{"entity": "researcher", "timestamp": "2026-08-23T09:26:32.677Z", "family": "Chaves-Sanjuan", "given": "Antonio", "initials": "A", "orcid": "0000-0003-3287-9024", "affiliations": ["Department of Biosciences, Universit\u00e0 degli Studi di Milano, Milan, 20133, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/07af9453cbe44bc1b914cbd112f3dd32.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/07af9453cbe44bc1b914cbd112f3dd32"}}, "publications": [{"entity": "publication", "iuid": "76b82d29b9c94000a91dac0fbf63a555", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/76b82d29b9c94000a91dac0fbf63a555.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/76b82d29b9c94000a91dac0fbf63a555"}}, "title": "Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis.", "authors": [{"family": "Schulte", "given": "Tim", "initials": "T"}, {"family": "Chaves-Sanjuan", "given": "Antonio", "initials": "A", "orcid": "0000-0003-3287-9024", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/07af9453cbe44bc1b914cbd112f3dd32.json"}}, {"family": "Speranzini", "given": "Valentina", "initials": "V"}, {"family": "Sicking", "given": "Kevin", "initials": "K"}, {"family": "Milazzo", "given": "Melissa", "initials": "M", "orcid": "0009-0000-7726-8580", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29c7955d773e4efb90ed36499c28c171.json"}}, {"family": "Mazzini", "given": "Giulia", "initials": "G", "orcid": "0000-0001-7695-2938", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a479824bf97d436d9c821b7b64438d50.json"}}, {"family": "Rognoni", "given": "Paola", "initials": "P", "orcid": "0000-0001-6350-1919", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8473ba7bb36448a88d510ddcc93be7d2.json"}}, {"family": "Caminito", "given": "Serena", "initials": "S", "orcid": "0000-0003-2381-1829", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a33c63f8c1d414aacc9eed44d01ae96.json"}}, {"family": "Milani", "given": "Paolo", "initials": "P", "orcid": "0000-0002-2268-9422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/91061a3c34e14dff97ca8c7f8ad57040.json"}}, {"family": "Marabelli", "given": "Chiara", "initials": "C", "orcid": "0000-0002-6613-4306", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/59ed1e08c23240daa422a9dbd7460998.json"}}, {"family": "Corbelli", "given": "Alessandro", "initials": "A"}, {"family": "Diomede", "given": "Luisa", "initials": "L", "orcid": "0000-0002-2258-0531", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71955a7a60e6420eb14971d0b43cf4e7.json"}}, {"family": "Fiordaliso", "given": "Fabio", "initials": "F", "orcid": "0000-0002-0172-4030", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f1f30f60b54449b8b4c8d02c4cbc48e.json"}}, {"family": "Anastasia", "given": "Luigi", "initials": "L", "orcid": "0000-0002-0712-2161", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d05b94e217b4266bc0b157d04d80a29.json"}}, {"family": "Pappone", "given": "Carlo", "initials": "C", "orcid": "0000-0002-0901-6135", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd0a861057a24837a114b1b74fee21f1.json"}}, {"family": "Merlini", "given": "Giampaolo", "initials": "G", "orcid": "0000-0001-7680-3254", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ba0f69f79fc4944841c26f7a87c2c11.json"}}, {"family": "Bolognesi", "given": "Martino", "initials": "M", "orcid": "0000-0002-9253-5170", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58bd69e6035a4838863b772f3140b442.json"}}, {"family": "Nuvolone", "given": "Mario", "initials": "M", "orcid": "0000-0001-8334-1684", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8cb7b49899654abc8417c362b463a1b2.json"}}, {"family": "Fern\u00e1ndez-Busnadiego", "given": "Rub\u00e9n", "initials": "R", "orcid": "0000-0002-8366-7622", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab09893ee58648c5b1985bb80ca092ee.json"}}, {"family": "Palladini", "given": "Giovanni", "initials": "G"}, {"family": "Ricagno", "given": "Stefano", "initials": "S", "orcid": "0000-0001-6678-5873", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98daac35c7914d1584403a45a81bd8c4.json"}}], "type": "journal article", "published": "2024-07-28", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "6359", "issn-l": "2041-1723"}, "abstract": "Systemic light chain (LC) amyloidosis (AL) is a disease where organs are damaged by an overload of a misfolded patient-specific antibody-derived LC, secreted by an abnormal B cell clone. The high LC concentration in the blood leads to amyloid deposition at organ sites. Indeed, cryogenic electron microscopy (cryo-EM) has revealed unique amyloid folds for heart-derived fibrils taken from different patients. Here, we present the cryo-EM structure of heart-derived AL amyloid (AL59) from another patient with severe cardiac involvement. The double-layered structure displays a u-shaped core that is closed by a \u03b2-arc lid and extended by a straight tail. Noteworthy, the fibril harbours an extended constant domain fragment, thus ruling out the variable domain as sole amyloid building block. Surprisingly, the fibrils were abundantly concatenated with a proteinaceous polymer, here identified as collagen VI (COLVI) by immuno-electron microscopy (IEM) and mass-spectrometry. Cryogenic electron tomography (cryo-ET) showed how COLVI wraps around the amyloid forming a helical superstructure, likely stabilizing and protecting the fibrils from clearance. Thus, here we report structural evidence of interactions between amyloid and collagen, potentially signifying a distinct pathophysiological mechanism of amyloid deposits.", "doi": "10.1038/s41467-024-50686-2", "pmid": "39069558", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11284220"}, {"db": "pii", "key": "10.1038/s41467-024-50686-2"}, {"db": "GENBANK", "key": "OR567864"}, {"db": "PDB", "key": "AL59"}, {"db": "PDB", "key": "9FAA"}], "notes": [], "created": "2026-08-21T11:49:53.105Z", "modified": "2026-08-21T11:49:53.806Z"}]}