{"entity": "researcher", "timestamp": "2026-09-23T15:25:32.820Z", "family": "Adcock", "given": "Ian M", "initials": "IM", "orcid": "0000-0003-2101-8843", "affiliations": ["National Heart and Lung Institute, Imperial College London, London, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0b61bb5380bf419c8e5ce461e36b7f7c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0b61bb5380bf419c8e5ce461e36b7f7c"}}, "publications": [{"entity": "publication", "iuid": "1e656547b1714f97affea326cd463d44", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1e656547b1714f97affea326cd463d44.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1e656547b1714f97affea326cd463d44"}}, "title": "The discovAIR project: a roadmap towards the Human Lung Cell Atlas.", "authors": [{"family": "Luecken", "given": "Malte D", "initials": "MD"}, {"family": "Zaragosi", "given": "Laure-Emmanuelle", "initials": "LE", "orcid": "0000-0001-6747-7928", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5973b289a0a84dddb87b3457ef554ace.json"}}, {"family": "Madissoon", "given": "Elo", "initials": "E"}, {"family": "Sikkema", "given": "Lisa", "initials": "L", "orcid": "0000-0001-9686-6295", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462d0024767146ebba699345e9deeb9e.json"}}, {"family": "Firsova", "given": "Alexandra B", "initials": "AB"}, {"family": "De Domenico", "given": "Elena", "initials": "E"}, {"family": "K\u00fcmmerle", "given": "Louis", "initials": "L"}, {"family": "Saglam", "given": "Adem", "initials": "A"}, {"family": "Berg", "given": "Marijn", "initials": "M"}, {"family": "Gay", "given": "Aurore C A", "initials": "ACA"}, {"family": "Schniering", "given": "Janine", "initials": "J", "orcid": "0000-0001-7869-4936", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9633364034714be8bb01be7d3e587664.json"}}, {"family": "Mayr", "given": "Christoph H", "initials": "CH"}, {"family": "Abalo", "given": "Xes\u00fas M", "initials": "XM", "orcid": "0000-0002-1643-0705", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccb96c37f02b45d290b89f5b615052df.json"}}, {"family": "Larsson", "given": "Ludvig", "initials": "L"}, {"family": "Sountoulidis", "given": "Alexandros", "initials": "A"}, {"family": "Teichmann", "given": "Sarah A", "initials": "SA"}, {"family": "van Eunen", "given": "Karen", "initials": "K"}, {"family": "Koppelman", "given": "Gerard H", "initials": "GH", "orcid": "0000-0001-8567-3252", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e9a287e31a64ec1a4a3cfc3dab53c6c.json"}}, {"family": "Saeb-Parsy", "given": "Kourosh", "initials": "K"}, {"family": "Leroy", "given": "Sylvie", "initials": "S"}, {"family": "Powell", "given": "Pippa", "initials": "P"}, {"family": "Sarkans", "given": "Ugis", "initials": "U"}, {"family": "Timens", "given": "Wim", "initials": "W", "orcid": "0000-0002-4146-6363", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c55e709b313044e8809ca651b283e93b.json"}}, {"family": "Lundeberg", "given": "Joakim", "initials": "J"}, {"family": "van den Berge", "given": "Maarten", "initials": "M"}, {"family": "Nilsson", "given": "Mats", "initials": "M"}, {"family": "Horv\u00e1th", "given": "Peter", "initials": "P"}, {"family": "Denning", "given": "Jessica", "initials": "J"}, {"family": "Papatheodorou", "given": "Irene", "initials": "I"}, {"family": "Schultze", "given": "Joachim L", "initials": "JL"}, {"family": "Schiller", "given": "Herbert B", "initials": "HB"}, {"family": "Barbry", "given": "Pascal", "initials": "P", "orcid": "0000-0001-9632-6483", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b90888809ec4532b824408fff59aab9.json"}}, {"family": "Petoukhov", "given": "Ilya", "initials": "I"}, {"family": "Misharin", "given": "Alexander V", "initials": "AV"}, {"family": "Adcock", "given": "Ian M", "initials": "IM", "orcid": "0000-0003-2101-8843", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0b61bb5380bf419c8e5ce461e36b7f7c.json"}}, {"family": "von Papen", "given": "Michael", "initials": "M"}, {"family": "Theis", "given": "Fabian J", "initials": "FJ"}, {"family": "Samakovlis", "given": "Christos", "initials": "C"}, {"family": "Meyer", "given": "Kerstin B", "initials": "KB"}, {"family": "Nawijn", "given": "Martijn C", "initials": "MC", "orcid": "0000-0003-3372-6521", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7551a303e7294578aa0c99966ffec1a2.