{"entity": "researcher", "timestamp": "2026-08-28T00:11:33.502Z", "family": "Gad", "given": "Annica Karin Britt", "initials": "AKB", "orcid": "0000-0002-1098-9129", "affiliations": ["Department of Oncology-Pathology, Karolinska Institutet, 171 64 Solna, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d66fa4c2ba64ddbbcc410b65234c892.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d66fa4c2ba64ddbbcc410b65234c892"}}, "publications": [{"entity": "publication", "iuid": "ed04fa15d77e4480b0c581a635e4c7e7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ed04fa15d77e4480b0c581a635e4c7e7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ed04fa15d77e4480b0c581a635e4c7e7"}}, "title": "Ex Vivo Drug Sensitivity of Pleural Effusion-Derived Cells from Lung Cancer and Pleural Mesothelioma Patients Is Linked to Clinical Response.", "authors": [{"family": "Hutyra-Gram \u00d6tv\u00f6s", "given": "Rita", "initials": "R"}, {"family": "Krynska", "given": "Hanna", "initials": "H", "orcid": "0000-0002-3759-3503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d80060cb378147db9edbb5b8e2b18c06.json"}}, {"family": "Gudoityte", "given": "Greta", "initials": "G", "orcid": "0000-0003-1963-7856", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4b2d8cfbdc804c2c996acef7d6cf4f26.json"}}, {"family": "Skribek", "given": "Marcus", "initials": "M", "orcid": "0000-0001-8692-6426", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/94e730abe32349699438862190f45b69.json"}}, {"family": "Oniscu", "given": "Anca", "initials": "A"}, {"family": "Berkovska", "given": "Olena", "initials": "O", "orcid": "0000-0002-8811-0591", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/887be29288744e6c860e1e00a2501dce.json"}}, {"family": "Strau\u00df", "given": "Katharina", "initials": "K"}, {"family": "Zipprick", "given": "Jenny", "initials": "J", "orcid": "0009-0001-1880-3261", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0bcef0390cfe416d8d2b3df728ae372f.json"}}, {"family": "Tamborero", "given": "David", "initials": "D"}, {"family": "Alexeyenko", "given": "Andrey", "initials": "A", "orcid": "0000-0001-8812-6481", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8078f1505d9747e1ac76cf2f6d4ee606.json"}}, {"family": "Gad", "given": "Annica Karin Britt", "initials": "AKB", "orcid": "0000-0002-1098-9129", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d66fa4c2ba64ddbbcc410b65234c892.json"}}, {"family": "Seashore-Ludlow", "given": "Brinton", "initials": "B", "orcid": "0000-0001-8658-5967", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a8ea4c3fdb14de1b651d0367b0a70a4.json"}}, {"family": "Dobra", "given": "Katalin", "initials": "K", "orcid": "0000-0002-0207-6733", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8218ca8a6a5451ca92a613260fb47dd.json"}}], "type": "journal article", "published": "2025-07-16", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "17", "issue": "14", "issn-l": "2072-6694"}, "abstract": "Tumors of the pleura, such as metastatic lung cancer and mesothelioma, are amongst the most lethal and therapy-resistant tumors. The first manifestation of the disease is often pleural effusion, the first available material for diagnosis. The five-year survival rate is exceptionally low, around 10-20%, and only a small proportion of patients harbor mutations that allow targeted treatments. Almost all patients develop resistance to treatment, which is often palliative. There is therefore an urgent need to refine the selection of drugs and patients for personalized treatment.\n\nWe isolated and cultured cells from pleural effusions in 3D cell aggregates and compared their drug sensitivity ex vivo to the clinical response to the same chemotherapeutic agents, combined with targeted sequencing and network analysis.\n\nThe ex vivo drug response showed a positive correlation with the treatment response and survival of patients in the clinic, with a stronger link to overall survival than to progression-free survival. Cryopreserved cells showed a similar response to freshly collected cells from the clinic.\n\nThe findings advance the field of ex vivo screening and present an opportunity to combine strategies for functional precision medicine with comprehensive characterization of disease for improved treatment and future management of lung cancer.", "doi": "10.3390/cancers17142363", "pmid": "40723246", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12293284"}, {"db": "pii", "key": "cancers17142363"}], "notes": [], "created": "2026-08-21T13:02:00.936Z", "modified": "2026-08-21T13:02:01.227Z"}, {"entity": "publication", "iuid": "afbc0635752e4d449f14dc8043925b34", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/afbc0635752e4d449f14dc8043925b34.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/afbc0635752e4d449f14dc8043925b34"}}, "title": "Vimentin Diversity in Health and Disease.", "authors": [{"family": "Danielsson", "given": "Frida", "initials": "F"}, {"family": "Peterson", "given": "McKenzie Kirsten", "initials": "MK"}, {"family": "Caldeira Ara\u00fajo", "given": "Helena", "initials": "H"}, {"family": "Lautenschl\u00e4ger", "given": "Franziska", "initials": "F", "orcid": "0000-0001-8263-3386", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d63dcb4bb0104b9ca190f588a9b92ca3.json"}}, {"family": "Gad", "given": "Annica Karin Britt", "initials": "AKB", "orcid": "0000-0002-1098-9129", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d66fa4c2ba64ddbbcc410b65234c892.json"}}], "type": "journal article", "published": "2018-09-21", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "7", "issue": "10", "issn-l": "2073-4409"}, "abstract": "Vimentin is a protein that has been linked to a large variety of pathophysiological conditions, including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also been shown to regulate a wide spectrum of basic cellular functions. In cells, vimentin assembles into a network of filaments that spans the cytoplasm. It can also be found in smaller, non-filamentous forms that can localise both within cells and within the extracellular microenvironment. The vimentin structure can be altered by subunit exchange, cleavage into different sizes, re-annealing, post-translational modifications and interacting proteins. Together with the observation that different domains of vimentin might have evolved under different selection pressures that defined distinct biological functions for different parts of the protein, the many diverse variants of vimentin might be the cause of its functional diversity. A number of review articles have focussed on the biology and medical aspects of intermediate filament proteins without particular commitment to vimentin, and other reviews have focussed on intermediate filaments in an in vitro context. In contrast, the present review focusses almost exclusively on vimentin, and covers both ex vivo and in vivo data from tissue culture and from living organisms, including a summary of the many phenotypes of vimentin knockout animals. Our aim is to provide a comprehensive overview of the current understanding of the many diverse aspects of vimentin, from biochemical, mechanical, cellular, systems biology and medical perspectives.", "doi": "10.3390/cells7100147", "pmid": "30248895", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6210396"}, {"db": "pii", "key": "cells7100147"}], "notes": [], "created": "2026-08-21T13:02:20.493Z", "modified": "2026-08-21T13:02:20.604Z"}]}