{"entity": "researcher", "timestamp": "2026-08-26T22:48:25.128Z", "family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "affiliations": ["Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Universit\u00e9 Paris Saclay, Villejuif, France.", "Centre de Recherche des Cordeliers, Equipe labellis\u00e9e par la Ligue contre le cancer, Universit\u00e9 de Paris, Sorbonne Universit\u00e9, Inserm U1138, Institut Universitaire de France, Paris, France.", "Institut du Cancer Paris CARPEM, Department of Biology, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/01f649cadac140c98456d4841b61a3d6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/01f649cadac140c98456d4841b61a3d6"}}, "publications": [{"entity": "publication", "iuid": "5707153848494d1a983f2c0703356b8a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5707153848494d1a983f2c0703356b8a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5707153848494d1a983f2c0703356b8a"}}, "title": "Apoptotic cell death in disease-Current understanding of the NCCD 2023.", "authors": [{"family": "Vitale", "given": "Ilio", "initials": "I", "orcid": "0000-0002-5918-1841", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/89b15581395b406ea845a20b37aa0de3.json"}}, {"family": "Pietrocola", "given": "Federico", "initials": "F"}, {"family": "Guilbaud", "given": "Emma", "initials": "E"}, {"family": "Aaronson", "given": "Stuart A", "initials": "SA"}, {"family": "Abrams", "given": "John M", "initials": "JM"}, {"family": "Adam", "given": "Dieter", "initials": "D"}, {"family": "Agostini", "given": "Massimiliano", "initials": "M"}, {"family": "Agostinis", "given": "Patrizia", "initials": "P"}, {"family": "Alnemri", "given": "Emad S", 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"initials": "P"}, {"family": "Porta", "given": "Giovanni", "initials": "G"}, {"family": "Prehn", "given": "Jochen H M", "initials": "JHM"}, {"family": "Puthalakath", "given": "Hamsa", "initials": "H"}, {"family": "Rabinovich", "given": "Gabriel A", "initials": "GA"}, {"family": "Rajalingam", "given": "Krishnaraj", "initials": "K"}, {"family": "Ravichandran", "given": "Kodi S", "initials": "KS"}, {"family": "Rehm", "given": "Markus", "initials": "M"}, {"family": "Ricci", "given": "Jean-Ehrland", "initials": "JE"}, {"family": "Rizzuto", "given": "Rosario", "initials": "R"}, {"family": "Robinson", "given": "Nirmal", "initials": "N"}, {"family": "Rodrigues", "given": "Cecilia M P", "initials": "CMP"}, {"family": "Rotblat", "given": "Barak", "initials": "B"}, {"family": "Rothlin", "given": "Carla V", "initials": "CV"}, {"family": "Rubinsztein", "given": "David C", "initials": "DC"}, {"family": "Rudel", "given": "Thomas", "initials": "T"}, {"family": "Rufini", "given": "Alessandro", 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"Andreas", "initials": "A"}, {"family": "Sun", "given": "Liming", "initials": "L"}, {"family": "Sun", "given": "Erwei", "initials": "E"}, {"family": "Sun", "given": "Qiang", "initials": "Q"}, {"family": "Szabadkai", "given": "Gyorgy", "initials": "G"}, {"family": "Tait", "given": "Stephen W G", "initials": "SWG"}, {"family": "Tang", "given": "Daolin", "initials": "D"}, {"family": "Tavernarakis", "given": "Nektarios", "initials": "N"}, {"family": "Troy", "given": "Carol M", "initials": "CM"}, {"family": "Turk", "given": "Boris", "initials": "B"}, {"family": "Urbano", "given": "Nicoletta", "initials": "N"}, {"family": "Vandenabeele", "given": "Peter", "initials": "P"}, {"family": "Vanden Berghe", "given": "Tom", "initials": "T"}, {"family": "Vander Heiden", "given": "Matthew G", "initials": "MG"}, {"family": "Vanderluit", "given": "Jacqueline L", "initials": "JL"}, {"family": "Verkhratsky", "given": "Alexei", "initials": "A"}, {"family": "Villunger", "given": "Andreas", "initials": "A"}, {"family": "von Karstedt", "given": "Silvia", "initials": "S"}, {"family": "Voss", "given": "Anne K", "initials": "AK"}, {"family": "Vousden", "given": "Karen H", "initials": "KH"}, {"family": "Vucic", "given": "Domagoj", "initials": "D"}, {"family": "Vuri", "given": "Daniela", "initials": "D"}, {"family": "Wagner", "given": "Erwin F", "initials": "EF"}, {"family": "Walczak", "given": "Henning", "initials": "H"}, {"family": "Wallach", "given": "David", "initials": "D"}, {"family": "Wang", "given": "Ruoning", "initials": "R"}, {"family": "Wang", "given": "Ying", "initials": "Y"}, {"family": "Weber", "given": "Achim", "initials": "A"}, {"family": "Wood", "given": "Will", "initials": "W"}, {"family": "Yamazaki", "given": "Takahiro", "initials": "T"}, {"family": "Yang", "given": "Huang-Tian", "initials": "HT"}, {"family": "Zakeri", "given": "Zahra", "initials": "Z"}, {"family": "Zawacka-Pankau", "given": "Joanna