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Eur. Respir. J.", "issn": "1399-3003", "volume": "60", "issue": "2", "issn-l": "0903-1936"}, "abstract": "The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The Lung Biological Network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and cell-cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework programme. discovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Human Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Human Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions.", "doi": "10.1183/13993003.02057-2021", "pmid": "35086829", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9386332"}, {"db": "pii", "key": "13993003.02057-2021"}], "notes": [], "created": "2026-09-23T10:12:25.272Z", "modified": "2026-09-23T10:50:46.742Z"}, {"entity": "publication", "iuid": "fa922a521fd2428b9f746a316907a579", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fa922a521fd2428b9f746a316907a579.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fa922a521fd2428b9f746a316907a579"}}, "title": "Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.", "authors": [{"family": "Sparreman Mikus", "given": "Maria", "initials": "M"}, {"family": "Kolmert", "given": "Johan", "initials": "J"}, {"family": "Andersson", "given": "Lars I", "initials": "LI"}, {"family": "\u00d6stling", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Knowles", "given": "Richard G", "initials": "RG"}, {"family": "G\u00f3mez", "given": "Cristina", "initials": "C", "orcid": "0000-0001-8518-0095", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa2cfd19e5e1481f9917ac73c00f0934.json"}}, {"family": "Ericsson", "given": "Magnus", "initials": "M"}, {"family": "Th\u00f6rngren", "given": "John-Olof", "initials": "JO"}, {"family": "Emami Khoonsari", "given": "Payam", "initials": "P"}, {"family": "Dahl\u00e9n", "given": "Barbro", "initials": "B"}, {"family": "Kupczyk", "given": "Maciej", "initials": "M"}, {"family": "De Meulder", "given": "Bertrand", "initials": "B"}, {"family": "Auffray", "given": "Charles", "initials": "C"}, {"family": "Bakke", "given": "Per S", "initials": "PS"}, {"family": "Beghe", "given": "Bianca", "initials": "B"}, {"family": "Bel", "given": "Elisabeth H", "initials": "EH"}, {"family": "Caruso", "given": "Massimo", "initials": "M", "orcid": "0000-0002-4412-2080", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef254e4ff45d4919a6ca0922bb6be1ac.json"}}, {"family": "Chanez", "given": "Pascal", "initials": "P"}, {"family": "Chawes", "given": "Bo", "initials": "B"}, {"family": "Fowler", "given": "Stephen J", "initials": "SJ", "orcid": "0000-0002-4524-1663", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/017b3977b2a245a4844c65f6e2bc9038.json"}}, {"family": "Gaga", "given": "Mina", "initials": "M", "orcid": "0000-0002-9949-6012", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d145e5de25554c61b2fda8de58af13cf.json"}}, {"family": "Geiser", "given": "Thomas", "initials": "T"}, {"family": "Gjomarkaj", "given": "Mark", "initials": "M"}, {"family": "Horv\u00e1th", "given": "Ildik\u00f3", "initials": "I"}, {"family": "Howarth", "given": "Peter H", "initials": "PH", "orcid": "0000-0003-0619-7927", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bec1e3ab30dc4d3d81479092aa59d818.json"}}, {"family": "Johnston", "given": "Sebastian