{"entity": "researcher", "timestamp": "2026-09-23T15:38:15.568Z", "family": "Al Nimer", "given": "Faiez", "initials": "F", "orcid": "0000-0003-0937-5995", "affiliations": ["Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/00758cc3da934cdbb9cb00c1df4b700f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/00758cc3da934cdbb9cb00c1df4b700f"}}, "publications": [{"entity": "publication", "iuid": "19f1838c0542481484e93214d3cd6b42", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/19f1838c0542481484e93214d3cd6b42.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/19f1838c0542481484e93214d3cd6b42"}}, "title": "Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis.", "authors": [{"family": "Bronge", "given": "Mattias", "initials": "M", "orcid": "0000-0002-1258-3982", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf585179ce31448a90a9b6b585214637.json"}}, {"family": "H\u00f6gelin", "given": "Klara Asplund", "initials": "KA"}, {"family": "Thomas", "given": "Olivia G", "initials": "OG", "orcid": "0000-0002-2011-1344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa20c46e0931406cafb75381f1fbabb8.json"}}, {"family": "Ruhrmann", "given": "Sabrina", "initials": "S"}, {"family": "Carvalho-Queiroz", "given": "Claudia", "initials": "C"}, {"family": "Nilsson", "given": "Ola B", "initials": "OB"}, {"family": "Kaiser", "given": "Andreas", "initials": "A"}, {"family": "Zeitelhofer", "given": "Manuel", "initials": "M"}, {"family": "Holmgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-2656-1864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae381ba7a9624e0c9361a56bcf2fea74.json"}}, {"family": "Linnerbauer", "given": "Mathias", "initials": "M", "orcid": "0000-0002-5528-5141", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7caf4ce60f6441089c2df1a02e4379b6.json"}}, {"family": "Adzemovic", "given": "Milena Z", "initials": "MZ"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a4f6cc50f094d36a281821ca78821a0.json"}}, {"family": "Jelcic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-6187-7098", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3317b07cac4b4d3d8a8bba30a02506db.json"}}, {"family": "Liu", "given": "Hao", "initials": "H", "orcid": "0000-0001-6572-2870", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8fd3a1e88f8b4363950aedfe5fe07383.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Hillert", "given": "Jan", "initials": "J", "orcid": "0000-0002-7386-6732", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f661fc2c98a4568a0fae89601b64f33.json"}}, {"family": "Brundin", "given": "Lou", "initials": "L", "orcid": "0000-0003-4408-7817", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/285bd0f3b11147c2a547a3239ea5f226.json"}}, {"family": "Fink", "given": "Katharina", "initials": "K"}, {"family": "Kockum", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-0867-4726", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/044ff0f987a642c7aa2aef33fe1d7ecd.json"}}, {"family": "Tengvall", "given": "Katarina", "initials": "K", "orcid": "0000-0003-0424-3571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8f6227041cc44b1bd163c99956bba78.json"}}, {"family": "Martin", "given": "Roland", "initials": "R"}, {"family": "Tegel", "given": "Hanna", "initials": "H", "orcid": "0000-0002-7067-9173", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7b9de19b82b4406d8904cb937a466e8b.json"}}, {"family": "Gr\u00e4slund", "given": "Torbj\u00f6rn", "initials": "T", "orcid": "0000-0002-5391-600X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/afff2431691348539334ab0e86158505.json"}}, {"family": "Al Nimer", "given": "Faiez", "initials": "F", "orcid": "0000-0003-0937-5995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00758cc3da934cdbb9cb00c1df4b700f.json"}}, {"family": "Guerreiro-Cacais", "given": "Andr\u00e9 Ortlieb", "initials": "AO", "orcid": "0000-0002-4561-2823", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c2ecf483cb7442b9de5c99dcc11c1a5.json"}}, {"family": "Khademi", "given": "Mohsen", "initials": "M", "orcid": "0000-0003-0801-1444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22f8dcc673264db484e284e484bc7311.json"}}, {"family": "Gafvelin", "given": "Guro", "initials": "G", "orcid": "0000-0003-1618-4011", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4d527debbb4246ddb4d35dd6b0903028.json"}}, {"family": "Olsson", "given": "Tomas", "initials": "T", "orcid": "0000-0002-2938-1877", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2003b9ba415e422fa27b0c7fdce9497f.json"}}, {"family": "Gr\u00f6nlund", "given": "Hans", "initials": "H", "orcid": "0000-0003-4882-7624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b91c9201b4d64b5b8d000d1f89e53be6.json"}}], "type": "journal article", "published": "2022-04-29", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "17", "pages": "eabn1823", "issn-l": "2375-2548"}, "abstract": "Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), in which pathological T cells, likely autoimmune, play a key role. Despite its central importance, the autoantigen repertoire remains largely uncharacterized. Using a novel in vitro antigen delivery method combined with the Human Protein Atlas library, we screened for T cell autoreactivity against 63 CNS-expressed proteins. We identified four previously unreported autoantigens in MS: fatty acid-binding protein 7, prokineticin-2, reticulon-3, and synaptosomal-associated protein 91, which were verified to induce interferon-\u03b3 responses in MS in two cohorts. Autoreactive profiles were heterogeneous, and reactivity to several autoantigens was MS-selective. Autoreactive T cells were predominantly CD4+ and human leukocyte antigen-DR restricted. Mouse immunization induced antigen-specific responses and CNS leukocyte infiltration. This represents one of the largest systematic efforts to date in the search for MS autoantigens, demonstrates the heterogeneity of autoreactive profiles, and