{"entity": "researcher", "timestamp": "2026-10-01T12:33:46.957Z", "family": "Borrero-Landazabal", "given": "Mayra A", "initials": "MA", "orcid": "0000-0003-3464-4042", "affiliations": ["IMol Polish Academy of Sciences, Warsaw, Poland."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/09e20b7b1e9f4f76884f987ba269d2f9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/09e20b7b1e9f4f76884f987ba269d2f9"}}, "publications": [{"entity": "publication", "iuid": "6829135730514c36a0f7620b95f6fd33", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6829135730514c36a0f7620b95f6fd33.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6829135730514c36a0f7620b95f6fd33"}}, "title": "MIA40 suppresses cell death induced by apoptosis-inducing factor 1.", "authors": [{"family": "Mussulini", "given": "Ben Hur Marins", "initials": "BHM", "orcid": "0000-0003-4321-5709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/df5232e4b06a4eecb6780417b46714d5.json"}}, {"family": "Maruszczak", "given": "Klaudia K", "initials": "KK", "orcid": "0000-0003-4080-9368", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c9087452ff942dbbbce207c0f002708.json"}}, {"family": "Draczkowski", "given": "Piotr", "initials": "P", "orcid": "0000-0002-9408-2670", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/90775ac16811416ba9e08df99e8c9168.json"}}, {"family": "Borrero-Landazabal", "given": "Mayra A", "initials": "MA", "orcid": "0000-0003-3464-4042", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09e20b7b1e9f4f76884f987ba269d2f9.json"}}, {"family": "Ayyamperumal", "given": "Selvaraj", "initials": "S", "orcid": "0000-0003-2634-391X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cdbbad94b9743868e23635a9c7bf85a.json"}}, {"family": "Wnorowski", "given": "Artur", "initials": "A"}, {"family": "Wasilewski", "given": "Michal", "initials": "M", "orcid": "0000-0002-4890-5103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/492b6d14029c426ea9b189988325fd02.json"}}, {"family": "Chacinska", "given": "Agnieszka", "initials": "A", "orcid": "0000-0002-2832-2568", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60827d14a98d4b34ac704360385d8bde.json"}}], "type": "journal article", "published": "2025-04-00", "journal": {"title": "EMBO Rep.", "issn": "1469-3178", "volume": "26", "issue": "7", "pages": "1835-1862", "issn-l": "1469-221X"}, "abstract": "Mitochondria harbor respiratory complexes that perform oxidative phosphorylation. Complex I is the first enzyme of the respiratory chain that oxidizes NADH. A dysfunction in complex I can result in higher cellular levels of NADH, which in turn strengthens the interaction between apoptosis-inducing factor 1 (AIFM1) and Mitochondrial intermembrane space import and assembly protein 40 (MIA40) in the mitochondrial intermembrane space. We investigated whether MIA40 modulates the activity of AIFM1 upon increased NADH/NAD+ balance. We found that in model cells characterized by an increase in NADH the AIFM1-MIA40 interaction is strengthened and these cells demonstrate resistance to AIFM1-induced cell death. Either silencing of MIA40, rescue of complex I, or depletion of NADH through the expression of yeast NADH-ubiquinone oxidoreductase-2 sensitized NDUFA13-KO cells to AIFM1-induced cell death. These findings indicate that the complex of MIA40 and AIFM1 suppresses AIFM1-induced cell death in a NADH-dependent manner. This study identifies an effector complex involved in regulating the programmed cell death that accommodates the metabolic changes in the cell and provides a molecular explanation for AIFM1-mediated chemoresistance of cancer cells.", "doi": "10.1038/s44319-025-00406-8", "pmid": "40055465", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11976965"}, {"db": "pii", "key": "10.1038/s44319-025-00406-8"}], "notes": [], "created": "2026-09-23T11:35:01.371Z", "modified": "2026-09-23T11:35:01.706Z"}]}