{"entity": "researcher", "timestamp": "2026-08-23T10:18:44.062Z", "family": "Morado", "given": "Dustin R", "initials": "DR", "orcid": "0000-0003-4693-3220", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0afbe6534a6d4f44996fe626924ec1a9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0afbe6534a6d4f44996fe626924ec1a9"}}, "publications": [{"entity": "publication", "iuid": "2d25bb662f744affbc213da464d49bf4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2d25bb662f744affbc213da464d49bf4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2d25bb662f744affbc213da464d49bf4"}}, "title": "Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus.", "authors": [{"family": "Zinzula", "given": "Luca", "initials": "L", "orcid": "0000-0001-6489-7070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2cab8f15b034e819ef2419f5590a820.json"}}, {"family": "Beck", "given": "Florian", "initials": "F"}, {"family": "Camasta", "given": "Marianna", "initials": "M", "orcid": "0009-0006-3516-9844", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/14fe236d31b64c4e832fc5e48825fed9.json"}}, {"family": "Bohn", "given": "Stefan", "initials": "S", "orcid": "0000-0001-9196-622X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8f9db5feac143c38eeb339f3ef98025.json"}}, {"family": "Liu", "given": "Chuan", "initials": "C"}, {"family": "Morado", "given": "Dustin", "initials": "D", "orcid": "0000-0003-4693-3220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0afbe6534a6d4f44996fe626924ec1a9.json"}}, {"family": "Bracher", "given": "Andreas", "initials": "A", "orcid": "0000-0001-8530-7594", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd933026846442e5aca23f1f1e7e8c56.json"}}, {"family": "Plitzko", "given": "Juergen M", "initials": "JM", "orcid": "0000-0002-6402-8315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6f57f9f827a49649460f9020d1d1ecf.json"}}, {"family": "Baumeister", "given": "Wolfgang", "initials": "W", "orcid": "0000-0001-8154-8809", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc41560fa5e6429585744e90733210a5.json"}}], "type": "journal article", "published": "2024-11-27", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "10307", "issn-l": "2041-1723"}, "abstract": "Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in single-layered conformation, which differs from the previously reported structure of a double-layered helix. Our findings illuminate novel RNP interactions and expand knowledge on MARV genome packaging and nucleocapsid assembly, both processes representing attractive targets for the development of antiviral therapeutics against MARV disease.", "doi": "10.1038/s41467-024-54431-7", "pmid": "39604358", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11603049"}, {"db": "pii", "key": "10.1038/s41467-024-54431-7"}, {"db": "PDB", "key": "9FVD"}, {"db": "PDB", "key": "5F5M"}, {"db": "PDB", "key": "5F5O"}, {"db": "PDB", "key": "5XSQ"}, {"db": "PDB", "key": "5Z9W"}, {"db": "PDB", "key": "6C54"}, {"db": "PDB", "key": "6NUT"}, {"db": "PDB", "key": "7F1M"}, {"db": "PDB", "key": "7YPW"}, {"db": "PDB", "key": "7YR8"}], "notes": [], "created": "2026-08-21T11:50:00.473Z", "modified": "2026-08-21T11:50:00.796Z"}, {"entity": "publication", "iuid": "7daf67ec7dd242868ffd351f0650f995", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7daf67ec7dd242868ffd351f0650f995.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7daf67ec7dd242868ffd351f0650f995"}}, "title": "Membrane-assisted assembly and selective autophagy of enteroviruses", "authors": [{"family": "Dahmane", "given": "Selma", "initials": "S", "orcid": "0000-0003-4193-1496", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d59721917c34747a2bad375d5441303.json"}}, {"family": "Kerviel", "given": "Adeline", "initials": "A", "orcid": "0000-0002-1315-9841", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7aee26885d8d46fdb02bf14579fafea7.json"}}, {"family": "Morado", "given": "Dustin R", "initials": "DR", "orcid": "0000-0003-4693-3220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0afbe6534a6d4f44996fe626924ec1a9.json"}}, {"family": "Shankar", "given": "Kasturika", "initials": "K", "orcid": "0000-0002-0011-3756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8cfbb61033844b68bfe185117e429c6c.json"}}, {"family": "Ahlman", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Lazarou", "given": "Michael", "initials": "M", "orcid": "0000-0003-2150-5545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ba68bcbba4e4db3a9eb729441a3a61b.json"}}, {"family": "Altan-Bonnet", "given": "Nihal", "initials": "N"}, {"family": "Carlson", "given": "Lars Anders", "initials": "LA", "orcid": "0000-0003-2342-6488", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ecec975111e44d3b3a9797301a3417c.json"}}], "type": "posted-content", "published": "2021-10-06", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.10.06.463375", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:07:05.626Z", "modified": "2026-08-20T10:07:05.843Z"}, {"entity": "publication", "iuid": "d7062827fb1743bb860bc7b0c23bce55", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d7062827fb1743bb860bc7b0c23bce55.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d7062827fb1743bb860bc7b0c23bce55"}}, "title": "Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.", "authors": [{"family": "Leneva", "given": "Natalya", "initials": "N", "orcid": "0000-0001-8102-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5604a5ddf7c64749a52558765a272732.json"}}, {"family": "Kovtun", "given": "Oleksiy", "initials": "O", "orcid": "0000-0001-6374-7863", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ead6bd37aeb4c2b8716101956e17ae4.json"}}, {"family": "Morado", "given": "Dustin R", "initials": "DR", "orcid": "0000-0003-4693-3220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0afbe6534a6d4f44996fe626924ec1a9.json"}}, {"family": "Briggs", "given": "John A G", "initials": "JAG", "orcid": "0000-0003-3990-6910", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/702ee550a75346c7ac1cb4832bcf3aef.json"}}, {"family": "Owen", "given": "David J", "initials": "DJ", "orcid": "0000-0002-8351-6322", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1d71f3ab9db4bdcbd1fa8c6df563377.json"}}], "type": "journal article", "published": "2021-03-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "7", "issue": "13", "issn-l": "2375-2548"}, "abstract": "Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many cellular processes including signaling, immunity, neuroprotection, and virus infection. The retromer core (VPS26/VPS29/VPS35) is present on cargo-transporting, tubular carriers along with a range of sorting nexins. Here, we elucidate the structural basis of membrane tubulation and coupled cargo recognition by metazoan and fungal retromer coats assembled with the non-Bin1/Amphiphysin/Rvs (BAR) sorting nexin SNX3 using cryo-electron tomography. The retromer core retains its arched, scaffolding structure but changes its mode of membrane recruitment when assembled with different SNX adaptors, allowing cargo recognition at subunit interfaces. Thus, membrane bending and cargo incorporation can be modulated to allow retromer to traffic cargoes along different cellular transport routes.", "doi": "10.1126/sciadv.abf8598", "pmid": "33762348", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7990337"}, {"db": "pii", "key": "7/13/eabf8598"}], "notes": [], "created": "2026-08-21T12:22:16.740Z", "modified": "2026-08-21T12:22:16.857Z"}]}