{"entity": "researcher", "timestamp": "2026-08-20T20:40:13.184Z", "family": "Al-Khalili Szigyarto", "given": "Cristina", "initials": "C", "orcid": "0000-0001-6990-1905", "affiliations": ["Department of Protein Sciences, SciLifeLab, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.", "Department of Protein Science, School of Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/050a127d5c354a2193d1aece35faa945.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/050a127d5c354a2193d1aece35faa945"}}, "publications": [{"entity": "publication", "iuid": "ac56650841ad46d4bea428f32815d5d4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ac56650841ad46d4bea428f32815d5d4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ac56650841ad46d4bea428f32815d5d4"}}, "title": "Identification of Gene\u2010Therapy Responsive Blood Biomarkers in mdx Mouse Model", "authors": [{"family": "Johansson", "given": "Camilla", "initials": "C"}, {"family": "Boehler", "given": "Jessica F", "initials": "JF"}, {"family": "Brown", "given": "Kristy J", "initials": "KJ"}, {"family": "Koeks", "given": "Za\u00efda", "initials": "Z"}, {"family": "Schrama", "given": "Esther J", "initials": "EJ"}, {"family": "van de Velde", "given": "Nienke", "initials": "N"}, {"family": "Verschuuren", "given": "Jan J G M", "initials": "JJGM"}, {"family": "Niks", "given": "Erik H", "initials": "EH"}, {"family": "Spitali", "given": "Pietro", "initials": "P"}, {"family": "Al\u2010Khalili\u00a0Szigyarto", "given": "Cristina", "initials": "C", "orcid": "0000-0001-6990-1905", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/050a127d5c354a2193d1aece35faa945.json"}}], "type": "journal-article", "published": "2024-07-00", "journal": {"title": "JCSM Communications", "issn": "2996-1394", "volume": "7", "issue": "2", "pages": "187-198", "issn-l": null}, "abstract": null, "doi": "10.1002/rco2.112", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:35:38.016Z", "modified": "2026-08-20T06:35:38.106Z"}, {"entity": "publication", "iuid": "92e866687d044f5cad569256e78f7449", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/92e866687d044f5cad569256e78f7449.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/92e866687d044f5cad569256e78f7449"}}, "title": "A Proof of Principle Proteomic Study Detects Dystrophin in Human Plasma: Implications in DMD Diagnosis and Clinical Monitoring.", "authors": [{"family": "Rossi", "given": "Rachele", "initials": "R"}, {"family": "Johansson", "given": "Camilla", "initials": "C"}, {"family": "Heywood", "given": "Wendy", "initials": "W"}, {"family": "Vinette", "given": "Heloise", "initials": "H", "orcid": "0009-0000-4360-1293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/afa61243ab3944b3881d66c739cd0fd5.json"}}, {"family": "Jensen", "given": "Gabriella", "initials": "G"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Jim\u00e9nez-Requena", "given": "Albert", "initials": "A"}, {"family": "Torelli", "given": "Silvia", "initials": "S"}, {"family": "Al-Khalili Szigyarto", "given": "Cristina", "initials": "C", "orcid": "0000-0001-6990-1905", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/050a127d5c354a2193d1aece35faa945.json"}}, {"family": "Ferlini", "given": "Alessandra", "initials": "A", "orcid": "0000-0001-8385-9870", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d4d8e209276d4c8094cd74d96988bff4.json"}}], "type": "journal article", "published": "2023-03-08", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "24", "issue": "6", "issn-l": null}, "abstract": "Duchenne muscular dystrophy (DMD) is a rare neuromuscular disease caused by pathogenic variations in the DMD gene. There is a need for robust DMD biomarkers for diagnostic screening and to aid therapy monitoring. Creatine kinase, to date, is the only routinely used blood biomarker for DMD, although it lacks specificity and does not correlate with disease severity. To fill this critical gap, we present here novel data about dystrophin protein fragments detected in human plasma by a suspension bead immunoassay using two validated anti-dystrophin-specific antibodies. Using both antibodies, a reduction of the dystrophin signal is detected in a small cohort of plasma