{"entity": "researcher", "timestamp": "2026-08-20T21:19:18.685Z", "family": "J\u00f8rgensen", "given": "Sofie E", "initials": "SE", "orcid": "0000-0002-2700-0882", "affiliations": ["Department of Biomedicine, Aarhus University, Aarhus, Denmark.", "Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0de6c2db43d54b648917d0a536c9167a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0de6c2db43d54b648917d0a536c9167a"}}, "publications": [{"entity": "publication", "iuid": "e01b3ba538af4554bf72dd77a53f4c62", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e01b3ba538af4554bf72dd77a53f4c62.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e01b3ba538af4554bf72dd77a53f4c62"}}, "title": "Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis.", "authors": [{"family": "Gervais", "given": "Adrian", "initials": "A", "orcid": "0000-0002-1083-5787", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/403e9764a6a44a3897457a3b8f48b13d.json"}}, {"family": "Marchal", "given": "Astrid", "initials": "A", "orcid": "0000-0003-0648-8126", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/efccc300b4f44335b827f4df4c704b3b.json"}}, {"family": "Boucherit", "given": "Soraya", "initials": "S", "orcid": "0000-0002-8819-7594", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f0a381a85064c359d5c9c8391537d32.json"}}, {"family": "Abi Haidar", "given": "Anthony", "initials": "A", "orcid": "0009-0001-8555-7988", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/07bda3dd2bd34ca6bfb8d698e953cef6.json"}}, {"family": "Bizien", "given": "Lucy", "initials": "L", "orcid": "0000-0001-9163-9122", "researcher": {"href": 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"given": "Lorenzo", "initials": "L", "orcid": "0000-0003-3292-1528", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb86f8c9a78b40d9a653b4c6d3727c4d.json"}}, {"family": "Schleinitz", "given": "Nicolas", "initials": "N", "orcid": "0000-0001-9449-3392", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/549ab52a38094bee9bec4d184d309695.json"}}, {"family": "Bousfiha", "given": "Mohamed", "initials": "M", "orcid": "0009-0002-3099-1127", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b80807444b0442ba2d62af4d237ac02.json"}}, {"family": "Amenzoui", "given": "Naima", "initials": "N", "orcid": "0009-0001-5904-9912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce5fae2632e04a6988463b41c356109d.json"}}, {"family": "Bousfiha", "given": "Ahmed Aziz", "initials": "AA", "orcid": "0000-0002-5011-9873", "researcher": {"href": 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"initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d106604b8ad84e67870302b906a94963.json"}}, {"family": "Borghesi", "given": "Alessandro", "initials": "A", "orcid": "0000-0002-8773-9144", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561898f673ca449ebe79aef02751e921.json"}}, {"family": "Rule", "given": "Jody A", "initials": "JA", "orcid": "0000-0002-4019-372X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2779649f7aac411a9b8eb25b0ed9a934.json"}}, {"family": "Lee", "given": "William M", "initials": "WM", "orcid": "0000-0002-2783-5441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0daeba0f2f7f497aa8defa1f568187ee.json"}}, {"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55186a4757e7417389f415061b59ab5c.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/264335517ad94440b23a027fe66f767d.json"}}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de52d6ee013c4d18888fed695f547f54.json"}}], "type": "journal article", "published": "2026-03-02", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "223", "issue": "3", "issn-l": "0022-1007"}, "abstract": "Fulminant viral hepatitis (FVH) is a devastating condition caused by hepatotropic viruses such as hepatitis A virus (HAV), hepatitis B virus (HBV), and HSV-1/2. We studied 149 FVH patients (73 males and 76 females, aged 1-76) for blood autoantibodies (auto-Abs) neutralizing type I interferons (IFNs; IFN-\u03b12, -\u03b2, -\u03c9). Six of 16 (37.5%) HSV-triggered FVH patients carried such auto-Abs on admission, including three with a previously known autoimmune disease. These patients contrasted with 133 HAV- (n = 46) or HBV-triggered (n = 87) patients, none of whom had such detectable auto-Abs. Odds ratios for HSV-triggered FVH in individuals with auto-Abs ranged from 35.3 (95% CI: 13.0-96.2; P < 10-7) for those neutralizing only 100 pg/ml IFN-\u03b1/\u03c9 to 1,895 (CI: 448.5-8,002; P < 10-12) for those neutralizing both IFN-\u03b1 and IFN-\u03c9 at 10 ng/ml. Over one third of HSV-triggered FVH cases in this international cohort were due to preexisting auto-Abs. This finding highlights auto-Abs against type I IFNs as a major determinant of HSV-FVH and paves the way for targeted preventive or therapeutic interventions.", "doi": "10.1084/jem.20251760", "pmid": "41348319", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12679989"}, {"db": "pii", "key": "278554"}], "notes": [], "created": "2026-08-20T09:38:20.673Z", "modified": "2026-08-20T09:38:22.004Z"}]}