highlights promising targets for future diagnostic tools and immunomodulatory therapies in MS.", "doi": "10.1126/sciadv.abn1823", "pmid": "35476434", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9045615"}], "notes": [], "created": "2026-09-23T08:48:17.478Z", "modified": "2026-09-23T08:48:17.929Z"}, {"entity": "publication", "iuid": "426d9d912b63461792789f8e74a3621d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/426d9d912b63461792789f8e74a3621d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/426d9d912b63461792789f8e74a3621d"}}, "title": "Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology.", "authors": [{"family": "Zheleznyakova", "given": "Galina Yurevna", "initials": "GY"}, {"family": "Piket", "given": "Eliane", "initials": "E"}, {"family": "Needhamsen", "given": "Maria", "initials": "M"}, {"family": "Hagemann-Jensen", "given": "Michael", "initials": "M"}, {"family": "Ekman", "given": "Diana", "initials": "D"}, {"family": "Han", "given": "Yanan", "initials": "Y"}, {"family": "James", "given": "Tojo", "initials": "T"}, {"family": "Khademi", "given": "Mohsen", "initials": "M", "orcid": "0000-0003-0801-1444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22f8dcc673264db484e284e484bc7311.json"}}, {"family": "Al Nimer", "given": "Faiez", "initials": "F", "orcid": "0000-0003-0937-5995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00758cc3da934cdbb9cb00c1df4b700f.json"}}, {"family": "Scicluna", "given": "Patrick", "initials": "P"}, {"family": "Huang", "given": "Jesse", "initials": "J"}, {"family": "Kockum", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-0867-4726", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/044ff0f987a642c7aa2aef33fe1d7ecd.json"}}, {"family": "Faridani", "given": "Omid R", "initials": "OR"}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F"}, {"family": "Jagodic", "given": "Maja", "initials": "M"}], "type": "journal article", "published": "2021-04-27", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "118", "issue": "17", "issn-l": "0027-8424"}, "abstract": "Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system (CNS). Small non-coding RNAs (sncRNAs) and, in particular, microRNAs (miRNAs) have frequently been associated with MS. Here, we performed a comprehensive analysis of all classes of sncRNAs in matching samples of peripheral blood mononuclear cells (PBMCs), plasma, cerebrospinal fluid (CSF) cells, and cell-free CSF from relapsing-remitting (RRMS, n = 12 in relapse and n = 11 in remission) patients, secondary progressive (SPMS, n = 6) MS patients, and noninflammatory and inflammatory neurological disease controls (NINDC, n = 11; INDC, n = 5). We show widespread changes in miRNAs and sncRNA-derived fragments of small nuclear, nucleolar, and transfer RNAs. In CSF cells, 133 out of 133 and 115 out of 117 differentially expressed sncRNAs were increased in RRMS relapse compared to remission and RRMS compared to NINDC, respectively. In contrast, 65 out of 67 differentially expressed PBMC sncRNAs were decreased in RRMS compared to NINDC. The striking contrast between the periphery and CNS suggests that sncRNA-mediated mechanisms, including alternative splicing, RNA degradation, and mRNA translation, regulate the transcriptome of pathogenic cells primarily in the CNS target organ.", "doi": "10.1073/pnas.2011574118", "pmid": "33879606", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8092379"}, {"db": "pii", "key": "2011574118"}], "notes": [], "created": "2026-09-23T09:59:44.535Z", "modified": "2026-09-23T10:37:18.884Z"}, {"entity": "publication", "iuid": "65c3afe6c5b842b0abcbd32859312626", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/65c3afe6c5b842b0abcbd32859312626.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/65c3afe6c5b842b0abcbd32859312626"}}, "title": "Profiling of small non-coding RNAs across cellular and biofluid compartments: implications for multiple sclerosis immunopathology", "authors": [{"family": "Zheleznyakova", "given": "Galina Yurevna", "initials": "GY", "orcid": "0000-0003-4660-4523", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6cd283aa02c401796036abc7741e6d0.json"}}, {"family": "Piket", "given": "Eliane", "initials": "E", "orcid": "0000-0003-2897-1311", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04ea727ae2074f6aad310fb1a42530cf.json"}}, {"family": "Needhamsen", "given": "Maria", "initials": "M"}, {"family": "Hagemann-Jensen", "given": "Michael", "initials": "M", "orcid": "0000-0002-6423-8216", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a67d94769764d37a2bf3febd4f79101.json"}}, {"family": "Ekman", "given": "Diana", "initials": "D"}, {"family": "Khademi", "given": "Mohsen", "initials": "M", "orcid": "0000-0003-0801-1444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22f8dcc673264db484e284e484bc7311.json"}}, {"family": "Nimer", "given": "Faiez Al", "initials": "FA", "orcid": "0000-0003-0937-5995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00758cc3da934cdbb9cb00c1df4b700f.json"}}, {"family": "Scicluna", "given": "Patrick", "initials": "P"}, {"family": "Faridani", "given": "Omid R", "initials": "OR", "orcid": "0000-0001-9330-887X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e25bf993bbee4163b352eef6f95cfd6c.json"}}, {"family": "Olsson", "given": "Tomas", "initials": "T"}, {"family": "Piehl", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-8329-5219", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/512835c06e9e476bbefa2734c08c8f7e.json"}}, {"family": "Jagodic", "given": "Maja", "initials": "M", "orcid": "0000-0003-0756-889X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e6419051c5746a8bf3fe7ce3d841a2a.json"}}], "type": "posted-content", "published": "2020-05-16", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.05.15.097519", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T14:41:22.336Z", "modified": "2026-09-23T14:41:22.619Z"}]}