{"entity": "publication", "iuid": "ffc8435578eb45fa8683122d05172dca", "timestamp": "2026-09-27T17:00:09.888Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ffc8435578eb45fa8683122d05172dca.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ffc8435578eb45fa8683122d05172dca"}}, "title": "High CD45 expression of CD8+ and CD4+ T cells correlates with the size of HIV-1 reservoir in blood.", "authors": [{"family": "Petkov", "given": "Stefan", "initials": "S"}, {"family": "Bekele", "given": "Yonas", "initials": "Y"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T"}, {"family": "Hejdeman", "given": "Bo", "initials": "B"}, {"family": "Zazzi", "given": "Maurizio", "initials": "M"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Chiodi", "given": "Francesca", "initials": "F"}], "type": "journal article", "published": "2020-11-24", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "10", "issue": "1", "pages": "20425", "issn-l": "2045-2322"}, "abstract": "Using mass cytometry, we investigated the expression of 28 markers on CD8+ and CD4+ T cells from HIV-1 infected patients with a variable size of HIV-1 reservoir defined as high (HR) and low (LR) reservoir; we aimed at identifying phenotypic associations of T cells with size of HIV-1 reservoir. We showed that the frequency of CD45+ CD8+ and CD4+ T cells was directly proportional to the size of HIV-1 reservoir; HR patients had a significantly larger frequency of blood CD45high T cells and higher CD45 expression on both CD8+ and CD4+ T cells. CD45 is a receptor-type protein tyrosine phosphatase essential in TCR signaling. Functional and phenotypical analysis of CD45high cells revealed that they express activation and proliferation markers (CD38 + HLA-DR + and Ki-67) and produce cytokines upon in vitro activation. CD45high T cells also expressed high levels of immune check-point PD-1. Our results link CD45 expression on T cells to HIV-1 reservoir; PD-1 expression on CD45high T cells may contribute to their exhaustion.", "doi": "10.1038/s41598-020-77433-z", "pmid": "33235273", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7686502"}, {"db": "pii", "key": "10.1038/s41598-020-77433-z"}], "notes": [], "created": "2026-09-23T12:47:09.626Z", "modified": "2026-09-23T12:47:09.639Z"}