{"entity": "publication", "iuid": "fc271c597f44434fb62fd220c6c65288", "timestamp": "2026-10-05T01:22:55.053Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fc271c597f44434fb62fd220c6c65288.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fc271c597f44434fb62fd220c6c65288"}}, "title": "A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status.", "authors": [{"family": "Zhou", "given": "Robin Ziyue", "initials": "RZ"}, {"family": "Vetrano", "given": "Davide Liborio", "initials": "DL"}, {"family": "Grande", "given": "Giulia", "initials": "G"}, {"family": "Duell", "given": "Frida", "initials": "F"}, {"family": "J\u00f6nsson", "given": "Linus", "initials": "L"}, {"family": "Laukka", "given": "Erika J", "initials": "EJ"}, {"family": "Fredolini", "given": "Claudia", "initials": "C"}, {"family": "Winblad", "given": "Bengt", "initials": "B"}, {"family": "Tjernberg", "given": "Lars", "initials": "L"}, {"family": "Schedin-Weiss", "given": "Sophia", "initials": "S"}], "type": "journal article", "published": "2023-07-00", "journal": {"title": "Alzheimers Dement", "issn": "1552-5279", "volume": "19", "issue": "7", "pages": "3244-3249", "issn-l": "1552-5260"}, "abstract": "There is an urgent need for novel blood biomarkers for the detection of Alzheimer's disease (AD). We previously showed that levels of the bisecting N-acetylglucosamine glycan epitope was elevated in cerebrospinal fluid in AD. However, its diagnostic value in blood is unknown.\n\nWe analyzed blood levels of bisecting N-acetylglucosamine and total tau in a retrospective cohort of 233 individuals. Progression to AD was compared between the groups using Cox regression. The predictive value of the biomarkers was determined by logistic regression.\n\nBisecting N-acetylglucosamine correlated with tau levels (p < 0.0001). Individuals with an intermediate tau/bisecting N-acetylglucosamine ratio had elevated AD risk (hazard ratio = 2.06, 95% confidence interval [CI]: 1.18-3.6). Moreover, a combined model including tau/bisecting N-acetylglucosamine ratio, apolipoprotein E (APOE) \u03b54 status, and Mini-Mental State Examination score predicted future AD (area under the curve = 0.81, 95% CI: 0.68-0.93).\n\nBisecting N-acetylglucosamine in combination with tau is a valuable blood biomarker for predicting AD.", "doi": "10.1002/alz.13024", "pmid": "37042462", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T11:17:58.867Z", "modified": "2026-09-23T11:17:58.886Z"}