Sun", "given": "Meng", "initials": "M"}, {"family": "Tong", "given": "Lin", "initials": "L"}, {"family": "Chen", "given": "Wei Min", "initials": "WM"}, {"family": "Ahmad", "given": "Meraj", "initials": "M"}, {"family": "Noordam", "given": "Raymond", "initials": "R"}, {"family": "Lim", "given": "Victor JY", "initials": "VJ"}, {"family": "Tam", "given": "Claudia HT", "initials": "CH"}, {"family": "Joo", "given": "Yoonjung Yoonie", "initials": "YY", "orcid": "0000-0001-9506-8742", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f82c468143c945cab6bce594a79881c2.json"}}, {"family": "Chen", "given": "Chien Hsiun", "initials": "CH"}, {"family": "Raffield", "given": "Laura M", "initials": "LM", "orcid": "0000-0002-7892-193X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/686393c583e94c919f8e39fc8a03d4bc.json"}}, {"family": "Lecoeur", "given": "C\u00e9cile", "initials": "C"}, {"family": "Maruthur", "given": "Nisa M", "initials": "NM"}, {"family": "Prins", "given": "Bram Peter", "initials": "BP"}, {"family": "Nicolas", "given": "Aude", "initials": "A"}, {"family": "Yanek", "given": "Lisa R", "initials": "LR"}, {"family": "Chen", "given": "Guanjie", "initials": "G"}, {"family": "Jensen", "given": "Richard A", "initials": "RA"}, {"family": "Tajuddin", "given": "Salman", "initials": "S"}, {"family": "Kabagambe", "given": "Edmond", "initials": "E"}, {"family": "An", "given": "Ping", "initials": "P"}, {"family": "Xiang", "given": "Anny H", "initials": "AH"}, {"family": "Choi", "given": "Hyeok Sun", "initials": "HS"}, {"family": "Cade", "given": "Brian E", "initials": "BE"}, {"family": "Tan", "given": "Jingyi", "initials": "J"}, {"family": "Abaitua", "given": "Fernando", "initials": "F"}, {"family": "Adair", "given": "Linda S", "initials": "LS"}, {"family": "Adeyemo", "given": "Adebowale", "initials": "A"}, {"family": "Aguilar-Salinas", "given": "Carlos A", "initials": "CA"}, {"family": "Akiyama", "given": "Masato", "initials": "M"}, {"family": "Anand", "given": "Sonia S", "initials": "SS"}, {"family": "Bertoni", "given": "Alain", "initials": "A"}, {"family": "Bian", "given": "Zheng", "initials": "Z"}, {"family": "Bork-Jensen", "given": "Jette", "initials": "J"}, {"family": "Brandslund", "given": "Ivan", "initials": "I", "orcid": "0000-0002-4203-5442", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/192ebfbb4fbd4a4a81c2c7b5e4e44051.json"}}, {"family": "Brody", "given": "Jennifer A", "initials": "JA"}, {"family": "Brummett", "given": "Chad M", "initials": "CM"}, {"family": "Buchanan", "given": "Thomas A", "initials": "TA"}, {"family": "Canouil", "given": "Micka\u00ebl", "initials": "M"}, {"family": "Chan", "given": "Juliana CN", "initials": "JC"}, {"family": "Chang", "given": "Li Ching", "initials": "LC"}, {"family": "Chee", "given": "Miao Li", "initials": "ML"}, {"family": "Chen", "given": "Ji", "initials": "J"}, {"family": "Chen", "given": "Shyh Huei", "initials": "SH"}, {"family": "Chen", "given": "Yuan Tsong", "initials": "YT"}, {"family": "Chen", "given": "Zhengming", "initials": "Z"}, {"family": "Chuang", "given": "Lee Ming", "initials": "LM"}, {"family": "Cushman", "given": "Mary", "initials": "M"}, {"family": "Das", "given": "Swapan K", "initials": "SK"}, {"family": "de Silva", "given": "H Janaka", "initials": "HJ"}, {"family": "Dedoussis", "given": "George", "initials": "G"}, {"family": "Dimitrov", "given": "Latchezar", "initials": "L"}, {"family": "Doumatey", "given": "Ayo P", "initials": "AP"}, {"family": "Du", "given": "Shufa", "initials": "S"}, {"family": "Duan", "given": "Qing", "initials": "Q"}, {"family": "Eckardt", "given": "Kai Uwe", "initials": "KU"}, {"family": "Emery", "given": "Leslie S", "initials": "LS"}, {"family": "Evans", "given": "Daniel S", "initials": "DS"}, {"family": "Evans", "given": "Michele K", "initials": "MK", "orcid": "0000-0002-8546-2831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cdd6d361831748a2ab1b940efa45a711.json"}}, {"family": "Fischer", "given": "Krista", "initials": "K"}, {"family": "Floyd", "given": "James S", "initials": "JS"}, {"family": "Ford", "given": "Ian", "initials": "I"}, {"family": "Fornage", "given": "Myriam", "initials": "M", "orcid": "0000-0003-0677-8158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f637ca1a5edd4ece9dd2f88f3620f0b2.json"}}, {"family": "Franco", "given": "Oscar H", "initials": "OH"}, {"family": "Frayling", "given": "Timothy M", "initials": "TM"}, {"family": "Freedman", "given": "Barry I", "initials": "BI"}, {"family": "Fuchsberger", "given": "Christian", "initials": "C"}, {"family": "Genter", "given": "Pauline", "initials": "P"}, {"family": "Gerstein", "given": "Hertzel C", "initials": "HC"}, {"family": "Giedraitis", "given": "Vilmantas", "initials": "V"}, {"family": "Gonz\u00e1lez-Villalpando", "given": "Clicerio", "initials": "C"}, {"family": "Gonz\u00e1lez-Villalpando", "given": "Maria Elena", "initials": "ME"}, {"family": "Goodarzi", "given": "Mark O", "initials": "MO"}, {"family": "Gordon-Larsen", "given": "Penny", "initials": "P"}, {"family": "Gorkin", "given": "David", "initials": "D"}, {"family": "Gross", "given": "Myron", "initials": "M"}, {"family": "Guo", "given": "Yu", "initials": "Y"}, {"family": "Hackinger", "given": "Sophie", "initials": "S"}, {"family": "Han", "given": "Sohee", "initials": "S"}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT"}, {"family": "Herder", "given": "Christian", "initials": "C"}, {"family": "Howard", "given": "Annie Green", "initials": "AG"}, {"family": "Hsueh", "given": "Willa", "initials": "W"}, {"family": "Huang", "given": "Mengna", "initials": "M"}, {"family": "Huang", "given": "Wei", "initials": "W"}, {"family": "Hung", "given": "Yi Jen", "initials": "YJ"}, {"family": "Hwang", "given": "Mi Yeong", "initials": "MY"}, {"family": "Hwu", "given": "Chii Min", "initials": "CM"}, {"family": "Ichihara", "given": "Sahoko", "initials": "S"}, {"family": "Ikram", "given": "Mohammad Arfan", "initials": "MA"}, {"family": "Ingelsson", "given": "Martin", "initials": "M"}, {"family": "Islam", "given": "Md Tariqul", "initials": "MT"}, {"family": "Isono", "given": "Masato", "initials": "M"}, {"family": "Jang", "given": "Hye Mi", "initials": "HM"}, {"family": "Jasmine", "given": "Farzana", "initials": "F"}, {"family": "Jiang", "given": "Guozhi", "initials": "G"}, {"family": "Jonas", "given": "Jost B", "initials": "JB"}, {"family": "J\u00f8rgensen", "given": "Marit E", "initials": "ME"}, {"family": "J\u00f8rgensen", "given": "Torben", "initials": "T"}, {"family": "Kamatani", "given": "Yoichiro", "initials": "Y"}, {"family": "Kandeel", "given": "Fouad R", "initials": "FR"}, {"family": "Kasturiratne", "given": "Anuradhani", "initials": "A"}, {"family": "Katsuya", "given": "Tomohiro", "initials": "T"}, {"family": "Kaur", "given": "Varinderpal", "initials": "V"}, {"family": "Kawaguchi", "given": "Takahisa", "initials": "T"}, {"family": "Keaton", "given": "Jacob M", "initials": "JM"}, {"family": "Kho", "given": "Abel N", "initials": "AN"}, {"family": "Khor", "given": "Chiea Chuen", "initials": "CC"}, {"family": "Kibriya", "given": "Muhammad G", "initials": "MG"}, {"family": "Kim", "given": "Duk Hwan", "initials": "DH"}, {"family": "Kohara", "given": "Katsuhiko", "initials": "K"}, {"family": "Kriebel", "given": "Jennifer", "initials": "J"}, {"family": "Kronenberg", "given": "Florian", "initials": "F"}, {"family": "Kuusisto", "given": "Johanna", "initials": "J"}, {"family": "L\u00e4ll", "given": "Kristi", "initials": "K"}, {"family": "Lange", "given": "Leslie A", "initials": "LA"}, {"family": "Lee", "given": "Myung Shik", "initials": "MS"}, {"family": "Lee", "given": "Nanette R", "initials": "NR"}, {"family": "Leong", "given": "Aaron", "initials": "A"}, {"family": "Li", "given": "Liming", "initials": "L"}, {"family": "Li", "given": "Yun", "initials": "Y"}, {"family": "Li-Gao", "given": "Ruifang", "initials": "R"}, {"family": "Ligthart", "given": "Symen", "initials": "S"}, {"family": "Lindgren", "given": "Cecilia M", "initials": "CM"}, {"family": "Linneberg", "given": "Allan", "initials": "A"}, {"family": "Liu", "given": "Ching Ti", "initials": "CT", "orcid": "0000-0002-0703-0742", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0df836bc876845a6af66828561f24a27.json"}}, {"family": "Liu", "given": "Jianjun", "initials": "J"}, {"family": "Locke", "given": "Adam E", "initials": "AE"}, {"family": "Louie", "given": "Tin", "initials": "T"}, {"family": "Luan", "given": "Jian\u2019an", "initials": "J"}, {"family": "Luk", "given": "Andrea O", "initials": "AO"}, {"family": "Luo", "given": "Xi", "initials": "X"}, {"family": "Lv", "given": "Jun", "initials": "J"}, {"family": "Lyssenko", "given": "Valeriya", "initials": "V"}, {"family": "Mamakou", "given": "Vasiliki", "initials": "V"}, {"family": "Mani", "given": "K Radha", "initials": "KR"}, {"family": "Meitinger", "given": "Thomas", "initials": "T", "orcid": "0000-0002-8838-8403", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a67d683cb3245d1a98a492a7e3850fe.json"}}, {"family": "Metspalu", "given": "Andres", "initials": "A"}, {"family": "Morris", "given": "Andrew D", "initials": "AD"}, {"family": "Nadkarni", "given": "Girish N", "initials": "GN"}, {"family": "Nadler", "given": "Jerry L", "initials": "JL"}, {"family": "Nalls", "given": "Michael A", "initials": "MA"}, {"family": "Nayak", "given": "Uma", "initials": "U"}, {"family": "Ntalla", "given": "Ioanna", "initials": "I"}, {"family": "Okada", "given": "Yukinori", "initials": "Y", "orcid": "0000-0002-0311-8472", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b7e4b24ebe8458592e8536be3da6164.json"}}, {"family": "Orozco", "given": "Lorena", "initials": "L"}, {"family": "Patel", "given": "Sanjay R", "initials": "SR"}, {"family": "Pereira", "given": "Mark A", "initials": "MA"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Pirie", "given": "Fraser J", "initials": "FJ"}, {"family": "Porneala", "given": "Bianca", "initials": "B"}, {"family": "Prasad", "given": "Gauri", "initials": "G"}, {"family": "Preissl", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-8971-5616", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e591aa9a38e44c0180030bbe6419fa04.json"}}, {"family": "Rasmussen-Torvik", "given": "Laura J", "initials": "LJ", "orcid": "0000-0002-0820-7300", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24b72e10b5414a7f8145a9f2e23d2823.json"}}, {"family": "Reiner", "given": "Alexander P", "initials": "AP"}, {"family": "Roden", "given": "Michael", "initials": "M"}, {"family": "Rohde", "given": "Rebecca", "initials": "R"}, {"family": "Roll", "given": "Katheryn", "initials": "K"}, {"family": "Sabanayagam", "given": "Charumathi", "initials": "C"}, {"family": "Sander", "given": "Maike", "initials": "M", "orcid": "0000-0001-5308-7785", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9719499b604c4ae2bbeea6369e22f364.json"}}, {"family": "Sandow", "given": "Kevin", "initials": "K"}, {"family": "Sattar", "given": "Naveed", "initials": "N"}, {"family": "Sch\u00f6nherr", "given": "Sebastian", "initials": "S"}, {"family": "Schurmann", "given": "Claudia", "initials": "C"}, {"family": "Shahriar", "given": "Mohammad", "initials": "M"}, {"family": "Shi", "given": "Jinxiu", "initials": "J"}, {"family": "Shin", "given": "Dong Mun", "initials": "DM"}, {"family": "Shriner", "given": "Daniel", "initials": "D"}, {"family": "Smith", "given": "Jennifer A", "initials": "JA"}, {"family": "So", "given": "Wing Yee", "initials": "WY"}, {"family": "Stan\u010d\u00e1kov\u00e1", "given": "Alena", "initials": "A"}, {"family": "Stilp", "given": "Adrienne M", "initials": "AM"}, {"family": "Strauch", "given": "Konstantin", "initials": "K"}, {"family": "Suzuki", "given": "Ken", "initials": "K"}, {"family": "Takahashi", "given": "Atsushi", "initials": "A"}, {"family": "Taylor", "given": "Kent D", "initials": "KD"}, {"family": "Thorand", "given": "Barbara", "initials": "B"}, {"family": "Thorleifsson", "given": "Gudmar", "initials": "G"}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Tomlinson", "given": "Brian", "initials": "B"}, {"family": "Torres", "given": "Jason M", "initials": "JM", "orcid": "0000-0002-7537-7035", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db2a1d7ae99a4a709ab5baaca9c58743.json"}}, {"family": "Tsai", "given": "Fuu Jen", "initials": "FJ"}, {"family": "Tuomilehto", "given": "Jaakko", "initials": "J"}, {"family": "Tusie-Luna", "given": "Teresa", "initials": "T"}, {"family": "Udler", "given": "Miriam S", "initials": "MS"}, {"family": "Valladares-Salgado", "given": "Adan", "initials": "A"}, {"family": "van Dam", "given": "Rob M", "initials": "RM"}, {"family": "van Klinken", "given": "Jan B", "initials": "JB"}, {"family": "Varma", "given": "Rohit", "initials": "R"}, {"family": "Vujkovic", "given": "Marijana", "initials": "M", "orcid": "0000-0003-4924-5714", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ca51991261a4fb2bee8a9f80595bf7c.json"}}, {"family": "Wacher-Rodarte", "given": "Niels", "initials": "N"}, {"family": "Wheeler", "given": "Ellie", "initials": "E"}, {"family": "Whitsel", "given": "Eric A", "initials": "EA"}, {"family": "Wickremasinghe", "given": "Ananda R", "initials": "AR"}, {"family": "van Dijk", "given": "Konstantin Willems", "initials": "KW"}, {"family": "Witte", "given": "Daniel R", "initials": "DR"}, {"family": "Yajnik", "given": "Chittaranjan S", "initials": "CS"}, {"family": "Yamamoto", "given": "Ken", "initials": "K"}, {"family": "Yamauchi", "given": "Toshimasa", "initials": "T"}, {"family": "Yengo", "given": "Lo\u00efc", "initials": "L"}, {"family": "Yoon", "given": "Kyungheon", "initials": "K"}, {"family": "Yu", "given": "Canqing", "initials": "C"}, {"family": "Yuan", "given": "Jian Min", "initials": "JM"}, {"family": "Yusuf", "given": "Salim", "initials": "S"}, {"family": "Zhang", "given": "Liang", "initials": "L"}, {"family": "Zheng", "given": "Wei", "initials": "W", "orcid": "0000-0003-1226-070X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80ec61dc4aa14746b4a8c3660820d77a.json"}}, {"family": "FinnGen", "given": "", "initials": ""}, {"family": "Raffel", "given": "Leslie