E", "initials": "JE"}, {"family": "Zhang", "given": "Lin", "initials": "L"}, {"family": "Zhang", "given": "Haibing", "initials": "H"}, {"family": "Zhivotovsky", "given": "Boris", "initials": "B"}, {"family": "Zhou", "given": "Wenzhao", "initials": "W"}, {"family": "Piacentini", "given": "Mauro", "initials": "M", "orcid": "0000-0003-2919-1296", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/050be19dfd9c478dab35b1a283732e41.json"}}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/01f649cadac140c98456d4841b61a3d6.json"}}, {"family": "Galluzzi", "given": "Lorenzo", "initials": "L", "orcid": "0000-0003-2257-8500", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec6445fd88f54bff8ebd3332d1e37a10.json"}}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Cell Death Differ.", "issn": "1476-5403", "volume": "30", "issue": "5", "pages": "1097-1154", "issn-l": "1350-9047"}, "abstract": "Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.", "doi": "10.1038/s41418-023-01153-w", "pmid": "37100955", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10130819"}, {"db": "pii", "key": "10.1038/s41418-023-01153-w"}], "notes": [], "created": "2026-08-20T08:49:28.445Z", "modified": "2026-08-20T08:49:28.665Z"}, {"entity": "publication", "iuid": "6ebc276626794ad0b637759cd26cc92f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6ebc276626794ad0b637759cd26cc92f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6ebc276626794ad0b637759cd26cc92f"}}, "title": "Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy.", "authors": [{"family": "Daill\u00e8re", "given": "Romain", "initials": "R"}, {"family": "Derosa", "given": "Lisa", "initials": "L"}, {"family": "Bonvalet", "given": "M\u00e9lodie", "initials": "M"}, {"family": "Segata", "given": "Nicola", "initials": "N"}, {"family": "Routy", "given": "Bertrand", "initials": "B"}, {"family": "Gariboldi", "given": "Manuela", "initials": "M"}, {"family": "Budinsk\u00e1", "given": "Eva", "initials": "E"}, {"family": "De Vries", "given": "I Jolanda M", "initials": "IJM"}, {"family": "Naccarati", "given": "Alessio Gordon", "initials": "AG"}, {"family": "Zitvogel", "given": "Val\u00e9rie", "initials": "V"}, {"family": "Caldas", "given": "Carlos", "initials": "C"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Loilbl", "given": "Sibylle", "initials": "S"}, {"family": "Fieschi", "given": "Jacques", "initials": "J"}, {"family": "Heinzerling", "given": "Lucie", "initials": "L"}, {"family": "Kroemer", "given": "Guido", "initials": "G", "orcid": "0000-0002-9334-4405", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/01f649cadac140c98456d4841b61a3d6.json"}}, {"family": "Zitvogel", "given": "Laurence", "initials": "L", "orcid": "0000-0003-1596-0998", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35782450d40b48998dd204b6f5fc96b3.json"}}], "type": "journal article", "published": "2020-06-03", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1774298", "issn-l": null}, "abstract": "Accumulating evidence demonstrates the decisive role of the gut microbiota in determining the effectiveness of anticancer therapeutics such as immunogenic chemotherapy or immune checkpoint blockade in preclinical tumor models, as well as in cancer patients. In synthesis, it appears that a normal intestinal microbiota supports therapeutic anticancer responses, while a dysbiotic microbiota that lacks immunostimulatory bacteria or contains overabundant immunosuppressive species causes treatment failure. These findings have led to the design of clinical trials that evaluate the capacity of modulation of the gut microbiota to synergize with treatment and hence limit tumor progression. Along the lines of this Trial Watch, we discuss the rationale for harnessing the gut microbiome in support of cancer therapy and the progress of recent clinical trials testing this new therapeutic paradigm in cancer patients.", "doi": "10.1080/2162402X.2020.1774298", "pmid": "32934879", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7466862"}, {"db": "pii", "key": "1774298"}], "notes": [], "created": "2026-08-21T12:05:30.771Z", "modified": "2026-08-21T12:05:30.844Z"}]}