samples from DMD patients when compared to healthy controls, female carriers, and other neuromuscular diseases. We also demonstrate the detection of dystrophin protein by an antibody-independent method using targeted liquid chromatography mass spectrometry. This last assay detects three different dystrophin peptides in all healthy individuals analysed and supports our finding that dystrophin protein is detectable in plasma. The results of our proof-of-concept study encourage further studies in larger sample cohorts to investigate the value of dystrophin protein as a low invasive blood biomarker for diagnostic screening and clinical monitoring of DMD.", "doi": "10.3390/ijms24065215", "pmid": "36982290", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10049465"}, {"db": "pii", "key": "ijms24065215"}], "notes": [], "created": "2026-08-20T13:41:40.286Z", "modified": "2026-08-20T13:41:40.438Z"}, {"entity": "publication", "iuid": "36447f6425334b0e9848fbb92a4f5a10", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/36447f6425334b0e9848fbb92a4f5a10.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/36447f6425334b0e9848fbb92a4f5a10"}}, "title": "Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy.", "authors": [{"family": "Signorelli", "given": "Mirko", "initials": "M", "orcid": "0000-0002-8102-3356", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/245cac089dea46b998ff175a8172b810.json"}}, {"family": "Ayoglu", "given": "Burcu", "initials": "B", "orcid": "0000-0001-8277-8999", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6411a998eeb940da8c2aa58a8d07ed70.json"}}, {"family": "Johansson", "given": "Camilla", "initials": "C"}, {"family": "Lochm\u00fcller", "given": "Hanns", "initials": "H", "orcid": "0000-0003-2324-8001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38f9670dd942483b92c7eb4e6ea96e9a.json"}}, {"family": "Straub", "given": "Volker", "initials": "V", "orcid": "0000-0001-9046-3540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/211f5ab5067648a5863873ac10f7edd9.json"}}, {"family": "Muntoni", "given": "Francesco", "initials": "F", "orcid": "0000-0002-9102-5232", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a58bfaeb32be4d198c3f9db63327b82e.json"}}, {"family": "Niks", "given": "Erik", "initials": "E", "orcid": "0000-0001-5892-5143", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bebfa8d914564e7383808dfc074f6393.json"}}, {"family": "Tsonaka", "given": "Roula", "initials": "R", "orcid": "0000-0002-3466-5401", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bbb1ce2569748449429d518668dd8c5.json"}}, {"family": "Persson", "given": "Anja", "initials": "A"}, {"family": "Aartsma-Rus", "given": "Annemieke", "initials": "A", "orcid": "0000-0003-1565-654X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a89779326d4545bb992a0c206f4e3cf1.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Al-Khalili Szigyarto", "given": "Cristina", "initials": "C", "orcid": "0000-0001-6990-1905", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/050a127d5c354a2193d1aece35faa945.json"}}, {"family": "Spitali", "given": "Pietro", "initials": "P", "orcid": "0000-0003-2783-688X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4655f0e8ec864789b4f2d6ca4c613c54.json"}}], "type": "journal article", "published": "2020-04-00", "journal": {"title": "J Cachexia Sarcopenia Muscle", "issn": "2190-6009", "volume": "11", "issue": "2", "pages": "505-517", "issn-l": null}, "abstract": "Duchenne muscular dystrophy (DMD) is a fatal disease for which no cure is available. Clinical trials have shown to be largely underpowered due to inter-individual variability and noisy outcome measures. The availability of biomarkers able to anticipate clinical benefit is highly needed to improve clinical trial design and facilitate drug development.\n\nIn this study, we aimed to appraise the value of protein biomarkers to predict prognosis and monitor disease progression or treatment outcome in patients affected by DMD. We collected clinical data and 303 blood samples from 157 DMD patients in three clinical centres; 78 patients contributed multiple blood samples over time, with a median follow-up time of 2 years. We employed linear mixed models to identify biomarkers that are associated with disease progression, wheelchair dependency, and treatment with corticosteroids and performed survival analysis to find biomarkers whose levels are associated with time to loss of ambulation.