{"entity": "researcher", "timestamp": "2026-08-20T20:58:16.530Z", "family": "Vi\u00f1uela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "affiliations": ["Biosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, NE1 4EP, United Kingdom. ana.vinuela@newcastle.ac.uk."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4"}}, "publications": [{"entity": "publication", "iuid": "97dcb877641d4da1b812ef995b72d5d3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/97dcb877641d4da1b812ef995b72d5d3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/97dcb877641d4da1b812ef995b72d5d3"}}, "title": "Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.", "authors": [{"family": "Brown", "given": "Andrew A", "initials": "AA", "orcid": "0000-0002-8087-3033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b690d27df56b44dc8a070e4265afc8ca.json"}}, {"family": "Fernandez-Tajes", "given": "Juan J", "initials": "JJ"}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Brorsson", "given": "Caroline A", "initials": "CA"}, {"family": "Koivula", "given": "Robert W", "initials": "RW"}, {"family": "Davtian", "given": "David", "initials": "D"}, {"family": "Dupuis", "given": "Th\u00e9o", "initials": "T"}, {"family": "Sartori", "given": "Ambra", "initials": "A"}, {"family": "Michalettou", "given": "Theodora-Dafni", "initials": "TD", "orcid": "0000-0003-2119-1099", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0a44cd4ea604ce4a93b16870965dcc2.json"}}, {"family": "Forgie", "given": "Ian M", "initials": "IM"}, {"family": "Adam", "given": "Jonathan", "initials": "J"}, {"family": "Allin", "given": "Kristine H", "initials": "KH"}, {"family": "Caiazzo", "given": "Robert", "initials": "R", "orcid": "0000-0001-5383-0540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/155b9c8799064e04be5118147542a25c.json"}}, {"family": "Cederberg", "given": "Henna", "initials": "H"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Elders", "given": "Petra J M", "initials": "PJM"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN", "orcid": "0000-0002-6719-6680", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc30138be60e49d481bfc5f03a8fe61f.json"}}, {"family": "Haid", "given": "Mark", "initials": "M", "orcid": "0000-0001-6118-1333", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4398da6ddb245bdb982ac3a0b352c40.json"}}, {"family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}}, {"family": "Hansen", "given": "Tue H", "initials": "TH", "orcid": "0000-0001-5948-8993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73418e2efdc1459483138da74b0abad6.json"}}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-5620-473X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfbb9bb951f04ed3ac56eb4890d3186a.json"}}, {"family": "Heggie", "given": "Alison J", "initials": "AJ"}, {"family": "Howald", "given": "C\u00e9dric", "initials": "C"}, {"family": "Jones", "given": "Angus G", "initials": "AG", "orcid": "0000-0002-0883-7599", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb98d0951469460d8e87bbd7e71741db.json"}}, {"family": "Kokkola", "given": "Tarja", "initials": "T", "orcid": "0000-0002-3303-3912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc389880431a46e49fcbe0eae12908ea.json"}}, {"family": "Laakso", "given": "Markku", "initials": "M", "orcid": "0000-0002-3394-7749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81c631c24b2e4c479ac6976eab7b1e88.json"}}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Mari", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1436-5591", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b7dd1ab06074d1188e40713d8807c48.json"}}, {"family": "McDonald", "given": "Timothy J", "initials": "TJ"}, {"family": "McEvoy", "given": "Donna", "initials": "D"}, {"family": "Mourby", "given": "Miranda", "initials": "M"}, {"family": "Musholt", "given": "Petra