J", "initials": "LJ"}, {"family": "Igase", "given": "Michiya", "initials": "M"}, {"family": "Ipp", "given": "Eli", "initials": "E"}, {"family": "Redline", "given": "Susan", "initials": "S"}, {"family": "Cho", "given": "Yoon Shin", "initials": "YS"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Province", "given": "Michael A", "initials": "MA"}, {"family": "Hanis", "given": "Craig L", "initials": "CL"}, {"family": "Peyser", "given": "Patricia A", "initials": "PA"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Zonderman", "given": "Alan B", "initials": "AB"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM"}, {"family": "Wang", "given": "Ya Xing", "initials": "YX"}, {"family": "Rotimi", "given": "Charles N", "initials": "CN"}, {"family": "Becker", "given": "Diane M", "initials": "DM"}, {"family": "Matsuda", "given": "Fumihiko", "initials": "F"}, {"family": "Liu", "given": "Yongmei", "initials": "Y"}, {"family": "Zeggini", "given": "Eleftheria", "initials": "E", "orcid": "0000-0003-4238-659X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/94df27518bb34428a8b1f8f2b278d778.json"}}, {"family": "Yokota", "given": "Mitsuhiro", "initials": "M"}, {"family": "Rich", "given": "Stephen S", "initials": "SS"}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Pankow", "given": "James S", "initials": "JS"}, {"family": "Engert", "given": "James C", "initials": "JC"}, {"family": "Chen", "given": "Yii Der Ida", "initials": "YDI"}, {"family": "Froguel", "given": "Philippe", "initials": "P"}, {"family": "Wilson", "given": "James G", "initials": "JG"}, {"family": "Sheu", "given": "Wayne HH", "initials": "WH"}, {"family": "Kardia", "given": "Sharon LR", "initials": "SL"}, {"family": "Wu", "given": "Jer Yuarn", "initials": "JY"}, {"family": "Hayes", "given": "M Geoffrey", "initials": "MG"}, {"family": "Ma", "given": "Ronald CW", "initials": "RC"}, {"family": "Wong", "given": "Tien Yin", "initials": "TY"}, {"family": "Groop", "given": "Leif", "initials": "L"}, {"family": "Mook-Kanamori", "given": "Dennis O", "initials": "DO"}, {"family": "Chandak", "given": "Giriraj R", "initials": "GR"}, {"family": "Collins", "given": "Francis S", "initials": "FS"}, {"family": "Bharadwaj", "given": "Dwaipayan", "initials": "D", "orcid": "0000-0001-5268-8482", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85b6440f59e9465dbd0a5dfbc3bc0365.json"}}, {"family": "Par\u00e9", "given": "Guillaume", "initials": "G", "orcid": "0000-0002-6795-4760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef5b393b30f54b5f9c4531ceddc51b90.json"}}, {"family": "Sale", "given": "Mich\u00e8le M", "initials": "MM"}, {"family": "Ahsan", "given": "Habibul", "initials": "H"}, {"family": "Motala", "given": "Ayesha A", "initials": "AA"}, {"family": "Shu", "given": "Xiao Ou", "initials": "XO"}, {"family": "Park", "given": "Kyong Soo", "initials": "KS"}, {"family": "Jukema", "given": "J Wouter", "initials": "JW"}, {"family": "Cruz", "given": "Miguel", "initials": "M"}, {"family": "McKean-Cowdin", "given": "Roberta", "initials": "R"}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Cheng", "given": "Ching Yu", "initials": "CY"}, {"family": "Bottinger", "given": "Erwin P", "initials": "EP"}, {"family": "Dehghan", "given": "Abbas", "initials": "A"}, {"family": "Tai", "given": "E Shyong", "initials": "ES"}, {"family": "Dupuis", "given": "Josee", "initials": "J"}, {"family": "Kato", "given": "Norihiro", "initials": "N"}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "K\u00f6ttgen", "given": "Anna", "initials": "A"}, {"family": "Koh", "given": "Woon Puay", "initials": "WP"}, {"family": "Palmer", "given": "Colin NA", "initials": "CN"}, {"family": "Liu", "given": "Simin", "initials": "S", "orcid": "0000-0003-2098-3844", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e85a24124ae4cb3a4d56d8acb284d86.json"}}, {"family": "Abecasis", "given": "Goncalo", "initials": "G"}, {"family": "Kooner", "given": "Jaspal S", "initials": "JS"}, {"family": "Loos", "given": "Ruth JF", "initials": "RJ"}, {"family": "North", "given": "Kari E", "initials": "KE"}, {"family": "Haiman", "given": "Christopher A", "initials": "CA"}, {"family": "Florez", "given": "Jose C", "initials": "JC"}, {"family": "Saleheen", "given": "Danish", "initials": "D"}, {"family": "Hansen", "given": "Torben", "initials": "T"}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "Maeda", "given": "Shiro", "initials": "S"}, {"family": "Kadowaki", "given": "Takashi", "initials": "T"}, {"family": "Lee", "given": "Juyoung", "initials": "J"}, {"family": "Millwood", "given": "Iona Y", "initials": "IY"}, {"family": "Walters", "given": "Robin G", "initials": "RG", "orcid": "0000-0002-9179-0321", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4c4c1c5209be401c91b60553e49c282c.json"}}, {"family": "Stefansson", "given": "Kari", "initials": "K"}, {"family": "Myers", "given": "Simon R", "initials": "SR"}, {"family": "Ferrer", "given": "Jorge", "initials": "J"}, {"family": "Gaulton", "given": "Kyle J", "initials": "KJ"}, {"family": "Meigs", "given": "James B", "initials": "JB"}, {"family": "Mohlke", "given": "Karen L", "initials": "KL"}, {"family": "Gloyn", "given": "Anna L", "initials": "AL"}, {"family": "Bowden", "given": "Donald W", "initials": "DW"}, {"family": "Below", "given": "Jennifer E", "initials": "JE"}, {"family": "Chambers", "given": "John C", "initials": "JC"}, {"family": "Sim", "given": "Xueling", "initials": "X"}, {"family": "Boehnke", "given": "Michael", "initials": "M"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI", "orcid": "0000-0002-4393-0510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/102c7e93640c43c9bbbedd1626adfd7b.json"}}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}], "type": "posted-content", "published": "2020-09-23", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.09.22.20198937", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T13:44:33.368Z", "modified": "2026-09-23T13:44:33.844Z"}, {"entity": "publication", "iuid": "a47af805c5644d568e267461ae8e9f42", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a47af805c5644d568e267461ae8e9f42.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a47af805c5644d568e267461ae8e9f42"}}, "title": "Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.", "authors": [{"family": "Justice", "given": "Anne E", "initials": "AE"}, {"family": "Karaderi", "given": "Tugce", "initials": "T"}, {"family": "Highland", "given": "Heather M", "initials": "HM"}, {"family": "Young", "given": "Kristin L", "initials": "KL", "orcid": "0000-0003-0070-6145", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a317f8776f149dabff61ef11aab6d74.json"}}, {"family": "Graff", "given": "Mariaelisa", "initials": "M"}, {"family": "Lu", "given": "Yingchang", "initials": "Y"}, {"family": "Turcot", "given": "Val\u00e9rie", "initials": "V"}, {"family": "Auer", "given": "Paul L", "initials": "PL"}, {"family": "Fine", "given": "Rebecca S", "initials": "RS"}, {"family": "Guo", "given": "Xiuqing", "initials": "X"}, {"family": "Schurmann", "given": "Claudia", "initials": "C"}, {"family": "Lempradl", "given": "Adelheid", "initials": "A"}, {"family": "Marouli", "given": "Eirini", "initials": "E"}, {"family": "Mahajan", "given": "Anubha", "initials": "A", "orcid": "0000-0001-5585-3420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41b3d44662484e0289f07fa25d045cf4.json"}}, {"family": "Winkler", "given": "Thomas W", "initials": "TW", "orcid": "0000-0003-0292-5421", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1511736ab1f4f3cab1a2ccef342db34.json"}}, {"family": "Locke", "given": "Adam E", "initials": "AE", "orcid": "0000-0001-6227-198X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2acdb3f67772472ea95cb2316e006555.json"}}, {"family": "Medina-Gomez", "given": "Carolina", "initials": "C", "orcid": "0000-0001-7999-5538", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b3600248dc46fda07e549541aa047c.json"}}, {"family": "Esko", "given": "T\u00f5nu", "initials": "T"}, {"family": "Vedantam", "given": "Sailaja", "initials": "S"}, {"family": "Giri", "given": "Ayush", "initials": "A", "orcid": "0000-0002-7786-4670", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/424e945c81e14434a13205bdd2e986ac.json"}}, {"family": "Lo", "given": "Ken Sin", "initials": "KS"}, {"family": "Alfred", "given": "Tamuno", "initials": "T"}, {"family": "Mudgal", "given": "Poorva", "initials": "P"}, {"family": "Ng", "given": "Maggie C Y", "initials": "MCY", "orcid": "0000-0002-4133-2007", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e15e903b28ef4766903bc2f0447704f2.json"}}, {"family": "Heard-Costa", "given": "Nancy L", "initials": "NL", "orcid": "0000-0001-9730-0306", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1da6a04aae7641359b0658b21cbf52a1.json"}}, {"family": "Feitosa", "given": "Mary F", "initials": "MF"}, {"family": "Manning", "given": "Alisa K", "initials": "AK", "orcid": "0000-0003-0247-902X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/906568c194b840e5843ba1d03c949e42.json"}}, {"family": "Willems", "given": "Sara M", "initials": "SM"}, {"family": "Sivapalaratnam", "given": "Suthesh", "initials": "S"}, {"family": "Abecasis", "given": "Goncalo", "initials": "G"}, {"family": "Alam", "given": "Dewan S", "initials": "DS", "orcid": "0000-0002-2051-3837", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/15e6135a38e34ec8aa52ee02f72e5355.json"}}, {"family": "Allison", "given": "Matthew", "initials": "M"}, {"family": "Amouyel", "given": "Philippe", "initials": "P", "orcid": "0000-0001-9088-234X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9bc53ec75293497bab1ec0419c6e5800.json"}}, {"family": "Arzumanyan", "given": "Zorayr", "initials": "Z"}, {"family": "Balkau", "given": "Beverley", "initials": "B"}, {"family": "Bastarache", "given": "Lisa", "initials": "L"}, {"family": "Bergmann", "given": "Sven", "initials": "S", "orcid": "0000-0002-6785-9034", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e7202443121d40b8b4b78835e31b6e16.json"}}, {"family": "Bielak", "given": "Lawrence F", "initials": "LF"}, {"family": "Bl\u00fcher", "given": "Matthias", "initials": "M"}, {"family": "Boehnke", "given": "Michael", "initials": "M", "orcid": "0000-0002-6442-7754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e36dfed05bd94a1588f0ad628a9e39c5.json"}}, {"family": "Boeing", "given": "Heiner", "initials": "H"}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "B\u00f6ger", "given": "Carsten A", "initials": "CA"}, {"family": "Bork-Jensen", "given": "Jette", "initials": "J"}, {"family": "Bottinger", "given": "Erwin P", "initials": "EP"}, {"family": "Bowden", "given": "Donald W", "initials": "DW"}, {"family": "Brandslund", "given": "Ivan", "initials": "I"}, {"family": "Broer", "given": "Linda", "initials": "L"}, {"family": "Burt", "given": "Amber A", "initials": "AA"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "Caulfield", "given": "Mark J", "initials": "MJ", "orcid": "0000-0001-9295-3594", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b025d12d083479b8c86347e83dd05d0.json"}}, {"family": "Cesana", "given": "Giancarlo", "initials": "G"}, {"family": "Chambers", "given": "John C", "initials": "JC"}, {"family": "Chasman", "given": "Daniel I", "initials": "DI"}, {"family": "Chen", "given": "Yii-Der Ida", "initials": "YI"}, {"family": "Chowdhury", "given": "Rajiv", "initials": "R"}, {"family": "Christensen", "given": "Cramer", "initials": "C"}, {"family": "Chu", "given": "Audrey Y", "initials": "AY"}, {"family": "Collins", "given": "Francis S", "initials": "FS", "orcid": "0000-0002-1023-7410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0c64926eb604a948a9250f525b7c867.json"}}, {"family": "Cook", "given": "James P", "initials": "JP"}, {"family": "Cox", "given": "Amanda J", "initials": "AJ"}, {"family": "Crosslin", "given": "David S", "initials": "DS"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "de Bakker", "given": "Paul I W", "initials": "PIW", "orcid": "0000-0001-7735-7858", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04f4c94b3df34700bb048701490d84a0.json"}}, {"family": "Denus", "given": "Simon de", "initials": "S"}, {"family": "Mutsert", "given": "Ren\u00e9e de", "initials": "R"}, {"family": "Dedoussis", "given": "George", "initials": "G"}, {"family": "Demerath", "given": "Ellen W", "initials": "EW"}, {"family": "Dennis", "given": "Joe G", "initials": "JG", "orcid": "0000-0003-4591-1214", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/032b9f64191b4deb9ed0bfa6e56652ed.json"}}, {"family": "Denny", "given": "Josh C", "initials": "JC"}, {"family": "Di Angelantonio", "given": "Emanuele", "initials": "E"}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M"}, {"family": "Drenos", "given": "Fotios", "initials": "F"}, {"family": "Dub\u00e9", "given": "Marie-Pierre", "initials": "MP"}, {"family": "Dunning", "given": "Alison M", "initials": "AM"}, {"family": "Easton", "given": "Douglas F", "initials": "DF", "orcid": "0000-0003-2444-3247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8b6855eae9f4e4d838e34644e82edd0.json"}}, {"family": "Elliott", "given": "Paul", "initials": "P", "orcid": "0000-0002-7511-5684", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f380d322e67841e7b47ff3202991c1c4.json"}}, {"family": "Evangelou", "given": "Evangelos", "initials": "E", "orcid": "0000-0002-5488-2999", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7726e145c634702b9b55f705feaa6d4.json"}}, {"family": "Farmaki", "given": "Aliki-Eleni", "initials": "AE"}, {"family": "Feng", "given": "Shuang", "initials": "S"}, {"family": "Ferrannini", "given": "Ele", "initials": "E"}, {"family": "Ferrieres", "given": "Jean", "initials": "J"}, {"family": "Florez", "given": "Jose C", "initials": "JC"}, {"family": "Fornage", "given": "Myriam", "initials": "M"}, {"family": "Fox", "given": "Caroline