{"entity": "researcher", "timestamp": "2026-08-22T09:13:14.903Z", "family": "Bass", "given": "Tarek Z", "initials": "TZ", "orcid": "0000-0003-1598-8894", "affiliations": ["Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0291a38a362242828bd1ca877a9c8372.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0291a38a362242828bd1ca877a9c8372"}}, "publications": [{"entity": "publication", "iuid": "e9ba7b5d6e1240168e0321a0362b6fd3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e9ba7b5d6e1240168e0321a0362b6fd3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e9ba7b5d6e1240168e0321a0362b6fd3"}}, "title": "Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111.", "authors": [{"family": "Rinne", "given": "Sara S", "initials": "SS"}, {"family": "Leitao", "given": "Charles Dahlsson", "initials": "CD"}, {"family": "Mitran", "given": "Bogdan", "initials": "B"}, {"family": "Bass", "given": "Tarek Z", "initials": "TZ", "orcid": "0000-0003-1598-8894", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0291a38a362242828bd1ca877a9c8372.json"}}, {"family": "Andersson", "given": "Ken G", "initials": "KG"}, {"family": "Tolmachev", "given": "Vladimir", "initials": "V", "orcid": "0000-0002-6122-1734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/896ae9fae8b74251afe11b4354c62794.json"}}, {"family": "St\u00e5hl", "given": "Stefan", "initials": "S"}, {"family": "L\u00f6fblom", "given": "John", "initials": "J", "orcid": "0000-0001-9423-0541", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf8479d43c1c45efb85ba0c0da634aeb.json"}}, {"family": "Orlova", "given": "Anna", "initials": "A", "orcid": "0000-0001-6120-2683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c374f429702489494c05f84f298b4b7.json"}}], "type": "journal article", "published": "2019-01-24", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "9", "issue": "1", "pages": "655", "issn-l": "2045-2322"}, "abstract": "Radionuclide molecular imaging of human epidermal growth factor receptor 3 (HER3) expression using affibody molecules could be used for patient stratification for HER3-targeted cancer therapeutics. We hypothesized that the properties of HER3-targeting affibody molecules might be improved through modification of the radiometal-chelator complex. Macrocyclic chelators NOTA (1,4,7-triazacyclononane-N,N',N''-triacetic acid), NODAGA (1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane), DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), and DOTAGA (1,4,7,10-tetraazacyclododececane,1-(glutaric acid)-4,7,10-triacetic acid) were conjugated to the C-terminus of anti-HER3 affibody molecule Z08698 and conjugates were labeled with indium-111. All conjugates bound specifically and with picomolar affinity to HER3 in vitro. In mice bearing HER3-expressing xenografts, no significant difference in tumor uptake between the conjugates was observed. Presence of the negatively charged 111In-DOTAGA-complex resulted in the lowest hepatic uptake and the highest tumor-to-liver ratio. In conclusion, the choice of chelator influences the biodistribution of indium-111 labeled anti-HER3 affibody molecules. Hepatic uptake of anti-HER3 affibody molecules could be reduced by the increase of negative charge of the radiometal-chelator complex on the C-terminus without significantly influencing the tumor uptake.", "doi": "10.1038/s41598-018-36827-w", "pmid": "30679757", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6345776"}, {"db": "pii", "key": "10.1038/s41598-018-36827-w"}], "notes": [], "created": "2026-08-21T11:52:40.052Z", "modified": "2026-08-21T11:52:40.223Z"}]}