B", "initials": "PB"}, {"family": "Nilsson", "given": "Birgitte", "initials": "B"}, {"family": "Pattou", "given": "Francois", "initials": "F", "orcid": "0000-0001-8388-3766", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0769cc7e166943cb98978c45c12d749a.json"}}, {"family": "Penet", "given": "Deborah", "initials": "D"}, {"family": "Raverdy", "given": "Violeta", "initials": "V"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M"}, {"family": "Romano", "given": "Luciana", "initials": "L"}, {"family": "Rutters", "given": "Femke", "initials": "F"}, {"family": "Sharma", "given": "Sapna", "initials": "S"}, {"family": "Teare", "given": "Harriet", "initials": "H"}, {"family": "'t Hart", "given": "Leen", "initials": "L", "orcid": "0000-0003-4401-2938", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c36c8ed413ed4d6f975341fe511035e3.json"}}, {"family": "Tsirigos", "given": "Konstantinos D", "initials": "KD"}, {"family": "Vangipurapu", "given": "Jagadish", "initials": "J"}, {"family": "Vestergaard", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3090-269X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2fa5c4f74894d6a833afd105ec72848.json"}}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8263a26f474946de8b61a2080051d37b.json"}}, {"family": "Frost", "given": "Gary", "initials": "G", "orcid": "0000-0003-0529-6325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/894534933d064d1f802f1690ea56f162.json"}}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Jablonka", "given": "Bernd", "initials": "B"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Pavo", "given": "Imre", "initials": "I", "orcid": "0000-0002-2016-7049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1691b459fdb84772b1e8595e8de617f3.json"}}, {"family": "Pedersen", "given": "Oluf", "initials": "O", "orcid": "0000-0002-3321-3972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0ef37542aea4e67a322b0d6179cd59e.json"}}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "DIRECT Consortium", "given": "", "initials": ""}, {"family": "Adamski", "given": "Jerzy", "initials": "J", "orcid": "0000-0001-9259-0199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6871f2a0d4414a58be2e7f26a59d3ca9.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Pearson", "given": "Ewan R", "initials": "ER", "orcid": "0000-0001-9237-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e27e9e47f1cc4a969268eb5a65b8045b.json"}}, {"family": "Dermitzakis", "given": "Emmanouil T", "initials": "ET", "orcid": "0000-0002-9302-6490", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6683f17defc34cad9389fd7fef36aca4.json"}}, {"family": "Vi\u00f1uela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}], "type": "journal article", "published": "2023-08-21", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "5062", "issn-l": "2041-1723"}, "abstract": "We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic regulation is detected between gene expression and proteins (66.6%), with a further median shared genetic associations across 49 different tissues of 78.3% and 62.4% between plasma proteins and gene expression. We represent the genetic and molecular associations in networks including 2828 known GWAS variants, showing that GWAS variants are more often connected to gene expression in trans than other molecular phenotypes in the network. Our work provides a roadmap to understanding molecular networks and deriving the underlying mechanism of action of GWAS variants using different molecular phenotypes in an accessible tissue.", "doi": "10.1038/s41467-023-40569-3", "pmid": "37604891", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10442420"}, {"db": "pii", "key": "10.1038/s41467-023-40569-3"}], "notes": [], "created": "2026-08-20T08:52:44.576Z", "modified": "2026-08-20T08:52:45.407Z"}, {"entity": "publication", "iuid": "ca320476e9aa498aaac894559da40b92", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ca320476e9aa498aaac894559da40b92.