L", "initials": "SL"}, {"family": "Joos", "given": "Guy", "initials": "G", "orcid": "0000-0002-3149-9444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/153de2cdf539481bab956ec616211575.json"}}, {"family": "Krug", "given": "Norbert", "initials": "N"}, {"family": "Montuschi", "given": "Paolo", "initials": "P"}, {"family": "Musial", "given": "Jacek", "initials": "J"}, {"family": "Ni\u017cankowska-Mogilnicka", "given": "Ewa", "initials": "E"}, {"family": "Olsson", "given": "Henric K", "initials": "HK"}, {"family": "Papi", "given": "Alberto", "initials": "A"}, {"family": "Rabe", "given": "Klaus F", "initials": "KF"}, {"family": "Sandstr\u00f6m", "given": "Thomas", "initials": "T"}, {"family": "Shaw", "given": "Dominick E", "initials": "DE", "orcid": "0000-0003-4106-8469", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2bf9d665f224457ab014cc6d936a127.json"}}, {"family": "Siafakas", "given": "Nikolaos M", "initials": "NM"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Riley", "given": "John H", "initials": "JH"}, {"family": "Bates", "given": "Stewart", "initials": "S"}, {"family": "Middelveld", "given": "Roelinde J M", "initials": "RJM"}, {"family": "Wheelock", "given": "Craig E", "initials": "CE", "orcid": "0000-0002-8113-0653", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d98abddc2b14a35ade5cb6d6d2f540d.json"}}, {"family": "Chung", "given": "Kian Fan", "initials": "KF"}, {"family": "Adcock", "given": "Ian M", "initials": "IM", "orcid": "0000-0003-2101-8843", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0b61bb5380bf419c8e5ce461e36b7f7c.json"}}, {"family": "Sterk", "given": "Peter J", "initials": "PJ"}, {"family": "Djukanovic", "given": "Ratko", "initials": "R"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Dahl\u00e9n", "given": "Sven-Erik", "initials": "SE"}, {"family": "James", "given": "Anna", "initials": "A"}, {"family": "U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group and the BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium", "given": "", "initials": ""}], "type": "controlled clinical trial", "published": "2022-02-00", "journal": {"title": "Eur. Respir. J.", "issn": "1399-3003", "volume": "59", "issue": "2", "issn-l": "0903-1936"}, "abstract": "Asthma phenotyping requires novel biomarker discovery.\n\nTo identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of severe (SA) and mild-to-moderate (MMA) asthmatics, COPD subjects and healthy controls (HCs).\n\nAn antibody-based array targeting 177 proteins predominantly involved in pathways relevant to inflammation, lipid metabolism, signal transduction and extracellular matrix was applied to plasma from 525 asthmatics and HCs in the U-BIOPRED cohort, and 142 subjects with asthma and COPD from the validation cohort BIOAIR. Effects of oral corticosteroids (OCS) were determined by a 2-week, placebo-controlled OCS trial in BIOAIR, and confirmed by relation to objective OCS measures in U-BIOPRED.\n\nIn U-BIOPRED, 110 proteins were significantly different, mostly elevated, in SA compared to MMA and HCs. 10 proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, TNF receptor superfamily member 11a, transforming growth factor-\u03b2 and glutathione S-transferase). OCS treatment decreased most proteins, yet differences between SA and MMA remained following correction for OCS use. Consensus clustering of U-BIOPRED protein data yielded six clusters associated with asthma control, quality of life, blood neutrophils, high-sensitivity C-reactive protein and body mass index, but not Type-2 inflammatory biomarkers. The mast cell specific enzyme carboxypeptidase A3 was one major contributor to cluster differentiation.\n\nThe plasma proteomic panel revealed previously unexplored yet potentially useful Type-2-independent biomarkers and validated several proteins with established involvement in the pathophysiology of SA.", "doi": "10.1183/13993003.00142-2021", "pmid": "34737220", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8850689"}, {"db": "pii", "key": "13993003.00142-2021"}], "notes": [], "created": "2026-09-23T09:54:30.140Z", "modified": "2026-09-23T10:28:41.711Z"}]}