{"entity": "publication", "iuid": "f80cf87c4f0a45bf8d00404ca231516a", "timestamp": "2026-08-26T22:46:51.893Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f80cf87c4f0a45bf8d00404ca231516a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f80cf87c4f0a45bf8d00404ca231516a"}}, "title": "Smad7 Enhances TGF-\u03b2-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells.", "authors": [{"family": "Thakur", "given": "Noopur", "initials": "N"}, {"family": "Hamidi", "given": "Anahita", "initials": "A"}, {"family": "Song", "given": "Jie", "initials": "J"}, {"family": "Itoh", "given": "Susumu", "initials": "S"}, {"family": "Bergh", "given": "Anders", "initials": "A"}, {"family": "Heldin", "given": "Carl-Henrik", "initials": "CH"}, {"family": "Landstr\u00f6m", "given": "Mar\u00e9ne", "initials": "M"}], "type": "journal article", "published": "2020-09-25", "journal": {"title": "iScience", "issn": "2589-0042", "volume": "23", "issue": "9", "pages": "101470", "issn-l": null}, "abstract": "Transforming growth factor \u03b2 (TGF-\u03b2) enhances migration and invasion of cancer cells, causing life-threatening metastasis. Smad7 expression is induced by TGF-\u03b2 to control TGF-\u03b2 signaling in a negative feedback manner. Here we report an additional function of Smad7, i.e., to enhance TGF-\u03b2 induction of c-Jun and HDAC6 via binding to their regulatory regions, promoting migration and invasion of prostate cancer cells. Lysine 102 in Smad7 is crucial for binding to specific consensus sites in c-Jun and HDAC6, even when endogenous Smad2, 3, and 4 were silenced by siRNA. A correlation between the mRNA expression of Smad7 and HDAC6, Smad7 and c-Jun, and c-Jun and HDAC6 was found in public databases from analyses of prostate cancer tissues. High expression of Smad7, HDAC6, and c-Jun correlated with poor prognosis for patients with prostate cancer. The knowledge that Smad7 can activate transcription of proinvasive genes leading to prostate cancer progression provides clinically relevant information.", "doi": "10.1016/j.isci.2020.101470", "pmid": "32888405", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7520897"}, {"db": "pii", "key": "S2589-0042(20)30662-3"}], "notes": [], "created": "2026-08-20T07:57:32.026Z", "modified": "2026-08-20T07:57:32.075Z"}