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ca320476e9aa498aaac894559da40b92"}}, "title": "Author Correction: Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.", "authors": [{"family": "Alles\u00f8e", "given": "Rosa Lundbye", "initials": "RL"}, {"family": "Lundgaard", "given": "Agnete Troen", "initials": "AT", "orcid": "0000-0001-7447-6560", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6d31459d60f4ce789790f6a6ef62328.json"}}, {"family": "Hern\u00e1ndez Medina", "given": "Ricardo", "initials": "R", "orcid": "0000-0001-6373-2362", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca886502c85a48b88ffca91c7bfd4199.json"}}, {"family": "Aguayo-Orozco", "given": "Alejandro", "initials": "A"}, {"family": "Johansen", "given": "Joachim", "initials": "J", "orcid": "0000-0001-7052-1870", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6632c093611e4773aa14b1e81d23e32d.json"}}, {"family": "Nissen", "given": "Jakob Nybo", "initials": "JN"}, {"family": "Brorsson", "given": "Caroline", "initials": "C"}, {"family": "Mazzoni", "given": "Gianluca", "initials": "G"}, {"family": "Niu", "given": "Lili", "initials": "L", "orcid": "0000-0003-4571-4368", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0bd02c00c9ed4bf6998b7d53a4869eaa.json"}}, {"family": "Biel", "given": "Jorge Hernansanz", "initials": "JH", "orcid": "0000-0002-3125-2951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4f7b4e611404a14babf48998278717b.json"}}, {"family": "Leal Rodr\u00edguez", "given": "Cristina", "initials": "C", "orcid": "0000-0002-3133-0630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/191706530d834312a25dc1135308064c.json"}}, {"family": "Brasas", "given": "Valentas", "initials": "V"}, {"family": "Webel", "given": "Henry", "initials": "H"}, {"family": "Benros", "given": "Michael Eriksen", "initials": "ME", "orcid": "0000-0003-4939-9465", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d2caccd100b4dbcba0be788cdcafedc.json"}}, {"family": "Pedersen", "given": "Anders Gorm", "initials": "AG", "orcid": "0000-0001-9650-8965", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3131dd5c0ceb4935a15971a8f621d41d.json"}}, {"family": "Chmura", "given": "Piotr Jaroslaw", "initials": "PJ"}, {"family": "Jacobsen", "given": "Ulrik Plesner", "initials": "UP", "orcid": "0000-0001-9181-6854", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce035ed82b6f456d8a1f08b12f77f68e.json"}}, {"family": "Mari", "given": "Andrea", "initials": "A"}, {"family": "Koivula", "given": "Robert", "initials": "R", "orcid": "0000-0002-1646-4163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ceb821c78774b9f8931463351046f1f.json"}}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Vinuela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}, {"family": "Tajes", "given": "Juan Fernandez", "initials": "JF"}, {"family": "Sharma", "given": "Sapna", "initials": "S"}, {"family": "Haid", "given": "Mark", "initials": "M", "orcid": "0000-0001-6118-1333", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4398da6ddb245bdb982ac3a0b352c40.json"}}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Musholt", "given": "Petra B", "initials": "PB"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Vogt", "given": "Josef", "initials": "J"}, {"family": "Pedersen", "given": "Helle Krogh", "initials": "HK"}, {"family": "Gudmundsdottir", "given": "Valborg", "initials": "V"}, {"family": "Jones", "given": "Angus", "initials": "A"}, {"family": "Kennedy", "given": "Gwen", "initials": "G", "orcid": "0000-0002-9856-3236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06b17b204aaa442293ac0b9981b84b43.json"}}, {"family": "Bell", "given": "Jimmy", "initials": "J"}, {"family": "Thomas", "given": "E Louise", "initials": "EL", "orcid": "0000-0003-4235-4694", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b85b142cc9748669e6b24272efb4728.json"}}, {"family": "Frost", "given": "Gary", "initials": "G", "orcid": "0000-0003-0529-6325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/894534933d064d1f802f1690ea56f162.json"}}, {"family": "Thomsen", "given": "Henrik", "initials": "H"}, {"family": "Hansen", "given": "Elizaveta", "initials": "E"}, {"family": "Hansen", "given": "Tue Haldor", "initials": "TH", "orcid": "0000-0001-5948-8993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73418e2efdc1459483138da74b0abad6.json"}}, {"family": "Vestergaard", "given": "Henrik", "initials": "H"}, {"family": "Muilwijk", "given": "Mirthe", "initials": "M"}, {"family": "Blom", "given": "Marieke T", "initials": "MT"}, {"family": "'t Hart", "given": "Leen