{"entity": "researcher", "timestamp": "2026-08-28T00:12:28.040Z", "family": "Herlin", "given": "Morten Krogh", "initials": "MK", "orcid": "0000-0001-7179-4643", "affiliations": ["Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.", "Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d267c8019a941919afcad35c891fa55.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d267c8019a941919afcad35c891fa55"}}, "publications": [{"entity": "publication", "iuid": "4ecb3b797f7347cb9b6b34ab398b603f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4ecb3b797f7347cb9b6b34ab398b603f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4ecb3b797f7347cb9b6b34ab398b603f"}}, "title": "Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.", "authors": [{"family": "Ryland", "given": "Georgina L", "initials": "GL", "orcid": "0000-0002-4990-0961", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ed7f10c3d6f469bb4e9133192be80f3.json"}}, {"family": "Umeda", "given": "Masayuki", "initials": "M"}, {"family": "Holmfeldt", "given": "Linda", "initials": "L", "orcid": "0000-0003-4140-3423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13a857b0c5b64d10a8e3b6b70d4dc662.json"}}, {"family": "Lehmann", "given": "S\u00f6ren", "initials": "S"}, {"family": "Herlin", "given": "Morten Krogh", "initials": "MK", "orcid": "0000-0001-7179-4643", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d267c8019a941919afcad35c891fa55.json"}}, {"family": "Ma", "given": "Jing", "initials": "J"}, {"family": "Khanlari", "given": "Mahsa", "initials": "M"}, {"family": "Rubnitz", "given": "Jeffrey E", "initials": "JE", "orcid": "0000-0001-9885-3527", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18bee93fc06247448c9efa05b098e1e1.json"}}, {"family": "Ries", "given": "Rhonda E", "initials": "RE"}, {"family": "Kosasih", "given": "Hansen J", "initials": "HJ", "orcid": "0000-0002-0428-6195", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ef6a0a90c10471cae6d2c9428a1517f.json"}}, {"family": "Ekert", "given": "Paul G", "initials": "PG"}, {"family": "Goh", "given": "Hwee Ngee", "initials": "HN"}, {"family": "Tiong", "given": "Ing S", "initials": "IS", "orcid": "0000-0001-7417-4343", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af393edc1fb84b9b94b8bcac24acea13.json"}}, {"family": "Grimmond", "given": "Sean M", "initials": "SM", "orcid": "0000-0002-8102-7998", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/545177bb833c49cda57327e574b6fd04.json"}}, {"family": "Haferlach", "given": "Claudia", "initials": "C"}, {"family": "Day", "given": "Ryan B", "initials": "RB", "orcid": "0000-0002-4376-4663", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1370debae39424f8d9a79ffd0721ee1.json"}}, {"family": "Ley", "given": "Timothy J", "initials": "TJ", "orcid": "0000-0002-9913-0520", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4c929eb0ddf84a31b7f9681761b11226.json"}}, {"family": "Meshinchi", "given": "Soheil", "initials": "S"}, {"family": "Ma", "given": "Xiaotu", "initials": "X"}, {"family": "Blombery", "given": "Piers", "initials": "P"}, {"family": "Klco", "given": "Jeffery M", "initials": "JM"}], "type": "journal article", "published": "2023-02-16", "journal": {"title": "Blood", "issn": "1528-0020", "volume": "141", "issue": "7", "pages": "800-805", "issn-l": "0006-4971"}, "abstract": null, "doi": "10.1182/blood.2022017874", "pmid": "36179268", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10273080"}, {"db": "pii", "key": "S0006-4971(22)01511-7"}], "notes": [], "created": "2026-08-21T12:33:06.229Z", "modified": "2026-08-21T12:33:06.636Z"}, {"entity": "publication", "iuid": "cae803c5e3bb474db086999bd9bef0b9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cae803c5e3bb474db086999bd9bef0b9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cae803c5e3bb474db086999bd9bef0b9"}}, "title": "What Is Abnormal in Normal Karyotype Acute Myeloid Leukemia in Children? Analysis of the Mutational Landscape and Prognosis of the TARGET-AML Cohort.", "authors": [{"family": "Herlin", "given": "Morten Krogh", "initials": "MK", "orcid": "0000-0001-7179-4643", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d267c8019a941919afcad35c891fa55.json"}}, {"family": "Yones", "given": "Sara A", "initials": "SA"}, {"family": "Kjeldsen", "given": "Eigil", "initials": "E"}, {"family": "Holmfeldt", "given": "Linda", "initials": "L", "orcid": "0000-0003-4140-3423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13a857b0c5b64d10a8e3b6b70d4dc662.json"}}, {"family": "Hasle", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2021-05-21", "journal": {"title": "Genes (Basel)", "issn": "2073-4425", "volume": "12", "issue": "6", "issn-l": "2073-4425"}, "abstract": "Normal karyotype acute myeloid leukemia (NK-AML) constitutes 20-25% of pediatric AML and detailed molecular analysis is essential to unravel the genetic background of this group. Using publicly available sequencing data from the TARGET-AML initiative, we investigated the mutational landscape of NK-AML in comparison with abnormal karyotype AML (AK-AML). In 164 (97.6%) of 168 independent NK-AML samples, at least one somatic protein-coding mutation was identified using whole-genome or targeted capture sequencing. We identified a unique mutational landscape of NK-AML characterized by a higher prevalence of mutated CEBPA, FLT3, GATA2, NPM1, PTPN11, TET2, and WT1 and a lower prevalence of mutated KIT, KRAS, and NRAS compared with AK-AML. Mutated CEBPA often co-occurred with mutated GATA2, whereas mutated FLT3 co-occurred with mutated WT1 and NPM1. In multivariate regression analysis, we identified younger age, WBC count \u226550 \u00d7 109/L, FLT3-internal tandem duplications, and mutated WT1 as independent predictors of adverse prognosis and mutated NPM1 and GATA2 as independent predictors of favorable prognosis in NK-AML. In conclusion, NK-AML in children is characterized by a unique mutational landscape which impacts the disease outcome.", "doi": "10.3390/genes12060792", "pmid": "34064268", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8224370"}, {"db": "pii", "key": "genes12060792"}], "notes": [], "created": "2026-08-21T13:02:31.367Z", "modified": "2026-08-21T13:02:31.414Z"}]}