{"entity": "researcher", "timestamp": "2026-08-20T20:48:41.049Z", "family": "Remnest\u00e5l", "given": "Julia", "initials": "J", "orcid": "0000-0002-3908-6476", "affiliations": ["Division of Affinity Proteomics, Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/0122e5bb49d3421696fcbb64f99eea41.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/0122e5bb49d3421696fcbb64f99eea41"}}, "publications": [{"entity": "publication", "iuid": "59b004c7df1d4131a8eedb6051b9167b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/59b004c7df1d4131a8eedb6051b9167b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/59b004c7df1d4131a8eedb6051b9167b"}}, "title": "Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.", "authors": [{"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J", "orcid": "0000-0002-3908-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0122e5bb49d3421696fcbb64f99eea41.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c4a7070f339466690b40d63ad6ea769.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Markaki", "given": "Ioanna", "initials": "I", "orcid": "0000-0003-3328-5746", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f31c405d780a4beeb64971dabd57cafd.json"}}, {"family": "Carvalho", "given": "Stephanie", "initials": "S"}, {"family": "Corvol", "given": "Jean-Christophe", "initials": "JC", "orcid": "0000-0001-7325-0199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81bf347acb7349dfa3d7c22483c1fba4.json"}}, {"family": "Kultima", "given": "Kim", "initials": "K", "orcid": "0000-0002-0680-1410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580.json"}}, {"family": "Kilander", "given": "Lena", "initials": "L"}, {"family": "L\u00f6wenmark", "given": "Malin", "initials": "M"}, {"family": "Ingelsson", "given": "Martin", "initials": "M", "orcid": "0000-0001-5466-8370", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9cdd74196957459fa3618c6bd2c35ff8.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B", "orcid": "0000-0001-6791-8893", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0815ffb8b9404272a26b28cb11f001ba.json"}}, {"family": "Brosseron", "given": "Frederic", "initials": "F", "orcid": "0000-0003-3137-7516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d8a371f4aaa4ba59389f30bd9349c1f.json"}}, {"family": "Heneka", "given": "Michael T", "initials": "MT", "orcid": "0000-0003-4996-1630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8da023abc6974d4582fe3c688a483950.json"}}, {"family": "Bosch", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-6094-0024", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd5741747488412c9c8334a97e7302ad.json"}}, {"family": "Sanchez-Valle", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7750-896X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bba6a10e4cd4b0180ccc900d70fd869.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "8", "issue": "7", "pages": "1456-1470", "issn-l": "2328-9503"}, "abstract": "Decreased amyloid beta (A\u03b2) 42 together with increased tau and phospho-tau in cerebrospinal fluid (CSF) is indicative of Alzheimer's disease (AD). However, the molecular pathophysiology underlying the slowly progressive cognitive decline observed in AD is not fully understood and it is not known what other CSF biomarkers may be altered in early disease stages.\n\nWe utilized an antibody-based suspension bead array to analyze levels of 216 proteins in CSF from AD patients, patients with mild cognitive impairment (MCI), and controls from two independent cohorts collected within the AETIONOMY consortium. Two additional cohorts from Sweden were used for biological verification.\n\nSix proteins, amphiphysin (AMPH), aquaporin 4 (AQP4), cAMP-regulated phosphoprotein 21 (ARPP21), growth-associated protein 43 (GAP43), neurofilament medium polypeptide (NEFM), and synuclein beta (SNCB) were found at increased levels in CSF from AD patients compared with controls. Next, we used CSF levels of A\u03b242 and tau for the stratification of the MCI patients and observed increased levels of AMPH, AQP4, ARPP21, GAP43, and SNCB in the MCI subgroups with abnormal tau levels compared with controls. Further characterization revealed strong to moderate correlations between these five proteins and tau concentrations.\n\nIn conclusion, we report six extensively replicated candidate biomarkers with the potential to reflect disease development. Continued evaluation of these proteins will determine to what extent they can aid in the discrimination of MCI patients with and without an underlying AD etiology, and if they have the potential to contribute to a better understanding of the AD continuum.", "doi": "10.1002/acn3.51402", "pmid": "34129723", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8283172"}], "notes": [], "created": "2026-08-20T06:27:18.835Z", "modified": "2026-08-20T06:27:19.431Z"}, {"entity": "publication", "iuid": "7eeee9d1d2884e55b87d5c50ba3abbad", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7eeee9d1d2884e55b87d5c50ba3abbad.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7eeee9d1d2884e55b87d5c50ba3abbad"}}, "title": "Association of CSF proteins with tau and amyloid \u03b2 levels in asymptomatic 70-year-olds.", "authors": [{"family": "Remnest\u00e5l", "given": "Julia", "initials": "J", "orcid": "0000-0002-3908-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0122e5bb49d3421696fcbb64f99eea41.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Sj\u00f6stedt", "given": "Evelina", "initials": "E", "orcid": "0000-0002-0327-7377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec6fb5a1c88b44798144fd2de255fb00.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Zettergren", "given": "Anna", "initials": "A"}, {"family": "Kern", "given": "Silke", "initials": "S"}, {"family": "Skoog", "given": "Ingmar", "initials": "I"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "journal article", "published": "2021-03-02", "journal": {"title": "Alzheimers Res Ther", "issn": "1758-9193", "volume": "13", "issue": "1", "pages": "54", "issn-l": null}, "abstract": "Increased knowledge of the evolution of molecular changes in neurodegenerative disorders such as Alzheimer's disease (AD) is important for the understanding of disease pathophysiology and also crucial to be able to identify and validate disease biomarkers. While several biological changes that occur early in the disease development have already been recognized, the need for further characterization of the pathophysiological mechanisms behind AD still remains.\n\nIn this study, we investigated cerebrospinal fluid (CSF) levels of 104 proteins in 307 asymptomatic 70-year-olds from the H70 Gothenburg Birth Cohort Studies using a multiplexed antibody- and bead-based technology.\n\nThe protein levels were first correlated with the core AD CSF biomarker concentrations of total tau, phospho-tau and amyloid beta (A\u03b242) in all individuals. Sixty-three proteins showed significant correlations to either total tau, phospho-tau or A\u03b242. Thereafter, individuals were divided based on CSF A\u03b242/A\u03b240 ratio and Clinical Dementia Rating (CDR) score to determine if early changes in pathology and cognition had an effect on the correlations. We compared the associations of the analysed proteins with CSF markers between groups and found 33 proteins displaying significantly different associations for amyloid-positive individuals and amyloid-negative individuals, as defined by the CSF A\u03b242/A\u03b240 ratio. No differences in the associations could be seen for individuals divided by CDR score.\n\nWe identified a series of transmembrane proteins, proteins associated with or anchored to the plasma membrane, and proteins involved in or connected to synaptic vesicle transport to be associated with CSF biomarkers of amyloid and tau pathology in AD. Further studies are needed to explore these proteins' role in AD pathophysiology.", "doi": "10.1186/s13195-021-00789-5", "pmid": "33653397", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7923505"}, {"db": "pii", "key": "10.1186/s13195-021-00789-5"}], "notes": [], "created": "2026-08-20T12:22:13.883Z", "modified": "2026-08-20T12:23:59.358Z"}]}