M", "initials": "LM"}, {"family": "Pattou", "given": "Francois", "initials": "F"}, {"family": "Raverdy", "given": "Violeta", "initials": "V"}, {"family": "Brage", "given": "Soren", "initials": "S"}, {"family": "Kokkola", "given": "Tarja", "initials": "T"}, {"family": "Heggie", "given": "Alison", "initials": "A"}, {"family": "McEvoy", "given": "Donna", "initials": "D"}, {"family": "Mourby", "given": "Miranda", "initials": "M"}, {"family": "Kaye", "given": "Jane", "initials": "J", "orcid": "0000-0002-7311-4725", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/119626aab80347b08e5143547fc8d921.json"}}, {"family": "Hattersley", "given": "Andrew", "initials": "A", "orcid": "0000-0001-5620-473X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfbb9bb951f04ed3ac56eb4890d3186a.json"}}, {"family": "McDonald", "given": "Timothy", "initials": "T"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M", "orcid": "0000-0002-3270-9167", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ce961d525f784428b1b6cdd4d3ed0c1a.json"}}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Forgie", "given": "Ian", "initials": "I"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN"}, {"family": "Pavo", "given": "Imre", "initials": "I"}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Pedersen", "given": "Oluf", "initials": "O", "orcid": "0000-0002-3321-3972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0ef37542aea4e67a322b0d6179cd59e.json"}}, {"family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}}, {"family": "Dermitzakis", "given": "Emmanouil", "initials": "E"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Adamski", "given": "Jerzy", "initials": "J"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Pearson", "given": "Ewan", "initials": "E"}, {"family": "Banasik", "given": "Karina", "initials": "K"}, {"family": "Rasmussen", "given": "Simon", "initials": "S", "orcid": "0000-0001-6323-9041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65dab4aefc624749a6b8d003bcd54200.json"}}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S", "orcid": "0000-0003-0316-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/560f89e3ea56424fb96ca55aad9b9814.json"}}, {"family": "IMI DIRECT Consortium", "given": "", "initials": ""}], "type": "published erratum", "published": "2023-07-00", "journal": {"title": "Nat. Biotechnol.", "issn": "1546-1696", "volume": "41", "issue": "7", "pages": "1026", "issn-l": "1087-0156"}, "abstract": null, "doi": "10.1038/s41587-023-01805-9", "pmid": "37130959", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10344774"}, {"db": "pii", "key": "10.1038/s41587-023-01805-9"}], "notes": [], "created": "2026-08-20T08:59:30.416Z", "modified": "2026-08-20T08:59:31.137Z"}, {"entity": "publication", "iuid": "0a5faded2b8248c6be219660ec518362", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0a5faded2b8248c6be219660ec518362.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0a5faded2b8248c6be219660ec518362"}}, "title": "Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study", "authors": [{"family": "Vi\u00f1uela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}, {"family": "Brown", "given": "Andrew A", "initials": "AA", "orcid": "0000-0002-8087-3033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b690d27df56b44dc8a070e4265afc8ca.json"}}, {"family": "Fernandez", "given": "Juan", "initials": "J"}, {"family": "Hong", "given": "Mun Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Brorsson", "given": "Caroline A", "initials": "CA", "orcid": "0000-0003-3473-1744", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93356b705c444fe883e86e24c76f8abd.json"}}, {"family": "Koivula", "given": "Robert W", "initials": "RW", "orcid": "0000-0002-1646-4163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ceb821c78774b9f8931463351046f1f.json"}}, {"family": "Davtian", "given": "David", "initials": "D", "orcid": "0000-0001-8785-3126", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e71fda3af4a94ee2bb6d84f6a3687c06.json"}}, {"family": "Dupuis", "given": "Th\u00e9o", "initials": "T"}, {"family": "Forgie", "given": "Ian M", "initials": "IM", "orcid": "0000-0002-8800-6145", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a6af8dca397443db706aeb078df7e92.json"}}, {"family": "Adam", "given": "Jonathan", "initials": "J"}, {"family": "Allin", "given": "Kristine