S", "initials": "CS"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Friedrich", "given": "Nele", "initials": "N"}, {"family": "Gan", "given": "Wei", "initials": "W"}, {"family": "Gandin", "given": "Ilaria", "initials": "I"}, {"family": "Gasparini", "given": "Paolo", "initials": "P"}, {"family": "Giedraitis", "given": "Vilmantas", "initials": "V", "orcid": "0000-0003-3423-2021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45fe36e9f3dc43abbc0c718a6babc9fe.json"}}, {"family": "Girotto", "given": "Giorgia", "initials": "G", "orcid": "0000-0003-4507-6589", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78f2cd3cf98d4be1ac3d4a5831f40e4e.json"}}, {"family": "Gorski", "given": "Mathias", "initials": "M"}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Grarup", "given": "Niels", "initials": "N", "orcid": "0000-0001-5526-1070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e8ba20d53c64da49ae4a339c34c64d8.json"}}, {"family": "Grove", "given": "Megan L", "initials": "ML"}, {"family": "Gustafsson", "given": "Stefan", "initials": "S", "orcid": "0000-0001-5894-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fedf8897d75744f5b17f7c91c892acbf.json"}}, {"family": "Haessler", "given": "Jeff", "initials": "J"}, {"family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT"}, {"family": "Hayward", "given": "Caroline", "initials": "C", "orcid": "0000-0002-9405-9550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/542b00d650124ce4a3776ae95571e2c1.json"}}, {"family": "Heid", "given": "Iris M", "initials": "IM"}, {"family": "Holmen", "given": "Oddgeir L", "initials": "OL"}, {"family": "Hovingh", "given": "G Kees", "initials": "GK"}, {"family": "Howson", "given": "Joanna M M", "initials": "JMM", "orcid": "0000-0001-7618-0050", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1dcd9d189da4d758df6a936d69cc5f6.json"}}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Hung", "given": "Yi-Jen", "initials": "YJ"}, {"family": "Hveem", "given": "Kristian", "initials": "K"}, {"family": "Ikram", "given": "M Arfan", "initials": "MA", "orcid": "0000-0003-0372-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef9df12e0e6743f5a97d73c58e75443b.json"}}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Jackson", "given": "Anne U", "initials": "AU", "orcid": "0000-0002-9672-2547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d63df156aa9247d3a547cdcb2c86bff5.json"}}, {"family": "Jarvik", "given": "Gail P", "initials": "GP"}, {"family": "Jia", "given": "Yucheng", "initials": "Y"}, {"family": "J\u00f8rgensen", "given": "Torben", "initials": "T"}, {"family": "Jousilahti", "given": "Pekka", "initials": "P"}, {"family": "Justesen", "given": "Johanne M", "initials": "JM", "orcid": "0000-0002-0484-8522", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce6af64e1828443fbebed4bb2cbade90.json"}}, {"family": "Kahali", "given": "Bratati", "initials": "B"}, {"family": "Karaleftheri", "given": "Maria", "initials": "M"}, {"family": "Kardia", "given": "Sharon L R", "initials": "SLR"}, {"family": "Karpe", "given": "Fredrik", "initials": "F"}, {"family": "Kee", "given": "Frank", "initials": "F"}, {"family": "Kitajima", "given": "Hidetoshi", "initials": "H"}, {"family": "Komulainen", "given": "Pirjo", "initials": "P"}, {"family": "Kooner", "given": "Jaspal S", "initials": "JS"}, {"family": "Kovacs", "given": "Peter", "initials": "P", "orcid": "0000-0002-0290-5423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e778718e9f943f98e6850ad26f14876.json"}}, {"family": "Kr\u00e4mer", "given": "Bernhard K", "initials": "BK"}, {"family": "Kuulasmaa", "given": "Kari", "initials": "K", "orcid": "0000-0003-2165-1411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ddeec8ab44f64bb5b003ed7a1912cc04.json"}}, {"family": "Kuusisto", "given": "Johanna", "initials": "J"}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "Lakka", "given": "Timo A", "initials": "TA"}, {"family": "Lamparter", "given": "David", "initials": "D"}, {"family": "Lange", "given": "Leslie A", "initials": "LA"}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Larson", "given": "Eric B", "initials": "EB"}, {"family": "Lee", "given": "Nanette R", "initials": "NR"}, {"family": "Lee", "given": "Wen-Jane", "initials": "WJ"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Lewis", "given": "Cora E", "initials": "CE"}, {"family": "Li", "given": "Huaixing", "initials": "H"}, {"family": "Li", "given": "Jin", "initials": "J"}, {"family": "Li-Gao", "given": "Ruifang", "initials": "R"}, {"family": "Lin", "given": "Li-An", "initials": "LA", "orcid": "0000-0003-2731-1346", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4fac1b736ce24b43ac6741f030b4c0b4.json"}}, {"family": "Lin", "given": "Xu", "initials": "X"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Lindstr\u00f6m", "given": "Jaana", "initials": "J"}, {"family": "Linneberg", "given": "Allan", "initials": "A", "orcid": "0000-0002-0994-0184", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a06e031f7ac448649c3986140c48d3fb.json"}}, {"family": "Liu", "given": "Ching-Ti", "initials": "CT", "orcid": "0000-0002-0703-0742", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0df836bc876845a6af66828561f24a27.json"}}, {"family": "Liu", "given": "Dajiang J", "initials": "DJ"}, {"family": "Luan", "given": "Jian'an", "initials": "J"}, {"family": "Lyytik\u00e4inen", "given": "Leo-Pekka", "initials": "LP", "orcid": "0000-0002-7200-5455", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d541c99c43642538b7578fc4ff810ad.json"}}, {"family": "MacGregor", "given": "Stuart", "initials": "S", "orcid": "0000-0001-6731-8142", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/058a9037d3874c9abe17960148df566c.json"}}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "M\u00e4nnist\u00f6", "given": "Satu", "initials": "S"}, {"family": "Marenne", "given": "Ga\u00eblle", "initials": "G"}, {"family": "Marten", "given": "Jonathan", "initials": "J"}, {"family": "Masca", "given": "Nicholas G D", "initials": "NGD"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI", "orcid": "0000-0002-4393-0510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/102c7e93640c43c9bbbedd1626adfd7b.json"}}, {"family": "Meidtner", "given": "Karina", "initials": "K"}, {"family": "Mihailov", "given": "Evelin", "initials": "E"}, {"family": "Moilanen", "given": "Leena", "initials": "L"}, {"family": "Moitry", "given": "Marie", "initials": "M"}, {"family": "Mook-Kanamori", "given": "Dennis O", "initials": "DO"}, {"family": "Morgan", "given": "Anna", "initials": "A", "orcid": "0000-0001-6290-445X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d33a0bfe24d144d6b4c8da038e05c8cd.json"}}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M", "orcid": "0000-0003-3793-5910", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29665b981f714acda0ab36b09ab04a22.json"}}, {"family": "Munroe", "given": "Patricia B", "initials": "PB", "orcid": "0000-0002-4176-2947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e956b6f17a64fb4b478dbc59950a790.json"}}, {"family": "Narisu", "given": "Narisu", "initials": "N", "orcid": "0000-0002-8483-1156", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/87d5ebff297c4340a1d7632bd33b5b7c.json"}}, {"family": "Nelson", "given": "Christopher P", "initials": "CP"}, {"family": "Neville", "given": "Matt", "initials": "M", "orcid": "0000-0002-6004-5433", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d39a795b6a24d4d9fe22724063c79de.json"}}, {"family": "Ntalla", "given": "Ioanna", "initials": "I"}, {"family": "O'Connell", "given": "Jeffrey R", "initials": "JR"}, {"family": "Owen", "given": "Katharine R", "initials": "KR"}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "Peloso", "given": "Gina M", "initials": "GM"}, {"family": "Pennell", "given": "Craig E", "initials": "CE"}, {"family": "Perola", "given": "Markus", "initials": "M"}, {"family": "Perry", "given": "James A", "initials": "JA"}, {"family": "Perry", "given": "John R B", "initials": "JRB"}, {"family": "Pers", "given": "Tune H", "initials": "TH"}, {"family": "Ewing", "given": "Ailith", "initials": "A"}, {"family": "Polasek", "given": "Ozren", "initials": "O"}, {"family": "Raitakari", "given": "Olli T", "initials": "OT"}, {"family": "Rasheed", "given": "Asif", "initials": "A"}, {"family": "Raulerson", "given": "Chelsea K", "initials": "CK"}, {"family": "Rauramaa", "given": "Rainer", "initials": "R"}, {"family": "Reilly", "given": "Dermot F", "initials": "DF", "orcid": "0000-0002-9456-1364", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d0b98112f2c438aa42a4af98e58d712.json"}}, {"family": "Reiner", "given": "Alex P", "initials": "AP"}, {"family": "Ridker", "given": "Paul M", "initials": "PM"}, {"family": "Rivas", "given": "Manuel A", "initials": "MA"}, {"family": "Robertson", "given": "Neil R", "initials": "NR"}, {"family": "Robino", "given": "Antonietta", "initials": "A"}, {"family": "Rudan", "given": "Igor", "initials": "I", "orcid": "0000-0001-6993-6884", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c9e99f2bcc74658ae0bcffca0a0abee.json"}}, {"family": "Ruth", "given": "Katherine S", "initials": "KS"}, {"family": "Saleheen", "given": "Danish", "initials": "D", "orcid": "0000-0001-6193-020X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bb4026b4a5a4d8eabbef4efd554114d.json"}}, {"family": "Salomaa", "given": "Veikko", "initials": "V", "orcid": "0000-0001-7563-5324", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98bbbbad9420401aab285fe61172c736.json"}}, {"family": "Samani", "given": "Nilesh J", "initials": "NJ"}, {"family": "Schreiner", "given": "Pamela J", "initials": "PJ"}, {"family": "Schulze", "given": "Matthias B", "initials": "MB"}, {"family": "Scott", "given": "Robert A", "initials": "RA"}, {"family": "Segura-Lepe", "given": "Marcelo", "initials": "M"}, {"family": "Sim", "given": "Xueling", "initials": "X", "orcid": "0000-0002-1233-7642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9aec75e482049f5b169a9cfc517a351.json"}}, {"family": "Slater", "given": "Andrew J", "initials": "AJ"}, {"family": "Small", "given": "Kerrin S", "initials": "KS", "orcid": "0000-0003-4566-0005", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee452bbc3e154accac677b9d885e6534.json"}}, {"family": "Smith", "given": "Blair H", "initials": "BH", "orcid": "0000-0002-5362-9430", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f30912f5a8e443eac572814f3990d7f.json"}}, {"family": "Smith", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0002-3575-5468", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0706f9fec8d14cfe88cc03e6c7bf06e3.json"}}, {"family": "Southam", "given": "Lorraine", "initials": "L", "orcid": "0000-0002-7546-9650", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b60092c66d6843fbb8e07e4dcd5f8b3b.json"}}, {"family": "Spector", "given": "Timothy D", "initials": "TD"}, {"family": "Speliotes", "given": "Elizabeth K", "initials": "EK"}, {"family": "Stefansson", "given": "Kari", "initials": "K", "orcid": "0000-0003-1676-864X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9edf80871ac84e76a4d1316fc7079d7d.json"}}, {"family": "Steinthorsdottir", "given": "Valgerdur", "initials": "V"}, {"family": "Stirrups", "given": "Kathleen E", "initials": "KE", "orcid": "0000-0002-6823-3252", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ca7e7404bd44d9582885e0ddf3ffa95.json"}}, {"family": "Strauch", "given": "Konstantin", "initials": "K"}, {"family": "Stringham", "given": "Heather M", "initials": "HM", "orcid": "0000-0002-2991-6392", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2dd6dfe13fc4068a83c42e06beaf853.json"}}, {"family": "Stumvoll", "given": "Michael", "initials": "M"}, {"family": "Sun", "given": "Liang", "initials": "L"}, {"family": "Surendran", "given": "Praveen", "initials": "P"}, {"family": "Swart", "given": "Karin M A", "initials": "KMA"}, {"family": "Tardif", "given": "Jean-Claude", "initials": "JC"}, {"family": "Taylor", "given": "Kent D", "initials": "KD"}, {"family": "Teumer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8309-094X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a40a959d1b8480cb8268e00f77a0449.json"}}, {"family": "Thompson", "given": "Deborah J", "initials": "DJ", "orcid": "0000-0003-1465-5799", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5dd3e9eddc444e18f005032909ee940.json"}}, {"family": "Thorleifsson", "given": "Gudmar", "initials": "G"}, {"family": "Thorsteinsdottir", "given": "Unnur", "initials": "U"}, {"family": "Thuesen", "given": "Betina H", "initials": "BH"}, {"family": "T\u00f6njes", "given": "Anke", "initials": "A"}, {"family": "Torres", "given": "Mina", "initials": "M"}, {"family": "Tsafantakis", "given": "Emmanouil", "initials": "E"}, {"family": "Tuomilehto", "given": "Jaakko", "initials": "J"}, {"family": "Uitterlinden", "given": "Andr\u00e9 G", "initials": "AG"}, {"family": "Uusitupa", "given": "Matti", "initials": "M"}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM"}, {"family": "Vanhala", "given": "Mauno", "initials": "M"}, {"family": "Varma", "given": "Rohit", "initials": "R"}, {"family": "Vermeulen", "given": "Sita H", "initials": "SH"}, {"family": "Vestergaard", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3090-269X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2fa5c4f74894d6a833afd105ec72848.json"}}, {"family": "Vitart", "given": "Veronique", "initials": "V", "orcid": "0000-0002-4991-3797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3270297f0f1b4de4bb181d7be8e1f447.json"}}, {"family": "Vogt", "given": "Thomas F", "initials": "TF"}, {"family": "Vuckovic", "given": "Dragana", "initials": "D"}, {"family": "Wagenknecht", "given": "Lynne E", "initials": "LE"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Wallentin", "given": "Lars", "initials": "L"}, {"family": "Wang", "given": "Feijie", "initials": "F"}, {"family": "Wang", "given": "Carol A", "initials": "CA", "orcid": "0000-0002-4301-3974", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4c220c449da54501bfec3d746b246ef2.json"}}, {"family": "Wang", "given": "Shuai", "initials": "S"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "Warren", "given": "Helen R", "initials": "HR"}, {"family": "Waterworth", "given": "Dawn M", "initials": "DM"}, {"family": "Wessel", "given": "Jennifer", "initials": "J", "orcid": "0000-0002-7031-0085", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c1332ed40b748dfb2faceb7ca161f41.json"}}, {"family": "White", "given": "Harvey