{"entity": "researcher", "timestamp": "2026-09-25T23:03:39.541Z", "family": "Reimeg\u00e5rd", "given": "Johan", "initials": "J", "orcid": "0000-0003-1518-2014", "affiliations": ["National Bioinformatics Infrastructure Sweden (NBIS), Science for Life Laboratory (SciLifeLab), Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0231200f87bc4dbeb92566439db2f7ce.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0231200f87bc4dbeb92566439db2f7ce"}}, "publications": [{"entity": "publication", "iuid": "8eb84a59488e46b9a8798a36ac2b47a2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8eb84a59488e46b9a8798a36ac2b47a2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8eb84a59488e46b9a8798a36ac2b47a2"}}, "title": "Early germline sequestration in a basidiomycete fungus.", "authors": [{"family": "Thor\u00e9n", "given": "Markus Hiltunen", "initials": "MH", "orcid": "0000-0002-8880-872X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8ab31cc80e1c43458c0d26ca9a7bb004.json"}}, {"family": "Olsson", "given": "Boel", "initials": "B", "orcid": "0009-0006-4157-2664", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac0a8aaf72024f189e94249f7dd50ea1.json"}}, {"family": "Vonk", "given": "Peter Jan", "initials": "PJ", "orcid": "0000-0001-5325-7430", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41c2981207704dee8268625a172a08ff.json"}}, {"family": "Siljestam", "given": "Mattias", "initials": "M", "orcid": "0000-0002-3720-4926", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bbb83adca0344c3a17a01bbe5138fdb.json"}}, {"family": "Reimeg\u00e5rd", "given": "Johan", "initials": "J", "orcid": "0000-0003-1518-2014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0231200f87bc4dbeb92566439db2f7ce.json"}}, {"family": "Ryberg", "given": "Martin", "initials": "M", "orcid": "0000-0002-6795-4349", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5917e3d7a89148689cccd59bfba4e47f.json"}}, {"family": "Johannesson", "given": "Hanna", "initials": "H", "orcid": "0000-0001-6359-9856", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/53fd9541dedf469fa9e83c20a4a32fc2.json"}}], "type": "journal article", "published": "2025-08-14", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "389", "issue": "6761", "pages": "720-723", "issn-l": "0036-8075"}, "abstract": "In sexual organisms, inheritance of new mutations is highly dependent on the timing of germline definition. Here, we used the fairy ring-forming fungus Marasmius oreades to challenge the general assumption of a late germline separation in the Fungi. We collected mushrooms from different parts of rings over a 7-year period and identified new mutations in different tissues by whole-genome sequencing. We found evidence that fertile and sterile tissues had accumulated different mutations, suggesting that the germ line, destined for spore production, is already defined in the mycelium in this species. Moreover, the germ line carried fewer mutations than sterile tissues, indicating a lower mutation rate. Our findings suggest that early germline sequestration is more widespread than previously considered across multicellular life.", "doi": "10.1126/science.adu8580", "pmid": "40811541", "labels": [], "xrefs": [{"db": "BioProject", "key": "PRJNA1083412"}], "notes": [], "created": "2026-09-23T11:36:59.774Z", "modified": "2026-09-23T11:37:00.052Z"}, {"entity": "publication", "iuid": "3459e46211a844608ec76e4c5be44dba", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3459e46211a844608ec76e4c5be44dba.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3459e46211a844608ec76e4c5be44dba"}}, "title": "Origin, structure, and composition of the spider major ampullate silk fiber revealed by genomics, proteomics, and single-cell and spatial transcriptomics.", "authors": [{"family": "Sonavane", "given": "Sumalata", "initials": "S", "orcid": "0000-0002-0728-4822", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6056f846ca44873bf97bb4d21e40ded.json"}}, {"family": "Hassan", "given": "Sameer", "initials": "S"}, {"family": "Chatterjee", "given": "Urmimala", "initials": "U", "orcid": "0000-0002-6681-1696", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb363a6130e040178b4a537e0853c254.json"}}, {"family": "Soler", "given": "Lucile", "initials": "L", "orcid": "0000-0002-0121-2393", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28aa7ece2c6d464685f8fe04b792f69c.json"}}, {"family": "Holm", "given": "Lena", "initials": "L", "orcid": "