H", "initials": "KH"}, {"family": "Caiazzo", "given": "Robert", "initials": "R"}, {"family": "Cederberg", "given": "Henna", "initials": "H"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Elders", "given": "Petra J M", "initials": "PJM"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN"}, {"family": "Haid", "given": "Mark", "initials": "M", "orcid": "0000-0001-6118-1333", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4398da6ddb245bdb982ac3a0b352c40.json"}}, {"family": "Hansen", "given": "Torben", "initials": "T"}, {"family": "Hansen", "given": "Tue", "initials": "T"}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT"}, {"family": "Heggie", "given": "Alison J", "initials": "AJ"}, {"family": "Howald", "given": "C\u00e9dric", "initials": "C"}, {"family": "Jones", "given": "Angus G", "initials": "AG"}, {"family": "Kokkola", "given": "Tarja", "initials": "T", "orcid": "0000-0002-3303-3912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc389880431a46e49fcbe0eae12908ea.json"}}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "Mahajan", "given": "Anubha", "initials": "A", "orcid": "0000-0001-5585-3420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41b3d44662484e0289f07fa25d045cf4.json"}}, {"family": "Mari", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1436-5591", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b7dd1ab06074d1188e40713d8807c48.json"}}, {"family": "McDonald", "given": "Timothy J", "initials": "TJ"}, {"family": "McEvoy", "given": "Donna", "initials": "D"}, {"family": "Mourby", "given": "Miranda", "initials": "M"}, {"family": "Musholt", "given": "Petra", "initials": "P"}, {"family": "Nilsson", "given": "Birgitte", "initials": "B"}, {"family": "Pattou", "given": "Fran\u00e7ois", "initials": "F", "orcid": "0000-0001-8388-3766", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0769cc7e166943cb98978c45c12d749a.json"}}, {"family": "Penet", "given": "Deborah", "initials": "D"}, {"family": "Raverdy", "given": "Violeta", "initials": "V"}, {"family": "Ridderstrale", "given": "Martin", "initials": "M"}, {"family": "Romano", "given": "Luciana", "initials": "L"}, {"family": "Rutters", "given": "Femke", "initials": "F"}, {"family": "Sharma", "given": "Sapna", "initials": "S"}, {"family": "Teare", "given": "Harriet", "initials": "H"}, {"family": "T\u2019Hart", "given": "Leen M", "initials": "LM"}, {"family": "Tsirigos", "given": "Kostas", "initials": "K"}, {"family": "Vangipurapu", "given": "Jagadish", "initials": "J"}, {"family": "Vestergaard", "given": "Henrik", "initials": "H"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Frost", "given": "Gary", "initials": "G"}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Jablonka", "given": "Bernd", "initials": "B"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI", "orcid": "0000-0002-4393-0510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/102c7e93640c43c9bbbedd1626adfd7b.json"}}, {"family": "Pavo", "given": "Imre", "initials": "I"}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Adamski", "given": "Jerzy", "initials": "J"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Pearson", "given": "Ewan R", "initials": "ER", "orcid": "0000-0001-9237-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e27e9e47f1cc4a969268eb5a65b8045b.json"}}, {"family": "Dermitzakis", "given": "Emmanouil T", "initials": "ET", "orcid": "0000-0002-9302-6490", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6683f17defc34cad9389fd7fef36aca4.json"}}], "type": "posted-content", "published": "2021-03-29", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.03.26.21254347", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:03:36.179Z", "modified": "2026-08-20T10:03:36.507Z"}, {"entity": "publication", "iuid": "b278c460903745109e2e319080ac66b2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b278c460903745109e2e319080ac66b2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b278c460903745109e2e319080ac66b2"}}, "title": "Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study.", "authors": [{"family": "Obura", "given": "Morgan", "initials": "M"}, {"family": "Beulens", "given": "Joline