D", "initials": "HD"}, {"family": "Willer", "given": "Cristen J", "initials": "CJ", "orcid": "0000-0001-5645-4966", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b75910e6eec8425ea2b1f17813e70ba0.json"}}, {"family": "Wilson", "given": "James G", "initials": "JG"}, {"family": "Wood", "given": "Andrew R", "initials": "AR"}, {"family": "Wu", "given": "Ying", "initials": "Y"}, {"family": "Yaghootkar", "given": "Hanieh", "initials": "H"}, {"family": "Yao", "given": "Jie", "initials": "J"}, {"family": "Yerges-Armstrong", "given": "Laura M", "initials": "LM"}, {"family": "Young", "given": "Robin", "initials": "R"}, {"family": "Zeggini", "given": "Eleftheria", "initials": "E", "orcid": "0000-0003-4238-659X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/94df27518bb34428a8b1f8f2b278d778.json"}}, {"family": "Zhan", "given": "Xiaowei", "initials": "X"}, {"family": "Zhang", "given": "Weihua", "initials": "W"}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Zhao", "given": "Wei", "initials": "W"}, {"family": "Zheng", "given": "He", "initials": "H"}, {"family": "Zhou", "given": "Wei", "initials": "W"}, {"family": "Zillikens", "given": "M Carola", "initials": "MC"}, {"family": "Rivadeneira", "given": "Fernando", "initials": "F", "orcid": "0000-0001-9435-9441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/052747cd28af4c308b064e88005985a2.json"}}, {"family": "Borecki", "given": "Ingrid B", "initials": "IB"}, {"family": "Pospisilik", "given": "J Andrew", "initials": "JA", "orcid": "0000-0002-9745-0977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/14d3d158e450498cb3900c4e4cab5c01.json"}}, {"family": "Deloukas", "given": "Panos", "initials": "P", "orcid": "0000-0001-9251-070X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d034d0cd32a84b959bd29f8ef8c91979.json"}}, {"family": "Frayling", "given": "Timothy M", "initials": "TM"}, {"family": "Lettre", "given": "Guillaume", "initials": "G"}, {"family": "Mohlke", "given": "Karen L", "initials": "KL", "orcid": "0000-0001-6721-153X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fac0e041c56347fe98cef9ae8f004b67.json"}}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "Kutalik", "given": "Zolt\u00e1n", "initials": "Z", "orcid": "0000-0001-8285-7523", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e566b994d65a4365b224cd4ae369827a.json"}}, {"family": "Hirschhorn", "given": "Joel N", "initials": "JN"}, {"family": "Cupples", "given": "L Adrienne", "initials": "LA"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF", "orcid": "0000-0002-8532-5087", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/179eb6511eba4d33b633599c5652e344.json"}}, {"family": "North", "given": "Kari E", "initials": "KE"}, {"family": "Lindgren", "given": "Cecilia M", "initials": "CM", "orcid": "0000-0002-4903-9374", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5c82df5e7bc43e4874726fb16924cf5.json"}}, {"family": "CHD Exome+ Consortium", "given": "", "initials": ""}, {"family": "Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium", "given": "", "initials": ""}, {"family": "EPIC-CVD Consortium", "given": "", "initials": ""}, {"family": "ExomeBP Consortium", "given": "", "initials": ""}, {"family": "Global Lipids Genetic Consortium", "given": "", "initials": ""}, {"family": "GoT2D Genes Consortium", "given": "", "initials": ""}, {"family": "InterAct", "given": "", "initials": ""}, {"family": "ReproGen Consortium", "given": "", "initials": ""}, {"family": "T2D-Genes Consortium", "given": "", "initials": ""}, {"family": "MAGIC Investigators", "given": "", "initials": ""}], "type": "journal article", "published": "2019-03-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "51", "issue": "3", "pages": "452-469", "issn-l": "1061-4036"}, "abstract": "Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF \u22655%) and nine low-frequency or rare (MAF <5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.", "doi": "10.1038/s41588-018-0334-2", "pmid": "30778226", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1016010"}, {"db": "pmc", "key": "PMC6560635"}, {"db": "pii", "key": "10.1038/s41588-018-0334-2"}], "notes": [], "created": "2026-09-23T07:38:33.413Z", "modified": "2026-09-23T07:38:34.499Z"}, {"entity": "publication", "iuid": "9d121885f7af43e39b27850d3d291ea7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9d121885f7af43e39b27850d3d291ea7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9d121885f7af43e39b27850d3d291ea7"}}, "title": "Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.", "authors": [{"family": "Wheeler", "given": "Eleanor", "initials": "E"}, {"family": "Leong", "given": "Aaron", "initials": "A"}, {"family": "Liu", "given": "Ching-Ti", "initials": "CT", "orcid": "0000-0002-0703-0742", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0df836bc876845a6af66828561f24a27.json"}}, {"family": "Hivert", "given": "Marie-France", "initials": "MF", "orcid": "0000-0001-7752-2585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/169db36efa684d52b695320a37217909.json"}}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ", "orcid": "0000-0001-8506-3585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cccd06a2fb54f769c5710c8758f2ebe.json"}}, {"family": "Podmore", "given": "Clara", "initials": "C", "orcid": "0000-0002-2452-8067", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/63d1e5046c8c40c8bf3860570dd067f7.json"}}, {"family": "Li", "given": "Man", "initials": "M", "orcid": "0000-0002-3839-0281", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5436bf44eb30448d8ff5b2d9216500f5.json"}}, {"family": "Yao", "given": "Jie", "initials": "J"}, {"family": "Sim", "given": "Xueling", "initials": "X", "orcid": "0000-0002-1233-7642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9aec75e482049f5b169a9cfc517a351.json"}}, {"family": "Hong", "given": "Jaeyoung", "initials": "J"}, {"family": "Chu", "given": "Audrey Y", "initials": "AY"}, {"family": "Zhang", "given": "Weihua", "initials": "W"}, {"family": "Wang", "given": "Xu", "initials": "X"}, {"family": "Chen", "given": "Peng", "initials": "P", "orcid": "0000-0002-1422-4641", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d910a8bdcd3b4a20858c3a6cecb5e682.json"}}, {"family": "Maruthur", "given": "Nisa M", "initials": "NM"}, {"family": "Porneala", "given": "Bianca C", "initials": "BC"}, {"family": "Sharp", "given": "Stephen J", "initials": "SJ", "orcid": "0000-0003-2375-1440", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2fa02d375f840ddbce9926676eb70fc.json"}}, {"family": "Jia", "given": "Yucheng", "initials": "Y"}, {"family": "Kabagambe", "given": "Edmond K", "initials": "EK"}, {"family": "Chang", "given": "Li-Ching", "initials": "LC"}, {"family": "Chen", "given": "Wei-Min", "initials": "WM"}, {"family": "Elks", "given": "Cathy E", "initials": "CE"}, {"family": "Evans", "given": "Daniel S", "initials": "DS", "orcid": "0000-0003-4185-7687", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b53ab5befa3a4a9db2765092f2421516.json"}}, {"family": "Fan", "given": "Qiao", "initials": "Q"}, {"family": "Giulianini", "given": "Franco", "initials": "F"}, {"family": "Go", "given": "Min Jin", "initials": "MJ"}, {"family": "Hottenga", "given": "Jouke-Jan", "initials": "JJ"}, {"family": "Hu", "given": "Yao", "initials": "Y"}, {"family": "Jackson", "given": "Anne U", "initials": "AU"}, {"family": "Kanoni", "given": "Stavroula", "initials": "S"}, {"family": "Kim", "given": "Young Jin", "initials": "YJ", "orcid": "0000-0002-4132-4437", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5fccb68c85a4720960894aa548f0001.json"}}, {"family": "Kleber", "given": "Marcus E", "initials": "ME"}, {"family": "Ladenvall", "given": "Claes", "initials": "C", "orcid": "0000-0002-7501-6598", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfe5cbb5d454552bdcbc464238f88fb.json"}}, {"family": "Lecoeur", "given": "Cecile", "initials": "C", "orcid": "0000-0003-0075-6417", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8fe32aa8fe5f48498c756e5dcbe24ec3.json"}}, {"family": "Lim", "given": "Sing-Hui", "initials": "SH", "orcid": "0000-0002-3793-9658", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/047443dd6f52404897502330b627a5e3.json"}}, {"family": "Lu", "given": "Yingchang", "initials": "Y"}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Marzi", "given": "Carola", "initials": "C"}, {"family": "Nalls", "given": "Mike A", "initials": "MA"}, {"family": "Navarro", "given": "Pau", "initials": "P", "orcid": "0000-0001-5576-8584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd1c6be37f30445e8d11b73f7ea54099.json"}}, {"family": "Nolte", "given": "Ilja M", "initials": "IM"}, {"family": "Rose", "given": "Lynda M", "initials": "LM"}, {"family": "Rybin", "given": "Denis V", "initials": "DV"}, {"family": "Sanna", "given": "Serena", "initials": "S", "orcid": "0000-0002-3768-1749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/34dda39900cb4971bdbeef61f721cab7.json"}}, {"family": "Shi", "given": "Yuan", "initials": "Y"}, {"family": "Stram", "given": "Daniel O", "initials": "DO"}, {"family": "Takeuchi", "given": "Fumihiko", "initials": "F", "orcid": "0000-0003-3185-5661", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b91c81f9a3242c080a08e774702691d.json"}}, {"family": "Tan", "given": "Shu Pei", "initials": "SP"}, {"family": "van der Most", "given": "Peter J", "initials": "PJ", "orcid": "0000-0001-8450-3518", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aab1c835d9be4682b250164838d5b4ec.json"}}, {"family": "Van Vliet-Ostaptchouk", "given": "Jana V", "initials": "JV", "orcid": "0000-0002-7943-3153", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f6a4a42230043238a865b4c4def5de3.json"}}, {"family": "Wong", "given": "Andrew", "initials": "A", "orcid": "0000-0003-2079-4779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d5de10edb24240449c7784bfb4703189.json"}}, {"family": "Yengo", "given": "Loic", "initials": "L", "orcid": "0000-0002-4272-9305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3114a5091cb4a888363e474c9561509.json"}}, {"family": "Zhao", "given": "Wanting", "initials": "W"}, {"family": "Goel", "given": "Anuj", "initials": "A"}, {"family": "Martinez Larrad", "given": "Maria Teresa", "initials": "MT"}, {"family": "Radke", "given": "D\u00f6rte", "initials": "D"}, {"family": "Salo", "given": "Perttu", "initials": "P"}, {"family": "Tanaka", "given": "Toshiko", "initials": "T", "orcid": "0000-0002-4161-3829", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78d4e7b987a2438b81fea5240cd9acd2.json"}}, {"family": "van Iperen", "given": "Erik P A", "initials": "EPA"}, {"family": "Abecasis", "given": "Goncalo", "initials": "G"}, {"family": "Afaq", "given": "Saima", "initials": "S"}, {"family": "Alizadeh", "given": "Behrooz Z", "initials": "BZ", "orcid": "0000-0002-1415-8007", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1ef114bd298417183c82d8d915b90ed.json"}}, {"family": "Bertoni", "given": "Alain G", "initials": "AG"}, {"family": "Bonnefond", "given": "Amelie", "initials": "A"}, {"family": "B\u00f6ttcher", "given": "Yvonne", "initials": "Y"}, {"family": "Bottinger", "given": "Erwin P", "initials": "EP", "orcid": "0000-0001-6868-6676", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d4176b9cbdde4db591753d1e3dcb4eba.json"}}, {"family": "Campbell", "given": "Harry", "initials": "H", "orcid": "0000-0002-6169-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cbbf669942f74901b43c9c191cf638f4.json"}}, {"family": "Carlson", "given": "Olga D", "initials": "OD", "orcid": "0000-0003-4099-7178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/491cc6eddf81414b843b862b6a2570ba.json"}}, {"family": "Chen", "given": "Chien-Hsiun", "initials": "CH"}, {"family": "Cho", "given": "Yoon Shin", "initials": "YS"}, {"family": "Garvey", "given": "W Timothy", "initials": "WT"}, {"family": "Gieger", "given": "Christian", "initials": "C"}, {"family": "Goodarzi", "given": "Mark O", "initials": "MO"}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Hartman", "given": "Catharina A", "initials": "CA"}, {"family": "Herder", "given": "Christian", "initials": "C", "orcid": "0000-0002-2050-093X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3897a084bd464fd59a16e0096d74ff44.json"}}, {"family": "Hsiung", "given": "Chao Agnes", "initials": "CA"}, {"family": "Huang", "given": "Jie", "initials": "J", "orcid": "0000-0002-9441-4698", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32cdeaa3562a4a5a88ed77e7c4b7aae7.json"}}, {"family": "Igase", "given": "Michiya", "initials": "M"}, {"family": "Isono", "given": "Masato", "initials": "M"}, {"family": "Katsuya", "given": "Tomohiro", "initials": "T", "orcid": "0000-0002-8892-8828", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/587f468984f847039721f916193f5710.json"}}, {"family": "Khor", "given": "Chiea-Chuen", "initials": "CC"}, {"family": "Kiess", "given": "Wieland", "initials": "W"}, {"family": "Kohara", "given": "Katsuhiko", "initials": "K"}, {"family": "Kovacs", "given": "Peter", "initials": "P", "orcid": "0000-0002-0290-5423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e778718e9f943f98e6850ad26f14876.json"}}, {"family": "Lee", "given": "Juyoung", "initials": "J"}, {"family": "Lee", "given": "Wen-Jane", "initials": "WJ", "orcid": "0000-0002-4390-8129", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38b00aadb7ac42e282a082cc0d93bd0e.json"}}, {"family": "Lehne", "given": "Benjamin", "initials": "B"}, {"family": "Li", "given": "Huaixing", "initials": "H"}, {"family": "Liu", "given": "Jianjun", "initials": "J"}, {"family": "Lobbens", "given": "Stephane", "initials": "S"}, {"family": "Luan", "given": "Jian'an", "initials": "J"}, {"family": "Lyssenko", "given": "Valeriya", "initials": "V"}, {"family": "Meitinger", "given": "Thomas", "initials": "T"}, {"family": "Miki", "given": "Tetsuro", "initials": "T"}, {"family": "Miljkovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-3155-9777", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8e78d643d6e4213b52e8449bf8f9a12.json"}}, {"family": "Moon", "given": "Sanghoon", "initials": "S"}, {"family": "Mulas", "given": "Antonella", "initials": "A"}, {"family": "M\u00fcller", "given": "Gabriele", "initials": "G", "orcid": "0000-0002-1591-0539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ffecb2437174d1c855548eeced44e83.json"}}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M"}, {"family": "Nagaraja", "given": "Ramaiah", "initials": "R"}, {"family": "Nauck", "given": "Matthias", "initials": "M"}, {"family": "Pankow", "given": "James