0000-0002-7717-4370", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6bf1b72a2e8a4071b1fd2c733499b0e6.json"}}, {"family": "Mollbrink", "given": "Annelie", "initials": "A", "orcid": "0009-0007-0542-0695", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7272fdbb91c04a0c90b61e238bde688e.json"}}, {"family": "Greco", "given": "Gabriele", "initials": "G", "orcid": "0000-0003-3356-7081", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef2f738e8fb04eb7b64ea56bf1239172.json"}}, {"family": "Fereydouni", "given": "Noah", "initials": "N", "orcid": "0000-0002-1786-4337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b545ae954a4d455a951cc327aa20cff3.json"}}, {"family": "Vinnere Pettersson", "given": "Olga", "initials": "O", "orcid": "0000-0002-5597-1870", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f513ec3fb924415a9e579d1c829c7d2d.json"}}, {"family": "Bunikis", "given": "Ignas", "initials": "I"}, {"family": "Churcher", "given": "Allison", "initials": "A", "orcid": "0000-0003-1902-3002", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2416708e29b04f1d8ec3703471853860.json"}}, {"family": "Lantz", "given": "Henrik", "initials": "H"}, {"family": "Johansson", "given": "Jan", "initials": "J"}, {"family": "Reimeg\u00e5rd", "given": "Johan", "initials": "J", "orcid": "0000-0003-1518-2014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0231200f87bc4dbeb92566439db2f7ce.json"}}, {"family": "Rising", "given": "Anna", "initials": "A", "orcid": "0000-0002-1872-1207", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21439efdc10449a4a6314610bef8f911.json"}}], "type": "journal article", "published": "2024-08-16", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "10", "issue": "33", "pages": "eadn0597", "issn-l": "2375-2548"}, "abstract": "Spiders produce nature's toughest fiber using renewable components at ambient temperatures and with water as solvent, making it highly interesting to replicate for the materials industry. Despite this, much remains to be understood about the bioprocessing and composition of spider silk fibers. Here, we identify 18 proteins that make up the spiders' strongest silk type, the major ampullate fiber. Single-cell RNA sequencing and spatial transcriptomics revealed that the secretory epithelium of the gland harbors six cell types. These cell types are confined to three distinct glandular zones that produce specific combinations of silk proteins. Image analysis of histological sections showed that the secretions from the three zones do not mix, and proteomics analysis revealed that these secretions form layers in the final fiber. Using a multi-omics approach, we provide substantial advancements in the understanding of the structure and function of the major ampullate silk gland as well as of the architecture and composition of the fiber it produces.", "doi": "10.1126/sciadv.adn0597", "pmid": "39141739", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11323941"}], "notes": [], "created": "2026-09-23T08:55:17.924Z", "modified": "2026-09-23T08:55:18.685Z"}, {"entity": "publication", "iuid": "35d4077f2686453681fa9ffb0236fb9b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/35d4077f2686453681fa9ffb0236fb9b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/35d4077f2686453681fa9ffb0236fb9b"}}, "title": "Genetic atlas of hygro- and thermosensory cells in the vinegar fly Drosophila melanogaster", "authors": [{"family": "Corthals", "given": "Kristina", "initials": "K", "orcid": "0000-0001-6106-4372", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd506aad1d6c4e61a0be952fddd70350.json"}}, {"family": "Andersson", "given": "Vilma", "initials": "V"}, {"family": "Churcher", "given": "Allison", "initials": "A", "orcid": "0000-0003-1902-3002", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2416708e29b04f1d8ec3703471853860.json"}}, {"family": "Reimeg\u00e5rd", "given": "Johan", "initials": "J", "orcid": "0000-0003-1518-2014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0231200f87bc4dbeb92566439db2f7ce.json"}}, {"family": "Enjin", "given": "Anders", "initials": "A", "orcid": "0000-0001-7167-9434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/39fb72a79ca34e01a709e793daccbc4e.json"}}], "type": "posted-content", "published": "2023-06-27", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.06.26.546511", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T15:27:50.712Z", "modified": "2026-09-23T15:27:50.810Z"}]}