W J", "initials": "JWJ", "orcid": "0000-0002-6788-5232", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e20a7d8bc053421187c08a4aa70ab559.json"}}, {"family": "Slieker", "given": "Roderick", "initials": "R"}, {"family": "Koopman", "given": "Anitra D M", "initials": "ADM"}, {"family": "Hoekstra", "given": "Trynke", "initials": "T"}, {"family": "Nijpels", "given": "Giel", "initials": "G"}, {"family": "Elders", "given": "Petra", "initials": "P"}, {"family": "Koivula", "given": "Robert W", "initials": "RW", "orcid": "0000-0002-1646-4163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ceb821c78774b9f8931463351046f1f.json"}}, {"family": "Kurbasic", "given": "Azra", "initials": "A"}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "Hansen", "given": "Tue H", "initials": "TH"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M"}, {"family": "Hansen", "given": "Torben", "initials": "T"}, {"family": "Pavo", "given": "Imre", "initials": "I", "orcid": "0000-0002-2016-7049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1691b459fdb84772b1e8595e8de617f3.json"}}, {"family": "Forgie", "given": "Ian", "initials": "I"}, {"family": "Jablonka", "given": "Bernd", "initials": "B"}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Mari", "given": "Andrea", "initials": "A"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Heggie", "given": "Alison", "initials": "A"}, {"family": "McDonald", "given": "Timothy J", "initials": "TJ"}, {"family": "Perry", "given": "Mandy H", "initials": "MH"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN"}, {"family": "Kokkola", "given": "Tarja", "initials": "T"}, {"family": "Dermitzakis", "given": "Emmanouil", "initials": "E"}, {"family": "Vi\u00f1uela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Adamski", "given": "Jurek", "initials": "J"}, {"family": "Teare", "given": "Harriet J A", "initials": "HJA"}, {"family": "Pearson", "given": "Ewan R", "initials": "ER"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "'t Hart", "given": "Leen M", "initials": "LM"}, {"family": "Rutters", "given": "Femke", "initials": "F"}, {"family": "IMI-DIRECT Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-30", "journal": {"title": "PLoS ONE", "issn": "1932-6203", "volume": "15", "issue": "11", "pages": "e0242360", "issn-l": "1932-6203"}, "abstract": "Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-meal tolerance test (MMT) and metabolic traits at baseline and glycaemic deterioration in individuals with T2D.\n\nThe study included 787 individuals with newly diagnosed T2D from the Diabetes Research on Patient Stratification (IMI-DIRECT) Study. Latent class trajectory analysis (LCTA) was used to identify distinct glucose curve subgroups during a five-point MMT. Using general linear models, these subgroups were associated with metabolic traits at baseline and after 18 months of follow up, adjusted for potential confounders.\n\nAt baseline, we identified three glucose curve subgroups, labelled in order of increasing glucose peak levels as subgroup 1-3. Individuals in subgroup 2 and 3 were more likely to have higher levels of HbA1c, triglycerides and BMI at baseline, compared to those in subgroup 1. At 18 months (n = 651), the beta coefficients (95% CI) for change in HbA1c (mmol/mol) increased across subgroups with 0.37 (-0.18-1.92) for subgroup 2 and 1.88 (-0.08-3.85) for subgroup 3, relative to subgroup 1. The same trend was observed for change in levels of triglycerides and fasting glucose.\n\nDifferent glycaemic profiles with different metabolic traits and different degrees of subsequent glycaemic deterioration can be identified using data from a frequently sampled mixed-meal tolerance test in individuals with T2D. Subgroups with the highest peaks had greater metabolic