{"entity": "researcher", "timestamp": "2026-08-20T20:53:54.233Z", "family": "De Rosa", "given": "Maria", "initials": "M", "orcid": "0000-0002-4087-2554", "affiliations": ["Department of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden. mderosa@fondazionerimed.com.", "Drug Discovery Unit, Ri.MED Foundation, 90133 Palermo, Italy. mderosa@fondazionerimed.com."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0723571cbae046a3b06daacced710bd9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0723571cbae046a3b06daacced710bd9"}}, "publications": [{"entity": "publication", "iuid": "f231ab25ca63453aabd43fca29e1bc82", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f231ab25ca63453aabd43fca29e1bc82.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f231ab25ca63453aabd43fca29e1bc82"}}, "title": "Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer.", "authors": [{"family": "Mitran", "given": "Bogdan", "initials": "B"}, {"family": "Varasteh", "given": "Zohreh", "initials": "Z"}, {"family": "Abouzayed", "given": "Ayman", "initials": "A"}, {"family": "Rinne", "given": "Sara S", "initials": "SS"}, {"family": "Puuvuori", "given": "Emmi", "initials": "E"}, {"family": "De Rosa", "given": "Maria", "initials": "M", "orcid": "0000-0002-4087-2554", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0723571cbae046a3b06daacced710bd9.json"}}, {"family": "Larhed", "given": "Mats", "initials": "M", "orcid": "0000-0001-6258-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/225695195abc4233bd141e6858e72e7f.json"}}, {"family": "Tolmachev", "given": "Vladimir", "initials": "V", "orcid": "0000-0002-6122-1734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/896ae9fae8b74251afe11b4354c62794.json"}}, {"family": "Orlova", "given": "Anna", "initials": "A", "orcid": "0000-0001-6120-2683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c374f429702489494c05f84f298b4b7.json"}}, {"family": "Rosenstr\u00f6m", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-0817-8140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec6820fcb786475d85969630b0b3860b.json"}}], "type": "journal article", "published": "2019-09-14", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "11", "issue": "9", "issn-l": "2072-6694"}, "abstract": "Simultaneous targeting of the prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) could improve the diagnostic accuracy in prostate cancer (PCa). The aim of this study was to develop a PSMA/GRPR-targeting bispecific heterodimer for SPECT and positron emission tomography (PET) diagnostic imaging of PCa. The heterodimer NOTA-DUPA-RM26 was produced by manual solid-phase peptide synthesis. NOTA-DUPA-RM26 was labeled with 111In and 68Ga, with yields >98%, and demonstrated a high stability and binding specificity to PSMA and GRPR. IC50 values for natIn-NOTA-DUPA-RM26 were 4 \u00b1 1 nM towards GRPR and 824 \u00b1 230 nM towards PSMA. An in vivo binding specificity 1 h pi of 111In-NOTA-DUPA-RM26 in PC3-PIP-xenografted mice demonstrated partially blockable tumor uptake when co-injected with an excess of PSMA- or GRPR-targeting agents. Simultaneous co-injection of both agents induced pronounced blocking. The biodistribution of 111In-NOTA-DUPA-RM26 and 68Ga-NOTA-DUPA-RM26 revealed fast activity clearance from the blood and normal organs via the kidneys. Tumor uptake exceeded normal organ uptake for both analogs 1 h pi. 68Ga-NOTA-DUPA-RM26 had a significantly lower tumor uptake (8 \u00b1 2%ID/g) compared to 111In-NOTA-DUPA-RM26 (12 \u00b1 2%ID/g) 1 h pi. Tumor-to-organ ratios increased 3 h pi, but decreased 24 h pi, for 111In-NOTA-DUPA-RM26. MicroPET/CT and microSPECT/CT scans confirmed biodistribution data, suggesting that 68Ga-NOTA-DUPA-RM26 and 111In-NOTA-DUPA-RM26 are suitable candidates for the imaging of GRPR and PSMA expression in PCa shortly after administration.", "doi": "10.3390/cancers11091371", "pmid": "31540122", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6771040"}, {"db": "pii", "key": "cancers11091371"}], "notes": [], "created": "2026-08-20T13:39:15.966Z", "modified": "2026-08-20T13:39:16.126Z"}]}