S", "initials": "JS"}, {"family": "Polasek", "given": "Ozren", "initials": "O"}, {"family": "Prokopenko", "given": "Inga", "initials": "I"}, {"family": "Ramos", "given": "Paula S", "initials": "PS", "orcid": "0000-0002-9433-6634", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d72392bd1f654a30aa2a4885f1817190.json"}}, {"family": "Rasmussen-Torvik", "given": "Laura", "initials": "L"}, {"family": "Rathmann", "given": "Wolfgang", "initials": "W"}, {"family": "Rich", "given": "Stephen S", "initials": "SS"}, {"family": "Robertson", "given": "Neil R", "initials": "NR"}, {"family": "Roden", "given": "Michael", "initials": "M"}, {"family": "Roussel", "given": "Ronan", "initials": "R"}, {"family": "Rudan", "given": "Igor", "initials": "I"}, {"family": "Scott", "given": "Robert A", "initials": "RA"}, {"family": "Scott", "given": "William R", "initials": "WR"}, {"family": "Sennblad", "given": "Bengt", "initials": "B"}, {"family": "Siscovick", "given": "David S", "initials": "DS"}, {"family": "Strauch", "given": "Konstantin", "initials": "K"}, {"family": "Sun", "given": "Liang", "initials": "L"}, {"family": "Swertz", "given": "Morris", "initials": "M", "orcid": "0000-0002-0979-3401", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ffa14b27daa54952b8ec539678a7adef.json"}}, {"family": "Tajuddin", "given": "Salman M", "initials": "SM", "orcid": "0000-0002-7919-8528", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/30ff30406cb346d8964f75644493b107.json"}}, {"family": "Taylor", "given": "Kent D", "initials": "KD"}, {"family": "Teo", "given": "Yik-Ying", "initials": "YY"}, {"family": "Tham", "given": "Yih Chung", "initials": "YC"}, {"family": "T\u00f6njes", "given": "Anke", "initials": "A"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "Willemsen", "given": "Gonneke", "initials": "G"}, {"family": "Wilsgaard", "given": "Tom", "initials": "T"}, {"family": "Hingorani", "given": "Aroon D", "initials": "AD", "orcid": "0000-0001-8365-0081", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f5a039a8e6140428c8921d603929e9c.json"}}, {"family": "EPIC-CVD Consortium", "given": "", "initials": ""}, {"family": "EPIC-InterAct Consortium", "given": "", "initials": ""}, {"family": "Lifelines Cohort Study", "given": "", "initials": ""}, {"family": "Egan", "given": "Josephine", "initials": "J"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L", "orcid": "0000-0002-6273-1613", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3157462173f3465395d0bd7f5cec4331.json"}}, {"family": "Hovingh", "given": "G Kees", "initials": "GK"}, {"family": "Jula", "given": "Antti", "initials": "A"}, {"family": "Kivimaki", "given": "Mika", "initials": "M", "orcid": "0000-0002-4699-5627", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/59d7f4b1a8f8464eba40b0abe733aae9.json"}}, {"family": "Kumari", "given": "Meena", "initials": "M"}, {"family": "Nj\u00f8lstad", "given": "Inger", "initials": "I"}, {"family": "Palmer", "given": "Colin N A", "initials": "CNA", "orcid": "0000-0002-6415-6560", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/062b9cf737914042946364fcc452a4ba.json"}}, {"family": "Serrano R\u00edos", "given": "Manuel", "initials": "M"}, {"family": "Stumvoll", "given": "Michael", "initials": "M"}, {"family": "Watkins", "given": "Hugh", "initials": "H"}, {"family": "Aung", "given": "Tin", "initials": "T"}, {"family": "Bl\u00fcher", "given": "Matthias", "initials": "M"}, {"family": "Boehnke", "given": "Michael", "initials": "M"}, {"family": "Boomsma", "given": "Dorret I", "initials": "DI", "orcid": "0000-0002-7099-7972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c72fda1412f432298582d8c0c5b3bb6.json"}}, {"family": "Bornstein", "given": "Stefan R", "initials": "SR"}, {"family": "Chambers", "given": "John C", "initials": "JC"}, {"family": "Chasman", "given": "Daniel I", "initials": "DI"}, {"family": "Chen", "given": "Yii-Der Ida", "initials": "YI"}, {"family": "Chen", "given": "Yduan-Tsong", "initials": "YT"}, {"family": "Cheng", "given": "Ching-Yu", "initials": "CY"}, {"family": "Cucca", "given": "Francesco", "initials": "F", "orcid": "0000-0002-7414-1995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2535f3e6f1f4487f976990152303456b.json"}}, {"family": "de Geus", "given": "Eco J C", "initials": "EJC", "orcid": "0000-0001-6022-2666", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfe61063c4644006a01e837b72ae3345.json"}}, {"family": "Deloukas", "given": "Panos", "initials": "P"}, {"family": "Evans", "given": "Michele K", "initials": "MK"}, {"family": "Fornage", "given": "Myriam", "initials": "M"}, {"family": "Friedlander", "given": "Yechiel", "initials": "Y", "orcid": "0000-0001-6783-3531", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea6fa0f51bc24f8cae9a1acf1ab94fdb.json"}}, {"family": "Froguel", "given": "Philippe", "initials": "P"}, {"family": "Groop", "given": "Leif", "initials": "L"}, {"family": "Gross", "given": "Myron D", "initials": "MD"}, {"family": "Harris", "given": "Tamara B", "initials": "TB"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Heng", "given": "Chew-Kiat", "initials": "CK", "orcid": "0000-0002-7309-9473", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3902546a97a14c268768ed26da7cc07a.json"}}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Kato", "given": "Norihiro", "initials": "N"}, {"family": "Kim", "given": "Bong-Jo", "initials": "BJ"}, {"family": "Koh", "given": "Woon-Puay", "initials": "WP"}, {"family": "Kooner", "given": "Jaspal S", "initials": "JS"}, {"family": "K\u00f6rner", "given": "Antje", "initials": "A"}, {"family": "Kuh", "given": "Diana", "initials": "D"}, {"family": "Kuusisto", "given": "Johanna", "initials": "J"}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "Lin", "given": "Xu", "initials": "X"}, {"family": "Liu", "given": "Yongmei", "initials": "Y"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE", "orcid": "0000-0002-7315-7899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6fa8b01df9f4bf68607603c51c5a106.json"}}, {"family": "M\u00e4rz", "given": "Winfried", "initials": "W"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI", "orcid": "0000-0002-4393-0510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/102c7e93640c43c9bbbedd1626adfd7b.json"}}, {"family": "Oldehinkel", "given": "Albertine J", "initials": "AJ", "orcid": "0000-0003-3925-3913", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b41e3ece7d3475c821424ec9e04fbd5.json"}}, {"family": "Ong", "given": "Ken K", "initials": "KK", "orcid": "0000-0003-4689-7530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2fc9a3caa450429e9fe6b6dbeb5f0a44.json"}}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Pereira", "given": "Mark A", "initials": "MA", "orcid": "0000-0002-6704-5276", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/215feea1f60f4bf996297dd81056f81b.json"}}, {"family": "Peters", "given": "Annette", "initials": "A", "orcid": "0000-0001-6645-0985", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8c01766387e4315bbae893182d39225.json"}}, {"family": "Ridker", "given": "Paul M", "initials": "PM"}, {"family": "Sabanayagam", "given": "Charumathi", "initials": "C", "orcid": "0000-0002-4042-4719", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b0fc12e7ca484bcd96348270ee0f01d7.json"}}, {"family": "Sale", "given": "Michele", "initials": "M", "orcid": "0000-0003-1644-9040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7c55af32d934f4298ba3ae3978a74fd.json"}}, {"family": "Saleheen", "given": "Danish", "initials": "D"}, {"family": "Saltevo", "given": "Juha", "initials": "J"}, {"family": "Schwarz", "given": "Peter Eh", "initials": "PE"}, {"family": "Sheu", "given": "Wayne H H", "initials": "WHH"}, {"family": "Snieder", "given": "Harold", "initials": "H"}, {"family": "Spector", "given": "Timothy D", "initials": "TD"}, {"family": "Tabara", "given": "Yasuharu", "initials": "Y"}, {"family": "Tuomilehto", "given": "Jaakko", "initials": "J"}, {"family": "van Dam", "given": "Rob M", "initials": "RM", "orcid": "0000-0002-7354-8734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d73dd7baccaa47fe80dd2568bdf6ef7a.json"}}, {"family": "Wilson", "given": "James G", "initials": "JG"}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Wolffenbuttel", "given": "Bruce H R", "initials": "BHR"}, {"family": "Wong", "given": "Tien Yin", "initials": "TY", "orcid": "0000-0002-8448-1264", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4fa41a34f4f045b2be3ed00dba0be24b.json"}}, {"family": "Wu", "given": "Jer-Yuarn", "initials": "JY"}, {"family": "Yuan", "given": "Jian-Min", "initials": "JM", "orcid": "0000-0002-4620-3108", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9eca50b3180443aaa7930e77f4e219e.json"}}, {"family": "Zonderman", "given": "Alan B", "initials": "AB"}, {"family": "Soranzo", "given": "Nicole", "initials": "N"}, {"family": "Guo", "given": "Xiuqing", "initials": "X"}, {"family": "Roberts", "given": "David J", "initials": "DJ"}, {"family": "Florez", "given": "Jose C", "initials": "JC"}, {"family": "Sladek", "given": "Robert", "initials": "R", "orcid": "0000-0002-2730-1204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/14b368334a704ae7b31036b3e0eccb9f.json"}}, {"family": "Dupuis", "given": "Jos\u00e9e", "initials": "J", "orcid": "0000-0003-2871-3603", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fdb74e8dee5d44c8ac7ee0d08de8180b.json"}}, {"family": "Morris", "given": "Andrew P", "initials": "AP", "orcid": "0000-0002-6805-6014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aaff6a0afcdf464a8de49c2ece7399e2.json"}}, {"family": "Tai", "given": "E-Shyong", "initials": "ES"}, {"family": "Selvin", "given": "Elizabeth", "initials": "E"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Barroso", "given": "In\u00eas", "initials": "I", "orcid": "0000-0001-5800-4520", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72e641d8461d415e8ab6c96f902b299a.json"}}, {"family": "Meigs", "given": "James B", "initials": "JB"}], "type": "journal article", "published": "2017-09-00", "journal": {"title": "PLoS Med.", "issn": "1549-1676", "volume": "14", "issue": "9", "pages": "e1002383", "issn-l": "1549-1277"}, "abstract": "Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with other glucose-related traits). In this study, we tested the hypotheses that, in a very large scale GWAS, we would identify more genetic variants associated with HbA1c and that HbA1c variants implicated in erythrocytic biology would affect the diagnostic accuracy of HbA1c. We therefore expanded the number of HbA1c-associated loci and tested the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance. Throughout this multiancestry study, we kept a focus on interancestry differences in HbA1c genetics performance that might influence race-ancestry differences in health outcomes.\n\nUsing genome-wide association meta-analyses in up to 159,940 individuals from 82 cohorts of European, African, East Asian, and South Asian ancestry, we identified 60 common genetic variants associated with HbA1c. We classified variants as implicated in glycemic, erythrocytic, or unclassified biology and tested whether additive genetic scores of erythrocytic variants (GS-E) or glycemic variants (GS-G) were associated with higher T2D incidence in multiethnic longitudinal cohorts (N = 33,241). Nineteen glycemic and 22 erythrocytic variants were associated with HbA1c at genome-wide significance. GS-G was associated with higher T2D risk (incidence OR = 1.05, 95% CI 1.04-1.06, per HbA1c-raising allele, p = 3 \u00d7 10-29); whereas GS-E was not (OR = 1.00, 95% CI 0.99-1.01, p = 0.60). In Europeans and Asians, erythrocytic variants in aggregate had only modest effects on the diagnostic accuracy of HbA1c. Yet, in African Americans, the X-linked G6PD G202A variant (T-allele frequency 11%) was associated with an absolute decrease in HbA1c of 0.81%-units (95% CI 0.66-0.96) per allele in hemizygous men, and 0.68%-units (95% CI 0.38-0.97) in homozygous women. The G6PD variant may cause approximately 2% (N = 0.65 million, 95% CI 0.55-0.74) of African American adults with T2D to remain undiagnosed when screened with HbA1c. Limitations include the smaller sample sizes for non-European ancestries and the inability to classify approximately one-third of the variants. Further studies in large multiethnic cohorts with HbA1c, glycemic, and erythrocytic traits are required to better determine the biological action of the unclassified variants.\n\nAs G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common. Screening with direct glucose measurements, or genetically-informed HbA1c diagnostic thresholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.", "doi": "10.1371/journal.pmed.1002383", "pmid": "28898252", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5595282"}, {"db": "pii", "key": "PMEDICINE-D-17-00599"}], "notes": [], "created": "2018-12-05T11:25:19.021Z", "modified": "2026-09-23T06:33:43.552Z"}, {"entity": "publication", "iuid": "3319ed3faaa04b37904ac096febd0936", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3319ed3faaa04b37904ac096febd0936.