\n\nOur analysis led to the identification of 21 proteins whose levels significantly decrease with age and nine proteins whose levels significantly increase. Seven of these proteins are also differentially expressed in non-ambulant patients, and three proteins are differentially expressed in patients treated with glucocorticosteroids. Treatment with corticosteroids was found to partly counteract the effect of disease progression on two biomarkers, namely, malate dehydrogenase 2 (MDH2, P = 0.0003) and ankyrin repeat domain 2 (P = 0.0005); however, patients treated with corticosteroids experienced a further reduction on collagen 1 serum levels (P = 0.0003), especially following administration of deflazacort. A time to event analysis allowed to further support the use of MDH2 as a prognostic biomarker as it was associated with an increased risk of wheelchair dependence (P = 0.0003). The obtained data support the prospective evaluation of the identified biomarkers in natural history and clinical trials as exploratory biomarkers.\n\nWe identified a number of serum biomarkers associated with disease progression, loss of ambulation, and treatment with corticosteroids. The identified biomarkers are promising candidate prognostic and surrogate biomarkers, which may support drug developers if confirmed in prospective studies. The serum levels of MDH2 are of particular interest, as they correlate with disease stage and response to treatment with corticosteroids, and are also associated with the risk of wheelchair dependency and pulmonary function.", "doi": "10.1002/jcsm.12517", "pmid": "31881125", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7113516"}], "notes": [], "created": "2026-08-20T06:34:03.516Z", "modified": "2026-08-20T06:34:03.973Z"}, {"entity": "publication", "iuid": "3fcd57a067db4e33a90326d550a72e4b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3fcd57a067db4e33a90326d550a72e4b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3fcd57a067db4e33a90326d550a72e4b"}}, "title": "Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.", "authors": [{"family": "Kennedy", "given": "Susan A", "initials": "SA"}, {"family": "Jarboui", "given": "Mohamed-Ali", "initials": "MA", "orcid": "0000-0002-5203-235X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66898fad22524e0eb7721b7aa71dc62a.json"}}, {"family": "Srihari", "given": "Sriganesh", "initials": "S"}, {"family": "Raso", "given": "Cinzia", "initials": "C"}, {"family": "Bryan", "given": "Kenneth", "initials": "K"}, {"family": "Dernayka", "given": "Layal", "initials": "L"}, {"family": "Charitou", "given": "Theodosia", "initials": "T"}, {"family": "Bernal-Llinares", "given": "Manuel", "initials": "M", "orcid": "0000-0002-7368-180X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22200b3dbd6641cebc812d66163a0d55.json"}}, {"family": "Herrera-Montavez", "given": "Carlos", "initials": "C"}, {"family": "Krstic", "given": "Aleksandar", "initials": "A"}, {"family": "Matallanas", "given": "David", "initials": "D", "orcid": "0000-0002-2360-3141", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7553949877143a3a8888fcb72916d91.json"}}, {"family": "Kotlyar", "given": "Max", "initials": "M"}, {"family": "Jurisica", "given": "Igor", "initials": "I"}, {"family": "Curak", "given": "Jasna", "initials": "J"}, {"family": "Wong", "given": "Victoria", "initials": "V"}, {"family": "Stagljar", "given": "Igor", "initials": "I", "orcid": "0000-0002-5260-3327", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f52a357d31524cd88b3692d749839e0d.json"}}, {"family": "LeBihan", "given": "Thierry", "initials": "T"}, {"family": "Imrie", "given": "Lisa", "initials": "L", "orcid": "0000-0003-1115-1720", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c243c84e2b724b0fa6c1dd925fd26530.json"}}, {"family": "Pillai", "given": "Priyanka", "initials": "P"}, {"family": "Lynn", "given": "Miriam