risk.", "doi": "10.1371/journal.pone.0242360", "pmid": "33253307", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7703960"}, {"db": "pii", "key": "PONE-D-20-16974"}], "notes": [], "created": "2026-08-20T12:44:09.441Z", "modified": "2026-08-20T12:44:09.551Z"}, {"entity": "publication", "iuid": "67ba27f099f64f6b931017b40921250b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/67ba27f099f64f6b931017b40921250b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/67ba27f099f64f6b931017b40921250b"}}, "title": "Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study", "authors": [{"family": "Atabaki-Pasdar", "given": "Naeimeh", "initials": "N", "orcid": "0000-0001-7229-1888", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a3b275f37d948a1af96477938ddfe5b.json"}}, {"family": "Ohlsson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1145-4297", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4fd8fb1306ae4becbb494fca9ad667aa.json"}}, {"family": "Vi\u00f1uela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}, {"family": "Frau", "given": "Francesca", "initials": "F"}, {"family": "Pomares-Millan", "given": "Hugo", "initials": "H", "orcid": "0000-0001-9245-4576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bfc3253ee46d47d7a37a94d1275501a0.json"}}, {"family": "Haid", "given": "Mark", "initials": "M"}, {"family": "Jones", "given": "Angus G", "initials": "AG"}, {"family": "Thomas", "given": "E Louise", "initials": "EL"}, {"family": "Koivula", "given": "Robert W", "initials": "RW", "orcid": "0000-0002-1646-4163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ceb821c78774b9f8931463351046f1f.json"}}, {"family": "Kurbasic", "given": "Azra", "initials": "A"}, {"family": "Mutie", "given": "Pascal M", "initials": "PM"}, {"family": "Fitipaldi", "given": "Hugo", "initials": "H"}, {"family": "Fernandez", "given": "Juan", "initials": "J"}, {"family": "Dawed", "given": "Adem Y", "initials": "AY"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN"}, {"family": "Forgie", "given": "Ian M", "initials": "IM"}, {"family": "McDonald", "given": "Timothy J", "initials": "TJ"}, {"family": "Rutters", "given": "Femke", "initials": "F"}, {"family": "Cederberg", "given": "Henna", "initials": "H"}, {"family": "Chabanova", "given": "Elizaveta", "initials": "E"}, {"family": "Dale", "given": "Matilda", "initials": "M"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Thomas", "given": "Cecilia Engel", "initials": "CE"}, {"family": "Allin", "given": "Kristine H", "initials": "KH"}, {"family": "Hansen", "given": "Tue H", "initials": "TH"}, {"family": "Heggie", "given": "Alison", "initials": "A"}, {"family": "Hong", "given": "Mun Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Elders", "given": "Petra JM", "initials": "PJ"}, {"family": "Kennedy", "given": "Gwen", "initials": "G"}, {"family": "Kokkola", "given": "Tarja", "initials": "T"}, {"family": "Pedersen", "given": "Helle Krogh", "initials": "HK"}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "McEvoy", "given": "Donna", "initials": "D"}, {"family": "Pattou", "given": "Francois", "initials": "F"}, {"family": "Raverdy", "given": "Violeta", "initials": "V"}, {"family": "H\u00e4ussler", "given": "Ragna S", "initials": "RS"}, {"family": "Sharma", "given": "Sapna", "initials": "S"}, {"family": "Thomsen", "given": "Henrik S", "initials": "HS"}, {"family": "Vangipurapu", "given": "Jagadish", "initials": "J"}, {"family": "Vestergaard", "given": "Henrik", "initials": "H"}, {"family": "\u2018t Hart", "given": "Leen M", "initials": "LM"}, {"family": "Adamski", "given": "Jerzy", "initials": "J"}, {"family": "Musholt", "given": "Petra B", "initials": "PB"}, {"family": "Brage", "given": "Soren", "initials": "S"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Dermitzakis", "given": "Emmanouil", "initials": "E"}, {"family": "Frost", "given": "Gary", "initials": "G"}, {"family": "Hansen", "given": "Torben", "initials": "T"}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M"}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Beulens", "given": "Joline WJ", "initials": "JW"}, {"family": "Mari", "given": "Andrea", "initials": "A"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Gupta", "given": "Ramneek", "initials": "R"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Pearson", "given": "Ewan R", "initials": "ER"}, {"family": "Bell", "given": "Jimmy