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3319ed3faaa04b37904ac096febd0936"}}, "title": "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.", "authors": [{"family": "Justice", "given": "Anne E", "initials": "AE", "orcid": "0000-0002-8903-8712", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bbbd25c5e044cb0b8d6c94dc9ad2f0b.json"}}, {"family": "Winkler", "given": "Thomas W", "initials": "TW", "orcid": "0000-0003-0292-5421", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1511736ab1f4f3cab1a2ccef342db34.json"}}, {"family": "Feitosa", "given": "Mary F", "initials": "MF"}, {"family": "Graff", "given": "Misa", "initials": "M"}, {"family": "Fisher", "given": "Virginia A", "initials": "VA"}, {"family": "Young", "given": "Kristin", "initials": "K", "orcid": "0000-0003-0070-6145", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a317f8776f149dabff61ef11aab6d74.json"}}, {"family": "Barata", "given": "Llilda", "initials": "L"}, {"family": "Deng", "given": "Xuan", "initials": "X"}, {"family": "Czajkowski", "given": "Jacek", "initials": "J"}, {"family": "Hadley", "given": "David", "initials": "D"}, {"family": "Ngwa", "given": "Julius S", "initials": "JS"}, {"family": "Ahluwalia", "given": "Tarunveer S", "initials": "TS", "orcid": "0000-0002-7464-3354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57fffd8a40e84ad48327676da4d93d82.json"}}, {"family": "Chu", "given": "Audrey Y", "initials": "AY"}, {"family": "Heard-Costa", "given": "Nancy L", "initials": "NL"}, {"family": "Lim", "given": "Elise", "initials": "E"}, {"family": "Perez", "given": "Jeremiah", "initials": "J"}, {"family": "Eicher", "given": "John D", "initials": "JD"}, {"family": "Kutalik", "given": "Zolt\u00e1n", "initials": "Z"}, {"family": "Xue", "given": "Luting", "initials": "L"}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Renstr\u00f6m", "given": "Frida", "initials": "F"}, {"family": "Wu", "given": "Joseph", "initials": "J"}, {"family": "Qi", "given": "Qibin", "initials": "Q"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "Alfred", "given": "Tamuno", "initials": "T"}, {"family": "Amin", "given": "Najaf", "initials": "N"}, {"family": "Bielak", "given": "Lawrence F", "initials": "LF"}, {"family": "Bonnefond", "given": "Amelie", "initials": "A"}, {"family": "Bragg", "given": "Jennifer", "initials": "J"}, {"family": "Cadby", "given": "Gemma", "initials": "G"}, {"family": "Chittani", "given": "Martina", "initials": "M"}, {"family": "Coggeshall", "given": "Scott", "initials": "S"}, {"family": "Corre", "given": "Tanguy", "initials": "T"}, {"family": "Direk", "given": "Nese", "initials": "N"}, {"family": "Eriksson", "given": "Joel", "initials": "J"}, {"family": "Fischer", "given": "Krista", "initials": "K"}, {"family": "Gorski", "given": "Mathias", "initials": "M"}, {"family": "Neergaard Harder", "given": "Marie", "initials": "M"}, {"family": "Horikoshi", "given": "Momoko", "initials": "M"}, {"family": "Huang", "given": "Tao", "initials": "T"}, {"family": "Huffman", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0002-9672-2491", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db300ba51fe547bbaa3c7dd94a48ae93.json"}}, {"family": "Jackson", "given": "Anne U", "initials": "AU", "orcid": "0000-0002-9672-2547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d63df156aa9247d3a547cdcb2c86bff5.json"}}, {"family": "Justesen", "given": "Johanne Marie", "initials": "JM"}, {"family": "Kanoni", "given": "Stavroula", "initials": "S"}, {"family": "Kinnunen", "given": "Leena", "initials": "L"}, {"family": "Kleber", "given": "Marcus E", "initials": "ME", "orcid": "0000-0003-0663-7275", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22bc3077d1244542bcd6222f70dd7c96.json"}}, {"family": "Komulainen", "given": "Pirjo", "initials": "P"}, {"family": "Kumari", "given": "Meena", "initials": "M"}, {"family": "Lim", "given": "Unhee", "initials": "U"}, {"family": "Luan", "given": "Jian'an", "initials": "J"}, {"family": "Lyytik\u00e4inen", "given": "Leo-Pekka", "initials": "LP"}, {"family": "Mangino", "given": "Massimo", "initials": "M", "orcid": "0000-0002-2167-7470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1c90171562c487392b4257d272d3c17.json"}}, {"family": "Manichaikul", "given": "Ani", "initials": "A"}, {"family": "Marten", "given": "Jonathan", "initials": "J"}, {"family": "Middelberg", "given": "Rita P S", "initials": "RPS"}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M"}, {"family": "Navarro", "given": "Pau", "initials": "P", "orcid": "0000-0001-5576-8584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd1c6be37f30445e8d11b73f7ea54099.json"}}, {"family": "P\u00e9russe", "given": "Louis", "initials": "L"}, {"family": "Pervjakova", "given": "Natalia", "initials": "N"}, {"family": "Sarti", "given": "Cinzia", "initials": "C"}, {"family": "Smith", "given": "Albert Vernon", "initials": "AV"}, {"family": "Smith", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0002-3575-5468", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0706f9fec8d14cfe88cc03e6c7bf06e3.json"}}, {"family": "Stan\u010d\u00e1kov\u00e1", "given": "Alena", "initials": "A"}, {"family": "Strawbridge", "given": "Rona J", "initials": "RJ", "orcid": "0000-0001-8506-3585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cccd06a2fb54f769c5710c8758f2ebe.json"}}, {"family": "Stringham", "given": "Heather M", "initials": "HM", "orcid": "0000-0002-2991-6392", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2dd6dfe13fc4068a83c42e06beaf853.json"}}, {"family": "Sung", "given": "Yun Ju", "initials": "YJ"}, {"family": "Tanaka", "given": "Toshiko", "initials": "T"}, {"family": "Teumer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8309-094X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a40a959d1b8480cb8268e00f77a0449.json"}}, {"family": "Trompet", "given": "Stella", "initials": "S"}, {"family": "van der Laan", "given": "Sander W", "initials": "SW", "orcid": "0000-0001-6888-1404", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2455076523fd44d899477daf43f44509.json"}}, {"family": "van der Most", "given": "Peter J", "initials": "PJ", "orcid": "0000-0001-8450-3518", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aab1c835d9be4682b250164838d5b4ec.json"}}, {"family": "Van Vliet-Ostaptchouk", "given": "Jana V", "initials": "JV", "orcid": "0000-0002-7943-3153", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f6a4a42230043238a865b4c4def5de3.json"}}, {"family": "Vedantam", "given": "Sailaja L", "initials": "SL"}, {"family": "Verweij", "given": "Niek", "initials": "N"}, {"family": "Vink", "given": "Jacqueline M", "initials": "JM"}, {"family": "Vitart", "given": "Veronique", "initials": "V"}, {"family": "Wu", "given": "Ying", "initials": "Y"}, {"family": "Yengo", "given": "Loic", "initials": "L"}, {"family": "Zhang", "given": "Weihua", "initials": "W"}, {"family": "Hua Zhao", "given": "Jing", "initials": "J"}, {"family": "Zimmermann", "given": "Martina E", "initials": "ME", "orcid": "0000-0002-6916-4404", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/146a40334a6943bba3b0e343c6de567c.json"}}, {"family": "Zubair", "given": "Niha", "initials": "N"}, {"family": "Abecasis", "given": "Gon\u00e7alo R", "initials": "GR"}, {"family": "Adair", "given": "Linda S", "initials": "LS"}, {"family": "Afaq", "given": "Saima", "initials": "S"}, {"family": "Afzal", "given": "Uzma", "initials": "U"}, {"family": "Bakker", "given": "Stephan J L", "initials": "SJL"}, {"family": "Bartz", "given": "Traci M", "initials": "TM"}, {"family": "Beilby", "given": "John", "initials": "J", "orcid": "0000-0002-4915-2254", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bd5ae88bf8844e6bcace2797c74a9b7.json"}}, {"family": "Bergman", "given": "Richard N", "initials": "RN"}, {"family": "Bergmann", "given": "Sven", "initials": "S", "orcid": "0000-0002-6785-9034", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e7202443121d40b8b4b78835e31b6e16.json"}}, {"family": "Biffar", "given": "Reiner", "initials": "R"}, {"family": "Blangero", "given": "John", "initials": "J"}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Bonnycastle", "given": "Lori L", "initials": "LL"}, {"family": "Bottinger", "given": "Erwin", "initials": "E"}, {"family": "Braga", "given": "Daniele", "initials": "D"}, {"family": "Buckley", "given": "Brendan M", "initials": "BM"}, {"family": "Buyske", "given": "Steve", "initials": "S", "orcid": "0000-0001-8539-5416", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/948afa6dcac1440e91468efd34830772.json"}}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Chambers", "given": "John C", "initials": "JC"}, {"family": "Collins", "given": "Francis S", "initials": "FS"}, {"family": "Curran", "given": "Joanne E", "initials": "JE"}, {"family": "de Borst", "given": "Gert J", "initials": "GJ"}, {"family": "de Craen", "given": "Anton J M", "initials": "AJM"}, {"family": "de Geus", "given": "Eco J C", "initials": "EJC"}, {"family": "Dedoussis", "given": "George", "initials": "G"}, {"family": "Delgado", "given": "Graciela E", "initials": "GE"}, {"family": "den Ruijter", "given": "Hester M", "initials": "HM"}, {"family": "Eiriksdottir", "given": "Gudny", "initials": "G"}, {"family": "Eriksson", "given": "Anna L", "initials": "AL"}, {"family": "Esko", "given": "T\u00f5nu", "initials": "T"}, {"family": "Faul", "given": "Jessica D", "initials": "JD"}, {"family": "Ford", "given": "Ian", "initials": "I"}, {"family": "Forrester", "given": "Terrence", "initials": "T"}, {"family": "Gertow", "given": "Karl", "initials": "K"}, {"family": "Gigante", "given": "Bruna", "initials": "B"}, {"family": "Glorioso", "given": "Nicola", "initials": "N"}, {"family": "Gong", "given": "Jian", "initials": "J"}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Grammer", "given": "Tanja B", "initials": "TB"}, {"family": "Grarup", "given": "Niels", "initials": "N", "orcid": "0000-0001-5526-1070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e8ba20d53c64da49ae4a339c34c64d8.json"}}, {"family": "Haitjema", "given": "Saskia", "initials": "S"}, {"family": "Hallmans", "given": "G\u00f6ran", "initials": "G"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Hansen", "given": "Torben", "initials": "T"}, {"family": "Harris", "given": "Tamara B", "initials": "TB"}, {"family": "Hartman", "given": "Catharina A", "initials": "CA"}, {"family": "Hassinen", "given": "Maija", "initials": "M"}, {"family": "Hastie", "given": "Nicholas D", "initials": "ND"}, {"family": "Heath", "given": "Andrew C", "initials": "AC"}, {"family": "Hernandez", "given": "Dena", "initials": "D"}, {"family": "Hindorff", "given": "Lucia", "initials": "L"}, {"family": "Hocking", "given": "Lynne J", "initials": "LJ"}, {"family": "Hollensted", "given": "Mette", "initials": "M"}, {"family": "Holmen", "given": "Oddgeir L", "initials": "OL"}, {"family": "Homuth", "given": "Georg", "initials": "G"}, {"family": "Jan Hottenga", "given": "Jouke", "initials": "J"}, {"family": "Huang", "given": "Jie", "initials": "J"}, {"family": "Hung", "given": "Joseph", "initials": "J"}, {"family": "Hutri-K\u00e4h\u00f6nen", "given": "Nina", "initials": "N"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "James", "given": "Alan L", "initials": "AL"}, {"family": "Jansson", "given": "John-Olov", "initials": "JO"}, {"family": "Jarvelin", "given": "Marjo-Riitta", "initials": "MR"}, {"family": "Jhun", "given": "Min A", "initials": "MA"}, {"family": "J\u00f8rgensen", "given": "Marit E", "initials": "ME"}, {"family": "Juonala", "given": "Markus", "initials": "M"}, {"family": "K\u00e4h\u00f6nen", "given": "Mika", "initials": "M"}, {"family": "Karlsson", "given": "Magnus", "initials": "M"}, {"family": "Koistinen", "given": "Heikki A", "initials": "HA", "orcid": "0000-0001-7870-070X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/198cb0149f194cbcb22e06cac2d7b9e9.json"}}, {"family": "Kolcic", "given": "Ivana", "initials": "I"}, {"family": "Kolovou", "given": "Genovefa", "initials": "G"}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Kr\u00e4mer", "given": "Bernhard K", "initials": "BK"}, {"family": "Kuusisto", "given": "Johanna", "initials": "J"}, {"family": "Kval\u00f8y", "given": "Kirsti", "initials": "K"}, {"family": "Lakka", "given": "Timo A", "initials": "TA"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Launer", "given": "Lenore J", "initials": "LJ"}, {"family": "Leander", "given": "Karin", "initials": "K"}, {"family": "Lee", "given": "Nanette R", "initials": "NR"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Lindgren", "given": "Cecilia M", "initials": "CM"}, {"family": "Linneberg", "given": "Allan", "initials": "A", "orcid": "0000-0002-0994-0184", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a06e031f7ac448649c3986140c48d3fb.json"}}, {"family": "Lobbens", "given": "Stephane", "initials": "S"}, {"family": "Loh", "given": "Marie", "initials": "M"}, {"family": "Lorentzon", "given": "Mattias", "initials": "M"}, {"family": "Luben", "given": "Robert", "initials": "R", "orcid": "0000-0002-5088-6343", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca4949cb6f6b41f5b5313d91e0eb94d9.json"}}, {"family": "Lubke", "given": "Gitta", "initials": "G"}, {"family": "Ludolph-Donislawski", "given": "Anja", "initials": "A"}, {"family": "Lupoli", "given": "Sara", "initials": "S"}, {"family": "Madden", "given": "Pamela A F", "initials": "PAF"}, {"family": "M\u00e4nnikk\u00f6", "given": "Reija", "initials": "R"}, {"family": "Marques-Vidal", "given": "Pedro", "initials": "P"}, {"family": "Martin", "given": "Nicholas G", "initials": "NG"}, {"family": "McKenzie", "given": "Colin A", "initials": "CA"}, {"family": "McKnight", "given": "Barbara", "initials": "B"}, {"family": "Mellstr\u00f6m", "given": "Dan", "initials": "D"}, {"family": "Menni", "given": "Cristina", "initials": "C"}, {"family": "Montgomery", "given": "Grant W", "initials": "GW"}, {"family": "Musk", "given": "Aw Bill", "initials": "AB"}, {"family": "Narisu", "given": "Narisu", "initials": "N"}, {"family": "Nauck", "given": "Matthias", "initials": "M"}, {"family": "Nolte", "given": "Ilja M", "initials": "IM", "orcid": "0000-0001-5047-4077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2f5412b9a3a24cd9886c668836025c1b.json"}}, {"family": "Oldehinkel", "given": "Albertine J", "initials": "AJ"}, {"family": "Olden", "given": "Matthias", "initials": "M"}, {"family": "Ong", "given": "Ken K", "initials": "KK"}, {"family": "Padmanabhan", "given": "Sandosh", "initials": "S"}, {"family": "Peyser", "given": "Patricia A", "initials": "PA"}, {"family": "Pisinger", "given": "Charlotta", "initials": "C"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Raitakari", "given": "Olli