A", "initials": "MA"}, {"family": "Fasterius", "given": "Erik", "initials": "E", "orcid": "0000-0003-0492-9960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6089752ffef34552a0b1aac7ae9dcb14.json"}}, {"family": "Al-Khalili Szigyarto", "given": "Cristina", "initials": "C", "orcid": "0000-0001-6990-1905", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/050a127d5c354a2193d1aece35faa945.json"}}, {"family": "Breen", "given": "James", "initials": "J"}, {"family": "Kiel", "given": "Christina", "initials": "C"}, {"family": "Serrano", "given": "Luis", "initials": "L", "orcid": "0000-0002-5276-1392", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f26d4773a744cb9ab7573ebfc10fdfb.json"}}, {"family": "Rauch", "given": "Nora", "initials": "N", "orcid": "0000-0001-6009-5177", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e7e19c1988a3480aa3f080e728b771aa.json"}}, {"family": "Rukhlenko", "given": "Oleksii", "initials": "O"}, {"family": "Kholodenko", "given": "Boris N", "initials": "BN"}, {"family": "Iglesias-Martinez", "given": "Luis F", "initials": "LF"}, {"family": "Ryan", "given": "Colm J", "initials": "CJ", "orcid": "0000-0003-2750-9854", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/52c899190e7847a1ab8f45d976458fc9.json"}}, {"family": "Pilkington", "given": "Ruth", "initials": "R"}, {"family": "Cammareri", "given": "Patrizia", "initials": "P"}, {"family": "Sansom", "given": "Owen", "initials": "O", "orcid": "0000-0001-9540-3010", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/785258a0a98445669cd3593f67a7402a.json"}}, {"family": "Shave", "given": "Steven", "initials": "S", "orcid": "0000-0001-6996-3663", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58f1cb976fe74d8eb9ce50465b46f4ec.json"}}, {"family": "Auer", "given": "Manfred", "initials": "M", "orcid": "0000-0001-8920-3522", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cac46fc8e154326a196d64bbe41557d.json"}}, {"family": "Horn", "given": "Nicola", "initials": "N"}, {"family": "Klose", "given": "Franziska", "initials": "F"}, {"family": "Ueffing", "given": "Marius", "initials": "M"}, {"family": "Boldt", "given": "Karsten", "initials": "K", "orcid": "0000-0002-2693-689X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/902be55dfb1748079935fca1f2e7d293.json"}}, {"family": "Lynn", "given": "David J", "initials": "DJ"}, {"family": "Kolch", "given": "Walter", "initials": "W", "orcid": "0000-0001-5777-5016", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6640e523e6b847a58f5b739f5b71bfff.json"}}], "type": "journal article", "published": "2020-01-24", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "11", "issue": "1", "pages": "499", "issn-l": "2041-1723"}, "abstract": "Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is extensively rewired in cells expressing transforming levels of KRASG13D (mtKRAS). The factors driving PPIN rewiring are multifactorial including changes in protein expression and phosphorylation. Mathematical modelling also suggests that the binding dynamics of low and high affinity KRAS interactors contribute to rewiring. PPIN rewiring substantially alters the composition of protein complexes, signal flow, transcriptional regulation, and cellular phenotype. These changes are validated by targeted and global experimental analysis. Importantly, genetic alterations in the most extensively rewired PPIN nodes occur frequently in CRC and are prognostic of poor patient outcomes.", "doi": "10.1038/s41467-019-14224-9", "pmid": "31980649", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6981206"}, {"db": "pii", "key": "10.1038/s41467-019-14224-9"}], "notes": [], "created": "2026-08-20T08:50:56.505Z", "modified": "2026-08-20T08:50:57.116Z"}, {"entity": "publication", "iuid": "1dcbe23c696745149f28d85bde14f62e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1dcbe23c696745149f28d85bde14f62e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1dcbe23c696745149f28d85bde14f62e"}}, "title": "seqCAT: a Bioconductor R-package for variant analysis of high throughput sequencing data", "authors": [{"family": "Fasterius", "given": "Erik", "initials": "E", "orcid": "0000-0003-0492-9960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6089752ffef34552a0b1aac7ae9dcb14.json"}}, {"family": "Al-Khalili