D", "initials": "JD"}, {"family": "Pavo", "given": "Imre", "initials": "I"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}], "type": "posted-content", "published": "2020-02-11", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.02.10.20021147", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:55:58.853Z", "modified": "2026-08-20T09:55:59.055Z"}, {"entity": "publication", "iuid": "2ead5ea6b1314b0ea33828665d478edb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2ead5ea6b1314b0ea33828665d478edb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2ead5ea6b1314b0ea33828665d478edb"}}, "title": "Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium", "authors": [{"family": "Koivula", "given": "Robert W", "initials": "RW", "orcid": "0000-0002-1646-4163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ceb821c78774b9f8931463351046f1f.json"}}, {"family": "Forgie", "given": "Ian M", "initials": "IM"}, {"family": "Kurbasic", "given": "Azra", "initials": "A"}, {"family": "Vi\u00f1uela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}, {"family": "Heggie", "given": "Alison", "initials": "A"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN"}, {"family": "Hansen", "given": "Tue H", "initials": "TH", "orcid": "0000-0001-5948-8993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73418e2efdc1459483138da74b0abad6.json"}}, {"family": "Hudson", "given": "Michelle", "initials": "M"}, {"family": "Koopman", "given": "Anitra", "initials": "A"}, {"family": "Rutters", "given": "Femke", "initials": "F"}, {"family": "Siloaho", "given": "Maritta", "initials": "M"}, {"family": "Allin", "given": "Kristine H", "initials": "KH"}, {"family": "Brage", "given": "S\u00f8ren", "initials": "S"}, {"family": "Brorsson", "given": "Caroline A", "initials": "CA"}, {"family": "Dawed", "given": "Adem Y", "initials": "AY"}, {"family": "Masi", "given": "Federico De", "initials": "FD"}, {"family": "Groves", "given": "Christopher J", "initials": "CJ"}, {"family": "Kokkola", "given": "Tarja", "initials": "T"}, {"family": "Mahajan", "given": "Anubha", "initials": "A", "orcid": "0000-0001-5585-3420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41b3d44662484e0289f07fa25d045cf4.json"}}, {"family": "Perry", "given": "Mandy H", "initials": "MH"}, {"family": "Rauh", "given": "Simone P", "initials": "SP"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M"}, {"family": "Teare", "given": "Harriet J A", "initials": "HJA"}, {"family": "Thomas", "given": "Louise", "initials": "L"}, {"family": "Tura", "given": "Andrea", "initials": "A"}, {"family": "Vestergaard", "given": "Henrik", "initials": "H"}, {"family": "White", "given": "Tom", "initials": "T", "orcid": "0000-0001-8456-0803", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f851cbeafad2485685a5a080649b5ddc.json"}}, {"family": "Adamski", "given": "Jerzy", "initials": "J"}, {"family": "Bell", "given": "Jimmy", "initials": "J"}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Dekker", "given": "Jacqueline", "initials": "J"}, {"family": "Dermitzakis", "given": "Emmanouil T", "initials": "ET"}, {"family": "Froguel", "given": "Philippe", "initials": "P"}, {"family": "Frost", "given": "Gary", "initials": "G"}, {"family": "Gupta", "given": "Ramneek", "initials": "R"}, {"family": "Hansen", "given": "Torben", "initials": "T"}, {"family": "Hattersley", "given": "Andrew", "initials": "A"}, {"family": "Jablonka", "given": "Bernd", "initials": "B"}, {"family": "Laakso", "given": "Markku", "initials": "M"}, {"family": "McDonald", "given": "Timothy J", "initials": "TJ"}, {"family": "Pedersen", "given": "Oluf", "initials": "O"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Pavo", "given": "Imre", "initials": "I"}, {"family": "Mari", "given": "Andrea", "initials": "A"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI", "orcid": "0000-0002-4393-0510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/102c7e93640c43c9bbbedd1626adfd7b.json"}}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "Pearson", "given": "Ewan", "initials": "E"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8263a26f474946de8b61a2080051d37b.json"}}], "type": "posted-content", "published": "2018-04-16", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/300244", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:10:01.566Z", "modified": "2026-08-20T11:10:01.671Z"}]}