T", "initials": "OT"}, {"family": "Rankinen", "given": "Tuomo", "initials": "T"}, {"family": "Rao", "given": "D C", "initials": "DC"}, {"family": "Rasmussen-Torvik", "given": "Laura J", "initials": "LJ"}, {"family": "Rawal", "given": "Rajesh", "initials": "R"}, {"family": "Rice", "given": "Treva", "initials": "T"}, {"family": "Ridker", "given": "Paul M", "initials": "PM"}, {"family": "Rose", "given": "Lynda M", "initials": "LM"}, {"family": "Bien", "given": "Stephanie A", "initials": "SA"}, {"family": "Rudan", "given": "Igor", "initials": "I", "orcid": "0000-0001-6993-6884", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c9e99f2bcc74658ae0bcffca0a0abee.json"}}, {"family": "Sanna", "given": "Serena", "initials": "S"}, {"family": "Sarzynski", "given": "Mark A", "initials": "MA"}, {"family": "Sattar", "given": "Naveed", "initials": "N"}, {"family": "Savonen", "given": "Kai", "initials": "K"}, {"family": "Schlessinger", "given": "David", "initials": "D"}, {"family": "Scholtens", "given": "Salome", "initials": "S"}, {"family": "Schurmann", "given": "Claudia", "initials": "C", "orcid": "0000-0003-4158-9192", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ad5e5cf1d3148b495830a8d4507c72b.json"}}, {"family": "Scott", "given": "Robert A", "initials": "RA"}, {"family": "Sennblad", "given": "Bengt", "initials": "B"}, {"family": "Siemelink", "given": "Marten A", "initials": "MA"}, {"family": "Silbernagel", "given": "G\u00fcnther", "initials": "G"}, {"family": "Slagboom", "given": "P Eline", "initials": "PE"}, {"family": "Snieder", "given": "Harold", "initials": "H"}, {"family": "Staessen", "given": "Jan A", "initials": "JA"}, {"family": "Stott", "given": "David J", "initials": "DJ"}, {"family": "Swertz", "given": "Morris A", "initials": "MA"}, {"family": "Swift", "given": "Amy J", "initials": "AJ"}, {"family": "Taylor", "given": "Kent D", "initials": "KD"}, {"family": "Tayo", "given": "Bamidele O", "initials": "BO"}, {"family": "Thorand", "given": "Barbara", "initials": "B"}, {"family": "Thuillier", "given": "Dorothee", "initials": "D"}, {"family": "Tuomilehto", "given": "Jaakko", "initials": "J"}, {"family": "Uitterlinden", "given": "Andre G", "initials": "AG"}, {"family": "Vandenput", "given": "Liesbeth", "initials": "L"}, {"family": "Vohl", "given": "Marie-Claude", "initials": "MC"}, {"family": "V\u00f6lzke", "given": "Henry", "initials": "H"}, {"family": "Vonk", "given": "Judith M", "initials": "JM"}, {"family": "Waeber", "given": "G\u00e9rard", "initials": "G"}, {"family": "Waldenberger", "given": "Melanie", "initials": "M"}, {"family": "Westendorp", "given": "R G J", "initials": "RGJ"}, {"family": "Wild", "given": "Sarah", "initials": "S"}, {"family": "Willemsen", "given": "Gonneke", "initials": "G"}, {"family": "Wolffenbuttel", "given": "Bruce H R", "initials": "BHR"}, {"family": "Wong", "given": "Andrew", "initials": "A", "orcid": "0000-0003-2079-4779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d5de10edb24240449c7784bfb4703189.json"}}, {"family": "Wright", "given": "Alan F", "initials": "AF"}, {"family": "Zhao", "given": "Wei", "initials": "W"}, {"family": "Zillikens", "given": "M Carola", "initials": "MC"}, {"family": "Baldassarre", "given": "Damiano", "initials": "D", "orcid": "0000-0002-2766-8882", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8b84ab3a8e94c5f9f9668e5550f6ace.json"}}, {"family": "Balkau", "given": "Beverley", "initials": "B"}, {"family": "Bandinelli", "given": "Stefania", "initials": "S"}, {"family": "B\u00f6ger", "given": "Carsten A", "initials": "CA"}, {"family": "Boomsma", "given": "Dorret I", "initials": "DI"}, {"family": "Bouchard", "given": "Claude", "initials": "C"}, {"family": "Bruinenberg", "given": "Marcel", "initials": "M"}, {"family": "Chasman", "given": "Daniel I", "initials": "DI"}, {"family": "Chen", "given": "Yii-DerIda", "initials": "YD"}, {"family": "Chines", "given": "Peter S", "initials": "PS"}, {"family": "Cooper", "given": "Richard S", "initials": "RS"}, {"family": "Cucca", "given": "Francesco", "initials": "F"}, {"family": "Cusi", "given": "Daniele", "initials": "D"}, {"family": "Faire", "given": "Ulf de", "initials": "U"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Froguel", "given": "Philippe", "initials": "P"}, {"family": "Gordon-Larsen", "given": "Penny", "initials": "P", "orcid": "0000-0001-5322-4188", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/480fa70683fb44a0bda6b322a1d36439.json"}}, {"family": "Grabe", "given": "Hans-J\u00f6rgen", "initials": "HJ"}, {"family": "Gudnason", "given": "Vilmundur", "initials": "V"}, {"family": "Haiman", "given": "Christopher A", "initials": "CA"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Hveem", "given": "Kristian", "initials": "K"}, {"family": "Johnson", "given": "Andrew D", "initials": "AD"}, {"family": "Wouter Jukema", "given": "J", "initials": "J", "orcid": "0000-0002-3246-8359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51be7e89ccfd4bbe93b216028c57a376.json"}}, {"family": "Kardia", "given": "Sharon L R", "initials": "SLR"}, {"family": "Kivimaki", "given": "Mika", "initials": "M", "orcid": "0000-0002-4699-5627", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/59d7f4b1a8f8464eba40b0abe733aae9.json"}}, {"family": "Kooner", "given": "Jaspal S", "initials": "JS"}, {"family": "Kuh", "given": "Diana", "initials": "D"}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Marchand", "given": "Loic Le", "initials": "LL"}, {"family": "M\u00e4rz", "given": "Winfried", "initials": "W"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Metspalu", "given": "Andres", "initials": "A"}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "Ohlsson", "given": "Claes", "initials": "C"}, {"family": "Palmer", "given": "Lyle J", "initials": "LJ"}, {"family": "Pasterkamp", "given": "Gerard", "initials": "G"}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Peters", "given": "Ulrike", "initials": "U"}, {"family": "Polasek", "given": "Ozren", "initials": "O"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM"}, {"family": "Qi", "given": "Lu", "initials": "L"}, {"family": "Rauramaa", "given": "Rainer", "initials": "R"}, {"family": "Smith", "given": "Blair H", "initials": "BH", "orcid": "0000-0002-5362-9430", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f30912f5a8e443eac572814f3990d7f.json"}}, {"family": "S\u00f8rensen", "given": "Thorkild I A", "initials": "TIA"}, {"family": "Strauch", "given": "Konstantin", "initials": "K"}, {"family": "Tiemeier", "given": "Henning", "initials": "H", "orcid": "0000-0002-4395-1397", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bed764abb33d4d9e8bcd05dd64379a7c.json"}}, {"family": "Tremoli", "given": "Elena", "initials": "E"}, {"family": "van der Harst", "given": "Pim", "initials": "P"}, {"family": "Vestergaard", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3090-269X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2fa5c4f74894d6a833afd105ec72848.json"}}, {"family": "Vollenweider", "given": "Peter", "initials": "P"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "Weir", "given": "David R", "initials": "DR"}, {"family": "Whitfield", "given": "John B", "initials": "JB"}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Tyrrell", "given": "Jessica", "initials": "J"}, {"family": "Frayling", "given": "Timothy M", "initials": "TM"}, {"family": "Barroso", "given": "In\u00eas", "initials": "I"}, {"family": "Boehnke", "given": "Michael", "initials": "M"}, {"family": "Deloukas", "given": "Panagiotis", "initials": "P"}, {"family": "Fox", "given": "Caroline S", "initials": "CS"}, {"family": "Hirschhorn", "given": "Joel N", "initials": "JN"}, {"family": "Hunter", "given": "David J", "initials": "DJ"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Strachan", "given": "David P", "initials": "DP", "orcid": "0000-0001-7854-1366", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d43385a350914b0a843fb49008d108b0.json"}}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM"}, {"family": "Heid", "given": "Iris M", "initials": "IM"}, {"family": "Mohlke", "given": "Karen L", "initials": "KL", "orcid": "0000-0001-6721-153X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fac0e041c56347fe98cef9ae8f004b67.json"}}, {"family": "Marchini", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-0610-8322", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7d0d3e23a76434098fa7731ac294cd1.json"}}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Kilpel\u00e4inen", "given": "Tuomas O", "initials": "TO"}, {"family": "Liu", "given": "Ching-Ti", "initials": "CT", "orcid": "0000-0002-0703-0742", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0df836bc876845a6af66828561f24a27.json"}}, {"family": "Borecki", "given": "Ingrid B", "initials": "IB"}, {"family": "North", "given": "Kari E", "initials": "KE"}, {"family": "Cupples", "given": "L Adrienne", "initials": "LA"}], "type": "journal article", "published": "2017-04-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "8", "issue": null, "pages": "14977", "issn-l": "2041-1723"}, "abstract": "Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.", "doi": "10.1038/ncomms14977", "pmid": "28443625", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5414044"}, {"db": "pii", "key": "ncomms14977"}], "notes": [], "created": "2018-12-05T09:47:57.139Z", "modified": "2026-09-23T06:42:25.568Z"}, {"entity": "publication", "iuid": "9a7ff9dbf92b44adb45071fe7e59718a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9a7ff9dbf92b44adb45071fe7e59718a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9a7ff9dbf92b44adb45071fe7e59718a"}}, "title": "Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.", "authors": [{"family": "Graff", "given": "Mariaelisa", "initials": "M", "orcid": "0000-0001-6380-1735", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c44b97dedfa44e9d8baa6bddd482bc36.json"}}, {"family": "Scott", "given": "Robert A", "initials": "RA"}, {"family": "Justice", "given": "Anne E", "initials": "AE"}, {"family": "Young", "given": "Kristin L", "initials": "KL", "orcid": "0000-0003-0070-6145", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a317f8776f149dabff61ef11aab6d74.json"}}, {"family": "Feitosa", "given": "Mary F", "initials": "MF"}, {"family": "Barata", "given": "Llilda", "initials": "L"}, {"family": "Winkler", "given": "Thomas W", "initials": "TW", "orcid": "0000-0003-0292-5421", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1511736ab1f4f3cab1a2ccef342db34.json"}}, {"family": "Chu", "given": "Audrey Y", "initials": "AY"}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Hadley", "given": "David", "initials": "D"}, {"family": "Xue", "given": "Luting", "initials": "L"}, {"family": "Workalemahu", "given": "Tsegaselassie", "initials": "T"}, {"family": "Heard-Costa", "given": "Nancy L", "initials": "NL", "orcid": "0000-0001-9730-0306", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1da6a04aae7641359b0658b21cbf52a1.json"}}, {"family": "den Hoed", "given": "Marcel", "initials": "M"}, {"family": "Ahluwalia", "given": "Tarunveer S", "initials": "TS"}, {"family": "Qi", "given": "Qibin", "initials": "Q"}, {"family": "Ngwa", "given": "Julius S", "initials": "JS"}, {"family": "Renstr\u00f6m", "given": "Frida", "initials": "F", "orcid": "0000-0001-6053-298X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b010d29393e4ef5b6be7974b13d84fd.json"}}, {"family": "Quaye", "given": "Lydia", "initials": "L"}, {"family": "Eicher", "given": "John D", "initials": "JD"}, {"family": "Hayes", "given": "James E", "initials": "JE"}, {"family": "Cornelis", "given": "Marilyn", "initials": "M"}, {"family": "Kutalik", "given": "Zoltan", "initials": "Z"}, {"family": "Lim", "given": "Elise", "initials": "E"}, {"family": "Luan", "given": "Jian'an", "initials": "J"}, {"family": "Huffman", "given": "Jennifer E", "initials": "JE"}, {"family": "Zhang", "given": "Weihua", "initials": "W"}, {"family": "Zhao", "given": "Wei", "initials": "W"}, {"family": "Griffin", "given": "Paula J", "initials": "PJ"}, {"family": "Haller", "given": "Toomas", "initials": "T"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "Marques-Vidal", "given": "Pedro M", "initials": "PM"}, {"family": "Bien", "given": "Stephanie", "initials": "S"}, {"family": "Yengo", "given": "Loic", "initials": "L"}, {"family": "Teumer", "given": "Alexander", "initials": "A"}, {"family": "Smith", "given": "Albert Vernon", "initials": "AV"}, {"family": "Kumari", "given": "Meena", "initials": "M"}, {"family": "Harder", "given": "Marie Neergaard", "initials": "MN"}, {"family": "Justesen", "given": "Johanne Marie", "initials": "JM"}, {"family": "Kleber", "given": "Marcus E", "initials": "ME"}, {"family": "Hollensted", "given": "Mette", "initials": "M"}, {"family": "Lohman", "given": "Kurt", "initials": "K"}, {"family": "Rivera", "given": "Natalia V", "initials": "NV"}, {"family": "Whitfield", "given": "John B", "initials": "JB"}, {"family": "Zhao", "given": "Jing Hua", "initials": "JH"}, {"family": "Stringham", "given": "Heather M", "initials": "HM"}, {"family": "Lyytik\u00e4inen", "given": "Leo-Pekka", "initials": "LP"}, {"family": "Huppertz", "given": "Charlotte", "initials": "C"}, {"family": "Willemsen", "given": "Gonneke", "initials": "G"}, {"family": "Peyrot", "given": "Wouter J", "initials": "WJ"}, {"family": "Wu", "given": "Ying", "initials": "Y"}, {"family": "Kristiansson", "given": "Kati", "initials": "K"}, {"family": "Demirkan", "given": "Ayse", "initials": "A"}, {"family": "Fornage", "given": "Myriam", "initials": "M"}, {"family": "Hassinen", "given": "Maija", "initials": "M"}, {"family": "Bielak", "given": "Lawrence F", "initials": "LF"}, {"family": "Cadby", "given": "Gemma", "initials": "G"}, {"family": "Tanaka", "given": "Toshiko", "initials": "T"}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "van der Most", "given": "Peter J", "initials": "PJ"}, {"family": "Jackson", "given": "Anne U", "initials": "AU"}, {"family": "Bragg-Gresham", "given": "Jennifer