Szigyarto", "given": "Cristina", "initials": "C", "orcid": "0000-0001-6990-1905", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/050a127d5c354a2193d1aece35faa945.json"}}], "type": "journal-article", "published": "2019-08-12", "journal": {"title": "F1000Res", "issn": "2046-1402", "volume": "7", "pages": "1466", "issn-l": "2046-1402"}, "abstract": null, "doi": "10.12688/f1000research.16083.2", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:41:33.113Z", "modified": "2026-08-20T12:41:33.186Z"}, {"entity": "publication", "iuid": "20f14a50c2a949df9c420d8a0892e6c9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/20f14a50c2a949df9c420d8a0892e6c9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/20f14a50c2a949df9c420d8a0892e6c9"}}, "title": "Single-cell RNA-seq variant analysis for exploration of genetic heterogeneity in cancer.", "authors": [{"family": "Fasterius", "given": "Erik", "initials": "E", "orcid": "0000-0003-0492-9960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6089752ffef34552a0b1aac7ae9dcb14.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Al-Khalili Szigyarto", "given": "Cristina", "initials": "C", "orcid": "0000-0001-6990-1905", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/050a127d5c354a2193d1aece35faa945.json"}}], "type": "journal article", "published": "2019-07-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "9", "issue": "1", "pages": "9524", "issn-l": "2045-2322"}, "abstract": "Inter- and intra-tumour heterogeneity is caused by genetic and non-genetic factors, leading to severe clinical implications. High-throughput sequencing technologies provide unprecedented tools to analyse DNA and RNA in single cells and explore both genetic heterogeneity and phenotypic variation between cells in tissues and tumours. Simultaneous analysis of both DNA and RNA in the same cell is, however, still in its infancy. We have thus developed a method to extract and analyse information regarding genetic heterogeneity that affects cellular biology from single-cell RNA-seq data. The method enables both comparisons and clustering of cells based on genetic variation in single nucleotide variants, revealing cellular subpopulations corroborated by gene expression-based methods. Furthermore, the results show that lymph node metastases have lower levels of genetic heterogeneity compared to their original tumours with respect to variants affecting protein function. The analysis also revealed three previously unknown variants common across cancer cells in glioblastoma patients. These results demonstrate the power and versatility of scRNA-seq variant analysis and highlight it as a useful complement to already existing methods, enabling simultaneous investigations of both gene expression and genetic variation.", "doi": "10.1038/s41598-019-45934-1", "pmid": "31267007", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6606766"}, {"db": "pii", "key": "10.1038/s41598-019-45934-1"}], "notes": [], "created": "2026-08-20T09:04:38.112Z", "modified": "2026-08-20T09:04:38.204Z"}, {"entity": "publication", "iuid": "1ffe23527e7947daaea4323d5bbc5c3f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1ffe23527e7947daaea4323d5bbc5c3f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1ffe23527e7947daaea4323d5bbc5c3f"}}, "title": "seqCAT: a Bioconductor R-package for variant analysis of high throughput sequencing data", "authors": [{"family": "Fasterius", "given": "Erik", "initials": "E", "orcid": "0000-0003-0492-9960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6089752ffef34552a0b1aac7ae9dcb14.json"}}, {"family": "Al-Khalili Szigyarto", "given": "Cristina", "initials": "C", "orcid": "0000-0001-6990-1905", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/050a127d5c354a2193d1aece35faa945.json"}}], "type": "journal-article", "published": "2018-09-14", "journal": {"title": "F1000Res", "issn": "2046-1402", "volume": "7", "pages": "1466", "issn-l": "2046-1402"}, "abstract": null, "doi": "10.12688/f1000research.16083.1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:41:31.302Z", "modified": "2026-08-20T12:41:31.396Z"}]}