L", "initials": "JL"}, {"family": "Vitart", "given": "Veronique", "initials": "V"}, {"family": "Marten", "given": "Jonathan", "initials": "J"}, {"family": "Navarro", "given": "Pau", "initials": "P"}, {"family": "Bellis", "given": "Claire", "initials": "C"}, {"family": "Pasko", "given": "Dorota", "initials": "D"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Snitker", "given": "S\u00f8ren", "initials": "S"}, {"family": "Cheng", "given": "Yu-Ching", "initials": "YC"}, {"family": "Eriksson", "given": "Joel", "initials": "J"}, {"family": "Lim", "given": "Unhee", "initials": "U"}, {"family": "Aadahl", "given": "Mette", "initials": "M"}, {"family": "Adair", "given": "Linda S", "initials": "LS"}, {"family": "Amin", "given": "Najaf", "initials": "N"}, {"family": "Balkau", "given": "Beverley", "initials": "B"}, {"family": "Auvinen", "given": "Juha", "initials": "J"}, {"family": "Beilby", "given": "John", "initials": "J"}, {"family": "Bergman", "given": "Richard N", "initials": "RN"}, {"family": "Bergmann", "given": "Sven", "initials": "S"}, {"family": "Bertoni", "given": "Alain G", "initials": "AG"}, {"family": "Blangero", "given": "John", "initials": "J"}, {"family": "Bonnefond", "given": "Am\u00e9lie", "initials": "A"}, {"family": "Bonnycastle", "given": "Lori L", "initials": "LL"}, {"family": "Borja", "given": "Judith B", "initials": "JB"}, {"family": "Brage", "given": "S\u00f8ren", "initials": "S"}, {"family": "Busonero", "given": "Fabio", "initials": "F"}, {"family": "Buyske", "given": "Steve", "initials": "S"}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Chines", "given": "Peter S", "initials": "PS"}, {"family": "Collins", "given": "Francis S", "initials": "FS"}, {"family": "Corre", "given": "Tanguy", "initials": "T"}, {"family": "Smith", "given": "George Davey", "initials": "GD"}, {"family": "Delgado", "given": "Graciela E", "initials": "GE"}, {"family": "Dueker", "given": "Nicole", "initials": "N"}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M"}, {"family": "Ebeling", "given": "Tapani", "initials": "T"}, {"family": "Eiriksdottir", "given": "Gudny", "initials": "G"}, {"family": "Esko", "given": "T\u00f5nu", "initials": "T"}, {"family": "Faul", "given": "Jessica D", "initials": "JD"}, {"family": "Fu", "given": "Mao", "initials": "M"}, {"family": "F\u00e6rch", "given": "Kristine", "initials": "K"}, {"family": "Gieger", "given": "Christian", "initials": "C"}, {"family": "Gl\u00e4ser", "given": "Sven", "initials": "S"}, {"family": "Gong", "given": "Jian", "initials": "J"}, {"family": "Gordon-Larsen", "given": "Penny", "initials": "P"}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Grammer", "given": "Tanja B", "initials": "TB"}, {"family": "Grarup", "given": "Niels", "initials": "N"}, {"family": "van Grootheest", "given": "Gerard", "initials": "G"}, {"family": "Harald", "given": "Kennet", "initials": "K"}, {"family": "Hastie", "given": "Nicholas D", "initials": "ND"}, {"family": "Havulinna", "given": "Aki S", "initials": "AS"}, {"family": "Hernandez", "given": "Dena", "initials": "D"}, {"family": "Hindorff", "given": "Lucia", "initials": "L"}, {"family": "Hocking", "given": "Lynne J", "initials": "LJ"}, {"family": "Holmens", "given": "Oddgeir L", "initials": "OL"}, {"family": "Holzapfel", "given": "Christina", "initials": "C"}, {"family": "Hottenga", "given": "Jouke Jan", "initials": "JJ"}, {"family": "Huang", "given": "Jie", "initials": "J"}, {"family": "Huang", "given": "Tao", "initials": "T"}, {"family": "Hui", "given": "Jennie", "initials": "J"}, {"family": "Huth", "given": "Cornelia", "initials": "C"}, {"family": "Hutri-K\u00e4h\u00f6nen", "given": "Nina", "initials": "N"}, {"family": "James", "given": "Alan L", "initials": "AL"}, {"family": "Jansson", "given": "John-Olov", "initials": "JO"}, {"family": "Jhun", "given": "Min A", "initials": "MA"}, {"family": "Juonala", "given": "Markus", "initials": "M"}, {"family": "Kinnunen", "given": "Leena", "initials": "L"}, {"family": "Koistinen", "given": "Heikki A", "initials": "HA"}, {"family": "Kolcic", "given": "Ivana", "initials": "I"}, {"family": "Komulainen", "given": "Pirjo", "initials": "P"}, {"family": "Kuusisto", "given": "Johanna", "initials": "J"}, {"family": "Kval\u00f8y", "given": "Kirsti", "initials": "K"}, {"family": "K\u00e4h\u00f6nen", "given": "Mika", "initials": "M"}, {"family": "Lakka", "given": "Timo A", "initials": "TA"}, {"family": "Launer", "given": "Lenore J", "initials": "LJ"}, {"family": "Lehne", "given": "Benjamin", "initials": "B"}, {"family": "Lindgren", "given": "Cecilia M", "initials": "CM"}, {"family": "Lorentzon", "given": "Mattias", "initials": "M"}, {"family": "Luben", "given": "Robert", "initials": "R"}, {"family": "Marre", "given": "Michel", "initials": "M"}, {"family": "Milaneschi", "given": "Yuri", "initials": "Y"}, {"family": "Monda", "given": "Keri L", "initials": "KL"}, {"family": "Montgomery", "given": "Grant W", "initials": "GW"}, {"family": "De Moor", "given": "Marleen H M", "initials": "MHM"}, {"family": "Mulas", "given": "Antonella", "initials": "A"}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M"}, {"family": "Musk", "given": "A W", "initials": "AW"}, {"family": "M\u00e4nnikk\u00f6", "given": "Reija", "initials": "R"}, {"family": "M\u00e4nnist\u00f6", "given": "Satu", "initials": "S"}, {"family": "Narisu", "given": "Narisu", "initials": "N"}, {"family": "Nauck", "given": "Matthias", "initials": "M"}, {"family": "Nettleton", "given": "Jennifer A", "initials": "JA"}, {"family": "Nolte", "given": "Ilja M", "initials": "IM"}, {"family": "Oldehinkel", "given": "Albertine J", "initials": "AJ"}, {"family": "Olden", "given": "Matthias", "initials": "M"}, {"family": "Ong", "given": "Ken K", "initials": "KK"}, {"family": "Padmanabhan", "given": "Sandosh", "initials": "S"}, {"family": "Paternoster", "given": "Lavinia", "initials": "L"}, {"family": "Perez", "given": "Jeremiah", "initials": "J"}, {"family": "Perola", "given": "Markus", "initials": "M"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Peters", "given": "Ulrike", "initials": "U"}, {"family": "Peyser", "given": "Patricia A", "initials": "PA"}, {"family": "Prokopenko", "given": "Inga", "initials": "I"}, {"family": "Puolijoki", "given": "Hannu", "initials": "H"}, {"family": "Raitakari", "given": "Olli T", "initials": "OT"}, {"family": "Rankinen", "given": "Tuomo", "initials": "T"}, {"family": "Rasmussen-Torvik", "given": "Laura J", "initials": "LJ"}, {"family": "Rawal", "given": "Rajesh", "initials": "R"}, {"family": "Ridker", "given": "Paul M", "initials": "PM"}, {"family": "Rose", "given": "Lynda M", "initials": "LM"}, {"family": "Rudan", "given": "Igor", "initials": "I"}, {"family": "Sarti", "given": "Cinzia", "initials": "C"}, {"family": "Sarzynski", "given": "Mark A", "initials": "MA"}, {"family": "Savonen", "given": "Kai", "initials": "K"}, {"family": "Scott", "given": "William R", "initials": "WR"}, {"family": "Sanna", "given": "Serena", "initials": "S"}, {"family": "Shuldiner", "given": "Alan R", "initials": "AR"}, {"family": "Sidney", "given": "Steve", "initials": "S"}, {"family": "Silbernagel", "given": "G\u00fcnther", "initials": "G"}, {"family": "Smith", "given": "Blair H", "initials": "BH"}, {"family": "Smith", "given": "Jennifer A", "initials": "JA"}, {"family": "Snieder", "given": "Harold", "initials": "H"}, {"family": "Stan\u010d\u00e1kov\u00e1", "given": "Alena", "initials": "A"}, {"family": "Sternfeld", "given": "Barbara", "initials": "B"}, {"family": "Swift", "given": "Amy J", "initials": "AJ"}, {"family": "Tammelin", "given": "Tuija", "initials": "T"}, {"family": "Tan", "given": "Sian-Tsung", "initials": "ST"}, {"family": "Thorand", "given": "Barbara", "initials": "B"}, {"family": "Thuillier", "given": "Doroth\u00e9e", "initials": "D"}, {"family": "Vandenput", "given": "Liesbeth", "initials": "L"}, {"family": "Vestergaard", "given": "Henrik", "initials": "H"}, {"family": "van Vliet-Ostaptchouk", "given": "Jana V", "initials": "JV"}, {"family": "Vohl", "given": "Marie-Claude", "initials": "MC"}, {"family": "V\u00f6lker", "given": "Uwe", "initials": "U"}, {"family": "Waeber", "given": "G\u00e9rard", "initials": "G"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Wild", "given": "Sarah", "initials": "S"}, {"family": "Wong", "given": "Andrew", "initials": "A"}, {"family": "Wright", "given": "Alan F", "initials": "AF"}, {"family": "Zillikens", "given": "M Carola", "initials": "MC"}, {"family": "Zubair", "given": "Niha", "initials": "N"}, {"family": "Haiman", "given": "Christopher A", "initials": "CA"}, {"family": "Lemarchand", "given": "Loic", "initials": "L"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}, {"family": "Ohlsson", "given": "Claes", "initials": "C"}, {"family": "Hofman", "given": "Albert", "initials": "A"}, {"family": "Rivadeneira", "given": "Fernando", "initials": "F"}, {"family": "Uitterlinden", "given": "Andr\u00e9 G", "initials": "AG"}, {"family": "P\u00e9russe", "given": "Louis", "initials": "L"}, {"family": "Wilson", "given": "James F", "initials": "JF"}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Polasek", "given": "Ozren", "initials": "O"}, {"family": "Cucca", "given": "Francesco", "initials": "F"}, {"family": "Hveem", "given": "Kristian", "initials": "K"}, {"family": "Hartman", "given": "Catharina A", "initials": "CA"}, {"family": "T\u00f6njes", "given": "Anke", "initials": "A"}, {"family": "Bandinelli", "given": "Stefania", "initials": "S"}, {"family": "Palmer", "given": "Lyle J", "initials": "LJ"}, {"family": "Kardia", "given": "Sharon L R", "initials": "SLR"}, {"family": "Rauramaa", "given": "Rainer", "initials": "R"}, {"family": "S\u00f8rensen", "given": "Thorkild I A", "initials": "TIA"}, {"family": "Tuomilehto", "given": "Jaakko", "initials": "J"}, {"family": "Salomaa", "given": "Veikko", "initials": "V"}, {"family": "Penninx", "given": "Brenda W J H", "initials": "BWJH"}, {"family": "de Geus", "given": "Eco J C", "initials": "EJC"}, {"family": "Boomsma", "given": "Dorret I", "initials": "DI"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Mangino", "given": "Massimo", "initials": "M"}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "Bouchard", "given": "Claude", "initials": "C"}, {"family": "Martin", "given": "Nicholas G", "initials": "NG"}, {"family": "Kuh", "given": "Diana", "initials": "D"}, {"family": "Liu", "given": "Yongmei", "initials": "Y"}, {"family": "Linneberg", "given": "Allan", "initials": "A"}, {"family": "M\u00e4rz", "given": "Winfried", "initials": "W"}, {"family": "Strauch", "given": "Konstantin", "initials": "K"}, {"family": "Kivim\u00e4ki", "given": "Mika", "initials": "M"}, {"family": "Harris", "given": "Tamara B", "initials": "TB"}, {"family": "Gudnason", "given": "Vilmundur", "initials": "V"}, {"family": "V\u00f6lzke", "given": "Henry", "initials": "H"}, {"family": "Qi", "given": "Lu", "initials": "L"}, {"family": "J\u00e4rvelin", "given": "Marjo-Riitta", "initials": "MR"}, {"family": "Chambers", "given": "John C", "initials": "JC"}, {"family": "Kooner", "given": "Jaspal S", "initials": "JS"}, {"family": "Froguel", "given": "Philippe", "initials": "P"}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Vollenweider", "given": "Peter", "initials": "P"}, {"family": "Hallmans", "given": "G\u00f6ran", "initials": "G"}, {"family": "Hansen", "given": "Torben", "initials": "T"}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "Metspalu", "given": "Andres", "initials": "A"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Weir", "given": "David R", "initials": "DR"}, {"family": "Porteous", "given": "David J", "initials": "DJ"}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Chasman", "given": "Daniel I", "initials": "DI"}, {"family": "CHARGE Consortium", "given": "", "initials": ""}, {"family": "EPIC-InterAct Consortium", "given": "", "initials": ""}, {"family": "PAGE Consortium", "given": "", "initials": ""}, {"family": "Abecasis", "given": "Gon\u00e7alo R", "initials": "GR"}, {"family": "Barroso", "given": "In\u00eas", "initials": "I", "orcid": "0000-0001-5800-4520", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72e641d8461d415e8ab6c96f902b299a.json"}}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Frayling", "given": "Timothy M", "initials": "TM"}, {"family": "O'Connell", "given": "Jeffrey R", "initials": "JR"}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM"}, {"family": "Boehnke", "given": "Michael", "initials": "M"}, {"family": "Heid", "given": "Iris M", "initials": "IM"}, {"family": "Mohlke", "given": "Karen L", "initials": "KL"}, {"family": "Strachan", "given": "David P", "initials": "DP", "orcid": "0000-0001-7854-1366", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d43385a350914b0a843fb49008d108b0.json"}}, {"family": "Fox", "given": "Caroline S", "initials": "CS"}, {"family": "Liu", "given": "Ching-Ti", "initials": "CT", "orcid": "0000-0002-0703-0742", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0df836bc876845a6af66828561f24a27.json"}}, {"family": "Hirschhorn", "given": "Joel N", "initials": "JN"}, {"family": "Klein", "given": "Robert J", "initials": "RJ", "orcid": "0000-0003-3539-5391", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b5e2d49cb3e4c2c8de7eed91e34b46b.json"}}, {"family": "Johnson", "given": "Andrew D", "initials": "AD"}, {"family": "Borecki", "given": "Ingrid B", "initials": "IB"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "North", "given": "Kari E", "initials": "KE"}, {"family": "Cupples", "given": "L Adrienne", "initials": "LA"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Kilpel\u00e4inen", "given": "Tuomas O", "initials": "TO"}], "type": "journal article", "published": "2017-04-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "volume": "13", "issue": "4", "pages": "e1006528", "issn-l": "1553-7390"}, "abstract": "Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.", "doi": "10.1371/journal.pgen.1006528", "pmid": "28448500", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5407576"}, {"db": "pii", "key": "PGENETICS-D-16-01816"}], "notes": [], "created": "2018-12-05T09:33:34.193Z", "modified": "2026-09-23T06:36:19.066Z"}]}